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Book ; Conference proceedings: Cell tissue injury and cytoprotection, organoprotection in the gastrointestinal tract

Filaretova, Ludmila P. / Takeuchi, Koji

mechanisms, prevention and treatment ; 10 tables; [presented at the 6th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection: Focus on GI Tract, held in St. Petersburg, Russia on October 12 - 14, 2011.]

(Frontiers of gastrointestinal research ; 30)

2012

Event/congress	International Symposium on Cell Tissue Injury and Cytoprotection, Organoprotection: Focus on GI Tract (6, 2011, SanktPetersburg)
Author's details	vol. ed. Ludmila P. Filaretova ; Koji Takeuchi
Series title	Frontiers of gastrointestinal research ; 30
Collection
Keywords	Gastrointestinal Diseases / physiopathology ; Cytoprotection / physiology ; Disease Models, Animal ; Gastrointestinal Tract / cytology ; Mucous Membrane / drug effects ; Protective Agents ; Gastrointestinale Krankheit ; Cytoprotektion
Subject	Zytoprotektion ; Zellschutz ; Magen-Darm-Krankheit ; Magen-Darm-Kanal
Language	English
Size	VIII, 249 S. : Ill., graph. Darst.
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Switzerland
Document type	Book ; Conference proceedings
HBZ-ID	HT017295326
ISBN	978-3-318-02183-7 ; 3-318-02183-0 ; 9783318021844 ; 3318021849
Database	Catalogue ZB MED Medicine, Health

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2012 A 2776	order for loan	Magazin

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Article ; Online: Gastroprotective Effect of Stress Preconditioning: Involvement of Glucocorticoids.

Filaretova, Ludmila

Current pharmaceutical design

2017 Volume 23, Issue 27, Page(s) 3923–3927

Abstract: Stress plays a leading role in maintaining the physical health of the body. Various health effects of preconditioning mild stress strongly confirm this statement. Preconditioning mild stress, which is everyday event of animal and human life, may ... ...

Abstract	Stress plays a leading role in maintaining the physical health of the body. Various health effects of preconditioning mild stress strongly confirm this statement. Preconditioning mild stress, which is everyday event of animal and human life, may attenuate the development and aggravation of diseases including such widespread pathology as gastric ulceration. Preconditioning mild stress may diminish gastric injury formation caused by severe stress. Gastroprotective influence of preconditioning mild stress is known to be mediated by prostaglandins. In the present article, we focus on the data suggesting that glucocorticoids released in response to preconditioning mild stressor are important players of gastroprotective influence of preconditioning stress.
MeSH term(s)	Animals ; Conditioning (Psychology)/physiology ; Gastric Mucosa/pathology ; Glucocorticoids/metabolism ; Humans ; Prostaglandins/metabolism ; Severity of Illness Index ; Stomach Ulcer/etiology ; Stomach Ulcer/prevention & control ; Stress, Psychological/complications ; Stress, Psychological/physiopathology
Chemical Substances	Glucocorticoids ; Prostaglandins
Language	English
Publishing date	2017-02-16
Publishing country	United Arab Emirates
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612823666170215145125
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Article ; Online: Environmental enrichment reverses proulcerogenic action of social isolation on the gastric mucosa and positively influences pain sensitivity and work capacity.

Filaretova, Ludmila P / Komkova, Olga P / Morozova, Olga Yu / Punina, Polina V / Yarushkina, Natalia I

Inflammopharmacology

2024 Volume 32, Issue 2, Page(s) 909–915

Abstract: The aim of the study was to investigate the effects of rat housing conditions-standard conditions, social isolation, environmental enrichment-and the subsequent reversal of these conditions on the vulnerability of the gastric mucosa to ulcerogenic ... ...

Abstract	The aim of the study was to investigate the effects of rat housing conditions-standard conditions, social isolation, environmental enrichment-and the subsequent reversal of these conditions on the vulnerability of the gastric mucosa to ulcerogenic stimuli, somatic pain sensitivity, and treadmill work capacity. Rats, aged 30 days, were placed in standard conditions (SC), social isolation (Is), and environmental enrichment (EE) for 4 weeks. Then half of each group underwent a reversal of housing conditions: SC rats were moved to Is, Is rats were placed in EE, EE rats were moved to Is, for 2 weeks. The other half served as a control with no change in their initial housing. Two weeks after the reversal, vulnerability of the gastric mucosa to ulcerogenic action of indomethacin (IM, 35 mg/kg, sc), somatic pain sensitivity (hot plate test), and work capacity (measured by the running distance on a treadmill) were assessed in control and reversed groups. Social isolation induced a proulcerogenic effect, increasing IM-induced gastric erosions, which was effectively reversed when rats were transferred to an environmental enrichment. Conversely, transferring rats from an environmental enrichment to social isolation exacerbated ulcerogenic action of IM. Somatic pain sensitivity and treadmill work capacity were also influenced by housing conditions, with environmental enrichment showing positive effects. The present findings show that social isolation of rats induces a proulcerogenic effect. Environmental enrichment reverses proulcerogenic action of social isolation on the gastric mucosa and increases resilience to pain stimuli and treadmill work capacity.
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Indomethacin/pharmacology ; Gastric Mucosa ; Social Isolation ; Nociceptive Pain
Chemical Substances	Indomethacin (XXE1CET956)
Language	English
Publishing date	2024-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01451-w
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Article: Non-Invasive Remote Ischemic Preconditioning May Protect the Gastric Mucosa Against Ischemia-Reperfusion-Induced Injury Through Involvement of Glucocorticoids.

Filaretova, Ludmila / Komkova, Olga / Sudalina, Maria / Yarushkina, Natalia

Frontiers in pharmacology

2021 Volume 12, Page(s) 682643

Abstract: Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only ... ...

Abstract	Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only on heart, but also on brain, lungs, kidneys, liver, intestine, and stomach. We previously demonstrated that glucocorticoids participate in protective effect of local gastric ischemic preconditioning against I/R-induced gastric injury. In the present study we investigated whether RIPC may protect the gastric mucosa against I/R-induced injury through involvement of glucocorticoids. Anesthetized fasted Sprague Dawley male rats were exposed to prolonged gastric I/R (30 min occlusion of celiac artery followed by 3 h of reperfusion) alone or with preliminary brief RIPC (10 min non-invasive occlusion of right hind limb blood flow followed by reperfusion for 30 min). First, we investigated the effect of RIPC on I/R-induced injury by itself. Then to study the role of glucocorticoids similar experiments were carried out: 1) in rats pretreated with the inhibitor of glucocorticoid synthesis, metyrapone (30 mg/kg, i.p), and in control animals; 2) in adrenalectomized rats without or with corticosterone replacement (4 mg/kg, s.c.) and in sham-operated animals; 3) in rats pretreated with glucocorticoid receptor antagonist RU-38486 (20 mg/kg, s.c.) and in control animals. I/R induced corticosterone rise and resulted in the gastric erosion formation. RIPC significantly reduced the erosion area in control animals. Metyrapone injected shortly before RIPC caused a decrease in plasma corticosterone levels and prevented the gastroprotective effect of RIPC and, moreover, further aggravated the deleterious effect of I/R. Adrenalectomy performed 1 week before experiment created long-lasting corticosterone deficiency and had no effect on the gastroprotective effect of RIPC. Nevertheless, corticosterone replacement which mimics the corticosterone rise, similar to RIPS, significantly reduced erosion areas of gastric mucosa in adrenalectomized rats supporting the role of glucocorticoids in gastroprotection. RU-38486, which occupied glucocorticoid receptors, similar to metyrapone prevented the gastroprotective effect of RIPC and, moreover, further aggravated the deleterious effect of I/R. The results of the present study demonstrate for the first time that RIPC may protect the gastric mucosa against I/R-induced injury through involvement of glucocorticoids.
Language	English
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.682643
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Article: Glucocorticoids are Gastroprotective under Physiologic Conditions.

Filaretova, Ludmila

Therapeutic advances in chronic disease

2012 Volume 2, Issue 5, Page(s) 333–342

Abstract: Stress may contribute to the development and progression of gastrointestinal disorders. Activation of the hypothalamic-pituitary-adrenocortical (HPA) axis is one of the main characteristics of stress. For several decades it was generally accepted that ... ...

Abstract	Stress may contribute to the development and progression of gastrointestinal disorders. Activation of the hypothalamic-pituitary-adrenocortical (HPA) axis is one of the main characteristics of stress. For several decades it was generally accepted that glucocorticoids released during stress are ulcerogenic hormones. We designed some experimental studies in rats to clarify the validity of this widely held view. To achieve this goal, we examined the effect of glucocorticoid deficiency followed by corticosterone replacement or the glucocorticoid receptor antagonist, RU-38486, on stress-induced gastric erosion and the parameters of gastric function in rats. The data obtained shows that the reduction in the stress-induced corticosterone release, or its actions, aggravates stress-caused gastric erosion. It is suggested that an acute increase in corticosterone during stress protects the stomach against stress-induced injury. According to our results, various ulcerogenic stimuli, similar to stress, induce an increase in corticosterone that helps the gastric mucosa to resist against a harmful action of ulcerogenic stimuli. Glucocorticoids exhibit their gastroprotective effect by both maintaining local defensive factors and inhibiting pathogenic elements. Furthermore, the contribution of glucocorticoids to gastroprotection is tightly related to their contribution to general body homeostasis. Glucocorticoids provide gastroprotective actions in co-operation with prosta-glandins, nitric oxide and capsaicin-sensitive sensory neurons. The results obtained do not support the traditional paradigm and suggest that glucocorticoids released during acute activation of the HPA axis are naturally occurring gastroprotective factors. In this article, we review our recent publications on the role of glucocorticoids in gastroprotection.
Language	English
Publishing date	2012-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2554816-5
ISSN	2040-6231 ; 2040-6223
ISSN (online)	2040-6231
ISSN	2040-6223
DOI	10.1177/2040622311412420
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Article ; Online: Physiological and Pharmacological Effects of Glucocorticoids on the Gastrointestinal Tract.

Filaretova, Ludmila / Podvigina, Tatiana / Yarushkina, Natalia

Current pharmaceutical design

2020 Volume 26, Issue 25, Page(s) 2962–2970

Abstract: The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological ... ...

Abstract	The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on the re-evaluation of the traditional notion that stress-produced glucocorticoids are ulcerogenic led us to the opposite conclusion suggested that these hormones play an important role in the maintenance of the gastric mucosal integrity. Exogenous glucocorticoids may exert both gastroprotective and proulcerogenic effects. Initially, gastroprotective effect of dexamethasone but not corticosterone, cortisol or prednisolone can be transformed into proulcerogenic one. The most significant factor for the transformation is the prolongation of its action rather the dose. Gastrointestinal injury can be accompanied by changes in somatic pain sensitivity and glucocorticoids contribute to these changes playing a physiological and pathological role.
MeSH term(s)	Corticosterone ; Gastric Mucosa ; Glucocorticoids/adverse effects ; Humans ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy
Chemical Substances	Glucocorticoids ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2020-05-21
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666200521142746
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Article ; Online: The peripheral corticotropin-releasing factor (CRF)-induced analgesic effect on somatic pain sensitivity in conscious rats: involving CRF, opioid and glucocorticoid receptors.

Yarushkina, Natalia I / Filaretova, Ludmila P

Inflammopharmacology

2018 Volume 26, Issue 2, Page(s) 305–318

Abstract: The corticotropin-releasing factor (CRF) is involved in somatic pain regulation and may produce an analgesic effect in humans and animals, although the mechanisms of the CRF-induced analgesia remain unclear. CRF action is mediated by the CRF receptors of ...

Abstract	The corticotropin-releasing factor (CRF) is involved in somatic pain regulation and may produce an analgesic effect in humans and animals, although the mechanisms of the CRF-induced analgesia remain unclear. CRF action is mediated by the CRF receptors of subtypes 1 and 2 (CRF-R1 and CRF-R2, respectively). Activation of the hypothalamic -pituitary -adrenocortical axis (HPA) is provided by CRF-R1; but CRF-R2 are also involved in the regulation of the HPA axis, and, respectively, glucocorticoids, the end hormones of the HPA axis, also participate in somatic pain regulation. Additionally, opioids may contribute to the CRF-induced analgesia. This article serves as an overview of the role of CRF-R1 and CRF-R2, as well as glucocorticoid and opioid receptors in peripheral CRF-induced analgesia in conscious rats, while we focused on the data obtained under normal (non-pathological) conditions including results of our studies in rats. The involvement of CRF-R1 and CRF-R2, glucocorticoids and opioid receptors was studied under the same experimental conditions following pretreatment with appropriate antagonists: NBI 27914, astressin
MeSH term(s)	Analgesics, Opioid/metabolism ; Animals ; Corticotropin-Releasing Hormone/metabolism ; Humans ; Nociceptive Pain/metabolism ; Rats ; Receptors, Glucocorticoid/metabolism
Chemical Substances	Analgesics, Opioid ; Receptors, Glucocorticoid ; Corticotropin-Releasing Hormone (9015-71-8)
Language	English
Publishing date	2018-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-018-0445-5
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Article ; Online: Gastroprotective role of glucocorticoids during NSAID-induced gastropathy.

Filaretova, Ludmila

Current pharmaceutical design

2011 Volume 19, Issue 1, Page(s) 29–33

Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) make significant contributions to gastric ulcer disease which remains widespread. Although several factors have been postulated as pathogenic elements of the gastric injury induced by NSAIDs, it is, however ... ...

Abstract	Nonsteroidal anti-inflammatory drugs (NSAIDs) make significant contributions to gastric ulcer disease which remains widespread. Although several factors have been postulated as pathogenic elements of the gastric injury induced by NSAIDs, it is, however believed that prostaglandin deficiency plays a critical role in the pathogenesis of this injury. During prostaglandin deficiency, other defensive mechanisms might operate to attenuate NSAID-induced gastropathy. According to our results, NSAIDs, similar to stress, induce an increase in glucocorticoid production that in turn helps the gastric mucosa to resist the harmful actions of these drugs. In this article, we review our experimental data suggesting that glucocorticoids may play a role as natural defensive factors in maintaining the integrity of the gastric mucosa during NSAID therapy and might operate to attenuate NSAID-induced gastropathy.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Gastrointestinal Diseases/chemically induced ; Gastrointestinal Diseases/pathology ; Gastrointestinal Diseases/prevention & control ; Glucocorticoids/metabolism ; Humans ; Prostaglandins/deficiency ; Stomach Ulcer/chemically induced ; Stomach Ulcer/pathology ; Stomach Ulcer/prevention & control
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Glucocorticoids ; Prostaglandins
Language	English
Publishing date	2011-10-24
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/13816128130106
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Article: The timing of weaning alters the vulnerability to stress-induced gastric erosion in adult rats.

Filaretova, Ludmila / Vataeva, Ludmila / Zelena, Dóra

Ideggyogyaszati szemle

2018 Volume 70, Issue 1-2, Page(s) 25–32

Abstract: Background and purpose: Weaning is an important period of life and its timing may influence the resilence for later stress. One of the most important stress-related disorder is gastric ulceration.: Methods: Therefore we aimed to investigate the ... ...

Title translation	Az elválasztás időzítése befolyásolja a stressz indukálta gyomorfekély-képződést felnőtt patkányban.
Abstract	Background and purpose: Weaning is an important period of life and its timing may influence the resilence for later stress. One of the most important stress-related disorder is gastric ulceration. Methods: Therefore we aimed to investigate the sensitivity of gastric mucosa to cold (at 16°C) water immersion stress (WIS for 3h) in adult (75-day-old) female and male rats after weaning them at different timepoints (at 17, 21, 30, 36 or 42 postnatal days). The connection with stress was studied by comparing control groups to those underwent WIS at the time of weaning and measuring corticosterone levels at the time of collecting the stomach samples. Results: The timing of weaning has strong impact on all studied parameters. Stress-induced erosion development was the smallest in rats weaned at 36-day independently from preconditioning with WIS at weaning, or sex, despite a clear sex-effect on blood corticosterone levels and body weight. WIS at weaning influenced only the body weight in adult rats weaned at 30-day, being higher in stressed than in control groups. There was no clear overall correlation between erosion area and blood corticosterone measures. Conclusion: Taken together our results confirm that the timing of weaning has long-lasting impact on the resiliance of gastric mucosa to ulcerogenic stressful events. In rats the postnatal day 30-36 seems to be optimal for weaning in both sexes as both earlier and later weaning increased vulnerability. Females seems to be more vulnerable to the effect of weaning than males.
MeSH term(s)	Animals ; Female ; Gastric Mucosa/pathology ; Male ; Rats ; Rats, Wistar ; Stomach Ulcer/etiology ; Stomach Ulcer/physiopathology ; Stress, Psychological/complications ; Stress, Psychological/physiopathology ; Weaning
Language	English
Publishing date	2018-02-22
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2240317-6
ISSN	0019-1442
ISSN	0019-1442
DOI	10.18071/isz.70.0025
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Article ; Online: The Realization of the Brain-Gut Interactions with Corticotropin-Releasing Factor and Glucocorticoids.

Filaretova, Ludmila / Bagaeva, Tatiana

Current neuropharmacology

2016 Volume 14, Issue 8, Page(s) 876–881

Abstract: ... of them were articles of Filaretova L. and co-authors. We will discuss in our articles how an endocrinological ...

Abstract	Background: The brain and the gut interact bi-directionally through the brain-gut axis. The interaction is mediated by the autonomic nervous system and the hypothalamic-pituitary-adrenocortical (HPA) system. The first brilliant demonstration of the brain-gut interactions was the cephalic phase of gastric and pancreatic secretion discovered by Ivan Pavlov, the first physiologist who was awarded the Nobel Prize for Physiology or Medicine in 1904. This review aims to identify the HPA system as a key hormonal branch of the brain-gut axis in stress. Methods: We first outlined main components of the brain-gut axis and then focused on the HPA system as a key hormonal branch of the brain-gut axis in stress. We undertook a structured search of bibliographic databases for peer-reviewed research literature using a focused review question. Results: Seventy-one articles were included in the review, the eleventh of them were articles of Filaretova L. and co-authors. We will discuss in our articles how an endocrinological approach to gastroenterological field can advance our understanding of the HPA axis role in regulation of gastric mucosal integrity and uncover new findings. According to these findings activation of the HPA system is gastroprotective component of the brain-gut axis in stress but not ulcerogenic one as it was generally accepted. Corticotropin-releasing factor (CRF) and glucocorticoids are important natural players provided gastroprotection. The results suggest that an initial action of endogenous glucocorticoids, including stress- and CRF-produced ones, as well as exogenous glucocorticoids, even used at pharmacological doses, is physiological gastroprotective. Prolongation of the hormonal action may lead to the transformation of gastroprotective hormonal effect to proulcerogenic one. Conclusion: The findings of this review demonstrate that corticotropin-releasing factor and glucocorticoids contribute to the realization of the brain-gut interactions and that activation of the HPA system is gastroprotective component of this interaction in stress.
MeSH term(s)	Animals ; Brain/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Gastrointestinal Tract/metabolism ; Glucocorticoids/metabolism ; Humans ; Stress, Psychological/metabolism
Chemical Substances	Glucocorticoids ; Corticotropin-Releasing Hormone (9015-71-8)
Language	English
Publishing date	2016-06-16
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159x14666160614094234
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