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Article ; Online: Studies on the structural and optical properties of samarium β-diketonate complex incorporated electrospun poly(methylmethacrylate) nanofibres with different architectures.

Philip, Princy / Jose, Tomlal / Jose, Adon / Cherian, Shijo K

Luminescence : the journal of biological and chemical luminescence

2021 Volume 36, Issue 4, Page(s) 1032–1047

Abstract: Electrospinning is the most favourable method for production of polymer nanofibres. In this study, we prepared a samarium β-diketonate complex that incorporated pure, surface-roughened and coaxial hollow poly(methylmethacrylate) (PMMA) nanofibres through ...

Abstract	Electrospinning is the most favourable method for production of polymer nanofibres. In this study, we prepared a samarium β-diketonate complex that incorporated pure, surface-roughened and coaxial hollow poly(methylmethacrylate) (PMMA) nanofibres through electrospinning. The successful incorporation of this samarium complex into the PMMA nanofibres with different architectures was elucidated through various structural and morphological studies. Optical investigations as well as other characterization techniques for the pure, surface-roughened and coaxial hollow PMMA nanofibres before and after incorporating the samarium β-diketonate complex explained the host matrix nature of the PMMA nanofibres. Photoluminescence properties of the pure and structurally modified PMMA nanofibres were enhanced two or three times after incorporating the samarium complex into the fibre. Comparison of the optical properties between the pure and structurally modified PMMA nanofibres incorporating the samarium β-diketonate complex demonstrated the structural and optical improvements as well as the better host matrix nature of the surface-roughened and coaxial hollow PMMA nanofibres over pure PMMA nanofibres for the samarium β-diketonate complex. These optical enhancements make these materials applicable for various optical devices.
MeSH term(s)	Nanofibers ; Polymers ; Polymethyl Methacrylate ; Samarium
Chemical Substances	Polymers ; Samarium (42OD65L39F) ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4029
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Article ; Online: Impact of jail-based methadone or buprenorphine treatment on non-fatal opioid overdose after incarceration.

Cherian, Teena / Lim, Sungwoo / Katyal, Monica / Goldfeld, Keith S / McDonald, Ryan / Wiewel, Ellen / Khan, Maria / Krawczyk, Noa / Braunstein, Sarah / Murphy, Sean M / Jalali, Ali / Jeng, Philip J / Rosner, Zachary / MacDonald, Ross / Lee, Joshua D

Drug and alcohol dependence

2024 Volume 259, Page(s) 111274

Abstract: Background: Non-fatal overdose is a leading predictor of subsequent fatal overdose. For individuals who are incarcerated, the risk of experiencing an overdose is highest when transitioning from a correctional setting to the community. We assessed if ... ...

Abstract	Background: Non-fatal overdose is a leading predictor of subsequent fatal overdose. For individuals who are incarcerated, the risk of experiencing an overdose is highest when transitioning from a correctional setting to the community. We assessed if enrollment in jail-based medications for opioid use disorder (MOUD) is associated with lower risk of non-fatal opioid overdoses after jail release among individuals with opioid use disorder (OUD). Methods: This was a retrospective, observational cohort study of adults with OUD who were incarcerated in New York City jails and received MOUD or did not receive any MOUD (out-of-treatment) within the last three days before release to the community in 2011-2017. The outcome was the first non-fatal opioid overdose emergency department (ED) visit within 1 year of jail release during 2011-2017. Covariates included demographic, clinical, incarceration-related, and other characteristics. We performed multivariable cause-specific Cox proportional hazards regression analysis to compare the risk of non-fatal opioid overdose ED visits within 1 year after jail release between groups. Results: MOUD group included 8660 individuals with 17,119 incarcerations; out-of-treatment group included 10,163 individuals with 14,263 incarcerations. Controlling for covariates and accounting for competing risks, in-jail MOUD was associated with lower non-fatal opioid overdose risk within 14 days after jail release (adjusted HR=0.49, 95% confidence interval=0.33-0.74). We found no significant differences 15-28, 29-56, or 57-365 days post-release. Conclusion: MOUD group had lower risk of non-fatal opioid overdose immediately after jail release. Wider implementation of MOUD in US jails could potentially reduce post-release overdoses, ED utilization, and associated healthcare costs.
Language	English
Publishing date	2024-03-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2024.111274
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Article ; Online: Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis.

Yao, Jiangwei / Cherian, Philip T / Frank, Matthew W / Rock, Charles O

The Journal of biological chemistry

2015 Volume 290, Issue 31, Page(s) 18874–18888

Abstract: The obligate intracellular parasite Chlamydia trachomatis has a reduced genome and is thought to rely on its mammalian host cell for nutrients. Although several lines of evidence suggest C. trachomatis utilizes host phospholipids, the bacterium encodes ... ...

Abstract	The obligate intracellular parasite Chlamydia trachomatis has a reduced genome and is thought to rely on its mammalian host cell for nutrients. Although several lines of evidence suggest C. trachomatis utilizes host phospholipids, the bacterium encodes all the genes necessary for fatty acid and phospholipid synthesis found in free living Gram-negative bacteria. Bacterially derived phospholipids significantly increased in infected HeLa cell cultures. These new phospholipids had a distinct molecular species composition consisting of saturated and branched-chain fatty acids. Biochemical analysis established the role of C. trachomatis-encoded acyltransferases in producing the new disaturated molecular species. There was no evidence for the remodeling of host phospholipids and no change in the size or molecular species composition of the phosphatidylcholine pool in infected HeLa cells. Host sphingomyelin was associated with C. trachomatis isolated by detergent extraction, but it may represent contamination with detergent-insoluble host lipids rather than being an integral bacterial membrane component. C. trachomatis assembles its membrane systems from the unique phospholipid molecular species produced by its own fatty acid and phospholipid biosynthetic machinery utilizing glucose, isoleucine, and serine.
MeSH term(s)	Acyltransferases/metabolism ; Bacterial Proteins/metabolism ; Biosynthetic Pathways ; Cardiolipins/biosynthesis ; Cell Membrane/metabolism ; Chlamydia Infections/microbiology ; Chlamydia trachomatis/metabolism ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Lipogenesis ; Phosphatidylethanolamines/biosynthesis
Chemical Substances	Bacterial Proteins ; Cardiolipins ; Phosphatidylethanolamines ; Acyltransferases (EC 2.3.-)
Language	English
Publishing date	2015-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M115.657148
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Article: Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. aureus Infection with Osseointegration in Murine Models of Implant-Associated Osteomyelitis.

Xie, Chao / Ren, Youliang / Weeks, Jason / Xue, Thomas / Rainbolt, Joshua / Bentley, Karen de Mesy / Shu, Ye / Liu, Yuting / Masters, Elysia / Cherian, Philip / McKenna, Charles / Neighbors, Jeffrey / Ebetino, Frank / Schwarz, Edward / Sun, Shuting

Research square

2023

Abstract: Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve "target-and- ...

Abstract	Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve "target-and-release" drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in vivo. Here we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA (USA300LAC::lux). Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging (BLI) after debridement and implant exchange surgery on day 7, and mice were randomized into seven groups: 1) Baseline (harvested at day 7, no treatment); 2) HPBP (bisphosphonate control for BCS) + vancomycin; 3) HPHBP (bisphosphonate control for HBCS) + vancomycin; 4) vancomycin; 5) sitafloxacin; 6) BCS + vancomycin; and 7) HBCS + vancomycin. BLI confirmed infection persisted in all groups except for mice treated with BCS or HBCS + vancomycin. Radiology revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS + vancomycin, which also displayed decreases in peri-implant bone loss, osteoclast numbers, and biofilm. To confirm this, we assessed the efficacy of vancomycin, sitafloxacin, and HBCS monotherapy in a transtibial implant model. The results showed complete lack of vancomycin efficacy, while all mice treated with HBCS had evidence of infection control, and some had evidence of osseous integrated septic implants, suggestive of biofilm eradication. Taken together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis.
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2856287/v1
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Article ; Online: New β-lactam - Tetramic acid hybrids show promising antibacterial activities.

Cherian, Philip T / Cheramie, Martin N / Marreddy, Ravi K R / Fernando, Dinesh M / Hurdle, Julian G / Lee, Richard E

Bioorganic & medicinal chemistry letters

2018 Volume 28, Issue 18, Page(s) 3105–3112

Abstract: β-Lactams are the most important class of antibiotics, for which the emergence of resistance threatens their utility. As such, we explored the extent to which the tetramic acid motif, frequently found in naturally occurring antibiotics, can be used to ... ...

Abstract	β-Lactams are the most important class of antibiotics, for which the emergence of resistance threatens their utility. As such, we explored the extent to which the tetramic acid motif, frequently found in naturally occurring antibiotics, can be used to generate novel β-lactam antibiotics with improved antibacterial activity. We synthesized new ampicillin - tetramic acid, cephalosporin - tetramic acid, and cephamycin - tetramic acid analogs and evaluated their activities against problematic Gram-positive and Gram-negative pathogens. Amongst the analogs, a 7-aminocephalosporanic acid analog, 3397, and a 7-amino-3-vinyl cephalosporanic acid, 3436, showed potent activities against S. aureus NRS 70 (MRSA) with MICs of 6.25 μg/mL and 3.13 μg/mL respectively. These new analogs were ≥16-fold more potent than cefaclor and cephalexin. Additionally, a Δ
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Dose-Response Relationship, Drug ; Escherichia coli/drug effects ; Klebsiella pneumoniae/drug effects ; Lactams/chemistry ; Lactams/pharmacology ; Microbial Sensitivity Tests ; Molecular Structure ; Pyrrolidinones/chemistry ; Pyrrolidinones/pharmacology ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship
Chemical Substances	Anti-Bacterial Agents ; Lactams ; Pyrrolidinones ; tetramic acid (503-83-3)
Language	English
Publishing date	2018-07-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2018.07.018
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Article: Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics.

Cherian, Philip T / Deshpande, Aditi / Cheramie, Martin N / Bruhn, David F / Hurdle, Julian G / Lee, Richard E

The Journal of antibiotics

2017 Volume 70, Issue 1, Page(s) 65–72

Abstract: Exploiting iron-uptake pathways by conjugating β-lactam antibiotics with iron-chelators, such as catechol and hydroxamic acid is a proven strategy to overcome permeability-related resistance in Gram-negative bacteria. As naturally occurring iron- ... ...

Abstract	Exploiting iron-uptake pathways by conjugating β-lactam antibiotics with iron-chelators, such as catechol and hydroxamic acid is a proven strategy to overcome permeability-related resistance in Gram-negative bacteria. As naturally occurring iron-chelating tetramic acids have not been previously examined for this purpose, an exploratory series of novel ampicillin-tetramic acid hybrids that structurally resemble ureidopenicillins was designed and synthesized. The new analogs were evaluated for the ability to chelate iron and their MIC activities determined against a representative panel of clinically significant bacterial pathogens. The tetramic acid β-lactam hybrids demonstrated a high affinity to iron in the order of 10
MeSH term(s)	Ampicillin/administration & dosage ; Ampicillin/chemical synthesis ; Ampicillin/pharmacology ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Drug Design ; Drug Resistance, Bacterial ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Microbial Sensitivity Tests ; Pyrrolidinones/administration & dosage ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/pharmacology ; Siderophores/metabolism ; Species Specificity ; beta-Lactamases/metabolism ; beta-Lactams/administration & dosage ; beta-Lactams/chemical synthesis ; beta-Lactams/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Pyrrolidinones ; Siderophores ; beta-Lactams ; tetramic acid (503-83-3) ; Ampicillin (7C782967RD) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2017-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390800-8
ISSN	1881-1469 ; 0021-8820 ; 0368-3532
ISSN (online)	1881-1469
ISSN	0021-8820 ; 0368-3532
DOI	10.1038/ja.2016.52
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Article: Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis.

Ren, Youliang / Weeks, Jason / Xue, Thomas / Rainbolt, Joshua / de Mesy Bentley, Karen L / Shu, Ye / Liu, Yuting / Masters, Elysia / Cherian, Philip / McKenna, Charles E / Neighbors, Jeffrey / Ebetino, Frank H / Schwarz, Edward M / Sun, Shuting / Xie, Chao

Bone research

2023 Volume 11, Issue 1, Page(s) 51

Abstract	Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve "target-and-release" drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in vivo. Here we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA (USA300LAC::lux). Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging (BLI) after debridement and implant exchange surgery on day 7, and mice were randomized into seven groups: 1) Baseline (harvested at day 7, no treatment); 2) HPBP (bisphosphonate control for BCS) + vancomycin; 3) HPHBP (hydroxybisphosphonate control for HBCS) + vancomycin; 4) vancomycin; 5) sitafloxacin; 6) BCS + vancomycin; and 7) HBCS + vancomycin. BLI confirmed infection persisted in all groups except for mice treated with BCS or HBCS + vancomycin. Radiology revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS + vancomycin, which also displayed decreases in peri-implant bone loss, osteoclast numbers, and biofilm. To confirm this, we assessed the efficacy of vancomycin, sitafloxacin, and HBCS monotherapy in a transtibial implant model. The results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control, and some had evidence of osseous integrated septic implants, suggestive of biofilm eradication. Taken together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis.
MeSH term(s)	Mice ; Animals ; Vancomycin/therapeutic use ; Methicillin/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Methicillin Resistance ; Staphylococcal Infections/drug therapy ; Osseointegration ; Disease Models, Animal ; Osteomyelitis/drug therapy
Chemical Substances	Vancomycin (6Q205EH1VU) ; Methicillin (Q91FH1328A) ; Anti-Bacterial Agents ; sitafloxacin (9TD681796G)
Language	English
Publishing date	2023-10-18
Publishing country	China
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2803313-9
ISSN	2095-6231 ; 2095-4700
ISSN (online)	2095-6231
ISSN	2095-4700
DOI	10.1038/s41413-023-00287-4
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Article ; Online: Jail-based medication for opioid use disorder and patterns of reincarceration and acute care use after release: A sequence analysis.

Lim, Sungwoo / Cherian, Teena / Katyal, Monica / Goldfeld, Keith S / McDonald, Ryan / Wiewel, Ellen / Khan, Maria / Krawczyk, Noa / Braunstein, Sarah / Murphy, Sean M / Jalali, Ali / Jeng, Philip J / Rosner, Zachary / MacDonald, Ross / Lee, Joshua D

Journal of substance use and addiction treatment

2023 Volume 158, Page(s) 209254

Abstract: Background: Treatment with methadone and buprenorphine medications for opioid use disorder (MOUD) during incarceration may lead to better community re-entry, but evidence on these relationships have been mixed. We aimed to identify community re-entry ... ...

Abstract	Background: Treatment with methadone and buprenorphine medications for opioid use disorder (MOUD) during incarceration may lead to better community re-entry, but evidence on these relationships have been mixed. We aimed to identify community re-entry patterns and examine the association between in-jail MOUD and a pattern of successful reentry defined by rare occurrence of reincarceration and preventable healthcare utilization. Methods: Data came from a retrospective, observational cohort study of 6066 adults with opioid use disorder who were incarcerated in New York City jails and released to the community during 2011-14. An outcome was community re-entry patterns identified by sequence analysis of 3-year post-release reincarceration, emergency department visits, and hospitalizations. An exposure was receipt of in-jail MOUD versus out-of-treatment (42 % vs. 58 %) for the last 3 days before discharge. The study accounted for differences in baseline demographic, clinical, behavioral, housing, and criminal legal characteristics between in-jail MOUD and out-of-treatment groups via propensity score matching. Results: This study identified five re-entry patterns: stability (64 %), hospitalization (23 %), delayed reincarceration (7 %), immediate reincarceration (4 %), and continuous incarceration (2 %). After addressing confounding, 64 % and 57 % followed the stability pattern among MOUD and out-of-treatment groups who were released from jail in 2011, respectively. In 2012-14, the prevalence of following the stability pattern increased year-by-year while a consistently higher prevalence was observed among those with in-jail MOUD. Conclusions: Sequence analysis helped define post-release stability based on health and criminal legal system involvement. Receipt of in-jail MOUD was associated with a marker of successful community re-entry.
MeSH term(s)	Adult ; Humans ; Jails ; Retrospective Studies ; Opioid-Related Disorders/drug therapy ; Methadone/therapeutic use ; Sequence Analysis
Chemical Substances	Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2023-12-10
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
ISSN	2949-8759
ISSN (online)	2949-8759
DOI	10.1016/j.josat.2023.209254
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Article ; Online: Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice.

Okawa, Hiroko / Kondo, Takeru / Hokugo, Akishige / Cherian, Philip / Sundberg, Oskar / Campagna, Jesus J / Kashemirov, Boris A / John, Varghese / Sun, Shuting / Ebetino, Frank H / McKenna, Charles E / Nishimura, Ichiro

Communications medicine

2022 Volume 2, Page(s) 112

Abstract: Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but serious side effect of nitrogen-containing bisphosphonate drugs (N-BPs) frequently prescribed to reduce skeletal-related events in bone malignancies and osteoporosis. ... ...

Abstract	Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but serious side effect of nitrogen-containing bisphosphonate drugs (N-BPs) frequently prescribed to reduce skeletal-related events in bone malignancies and osteoporosis. BRONJ is associated with abnormal oral wound healing after dentoalveolar surgery and tooth extraction. We previously found that N-BP chemisorbed to bone mineral hydroxyapatite was dissociated by secondary applied N-BP. This study investigated the effect of the surface equilibrium-based removal of N-BP from jawbone on tooth extraction wound healing of zoledronate (ZOL)-treated mice. Methods: A pharmacologically inactive N-BP derivative (the 4-pyridyl isomer of risedronate equipped with a near-infrared 800CW fluorescent imaging dye, 800CW-pRIS) was designed and synthesized. 800CW-pRIS was intra-orally injected or topically applied in a deformable nano-scale vesicle formulation (DNV) to the palatal tissue of mice pretreated with ZOL, a potent N-BP. The female C56BL6/J mice were subjected to maxillary molar extraction and oral wound healing was compared for 800CW-pRIS/ZOL, ZOL and untreated control groups. Results: 800CW-pRIS is confirmed to be inactive in inhibiting prenylation in cultured osteoclasts while retaining high affinity for hydroxyapatite. ZOL-injected mice exhibit delayed tooth extraction wound healing with osteonecrosis relative to the untreated controls. 800CW-pRIS applied topically to the jaw one week before tooth extraction significantly reduces gingival oral barrier inflammation, improves extraction socket bone regeneration, and prevents development of osteonecrosis in ZOL-injected mice. Conclusions: Topical pre-treatment with 800CW-RIS in DNV is a promising approach to prevent the complication of abnormal oral wound healing associated with BRONJ while retaining the anti-resorptive benefit of legacy N-BP in appendicular or vertebrate bones.
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-022-00172-x
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Article ; Online: Association between jail-based methadone or buprenorphine treatment for opioid use disorder and overdose mortality after release from New York City jails 2011-17.

Addiction (Abingdon, England)

2022 Volume 118, Issue 3, Page(s) 459–467

Abstract: Background and aims: Opioid overdose is a leading cause of death during the immediate time after release from jail or prison. Most jails in the United States do not provide methadone and buprenorphine treatment for opioid use disorder (MOUD), and ... ...

Abstract	Background and aims: Opioid overdose is a leading cause of death during the immediate time after release from jail or prison. Most jails in the United States do not provide methadone and buprenorphine treatment for opioid use disorder (MOUD), and research in estimating its impact in jail settings is limited. We aimed to test the hypothesis that in-jail MOUD is associated with lower overdose mortality risk post-release. Design, setting and participants: Retrospective, observational cohort study of 15 797 adults with opioid use disorder who were released from New York City jails to the community in 2011-2017. They experienced 31 382 incarcerations and were followed up to 1 year. Measurements: The primary outcomes were death caused by accidental drug poisoning and all-cause death. The exposure was receipt of MOUD (17 119 events) versus out-of-treatment (14 263 events) during the last 3 days before community re-entry. Covariates included demographic, clinical, behavioral, housing, health-care utilization and legal characteristics variables. We performed a multivariable, mixed-effect Cox regression analysis to test association between in-jail MOUD and deaths. Findings: The majority were male (82%) and their average age was 42 years. Receiving MOUD was associated with misdemeanor charges, being female, injection drug use and homelessness. During 1 year post-release, 111 overdose deaths occurred and crude death rates were 0.49 and 0.83 per 100 person-years for in-jail MOUD and out-of-treatment groups, respectively. Accounting for confounding and random effects, in-jail MOUD was associated with lower overdose mortality risk [adjusted hazard ratio (aHR) = 0.20, 95% confidence interval (CI) = 0.08-0.46] and all-cause mortality risk (aHR = 0.22, 95% CI = 0.11-0.42) for the first month post-release. Conclusions: Methadone and buprenorphine treatment for opioid use disorder during incarceration was associated with an 80% reduction in overdose mortality risk for the first month post-release.
MeSH term(s)	Adult ; Male ; Humans ; Female ; United States ; Methadone/therapeutic use ; Buprenorphine/therapeutic use ; Jails ; Retrospective Studies ; New York City/epidemiology ; Opiate Substitution Treatment ; Opioid-Related Disorders/therapy ; Drug Overdose ; Analgesics, Opioid/therapeutic use
Chemical Substances	Methadone (UC6VBE7V1Z) ; Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.16071
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In stock of ZB MED Cologne/Königswinter

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