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Article ; Online: Hexagonal Lu

Liu, Mei Ying / Yu, Jun Xi / Zhu, Xiao Li / Bian, Zhi Ping / Zhou, Xiang / Liang, Yu Hang / Luo, Zhen Lin / Yin, Yue Wei / Li, Jiang Yu / Chen, Xiang Ming

ACS applied materials & interfaces

2022 Volume 14, Issue 46, Page(s) 52117–52123

Abstract: The hexagonal rare earth ... ...

Abstract	The hexagonal rare earth ferrites
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c11927
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Two-dimensional semiconducting Lu

Bai, Xiaojing / Zha, Xian-Hu / Qiao, Yingjie / Qiu, Nianxiang / Zhang, Yiming / Luo, Kan / He, Jian / Li, Qiuwu / Huang, Qing / Francisco, Joseph S / Lin, Cheng-Te / Du, Shiyu

Nanoscale

2020 Volume 12, Issue 6, Page(s) 3795–3802

Abstract: ... principles density functional calculations, the bare lutetium-based carbide MXene Lu ...

Abstract	As a new family of two-dimensional materials, MXenes have attracted increasing attention in recent years due to their widespread potential applications. In contrast to early transition metals in convention, here we expand the M element of MXene to the rare earth element lutetium. Based on the first-principles density functional calculations, the bare lutetium-based carbide MXene Lu
Language	English
Publishing date	2020-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c9nr10806h
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Article ; Online: Managing Catecholamine Release Syndrome During and Following Lu-177-DOTATATE in High-Risk Pheochromocytoma Patients.

Phelps, Tim E / Del Rivero, Jaydira / Chertow, Daniel S / Rosing, Douglas / Pacak, Karel / Lin, Frank I

JCEM case reports

2024 Volume 2, Issue 4, Page(s) luae049

Abstract: ... somatostatin receptors (SSTR) that can be treated with lutetium-177 DOTATATE (Lu-177-TRT); however, treatment can be ... risk PPGL patients receiving Lu-177-TRT is described. The 78-year-old patient with metastatic ... a severe hypertensive reaction with systolic blood pressure of 240 mmHg within minutes of Lu-177-TRT ...

Abstract	Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-producing tumors that express somatostatin receptors (SSTR) that can be treated with lutetium-177 DOTATATE (Lu-177-TRT); however, treatment can be associated with life-threatening cardiovascular events. A patient case with management strategies for high-risk PPGL patients receiving Lu-177-TRT is described. The 78-year-old patient with metastatic paraganglioma was enrolled and treated under NCT03206060. Deemed to be at high risk, the patient was preemptively admitted to the intensive care unit (ICU) with central line access placed. Due to comorbidities, a reduced dose of 100 mCi x 4 cycles was used for this patient. Vital signs, blood work, and serum catecholamine levels were obtained at various time points. Despite reduced dosing, the patient still developed a severe hypertensive reaction with systolic blood pressure of 240 mmHg within minutes of Lu-177-TRT infusion, which was controlled with an intravenous nicardipine drip. The patient remained in the ICU for 24 hours post Lu-177-TRT before moving to an inpatient ward for an additional 24 hours. All subsequent infusions were performed using reduced doses with elective ICU admissions and were well-tolerated. Despite the increased risk, metastatic PPGL patients can be safely treated with proper staff training, monitoring, and preparation for intravenous medications, especially nicardipine.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luae049
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Article ; Online: Manipulating Spin Alignments of (Y,Lu)

Cao, Yili / Lin, Kun / Liu, Zhanning / Hu, Jinyu / Wang, Chin-Wei / Liu, Xinzhi / Tereshina-Chitrova, Evgenia / Kato, Kenichi / Li, Qiang / Deng, Jinxia / Chen, Jun / Zhang, Hongjie / Xing, Xianran

Inorganic chemistry

2020 Volume 59, Issue 8, Page(s) 5247–5251

Abstract: ... we report a new strategy to manipulate the spin alignments of (Y,Lu) ...

Abstract	External pressure has been successfully employed to achieve desirable spin alignments in the field of materials science but is seriously restricted by the difficulty of reaching high pressure with conventional methods. The search for simple and effective ways to apply pressure on the lattice is challenging but intriguing. Here we report a new strategy to manipulate the spin alignments of (Y,Lu)
Language	English
Publishing date	2020-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.9b03570
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Article ; Online: Response to Jacques Caton, MD's comments on the article "Distraction osteogenesis at the proximal third of the ulna for the treatment of Masada type I/IIb deformities in children with hereditary multiple exostoses: a retrospective review of twenty cases" by Lu et al.

Lu, Yunan / Canavese, Federico / Lin, Ran / Huang, Yuling / Wu, Xinwu / Lin, Binbin / Chen, Shunyou

International orthopaedics

2023 Volume 47, Issue 5, Page(s) 1383–1384

MeSH term(s)	Child ; Humans ; Osteogenesis, Distraction ; Retrospective Studies ; Exostoses, Multiple Hereditary/surgery ; Ulna/surgery ; Forearm
Language	English
Publishing date	2023-02-17
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-023-05732-x
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Zs.A 1324: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: 177 Lu-DOTATATE Therapy: Effects of Water Intake and Drinking Duration on Patient Peripheral Dose Equivalent Rates.

Ni, Yudan / Ye, Qing / Liu, Xiangnan / Wang, Ke / Yu, Fei / Fu, Jingjing / Wang, Feng / Li, Lin

Health physics

2023 Volume 125, Issue 3, Page(s) 155–158

Abstract: ... in neuroendocrine tumor patients after receiving 177 Lu-DOTATATE radionuclide therapy. We recruited 39 patients ... with neuroendocrine tumors, all of whom were treated with 177 Lu-DOTATATE radionuclide while in the nuclear medicine ward ... 24 h after treatment with 177 Lu-DOTATATE radionuclides. Drinking water in the first 24 h ...

Abstract	Abstract: This study investigated the amount and duration of water consumption in neuroendocrine tumor patients after receiving 177 Lu-DOTATATE radionuclide therapy. We recruited 39 patients with neuroendocrine tumors, all of whom were treated with 177 Lu-DOTATATE radionuclide while in the nuclear medicine ward of a tertiary hospital in Nanjing from January 2021 to April 2022. We conducted a cross-sectional survey to investigate their drinking times, water consumption, and urine volumes at 0 min, 30 min, 60 min, 2 h, 24 h, and 48 h after radionuclide treatment. At each timepoint, their radiation dose equivalent rates were monitored at 0 m, 1 m, and 2 m from the middle abdomen. f at 24 h were significantly lower than those at 0 min, 30 min, 60 min, and 2 h (all p < 0.05). The dose equivalent rates at 48 h were significantly lower than those at 24 h (all p < 0.05). At 1 m or 2 m from the patient, the dose equivalent rate gradually decreased at all six timepoints and was significantly different between groups ( P < 0.05). To achieve lower radiation doses, there was a correlation with 24 h water consumption (P < 0.05) but no correlation with 48 h water consumption (P > 0.05); there were lower peripheral dose equivalents for patients when 24 h water consumption was no less than 2,750 mL. Patients with neuroendocrine tumors should drink at least 2,750 mL of water 24 h after treatment with 177 Lu-DOTATATE radionuclides. Drinking water in the first 24 h after treatment is more critical to reduce the peripheral dose equivalent, which can accelerate the reduction of peripheral radiation dose equivalent in early patients.
MeSH term(s)	Humans ; Drinking ; Octreotide/therapeutic use ; Cross-Sectional Studies ; Organometallic Compounds/therapeutic use ; Organometallic Compounds/pharmacology ; Radioisotopes/therapeutic use ; Neuroendocrine Tumors/radiotherapy ; Radiopharmaceuticals/therapeutic use
Chemical Substances	copper dotatate CU-64 ; Octreotide (RWM8CCW8GP) ; Organometallic Compounds ; Lutetium-177 (BRH40Y9V1Q) ; Radioisotopes ; Radiopharmaceuticals
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2406-5
ISSN	1538-5159 ; 0017-9078
ISSN (online)	1538-5159
ISSN	0017-9078
DOI	10.1097/HP.0000000000001700
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Zs.A 128: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 253: Show issues

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Article ; Online: Lu-177-Labeled Hetero-Bivalent Agents Targeting PSMA and Bone Metastases for Radionuclide Therapy.

Zha, Zhihao / Ploessl, Karl / Choi, Seok Rye / Zhao, Ruiyue / Jin, Wenbin / Wang, Ran / Alexoff, David / Zhu, Lin / Kung, Hank F

Journal of medicinal chemistry

2023 Volume 66, Issue 17, Page(s) 12602–12613

Abstract: Prostate-specific membrane antigen (PSMA) is an excellent target for imaging and radionuclide therapy of prostate cancer. Recently, [ ...

Abstract	Prostate-specific membrane antigen (PSMA) is an excellent target for imaging and radionuclide therapy of prostate cancer. Recently, [
MeSH term(s)	Male ; Humans ; Animals ; Mice ; Radioisotopes/therapeutic use ; Lutetium/therapeutic use ; Gallium Radioisotopes ; Tissue Distribution ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/drug therapy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/drug therapy
Chemical Substances	Lutetium-177 (BRH40Y9V1Q) ; Radioisotopes ; Lutetium (5H0DOZ21UJ) ; Gallium Radioisotopes
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01294
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Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Safety and Efficacy of 68 Ga- or 177 Lu-Labeled DOTA-IBA as a Novel Theranostic Radiopharmaceutical for Bone Metastases : A Phase 0/I Study.

Qiu, Lin / Wang, Yingwei / Liu, Hanxiang / Wang, Qixin / Chen, Lin / Liu, Lin / Wang, Li / Feng, Yue / Chen, Yue

Clinical nuclear medicine

2023 Volume 48, Issue 6, Page(s) 489–496

Abstract: ... Ga- or 177 Lu-labeled DOTA-ibandronic acid [ 68 Ga/ 177 Lu-DOTA-IBA]) for bone metastasis ... In this study, the dosimetry, safety, and efficacy of 68 Ga/ 177 Lu-DOTA-IBA as a theranostic ... radiopharmaceutical for bone metastases were evaluated in patients with malignancy based on 68 Ga- and 177 Lu-DOTA-IBA ...

Abstract	Purpose: We designed and synthesized a novel theranostic bisphosphonate radiopharmaceutical ( 68 Ga- or 177 Lu-labeled DOTA-ibandronic acid [ 68 Ga/ 177 Lu-DOTA-IBA]) for bone metastasis. In this study, the dosimetry, safety, and efficacy of 68 Ga/ 177 Lu-DOTA-IBA as a theranostic radiopharmaceutical for bone metastases were evaluated in patients with malignancy based on 68 Ga- and 177 Lu-DOTA-IBA images, blood samples, and dosimetric analysis. Patients and methods: Eighteen patients with bone metastasis and progression under conventional therapies were included in this study. Baseline 99m Tc-MDP SPECT and 68 Ga-DOTA-IBA PET/CT were performed for comparative purposes within 3 days. After receiving 891.5 ± 301.3 MBq 177 Lu-DOTA-IBA, serial 177 Lu-DOTA-IBA SPECT bone scan was performed over 14 days. Dosimetric evaluation was performed for main organs and tumor lesions. Safety was assessed by blood biomarkers. Karnofsky Performance Status, pain score, and follow-up 68 Ga-DOTA-IBA PET/CT were performed for response evaluation. Results: Baseline 68 Ga-DOTA-IBA PET demonstrated a higher efficacy for detecting bone metastases compared with 99m Tc-MDP SPECT. The time-activity curves showed fast uptake and high retention of 177 Lu-DOTA-IBA in bone metastases (24 hours: 9.43 ± 2.75 %IA; 14 days: 5.45 ± 2.52 %IA). Liver, kidneys, and red marrow time-activity curves revealed a low uptake and fast clearance. The radiation-absorbed dose in bone metastasis lesions (6.40 ± 2.13 Gy/GBq) was significantly higher than that in red marrow (0.47 ± 0.19 Gy/GBq), kidneys (0.56 ± 0.19 Gy/GBq), or liver (0.28 ± 0.07 Gy/GBq), with all P 's < 0.001. Compared with baseline level, only one patient developed new grade 1 leukopenia (toxicity rate, 6%). The 177 Lu-DOTA-IBA therapy had no statistically significant effect on bone marrow hematopoietic function, liver function, and kidney function at any follow-up visit. Bone pain palliation was achieved in 82% (14/17) of patients. The 8-week follow-up 68 Ga-DOTA-IBA PET/CT demonstrated partial response in 3 patients, disease progression in 1 patient, and stable disease in 14 patients. Conclusions: 68 Ga/ 177 Lu-DOTA-IBA provides a set of potential theranostic radiopharmaceuticals and may have a good prospect for the management of bone metastasis.
MeSH term(s)	Humans ; Radiopharmaceuticals/adverse effects ; Positron Emission Tomography Computed Tomography/methods ; Precision Medicine ; Tomography, X-Ray Computed ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/secondary ; Bone Marrow Diseases ; Pain
Chemical Substances	Radiopharmaceuticals ; 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (1HTE449DGZ) ; Lutetium-177 (BRH40Y9V1Q) ; Gallium-68 (98B30EPP5S)
Language	English
Publishing date	2023-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004634
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Zs.A 1276: Show issues

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Article ; Online: Lu Tong Ke Li protects neurons from injury by regulating inflammation in rats with brain trauma.

Chen, Jie / Li, Ting-Ting / Chen, Ting-Bao / Niu, Rui-Ze / Chen, Ji-Lin / Chen, Yong / Huang, Jin

Ibrain

2022 Volume 8, Issue 1, Page(s) 100–108

Abstract: ... was conducted to determine the protective effect of Lu Tong Ke Li (LTKL), a Chinese medicine, for TBI ...

Abstract	Currently, there is no effective therapy for traumatic brain injury (TBI). Therefore, this study was conducted to determine the protective effect of Lu Tong Ke Li (LTKL), a Chinese medicine, for TBI in experimental animals. The TBI rat model was induced using the modified Feeney's protocol. The rats were divided into four groups: Sham group, Control group, LTKL lower-dose group (LTL, 2 g/kg/day, p.o.), and LTKL higher-dose group (LTH, 4 g/kg/day, p.o.). The Neurological Severity Score (NSS) was used to examine neurological function. Magnetic resonance imaging was performed to check the brain tissue lesions in rats. Cell apoptosis in the damaged area was evaluated using the Terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling assay. Reverse-transcription polymerase chain reaction was used to investigate the expression of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and interleukin 10 (IL-10). The TBI rat model was successfully constructed. Neurological function was enhanced at 14, 21, and 28 days post TBI in the LTH groups, indicated by gradually decreased NSS scores. Administration of LTH led to fewer brain defects in the damaged area, and the number of apoptosis cells in the brain injury area markedly decreased. LTKL treatment led to upregulation of IL-10 expression and downregulation of TNF-α and IL-1β expressions at the molecular level. LTKL can improve the neurobehavior of TBI. The neuroprotective effect was probably related to regulation of inflammation cytokines. Our results provide crucial evidence of the potentially useful application of LTKL in the therapy of TBI in clinic practice in the future.
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ISSN	2769-2795
ISSN (online)	2769-2795
DOI	10.1002/ibra.12029
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Article ; Online: New PSMA-Targeting Ligands: Transformation from Diagnosis (Ga-68) to Radionuclide Therapy (Lu-177).

Zha, Zhihao / Choi, Seok Rye / Li, Linlin / Zhao, Ruiyue / Ploessl, Karl / Yao, Xinyue / Alexoff, David / Zhu, Lin / Kung, Hank F

Journal of medicinal chemistry

2022 Volume 65, Issue 19, Page(s) 13001–13012

Abstract: Prostate-specific membrane antigen (PSMA) is a promising target for the diagnosis and radionuclide therapy of prostate cancer. This study reports conversion of a previously ... ...

Abstract	Prostate-specific membrane antigen (PSMA) is a promising target for the diagnosis and radionuclide therapy of prostate cancer. This study reports conversion of a previously reported
MeSH term(s)	Albumins/metabolism ; Animals ; Antigens, Surface/metabolism ; Cell Line, Tumor ; Chelating Agents/therapeutic use ; Edetic Acid/analogs & derivatives ; Gallium Radioisotopes ; Glutamate Carboxypeptidase II/metabolism ; Humans ; Ligands ; Lutetium/therapeutic use ; Male ; Mice ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/radiotherapy ; Radioisotopes/therapeutic use ; Tissue Distribution
Chemical Substances	Albumins ; Antigens, Surface ; Chelating Agents ; Gallium Radioisotopes ; Ligands ; Radioisotopes ; N,N'-bis(2-hydroxy-5-(ethylene-beta-carboxy)benzyl)ethylenediamine N,N'-diacetic acid (143557-99-7) ; Lutetium (5H0DOZ21UJ) ; Gallium-68 (98B30EPP5S) ; Edetic Acid (9G34HU7RV0) ; Lutetium-177 (BRH40Y9V1Q) ; Glutamate Carboxypeptidase II (EC 3.4.17.21)
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c00852
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Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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