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Article: O que podemos fazer para evitar as doenças inflamatórias intestinais? A importância da microbiota

Oba, Jane

International Journal of Nutrology

2017 Volume 10, Issue S 01, Page(s) S306–S312

Abstract: As doenças inflamatórias intestinais (DII) são doenças crônicas, multifatoriais, idiopáticas, caracterizadas pela inflamação crônica recidivante do trato gastrointestinal. As DII abrangem duas principais doenças, a retocolite ulcerativa (RCU) e a Doença ... ...

Abstract	As doenças inflamatórias intestinais (DII) são doenças crônicas, multifatoriais, idiopáticas, caracterizadas pela inflamação crônica recidivante do trato gastrointestinal. As DII abrangem duas principais doenças, a retocolite ulcerativa (RCU) e a Doença de Crohn (DC). A RCU é caracterizada por uma inflamação crônica da mucosa, limitada ao cólon, enquanto que a Doença de Crohnpode ocorrer em qualquer local do trato gastrointestinal e é caracterizada por uma inflamação focal, transmural. O curso clínico da RCU e DC é caracterizado por períodos de remissão alternados com exacerbação da doença e manifestações extra intestinais. É a interação mútua entre os fatores ambientais, os fatores imunológicos, os genes e a microbiota, que induz a doença. Todavia a sua etiopatogenia está longe de ser totalmente esclarecida. Nos últimos anos foram publicados vários estudos sobre as alterações da microbiota nesses pacientes demonstrando a importância desse fator. Conhecer os fatores de risco ambientais corrobora para o planejamento internacional na utilização de recursos para a saúde, iniciativas de pesquisa e podem ser um potencial alvo terapêutico, como foi exposto no último ESPGHAN 2016.
Keywords	Doença de Crohn ; Retocolite Ulcerativa ; microbiota ; Crohn’s Disease ; Ulcerative Colitis ; microbiota
Language	Portuguese
Publishing date	2017-03-01
Publisher	Thieme Revinter Publicações Ltda
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2595-2854 ; 1984-3011
ISSN (online)	2595-2854
ISSN	1984-3011
DOI	10.1055/s-0040-1705653
Database	Thieme publisher's database

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Article ; Online: Gastrointestinal manifestations and nutritional therapy during COVID-19 pandemic: a practical guide for pediatricians.

Oba, Jane / Carvalho, Werther Brunow de / Silva, Clovis Artur / Delgado, Artur Figueiredo

Einstein (Sao Paulo, Brazil)

2020 Volume 18, Page(s) eRW5774

Abstract: Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through the ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through the digestive system, the so-called fecal-oral route of transmission, and may induce several gastrointestinal manifestations. MEDLINE® and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. Findings and recommendations were pragmatically described to facilitate overall pediatric approach. A total of 196 studies addressing gastrointestinal or nutritional aspects associated with the global COVID-19 pandemic were found. Of these, only 17 focused specifically on pediatric patients with regard to aforementioned gastrointestinal or nutritional aspects. Most articles were descriptive and six addressed guidelines, established protocols, or expert opinions. Children and adolescents with gastrointestinal symptoms, such as nausea, vomiting and diarrhea, should be seriously suspected of COVID-19. Gastrointestinal signs and symptoms may occur in 3% to 79% of children, adolescents and adults with COVID-19, and are more common in severe cases. These include diarrhea (2% to 50%), anorexia (40% to 50%), vomiting (4% to 67%), nausea (1% to 30%), abdominal pain (2% to 6%) and gastrointestinal bleeding (4% to 14%). Patients with inflammatory bowel disease or chronic liver disease are not at greater risk of infection by SARS-CoV-2 relative to the general population. Nutritional support plays an important role in treatment of pediatric patients, particularly those with severe or critical forms of the disease. The digestive system may be a potential route of COVID-19 transmission. Further research is needed to determine whether the fecal-oral route may be involved in viral spread. Nutritional therapy is vital to prevent malnutrition and sarcopenia in severe cases.
MeSH term(s)	Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Gastrointestinal Diseases/virology ; Humans ; Nutritional Support ; Pandemics ; Pediatricians ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.31744/einstein_journal/2020rw5774
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Article ; Online: Label-free autofluorescence and hyperspectral imaging of cerebral amyloid-β lesions in aged squirrel monkeys

Oba, Ryohei / Ujike, Naoki / Ono, Yuki / Okano, Takayuki / Murakami, Tomoaki

Journal of Veterinary Diagnostic Investigation. 2024 Jan., v. 36, no. 1 p.41-45

2024

Abstract: The observation of amyloid-β (Aβ) lesions using autofluorescence in transgenic mice and human Alzheimer disease patients has been reported frequently. However, no reports verify the autofluorescence of spontaneous Aβ amyloidosis in animals, to our ... ...

Abstract	The observation of amyloid-β (Aβ) lesions using autofluorescence in transgenic mice and human Alzheimer disease patients has been reported frequently. However, no reports verify the autofluorescence of spontaneous Aβ amyloidosis in animals, to our knowledge. We validated the autofluorescence of Aβ lesions in spontaneous squirrel monkey cases under label-free conditions; lesions had intense blue-white autofluorescence in fluorescence microscopy using excitation light at 400–440 nm. Thioflavin S staining and immunohistochemistry of the same specimens revealed that this blue-white autofluorescence was derived from Aβ lesions. Hyperspectral analysis of these lesions revealed a characteristic spectrum with bimodal peaks at 440 and 460 nm, as reported for Aβ lesions in mice. Principal component analysis using hyperspectral data specifically separated the Aβ lesions from other autofluorescent substances, such as lipofuscin. A non-labeled and mechanistic detection of Aβ lesions by hyperspectral imaging could provide valuable insights for developing early diagnostic techniques.
Keywords	Alzheimer disease ; Saimiri ; amyloidosis ; fluorescence microscopy ; genetically modified organisms ; humans ; hyperspectral imagery ; immunohistochemistry ; principal component analysis ; squirrels ; amyloid-β ; autofluorescence ; hyperspectral imaging
Language	English
Dates of publication	2024-01
Size	p. 41-45.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387231204876
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: COVID-19 and coinfection with Clostridioides (Clostridium) difficile in an infant with gastrointestinal manifestation.

Oba, Jane / Silva, Clovis Artur / Toma, Ricardo Katsuya / Carvalho, Werther Brunow de / Delgado, Artur Figueiredo

Einstein (Sao Paulo, Brazil)

2020 Volume 18, Page(s) eRC6048

Abstract: We report the clinical case of an infant with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with gastrointestinal signs and symptoms, predominantly vomiting. The patient also had colic, poor feeding, mild diarrhea and mild ... ...

Abstract	We report the clinical case of an infant with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with gastrointestinal signs and symptoms, predominantly vomiting. The patient also had colic, poor feeding, mild diarrhea and mild rhinorrhea without fever. The child had evidence of altered coagulation, increased interleukin 10, moderate dehydration and she was admitted to the pediatric intensive care unit. Simultaneously, the patient was diagnosed as Clostridioides difficile infection, which possibly may have facilitated the persistence of SARS-CoV-2 in feces, for more than 27 days, even after the nasopharyngeal test turned negative. This coinfection might exacerbate the gastrointestinal signs and symptoms and increased the possibility of fecal-oral transmission of SARS-CoV-2 and Clostridioides . The patient was breastfed and received complementary infant formula, hydrated with intravenous fluid, and was discharged without complications, 4 days after admission.
MeSH term(s)	COVID-19 ; Clostridioides ; Clostridium ; Coinfection/epidemiology ; Female ; Humans ; Infant ; SARS-CoV-2
Language	Portuguese
Publishing date	2020-12-07
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.31744/einstein_journal/2020RC6048
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Article ; Online: 'We are not all in the same boat. We are in the same storm. Some are on super-yachts. Some have just the one oar.' How COVID-19 exaggerated global inequities in professional sport.

Mkumbuzi, Nonhlanhla Sharon / Zondi, Phathokuhle Cele / Owoeye, Oluwatoyosi B A / Thornton, Jane S / Kemp, Joanne / Drezner, Jonathan A

British journal of sports medicine

2022 Volume 57, Issue 4, Page(s) 191–192

MeSH term(s)	Humans ; COVID-19 ; Sports
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Editorial
ZDB-ID	600592-5
ISSN	1473-0480 ; 0306-3674
ISSN (online)	1473-0480
ISSN	0306-3674
DOI	10.1136/bjsports-2022-106048
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Article ; Online: Gastrointestinal manifestations and nutritional therapy during COVID-19 pandemic

Oba, Jane / Carvalho, Werther Brunow de / Silva, Clovis Artur / Delgado, Artur Figueiredo

Einstein (São Paulo) v.18 2020

a practical guide for pediatricians

2020

Abstract: ABSTRACT Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through ... ...

Abstract	ABSTRACT Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through the digestive system, the so-called fecal-oral route of transmission, and may induce several gastrointestinal manifestations. MEDLINE® and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. Findings and recommendations were pragmatically described to facilitate overall pediatric approach. A total of 196 studies addressing gastrointestinal or nutritional aspects associated with the global COVID-19 pandemic were found. Of these, only 17 focused specifically on pediatric patients with regard to aforementioned gastrointestinal or nutritional aspects. Most articles were descriptive and six addressed guidelines, established protocols, or expert opinions. Children and adolescents with gastrointestinal symptoms, such as nausea, vomiting and diarrhea, should be seriously suspected of COVID-19. Gastrointestinal signs and symptoms may occur in 3% to 79% of children, adolescents and adults with COVID-19, and are more common in severe cases. These include diarrhea (2% to 50%), anorexia (40% to 50%), vomiting (4% to 67%), nausea (1% to 30%), abdominal pain (2% to 6%) and gastrointestinal bleeding (4% to 14%). Patients with inflammatory bowel disease or chronic liver disease are not at greater risk of infection by SARS-CoV-2 relative to the general population. Nutritional support plays an important role in treatment of pediatric patients, particularly those with severe or critical forms of the disease. The digestive system may be a potential route of COVID-19 transmission. Further research is needed to determine whether the fecal-oral route may be involved in viral spread. Nutritional therapy is vital to prevent malnutrition and sarcopenia in severe cases.
Keywords	Coronavirus infections/complications ; COVID-19 ; Betacoronavirus ; SARS-CoV-2 ; Gastrointestinal diseases/etiology ; Nutritional therapy ; Inflammatory bowel diseases ; Child ; Adolescent ; covid19
Subject code	610
Language	English
Publishing date	2020-01-01
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gastrointestinal manifestations and nutritional therapy during COVID-19 pandemic

Jane Oba / Werther Brunow de Carvalho / Clovis Artur Silva / Artur Figueiredo Delgado

Einstein (São Paulo), Vol

a practical guide for pediatricians

2020 Volume 18

Abstract	ABSTRACT Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through the digestive system, the so-called fecal-oral route of transmission, and may induce several gastrointestinal manifestations. MEDLINE® and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. Findings and recommendations were pragmatically described to facilitate overall pediatric approach. A total of 196 studies addressing gastrointestinal or nutritional aspects associated with the global COVID-19 pandemic were found. Of these, only 17 focused specifically on pediatric patients with regard to aforementioned gastrointestinal or nutritional aspects. Most articles were descriptive and six addressed guidelines, established protocols, or expert opinions. Children and adolescents with gastrointestinal symptoms, such as nausea, vomiting and diarrhea, should be seriously suspected of COVID-19. Gastrointestinal signs and symptoms may occur in 3% to 79% of children, adolescents and adults with COVID-19, and are more common in severe cases. These include diarrhea (2% to 50%), anorexia (40% to 50%), vomiting (4% to 67%), nausea (1% to 30%), abdominal pain (2% to 6%) and gastrointestinal bleeding (4% to 14%). Patients with inflammatory bowel disease or chronic liver disease are not at greater risk of infection by SARS-CoV-2 relative to the general population. Nutritional support plays an important role in treatment of pediatric patients, particularly those with severe or critical forms of the disease. The digestive system may be a potential route of COVID-19 transmission. Further research is needed to determine whether the fecal-oral route may be involved in viral spread. Nutritional therapy is vital to ...
Keywords	Coronavirus infections/complications ; COVID-19 ; Betacoronavirus ; SARS-CoV-2 ; Gastrointestinal diseases/etiology ; Nutritional therapy ; Inflammatory bowel diseases ; Child ; Adolescent ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Active tuberculosis in inflammatory bowel disease patients: a case-control study.

Freitas Cardoso de Azevedo, Matheus / Barros, Luísa Leite / Fernandes Justus, Filipe / Oba, Jane / Soares Garcia, Karoline / de Almeida Martins, Camilla / de Sousa Carlos, Alexandre / Arruda Leite, André Zonetti / Miranda Sipahi, Aytan / Queiroz, Natália Sousa Freitas / Omar Mourão Cintra Damião, Adérson

Therapeutic advances in gastroenterology

2023 Volume 16, Page(s) 17562848231179871

Abstract: Background/aims: Anti-tumor necrosis factor (anti-TNF) drugs have been the mainstay therapy for moderate to severe inflammatory bowel disease (IBD) over the past 25 years. Nevertheless, these drugs are associated with serious opportunistic infections ... ...

Abstract	Background/aims: Anti-tumor necrosis factor (anti-TNF) drugs have been the mainstay therapy for moderate to severe inflammatory bowel disease (IBD) over the past 25 years. Nevertheless, these drugs are associated with serious opportunistic infections like tuberculosis (TB). Brazil is ranked among the 30 countries with the highest incidence of TB in the world. This study aimed at identifying risk factors for the development of active TB and describing clinical characteristics and outcomes in IBD patients followed at a tertiary referral center in Brazil. Methods: We conducted a retrospective, case-control study between January 2010 and December 2021. Active TB cases in IBD patients were randomly matched 1:3 to controls (IBD patients with no previous history of active TB) according to gender, age, and type of IBD. Design: This was a retrospective, case-control study. Results: A total of 38 (2.2%) cases of TB were identified from 1760 patients under regular follow-up at our outpatient clinics. Of the 152 patients included in the analysis (cases and controls), 96 (63.2%) were male, and 124 (81.6%) had Crohn's disease. Median age at TB diagnosis was 39.5 [interquartile range (IQR) 30.8-56.3]. Half of the active TB cases were disseminated (50%). Overall, 36 patients with TB (94.7%) were being treated with immunosuppressive medications. Of those, 31 (86.1%) were under anti-TNF drugs. Diagnosis of TB occurred at a median of 32 months after the first dose of anti-TNF (IQR 7-84). In multivariate analysis, IBD diagnosis older than 17 years and anti-TNF therapy were significantly associated with the development of TB ( Conclusions: TB remains a significant health problem in IBD patients from endemic regions, especially those treated with anti-TNFs. In addition, age at IBD diagnosis (>17 years old) was also a risk factor for active TB. Most cases occur after long-term therapy, suggesting a new infection. The reintroduction of anti-TNFs agents after the anti-TB treatment seems safe. These data highlight the importance of TB screening and monitoring in IBD patients living in endemic areas.
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2440710-0
ISSN	1756-2848 ; 1756-283X
ISSN (online)	1756-2848
ISSN	1756-283X
DOI	10.1177/17562848231179871
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: BRAZILIAN CONSENSUS ON THE MANAGEMENT OF INFLAMMATORY BOWEL DISEASES IN PEDIATRIC PATIENTS: A CONSENSUS OF THE BRAZILIAN ORGANIZATION FOR CROHN'S DISEASE AND COLITIS (GEDIIB).

Lomazi, Elizete Aparecida / Oba, Jane / Rodrigues, Maraci / Marmo, Michela Cynthia da Rocha / Sandy, Natascha Silva / Sdepanian, Vera Lucia / Imbrizi, Marcello / Baima, Júlio Pinheiro / Magro, Daniéla Oliveira / Albuquerque, Idblan Carvalho de / Zabot, Gilmara Pandolfo / Cassol, Ornella Sari / Saad-Hossne, Rogério

Arquivos de gastroenterologia

2023 Volume 59, Issue suppl 1, Page(s) 85–124

Abstract: Background: Approximately 25% of patients with inflammatory bowel disease (IBD) develop the disease during childhood or adolescence and treatment aims to control active symptoms and prevent long-term complications. The management of Crohn's disease (CD) ...

Abstract	Background: Approximately 25% of patients with inflammatory bowel disease (IBD) develop the disease during childhood or adolescence and treatment aims to control active symptoms and prevent long-term complications. The management of Crohn's disease (CD) and ulcerative colitis (UC) can be especially challenging in children and adolescents, related to particularities that may affect growth, development, and puberty. Objective: This consensus aims to provide guidance on the most effective medical and surgical management of pediatric patients with CD or UC. Methods: Experts in Pediatric IBD representing Brazilian gastroenterologists (Brazilian Organization for Crohn's Disease and Colitis [GEDIIB]) developed this consensus. A rapid review was performed to support the recommendations/statements. Medical and surgical recommendations were structured and mapped according to the disease type, disease activity, and indications and contraindications for medical and surgical treatment. After structuring the statements, the modified Delphi Panel methodology was used to conduct the voting. The process took place in three rounds: two using a personalized and anonymous online voting platform and one face-to-face. Whenever participants did not agree with a specific recommendation, an option to explain why was offered to enable free-text responses and provide the opportunity for the experts to elaborate or explain disagreement. The consensus of recommendations in each round was accepted when reached ≥80% agreement. Results and conclusion: The recommendations are presented according to the stage of treatment and severity of the disease in three domains: management and treatment (drug and surgical interventions), criteria for evaluating the effectiveness of medical treatment, and follow-up/ patient monitoring after initial treatment, follow-up/ patient monitoring after initial treatment. Surgical recommendations were grouped according to disease type and recommended surgery. The target audience for this consensus was general practitioners, gastroenterologists, and surgeons interested in the treatment and management of pediatric CD and UC. Additionally, the consensus aimed to support the decision-making of health insurance companies, regulatory agencies, and health institutional leaders and/or administrators.
MeSH term(s)	Adolescent ; Humans ; Child ; Crohn Disease/therapy ; Crohn Disease/diagnosis ; Consensus ; Brazil ; Inflammatory Bowel Diseases/therapy ; Colitis, Ulcerative/diagnosis
Language	English
Publishing date	2023-03-24
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-2803.2022005S1-04
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Gastrointestinal manifestations and nutritional therapy during COVID-19 pandemic: a practical guide for pediatricians

Oba, Jane / Carvalho, Werther Brunow de / Silva, Clovis Artur / Delgado, Artur Figueiredo

Einstein (Sao Paulo)

Abstract	Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through the digestive system, the so-called fecal-oral route of transmission, and may induce several gastrointestinal manifestations. MEDLINE® and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. Findings and recommendations were pragmatically described to facilitate overall pediatric approach. A total of 196 studies addressing gastrointestinal or nutritional aspects associated with the global COVID-19 pandemic were found. Of these, only 17 focused specifically on pediatric patients with regard to aforementioned gastrointestinal or nutritional aspects. Most articles were descriptive and six addressed guidelines, established protocols, or expert opinions. Children and adolescents with gastrointestinal symptoms, such as nausea, vomiting and diarrhea, should be seriously suspected of COVID-19. Gastrointestinal signs and symptoms may occur in 3% to 79% of children, adolescents and adults with COVID-19, and are more common in severe cases. These include diarrhea (2% to 50%), anorexia (40% to 50%), vomiting (4% to 67%), nausea (1% to 30%), abdominal pain (2% to 6%) and gastrointestinal bleeding (4% to 14%). Patients with inflammatory bowel disease or chronic liver disease are not at greater risk of infection by SARS-CoV-2 relative to the general population. Nutritional support plays an important role in treatment of pediatric patients, particularly those with severe or critical forms of the disease. The digestive system may be a potential route of COVID-19 transmission. Further research is needed to determine whether the fecal-oral route may be involved in viral spread. Nutritional therapy is vital to prevent malnutrition and sarcopenia in severe cases.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #646760
Database	COVID19

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