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  1. Article ; Online: Removing antigens but not cells: a key to AMIS?

    Kapur, Rick

    Blood

    2023  Volume 142, Issue 12, Page(s) 1034–1036

    MeSH term(s) Antibodies ; Immune Tolerance ; Immunosuppression Therapy
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Boosting mAb therapy: CAR T cells unblock macrophages.

    Kapur, Rick

    Blood

    2023  Volume 141, Issue 16, Page(s) 1904–1906

    MeSH term(s) Humans ; CD47 Antigen ; Neoplasms ; Macrophages ; Antibodies ; T-Lymphocytes
    Chemical Substances CD47 Antigen ; Antibodies ; CD47 protein, human
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023019822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: When immune thrombocytopenia gets on your nerves: β2-adrenergic receptor agonists as a potential treatment?

    Kapur, Rick

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 7, Page(s) 1753–1754

    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Thrombocytopenia ; Adrenergic Agonists
    Chemical Substances Adrenergic Agonists
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  4. Article ; Online: Antinuclear antibodies in childhood immune thrombocytopaenia: An increased risk for development of autoimmune disorders?

    Kapur, Rick

    British journal of haematology

    2023  Volume 202, Issue 2, Page(s) 215–216

    Abstract: Antinuclear antibodies (ANA) have been detected in children with primary immune thrombocytopaenia (ITP), but the effect of ANA titres on clinical outcomes is unclear. Liu et al. retrospectively analysed a cohort of 324 children with primary ITP with a ... ...

    Abstract Antinuclear antibodies (ANA) have been detected in children with primary immune thrombocytopaenia (ITP), but the effect of ANA titres on clinical outcomes is unclear. Liu et al. retrospectively analysed a cohort of 324 children with primary ITP with a median follow-up time of 25 months and found that patients with high-ANA titres (≥1:160) had lower platelet counts at the onset with a higher subsequent platelet count recovery rate, and additionally were at an increased risk to develop autoimmune disease. These data highlight the possible predictive potential of ANA titres with respect to platelet counts and the development of autoimmunity in children with primary ITP. Commentary on: Liu, et al. The effect of antinuclear antibody titre and its variation on outcomes in children with primary immune thrombocytopaenia. Br J Haematol 2023;202:412-421.
    MeSH term(s) Child ; Humans ; Antibodies, Antinuclear/analysis ; Purpura, Thrombocytopenic, Idiopathic ; Retrospective Studies ; Autoimmune Diseases ; Thrombocytopenia ; Platelet Count
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The potential of metabolomics as a predictive guide for clinical management in autoimmunity against red blood cells.

    Kapur, Rick

    British journal of haematology

    2023  Volume 201, Issue 1, Page(s) 13–14

    Abstract: Autoimmune-responses leading to increased destruction of red blood cells occur in autoimmune haemolytic anaemia (AIHA). The pathophysiology of AIHA is multifactorial and not fully understood, and clinically it remains challenging to manage relapsed and ... ...

    Abstract Autoimmune-responses leading to increased destruction of red blood cells occur in autoimmune haemolytic anaemia (AIHA). The pathophysiology of AIHA is multifactorial and not fully understood, and clinically it remains challenging to manage relapsed and treatment-refractory cases. Rabelo and colleagues conduct metabolomic profiling in plasma of 26 patients with primary warm AIHA, with consideration of haemolytic activity and relapse occurrence. They identify distinct metabolites to be increased in primary warm AIHA patients, thereby providing an encouraging basis for further validation and exploration of metabolomic profiling as a predictive tool for the management of AIHA. Commentary on: Rabelo et al. Metabolomic profile in patients with primary warm autoimmune haemolytic anaemia. Br J Haematol 2023;200:140-149.
    MeSH term(s) Humans ; Anemia, Hemolytic, Autoimmune/diagnosis ; Anemia, Hemolytic, Autoimmune/therapy ; Autoimmunity ; Autoantibodies ; Erythrocytes ; Hemolysis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intravenous immunoglobulins ameliorate thrombin-related platelet functions in childhood immune thrombocytopenia.

    Kapur, Rick

    British journal of haematology

    2023  Volume 201, Issue 6, Page(s) 1019–1020

    Abstract: Childhood immune thrombocytopenia (ITP) is an acquired haematological disorder characterized by low platelet counts, with a disease course which is usually benign and self-limiting within 3-12 months. An estimated 28%, however, continue to develop ... ...

    Abstract Childhood immune thrombocytopenia (ITP) is an acquired haematological disorder characterized by low platelet counts, with a disease course which is usually benign and self-limiting within 3-12 months. An estimated 28%, however, continue to develop chronic ITP and may experience bleeding symptoms and an impaired quality of life. Treatment options in case of severe bleedings include corticosteroids, anti-D or intravenous immunoglobulins (IVIg). The general working mechanism of IVIg remains unresolved and a matter of debate. Schmugge et al now identify that IVIg may have the ability to improve thrombin-induced platelet activation and enhance thrombin generation in a prospective study of 23 children with primary ITP, demonstrating that besides increasing platelet counts IVIg can be efficacious on the level of thrombin-induced platelet activation and coagulation support. Commentary on: Schmugge et al. IVIg treatment increases thrombin activation of platelets and thrombin generation in paediatric patients with immune thrombocytopenia. Br J Haematol 2023;201:1209-1219.
    MeSH term(s) Child ; Humans ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Immunoglobulins, Intravenous/therapeutic use ; Thrombin ; Prospective Studies ; Quality of Life ; Thrombocytopenia ; Hemorrhage
    Chemical Substances Immunoglobulins, Intravenous ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impaired glucocorticoid receptor expression and mitochondrial metabolism in MDSCs contribute to glucocorticoid resistance in immune thrombocytopenia.

    Kapur, Rick

    Cellular & molecular immunology

    2022  Volume 19, Issue 7, Page(s) 858–860

    MeSH term(s) Glucocorticoids ; Humans ; Metabolism, Inborn Errors ; Myeloid-Derived Suppressor Cells/metabolism ; Purpura, Thrombocytopenic, Idiopathic/metabolism ; Receptors, Glucocorticoid/deficiency ; Receptors, Glucocorticoid/metabolism
    Chemical Substances Glucocorticoids ; Receptors, Glucocorticoid
    Language English
    Publishing date 2022-06-15
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-022-00880-3
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    Zs.A 6681: Show issues Location:
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  8. Article ; Online: Platelet activation and mitophagy induction by thymic stromal lymphopoietin (TSLP) is associated with thrombosis in Kawasaki disease.

    Kapur, Rick

    British journal of haematology

    2022  Volume 200, Issue 6, Page(s) 689–690

    Abstract: Kawasaki disease (KD) is an acute vasculitis of early childhood with unknown cause, which can be complicated by coronary artery lesions resulting in thrombosis. Fu and coworkers identify thymic stromal lymphopoietin (TSLP) to be increased in KD patients ... ...

    Abstract Kawasaki disease (KD) is an acute vasculitis of early childhood with unknown cause, which can be complicated by coronary artery lesions resulting in thrombosis. Fu and coworkers identify thymic stromal lymphopoietin (TSLP) to be increased in KD patients with thrombosis. They demonstrate that TSLP can activate platelets, induce mitophagy and trigger thrombus formation in vitro, suggesting that TSLP may have potential as a therapeutic target against KD-associated thrombosis. Commentary on: Fu L, et al. TSLP induces platelet mitophagy and promotes thrombosis in Kawasaki disease. Br J Haematol. 2023; 200:776-791.
    MeSH term(s) Child, Preschool ; Humans ; Thymic Stromal Lymphopoietin ; Mucocutaneous Lymph Node Syndrome ; Mitophagy ; Cytokines ; Platelet Activation
    Chemical Substances Thymic Stromal Lymphopoietin (GT0IL38SP4) ; Cytokines
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18555
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  9. Article ; Online: Regulatory T cells are replenished in the splenic microenvironment of patients with immune thrombocytopenia by treatment with thrombopoietin receptor agonists.

    Kapur, Rick

    British journal of haematology

    2022  Volume 198, Issue 5, Page(s) 803–804

    Abstract: Therapeutic management of patients with immune thrombocytopenia (ITP) remains challenging; however, thrombopoietin receptor agonists (TPO-RAs) have revolutionised the treatment landscape of ITP. It is increasingly hypothesised that TPO-RAs may have an ... ...

    Abstract Therapeutic management of patients with immune thrombocytopenia (ITP) remains challenging; however, thrombopoietin receptor agonists (TPO-RAs) have revolutionised the treatment landscape of ITP. It is increasingly hypothesised that TPO-RAs may have an immune modulatory role and Pizzi and colleagues provide evidence in support of this by demonstrating that TPO-RA treatment restores the decreased regulatory T cell (Treg) numbers in the splenic microenvironment of patients with ITP. Commentary on: Pizzi M, Vianello F, Binotto G, Vianelli N, Carli G, Auteri G, et al. Thrombopoietin receptor agonists increase splenic regulatory T-cell numbers in Immune Thrombocytopenia. Br J Haematol. 2022;198:916-922.
    MeSH term(s) Benzoates/therapeutic use ; Humans ; Hydrazines/pharmacology ; Hydrazines/therapeutic use ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Receptors, Fc/therapeutic use ; Receptors, Thrombopoietin/agonists ; Recombinant Fusion Proteins/therapeutic use ; T-Lymphocytes, Regulatory ; Thrombocytopenia/drug therapy ; Thrombopoietin/therapeutic use
    Chemical Substances Benzoates ; Hydrazines ; Receptors, Fc ; Receptors, Thrombopoietin ; Recombinant Fusion Proteins ; Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anti-CD44 (Kur)lander hits ITP.

    Kapur, Rick

    Blood

    2021  Volume 137, Issue 15, Page(s) 1997–1999

    MeSH term(s) Humans ; Inosine Triphosphate ; Thrombocytopenia
    Chemical Substances Inosine Triphosphate (132-06-9)
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011369
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