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Article: Minimal Residual Disease Detection at RNA and Leukemic Stem Cell (LSC) Levels: Comparison of RT-qPCR, d-PCR and CD26+ Stem Cell Measurements in Chronic Myeloid Leukemia (CML) Patients in Deep Molecular Response (DMR).

Abruzzese, Elisabetta / Bocchia, Monica / Trawinska, Malgorzata Monika / Raspadori, Donatella / Bondanini, Francesco / Sicuranza, Anna / Pacelli, Paola / Re, Federica / Cavalleri, Alessia / Farina, Mirko / Malagola, Michele / Russo, Domenico / De Fabritiis, Paolo / Bernardi, Simona

Cancers

2023 Volume 15, Issue 16

Abstract: A Deep Molecular Response (DMR), defined as ... ...

Abstract	A Deep Molecular Response (DMR), defined as a
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15164112
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Article ; Online: Vitamin D, SARS-CoV-2 and Causal Associations in Transversal Studies

Cristiano Ialongo / Antonella Farina / Raffaella Labriola / Antonio Angeloni / Emanuela Anastasi

International Journal of Environmental Research and Public Health, Vol 18, Iss 6793, p

The Time-Series Analysis to Reveal Potential Confounders. Comment on Gaudio et al. Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients. Int. J. Environ. Res. Public Health 2021, 18 , 3491

2021 Volume 6793

Abstract: We read with great interest the paper by Gaudio and colleagues on vitamin D and on the state ...

Abstract	We read with great interest the paper by Gaudio and colleagues on vitamin D and on the state of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the time of admission [.]
Keywords	n/a ; Medicine ; R
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vitamin D, SARS-CoV-2 and Causal Associations in Transversal Studies: The Time-Series Analysis to Reveal Potential Confounders. Comment on Gaudio et al. Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients.

Ialongo, Cristiano / Farina, Antonella / Labriola, Raffaella / Angeloni, Antonio / Anastasi, Emanuela

International journal of environmental research and public health

2021 Volume 18, Issue 13

Abstract: We read with great interest the paper by Gaudio and colleagues on vitamin D and on the state ...

Abstract	We read with great interest the paper by Gaudio and colleagues on vitamin D and on the state of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the time of admission [...].
MeSH term(s)	COVID-19 ; Hospitals ; Humans ; Public Health ; SARS-CoV-2 ; Vitamin D
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2021-06-24
Publishing country	Switzerland
Document type	Journal Article ; Comment
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18136793
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Article ; Online: Vitamin D status in patients with chronic plaque psoriasis.

Gisondi, P / Rossini, M / Di Cesare, A / Idolazzi, L / Farina, S / Beltrami, G / Peris, K / Girolomoni, G

The British journal of dermatology

2012 Volume 166, Issue 3, Page(s) 505–510

Abstract: Background: Vitamin D could have important immunomodulatory effects in psoriasis.: Objectives ... To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients ... with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured ...

Abstract	Background: Vitamin D could have important immunomodulatory effects in psoriasis. Objectives: To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features. Methods: A cross-sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected. Results: The prevalence of vitamin D deficiency [25(OH)D levels <20ngmL(-1) ] in patients with psoriasis was 57·8% vs. 37·5% in patients with RA and 29·7% in healthy controls (P<0·001). In winter, the prevalence of vitamin D deficiency rose to 80·9% in patients with psoriasis, to 41·3% in those with RA and to 30·3% in healthy controls (P<0·001). Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established. Conclusions: Vitamin D deficiency may be common in patients with psoriasis, especially in winter.
MeSH term(s)	Adult ; Aged ; Arthritis, Rheumatoid/blood ; Calcium/metabolism ; Case-Control Studies ; Chronic Disease ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Psoriasis/blood ; Psoriasis/complications ; Seasons ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis
Chemical Substances	Parathyroid Hormone ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/j.1365-2133.2011.10699.x
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Article ; Online: In vitro and in vivo evaluation of desmopressin-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles for its potential use in cancer treatment.

Chevalier, Merari T / Garona, Juan / Sobol, Natasha T / Farina, Hernan G / Alonso, Daniel F / Álvarez, Vera A

Nanomedicine (London, England)

2018 Volume 13, Issue 22, Page(s) 2835–2849

Abstract: Aim: To develop and characterize the antitumor activity of poly(D,L-lactic-co-glycolic acid ... full physicochemical characterization, anticancer activity of dDAVP-loaded poly(D,L-lactic-co-glycolic ... model.: Results: After efficiently loading desmopressin in poly(D,L-lactic-co-glycolic acid) matrix ...

Abstract	Aim: To develop and characterize the antitumor activity of poly(D,L-lactic-co-glycolic acid) nanoparticles loaded with hemostatic and anticancer drug desmopressin (dDAVP). Materials & methods: After full physicochemical characterization, anticancer activity of dDAVP-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles (NPdDAVP) was evaluated in vitro and in vivo on a highly aggressive breast cancer model. Results: After efficiently loading desmopressin in poly(D,L-lactic-co-glycolic acid) matrix, NPdDAVP exhibited suitable physicochemical characteristics for biomedical applications. NPdDAVP displayed a potent cytostatic effect in vitro, inhibiting tumor cell proliferation and colony forming ability. Moreover, intravenous treatment using nanoparticulated-dDAVP inhibited tumor progression and prolonged survival in animals bearing rapidly-growing mammary tumors. Conclusion: Within the framework of promising dDAVP repurposing studies, these findings support further preclinical development of the NPdDAVP for the management of highly aggressive cancer.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Deamino Arginine Vasopressin/pharmacology ; Drug Carriers/chemistry ; Drug Compounding/methods ; Drug Liberation ; Female ; Humans ; Mice, Inbred BALB C ; Nanoparticles/chemistry ; Particle Size ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Polymers/chemistry ; Surface Properties
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; Polymers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2018-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2018-0065
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Article ; Online: Temporal trends in dietary supplement prescriptions of United States military service members suggest a decrease in pyridoxine and increase in vitamin D supplements from 2005 to 2013.

Knapik, Joseph J / T Jean, Rosenie / Austin, Krista G / Steelman, Ryan A / Gannon, Julia / Farina, Emily K / Lieberman, Harris R

Nutrition research (New York, N.Y.)

2016 Volume 36, Issue 10, Page(s) 1140–1152

Abstract: ... a decline in early years and leveling off in later years, and vitamin D indicating little change in early ...

Abstract	Dietary supplements (DSs) can be obtained over-the-counter but can also be prescribed by health-care providers for therapeutic reasons. Few studies have documented this later source despite the fact that 79% of physicians and 82% of nurses have recommended DSs to patients. This investigation assessed prevalence and temporal trends in oral DS prescriptions filled by all United States service members (SMs) from 2005 to 2013 (n = 1 427 080 ± 22 139, mean ± standard deviation (SD)/y). We hypothesize that there would be temporal variations in specific types of DSs. Data obtained from Department of Defense Pharmacy Data Transaction System were grouped by American Hospital Formulary System pharmacologic-therapeutic classifications and prevalence examined over time. About 11% of SMs filled one or more DS prescriptions of 235 180 ± 4926 (mean ± SD) prescriptions/y over the 9-year period. Curve-fitting techniques indicated significant linear declines over time for multivitamins (P = .004), iron preparations (P < .001), antacids (P < .001), and vitamin B and B complex vitamins (P < .001). There were significant quadratic trends indicating a rise in early years followed by a leveling off in later years for replacement preparations (P < .001) and vitamin C (P < .001). There were significant quadratic trends (P < .001) for vitamin E indicating a decline in early years and leveling off in later years, and vitamin D indicating little change in early years followed by a large rise subsequently (P < .001). This study identified temporal trends in specific DS categories that may be associated with changing perceptions of prescribers and/or patients of the appropriate roles of DSs in medicine and public health.
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	582432-1
ISSN	1879-0739 ; 0271-5317
ISSN (online)	1879-0739
ISSN	0271-5317
DOI	10.1016/j.nutres.2016.09.001
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Article ; Online: Novel high-sensitive D-dimer determination predicts chemotherapy-associated venous thromboembolism in intermediate risk lung cancer patients.

Ferroni, Patrizia / Martini, Francesca / Portarena, Ilaria / Massimiani, Gioia / Riondino, Silvia / La Farina, Francesca / Mariotti, Sabrina / Guadagni, Fiorella / Roselli, Mario

Clinical lung cancer

2012 Volume 13, Issue 6, Page(s) 482–487

Abstract: Introduction: We hypothesized that the use of a novel high sensitivity (HS) assay for D-dimer ... HS D-dimer levels were retrospectively evaluated in 108 lung cancer outpatients using a novel ... value (PPV) of 31%, a negative predictive value (NPV) of 96%, and an accuracy of 70%. Patients with HS D ...

Abstract	Introduction: We hypothesized that the use of a novel high sensitivity (HS) assay for D-dimer determination might ameliorate venous thromboembolism (VTE) risk prediction in intermediate risk lung cancer patients in whom chemotherapy could act as a trigger for VTE onset. Patients and methods: Pretreatment HS D-dimer levels were retrospectively evaluated in 108 lung cancer outpatients using a novel automated latex enhanced turbidimetric immunoassay. All patients were at the start of a new platinum-based chemotherapy regimen and were classified as intermediate risk according to Khorana's assessment model. Patients were followed-up for a median period of 6.9 months. Results: Receiver operating characteristic (ROC) curves and corresponding Bayesian analysis showed that the best performance was obtained at a cutoff level of 1500 ng/mL, which resulted in a sensitivity of 81%, a specificity of 69%, a positive predictive value (PPV) of 31%, a negative predictive value (NPV) of 96%, and an accuracy of 70%. Patients with HS D-dimer levels above the cutoff had a worse VTE-free survival (60%) compared with those with levels below the cutoff (95%; P = .0001). Multivariate Cox proportional hazards survival analysis confirmed that pretreatment HS D-dimer levels were able to significantly predict VTE with a hazard ratio of 11 (95% confidence interval, 2.62-46.2; P = .001), independently of classic VTE risk factors. Conclusions: The use of HS D-dimer determination prior to chemotherapy might allow for VTE risk stratification of intermediate risk cancer patients, helping in identifying those individuals who could benefit from thromboprophylaxis.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Automation, Laboratory ; Bayes Theorem ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Follow-Up Studies ; Humans ; Immunoassay ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Multivariate Analysis ; Nephelometry and Turbidimetry/methods ; Outpatients ; Platinum Compounds/administration & dosage ; Predictive Value of Tests ; Proportional Hazards Models ; ROC Curve ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Survival Rate ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/diagnosis
Chemical Substances	Fibrin Fibrinogen Degradation Products ; Platinum Compounds ; fibrin fragment D
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2012.03.005
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Article: Predictive value of high-sensitive D-dimer determination for chemotherapy-associated venous thromboembolism in gastrointestinal cancer patients.

Roselli, Mario / Ferroni, Patrizia / Portarena, Ilaria / Riondino, Silvia / La Farina, Francesca / Formica, Vincenzo / Vergati, Matteo / Guadagni, Fiorella

Thrombosis and haemostasis

2012 Volume 108, Issue 6, Page(s) 1243–1245

MeSH term(s)	Aged ; Antineoplastic Agents/adverse effects ; Biomarkers/blood ; Blood Chemical Analysis ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Gastrointestinal Neoplasms/blood ; Gastrointestinal Neoplasms/complications ; Gastrointestinal Neoplasms/drug therapy ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Factors ; Venous Thromboembolism/blood ; Venous Thromboembolism/etiology
Chemical Substances	Antineoplastic Agents ; Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2012-12
Publishing country	Germany
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	518294-3
ISSN	0340-6245
ISSN	0340-6245
DOI	10.1160/TH12-06-0418
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Article ; Online: Deep Metric Learning With Locality Sensitive Mining for Self-Correcting Source Separation of Neural Spiking Signals.

Clarke, Alexander Kenneth / Farina, Dario

IEEE transactions on cybernetics

2024 Volume 54, Issue 3, Page(s) 1366–1376

Abstract: Automated source separation algorithms have become a central tool in neuroengineering and neuroscience, where they are used to decompose neurophysiological signal into its constituent spiking sources. However, in noisy or highly multivariate recordings ... ...

Abstract	Automated source separation algorithms have become a central tool in neuroengineering and neuroscience, where they are used to decompose neurophysiological signal into its constituent spiking sources. However, in noisy or highly multivariate recordings these decomposition techniques often make a large number of errors. Such mistakes degrade online human-machine interfacing methods and require costly post-hoc manual cleaning in the offline setting. In this article we propose an automated error correction methodology using a deep metric learning (DML) framework, generating embedding spaces in which spiking events can be both identified and assigned to their respective sources. Furthermore, we investigate the relative ability of different DML techniques to preserve the intraclass semantic structure needed to identify incorrect class labels in neurophysiological time series. Motivated by this analysis, we propose locality sensitive mining, an easily implemented sampling-based augmentation to typical DML losses which substantially improves the local semantic structure of the embedding space. We demonstrate the utility of this method to generate embedding spaces which can be used to automatically identify incorrectly labeled spiking events with high accuracy.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2023.3290825
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Article: Temporal trends in dietary supplement prescriptions of United States military service members suggest a decrease in pyridoxine and increase in vitamin D supplements from 2005 to 2013

Knapik, Joseph J / Emily K. Farina / Harris R. Lieberman / Julia Gannon / Krista G. Austin / Rosenie T. Jean / Ryan A. Steelman

Nutrition research. 2016 Oct., v. 36, no. 10

2016

Abstract: ... a decline in early years and leveling off in later years, and vitamin D indicating little change in early ...

Abstract	Dietary supplements (DSs) can be obtained over-the-counter but can also be prescribed by health-care providers for therapeutic reasons. Few studies have documented this later source despite the fact that 79% of physicians and 82% of nurses have recommended DSs to patients. This investigation assessed prevalence and temporal trends in oral DS prescriptions filled by all United States service members (SMs) from 2005 to 2013 (n = 1 427 080 ± 22 139, mean ± standard deviation (SD)/y). We hypothesize that there would be temporal variations in specific types of DSs. Data obtained from Department of Defense Pharmacy Data Transaction System were grouped by American Hospital Formulary System pharmacologic-therapeutic classifications and prevalence examined over time. About 11% of SMs filled one or more DS prescriptions of 235 180 ± 4926 (mean ± SD) prescriptions/y over the 9-year period. Curve-fitting techniques indicated significant linear declines over time for multivitamins (P = .004), iron preparations (P < .001), antacids (P < .001), and vitamin B and B complex vitamins (P < .001). There were significant quadratic trends indicating a rise in early years followed by a leveling off in later years for replacement preparations (P < .001) and vitamin C (P < .001). There were significant quadratic trends (P < .001) for vitamin E indicating a decline in early years and leveling off in later years, and vitamin D indicating little change in early years followed by a large rise subsequently (P < .001). This study identified temporal trends in specific DS categories that may be associated with changing perceptions of prescribers and/or patients of the appropriate roles of DSs in medicine and public health.
Keywords	antacids ; ascorbic acid ; health services ; hospitals ; iron ; medicine ; nurses ; patients ; physicians ; public health ; pyridoxine ; statistical analysis ; temporal variation ; therapeutics ; vitamin D ; vitamin E ; vitamin supplements ; United States
Language	English
Dates of publication	2016-10
Size	p. 1140-1152.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	582432-1
ISSN	1879-0739 ; 0271-5317
ISSN (online)	1879-0739
ISSN	0271-5317
DOI	10.1016/j.nutres.2016.09.001
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