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Article ; Online: Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders.

Goodwill, Alicia M / Low, Li Tong / Fox, Peter T / Fox, P Mickle / Poon, Kenneth K / Bhowmick, Sourav S / Chen, S H Annabel

Brain imaging and behavior

2023 Volume 17, Issue 2, Page(s) 257–269

Abstract: Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls ... ...

Abstract	Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range = 18-41 years) were included. For all tasks combined, the ASD group showed significant (p < .05) hypo-activation in one cluster around the left amygdala (peak - 26, -2, -20, volume = 1336 mm
MeSH term(s)	Adult ; Humans ; Adolescent ; Young Adult ; Autism Spectrum Disorder/pathology ; Magnetic Resonance Imaging/methods ; Cerebellum ; Language ; Semantics ; Brain Mapping/methods ; Brain
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	2377165-3
ISSN	1931-7565 ; 1931-7557
ISSN (online)	1931-7565
ISSN	1931-7557
DOI	10.1007/s11682-022-00754-2
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Article ; Online: Examining Participant Dosage and Skill Utilization Associated with Receipt of a Perinatal Depression Preventive Intervention.

Johnson, Jessica K / Diebold, Alicia / Yeh, Chen / Ciolino, Jody D / Tandon, S Darius

Prevention science : the official journal of the Society for Prevention Research

2022 Volume 23, Issue 7, Page(s) 1241–1250

Abstract: This study assessed participant, facilitator, and program-level characteristics associated with intervention dosage among women receiving an evidence-based perinatal depression preventive intervention, Mothers and Babies (MB). We also explored how ... ...

Abstract	This study assessed participant, facilitator, and program-level characteristics associated with intervention dosage among women receiving an evidence-based perinatal depression preventive intervention, Mothers and Babies (MB). We also explored how intervention dosage affected the use and maintenance of core skills taught in the six-session group-based intervention. We conducted a secondary analysis of data from a cluster-randomized controlled trial in which 679 women enrolled in home visiting (HV) programs received MB prenatally. High dose of intervention was defined as attendance at > 50% of MB sessions, while MB skill utilization was measured by asking participants to indicate at 12 and 24 weeks postpartum the extent to which they used 12 core MB skills taught during the intervention. Age and racial concordance between participant and facilitator were significantly associated with intervention dosage. Those receiving higher intervention dosage tended to be older (27.25 ± 5.96 vs. 24.99 ± 5.60, p < 0.01, OR = 1.068 [1.038-1.098]), and received MB from a facilitator with a self-identified race similar to their own (58% vs. 48%, p = 0.04, OR = 1.485 [1.014-2.176]). Primary language of participants was marginally associated with dosage. Participants receiving a higher dose of intervention tended to exhibit greater MB skill utilization, on average at 24 weeks postpartum. These results can be used to identify strategies to promote intervention engagement. They further suggest that greater intervention dosage leads to increased use of core intervention skills that can promote improvements in participants' behaviors and thoughts.
MeSH term(s)	Depression/prevention & control ; Depression, Postpartum/prevention & control ; Female ; House Calls ; Humans ; Infant ; Postnatal Care/methods ; Postpartum Period ; Pregnancy
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-022-01395-z
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Article ; Online: Nanobubbles in water and wastewater treatment systems: Small bubbles making big difference.

Jia, Mingyi / Farid, Muhammad Usman / Kharraz, Jehad A / Kumar, Nallapaneni Manoj / Chopra, Shauhrat S / Jang, Am / Chew, John / Khanal, Samir Kumar / Chen, Guanghao / An, Alicia Kyoungjin

Water research

2023 Volume 245, Page(s) 120613

Abstract: Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater treatment. However, ... ...

Abstract	Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater treatment. However, despite the intensive research efforts on NBs' fundamental properties, especially in the past five years, controversies and disagreements in the published literature have hindered their practical implementation. So far, reviews of NB research have mainly focused on NBs' role in specific treatment processes or general applications, highlighting proof-of-concept and success stories primarily at the laboratory scale. As such, there lacks a rigorous review that authenticates NBs' potential beyond the bench scale. This review aims to provide a comprehensive and up-to-date analysis of the recent progress in NB research in the field of water and wastewater treatment at different scales, along with identifying and discussing the challenges and prospects of the technology. Herein, we systematically analyze (1) the fundamental properties of NBs and their relevancy to water treatment processes, (2) recent advances in NB applications for various treatment processes beyond the lab scale, including over 20 pilot and full-scale case studies, (3) a preliminary economic consideration of NB-integrated treatment processes (the case of NB-flotation), and (4) existing controversies in NBs research and the outlook for future research. This review is organized with the aim to provide readers with a step-by-step understanding of the subject matter while highlighting key insights as well as knowledge gaps requiring research to advance the use of NBs in the wastewater treatment industry.
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.120613
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Article ; Online: Cardiometabolic risk factors, peripheral arterial tonometry and metformin in adults with type 1 diabetes participating in the REducing with MetfOrmin Vascular Adverse Lesions trial.

Chen, David / Jenkins, Alicia J / Greenlaw, Nicola / Dudman, Katie / Fernandes, Tamsin / Carty, David M / Hughes, Alun D / Januszewski, Andrzej S / Stehouwer, Coen DA / Petrie, John R

Diabetes & vascular disease research

2023 Volume 20, Issue 3, Page(s) 14791641231183634

Abstract: Background: Peripheral arterial tonometry (PAT) provides non-invasive measures of vascular health. Beneficial effects of metformin on vascular function have been reported in youth with type 1 diabetes (T1D). In the REducing with MetfOrmin Vascular ... ...

Abstract	Background: Peripheral arterial tonometry (PAT) provides non-invasive measures of vascular health. Beneficial effects of metformin on vascular function have been reported in youth with type 1 diabetes (T1D). In the REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL) trial in adults with T1D and high cardiovascular risk, we examined: (i) the extent to which routinely-measured cardiometabolic risk factors explain variance in baseline PAT; and (ii) the effects of metformin on PAT measures. Methods: Cross-sectional univariable and multivariable analyses of baseline reactive hyperaemia index (RHI) and augmentation index (AI) (EndoPAT® (Itamar, Israel); and analysis of 36-months metformin versus placebo on vascular tonometry. Results: In 364 adults ((mean ± SD) age 55.2 ± 8.5 years, T1D 34.0 ± 10.6 years, HbA1c 64.5 ± 9.0 mmol/mol (8.1 ± 0.8%)), RHI was 2.26 ± 0.74 and AI was 15.9 ± 19.2%. In an exhaustive search, independent associates of (i) RHI were smoking, waist circumference, systolic blood pressure and vitamin B12 (adjusted Conclusion: Cardiometabolic risk factors explained only a modest proportion of variance in PAT measures of vascular health in adults with T1D and high cardiovascular risk. PAT measures were not affected by metformin.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Arteries ; Cardiometabolic Risk Factors ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/drug therapy ; Metformin/adverse effects ; Adult
Chemical Substances	Metformin (9100L32L2N)
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2250793-0
ISSN	1752-8984 ; 1479-1641
ISSN (online)	1752-8984
ISSN	1479-1641
DOI	10.1177/14791641231183634
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Article ; Online: The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.

Bellfy, Lauren / Smies, Chad W / Bernhardt, Alicia R / Bodinayake, Kasuni K / Sebastian, Aswathy / Stuart, Emily M / Wright, Destiny S / Lo, Chen-Yu / Murakami, Shoko / Boyd, Hannah M / von Abo, Megan J / Albert, Istvan / Kwapis, Janine L

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2023 Volume 48, Issue 12, Page(s) 1789–1797

Abstract: The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, downstream "satellite clocks" may also regulate local functions based ... ...

Abstract	The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, downstream "satellite clocks" may also regulate local functions based on the time of day. Within the dorsal hippocampus (DH), for example, local molecular oscillations may contribute to time-of-day effects on memory. Here, we used the hippocampus-dependent Object Location Memory task to determine how memory is regulated across the day/night cycle in mice. First, we systematically determined which phase of memory (acquisition, consolidation, or retrieval) is modulated across the 24 h day. We found that mice show better long-term memory performance during the day than at night, an effect that was specifically attributed to diurnal changes in memory consolidation, as neither memory acquisition nor memory retrieval fluctuated across the day/night cycle. Using RNA-sequencing we identified the circadian clock gene Period1 (Per1) as a key mechanism capable of supporting this diurnal fluctuation in memory consolidation, as learning-induced Per1 oscillates in tandem with memory performance in the hippocampus. We then show that local knockdown of Per1 within the DH impairs spatial memory without affecting either the circadian rhythm or sleep behavior. Thus, Per1 may independently function within the DH to regulate memory in addition to its known role in regulating the circadian system within the SCN. Per1 may therefore exert local diurnal control over memory consolidation within the DH.
MeSH term(s)	Animals ; Mice ; Circadian Rhythm/physiology ; Hippocampus/metabolism ; Memory Consolidation/physiology ; Period Circadian Proteins/genetics ; Spatial Memory ; Suprachiasmatic Nucleus/metabolism
Chemical Substances	Per1 protein, mouse ; Period Circadian Proteins
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-023-01616-1
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Article ; Online: The Impact of Whole Egg Consumption on Bone Accrual in Healthy Children: A Randomized Controlled Trial.

Coheley, Lauren M / Yu, Mengyun / Chen, Xianyan / O'Connor, Patrick J / Kealey, Kirk S / Laing, Emma M / Oshri, Assaf / Marand, Alicia K / Lance, Julia M / Kindler, Joseph M / Lewis, Richard D

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2023 Volume 38, Issue 12, Page(s) 1809–1821

Abstract: Dietary interventions designed to examine the role of nutrition on childhood bone accrual have often focused on the role of individual micronutrients (eg, calcium, vitamin D, and zinc) and macronutrients (eg, protein). The osteogenic benefits of whole ... ...

Abstract	Dietary interventions designed to examine the role of nutrition on childhood bone accrual have often focused on the role of individual micronutrients (eg, calcium, vitamin D, and zinc) and macronutrients (eg, protein). The osteogenic benefits of whole foods, such as eggs, are not well understood despite eggs being a source of high-quality nutrients and bioactive compounds known to positively influence bone. A significant positive cross-sectional association between whole egg consumption and tibia cortical bone mass has recently been shown in young children; however, randomized controlled trials (RCTs) have not been conducted. This study is a double-blind RCT in male and female children ages 9-13 years of different ancestries, designed to determine if consuming food products with whole eggs (equivalent to 8-10 eggs/wk) versus foods with milk or gelatin (placebo) over a 9-month period will improve measures of bone strength. Total body less head (TBLH) and lumbar spine bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed using dual-energy X-ray absorptiometry (DXA). DXA Z-scores were computed using published pediatric growth charts and were adjusted for height-for-age Z-score (HAZ). Mid-tibia cortical volumetric BMD, BMC, cortical area, total bone area, cortical thickness, and strength strain index were measured using peripheral quantitative computed tomography. Overall, there were no significant intervention effects for any bone outcomes. The increase in spine BMC
MeSH term(s)	Male ; Female ; Humans ; Child ; Child, Preschool ; Gelatin ; Bone and Bones ; Bone Density/physiology ; Absorptiometry, Photon/methods ; Lumbar Vertebrae ; Minerals ; Randomized Controlled Trials as Topic
Chemical Substances	Gelatin (9000-70-8) ; Minerals
Language	English
Publishing date	2023-12-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.4929
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Article ; Online: COVID-19-related intrusive thoughts and associated ritualistic behaviors.

Leong, Alicia / Colah, Ziba A / Guzick, Andrew G / Chen, Eugenia Y / Shah, Salonee S / Fall, Dylan A / Chen, Ruiqi / Zhang, YingYing / Zhang, Chencheng / Cepeda, Sandra L / Weinzimmer, Saira A / Schneider, Sophie C / Zhou, Xiaolu / Goodman, Wayne K / Liu, Wenjuan / Storch, Eric A

Bulletin of the Menninger Clinic

2023 Volume 87, Issue 3, Page(s) 225–249

Abstract: This study evaluated COVID-19-related intrusive thoughts and associated ritualistic behaviors (CITRB). From March to May 2020, 1,118 Chinese high school students, college students, psychiatric outpatients, and community members completed a survey ... ...

Abstract	This study evaluated COVID-19-related intrusive thoughts and associated ritualistic behaviors (CITRB). From March to May 2020, 1,118 Chinese high school students, college students, psychiatric outpatients, and community members completed a survey assessing CITRB, generalized anxiety, depression, somatization, obsessive-compulsive symptoms, and pandemic-related disruptions. Overall, participants reported mild to moderate CITRB, although certain thoughts/behaviors were more frequently endorsed, such as repeatedly telling others to take precautions against COVID-19 and checking COVID-19-related news. Being male, younger, a health-care worker, or in isolation/quarantine was associated with CITRB severity in community members. Obsessive-compulsive symptom severity, depression, somatic symptoms, and anxiety were associated with CITRB severity, although only obsessive-compulsive symptoms were uniquely associated with CITRB. This study provided evidence for the construct of CITRB, which may help mental health providers identify the nature and sources of COVID-19-related distress for some individuals as well as serve as a framework for evaluating obsessive-compulsive symptoms specific to large-scale crises.
MeSH term(s)	Female ; Humans ; Male ; Anxiety ; Anxiety Disorders ; Asian People ; COVID-19/complications ; COVID-19/psychology ; Mental Health ; Health Surveys ; Mental Disorders/etiology ; Mental Disorders/psychology ; Obsessive-Compulsive Disorder/etiology ; Obsessive-Compulsive Disorder/psychology ; Psychological Distress ; China
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	390416-7
ISSN	1943-2828 ; 0025-9284
ISSN (online)	1943-2828
ISSN	0025-9284
DOI	10.1521/bumc.2023.87.3.225
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Article ; Online: Evaluating performance of covariate-constrained randomization (CCR) techniques under misspecification of cluster-level variables in cluster-randomized trials.

Organ, Madeleine / Tandon, S Darius / Diebold, Alicia / Johnson, Jessica K / Yeh, Chen / Ciolino, Jody D

Contemporary clinical trials communications

2021 Volume 22, Page(s) 100754

Abstract: Covariate constrained randomization (CCR) is a method of controlling imbalance in important baseline covariates in cluster-randomized trials (CRT). We use simulated CRTs to investigate the performance (control of imbalance) of CCR relative to simple ... ...

Abstract	Covariate constrained randomization (CCR) is a method of controlling imbalance in important baseline covariates in cluster-randomized trials (CRT). We use simulated CRTs to investigate the performance (control of imbalance) of CCR relative to simple randomization (SR) under conditions of misspecification of the cluster-level variable used in the CCR algorithm. We use data from a Patient-Centered Outcomes Research Institute (PCORI)-funded CRT evaluating the Mothers and Babies (MB) intervention (AD-1507-31,473). CCR methodology was used in the MB study to control imbalance in, among other baseline variables, the percent minority (i.e., non-White) participants at each study site. Simulation schemes explored variation in degree of misspecification in the baseline covariate of interest, and include correct report, observed misspecification, and a range of simulated misspecification for intervals within and beyond that observed in the MB study. We also consider three within-site sample size scenarios: that observed in the MB study, small (mean 10) and large (mean 50). Simulations at every level of baseline covariate misspecification suggest that use of the CCR strategy provides between-arm imbalance that is simultaneously lower and less variable, on average, than that produced from the SR strategy. We find that the gains to using CCR over SR are nearly twice as high with accurate reporting (Δ = -5.33) compared to the observed study-level misspecification (Δ = -3.03). Although CCR still outperforms SR as the level of misspecification increases, the gains to using CCR over SR decrease; thus, every effort should still be made to obtain high-quality baseline data.
Language	English
Publishing date	2021-02-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-8654
ISSN (online)	2451-8654
DOI	10.1016/j.conctc.2021.100754
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Article ; Online: Sex difference in tDCS current mediated by changes in cortical anatomy: A study across young, middle and older adults.

Bhattacharjee, Sagarika / Kashyap, Rajan / Goodwill, Alicia M / O'Brien, Beth Ann / Rapp, Brenda / Oishi, Kenichi / Desmond, John E / Chen, S H Annabel

Brain stimulation

2021 Volume 15, Issue 1, Page(s) 125–140

Abstract: Introduction: The observed variability in the effects of transcranial direct current stimulation (tDCS) is influenced by the amount of current reaching the targeted region-of-interest (ROI). Age and sex might affect current density at target ROI due to ... ...

Abstract	Introduction: The observed variability in the effects of transcranial direct current stimulation (tDCS) is influenced by the amount of current reaching the targeted region-of-interest (ROI). Age and sex might affect current density at target ROI due to their impact on cortical anatomy. The present tDCS simulation study investigates the effects of cortical anatomical parameters (volumes, dimension, and torque) on simulated tDCS current density in healthy young, middle-aged, and older males and females. Methodology: Individualized head models from 240 subjects (120 males, 18-87 years of age) were used to identify the estimated current density (2 mA current intensity, 25 cm Results: For both tDCS montages, females in the older age group received higher current density than their male counterparts at the target ROIs. No sex differences were observed in the middle-aged group. Males in the younger age group had a higher current density than females, only for the parietal montage. Across all age groups, CSF, and grey matter volumes significantly predicted the current intensity estimated at the target sites. In the older age group only, brain-torque was a significant mediator of the sex difference. Conclusions: Our findings demonstrate the presence of sex differences in the simulated tDCS current density, however this pattern differed across age groups and stimulation locations. Future studies should consider influence of age and sex on individual cortical anatomy and tailor tDCS stimulation parameters accordingly.
MeSH term(s)	Aged ; Brain/diagnostic imaging ; Brain/pathology ; Female ; Head/anatomy & histology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Sex Characteristics ; Transcranial Direct Current Stimulation/methods
Language	English
Publishing date	2021-11-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2021.11.018
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Article ; Online: Evaluating performance of covariate-constrained randomization (CCR) techniques under misspecification of cluster-level variables in cluster-randomized trials

Madeleine Organ / S. Darius Tandon / Alicia Diebold / Jessica K. Johnson / Chen Yeh / Jody D. Ciolino

Contemporary Clinical Trials Communications, Vol 22, Iss , Pp 100754- (2021)

2021

Abstract	Covariate constrained randomization (CCR) is a method of controlling imbalance in important baseline covariates in cluster-randomized trials (CRT). We use simulated CRTs to investigate the performance (control of imbalance) of CCR relative to simple randomization (SR) under conditions of misspecification of the cluster-level variable used in the CCR algorithm.We use data from a Patient-Centered Outcomes Research Institute (PCORI)-funded CRT evaluating the Mothers and Babies (MB) intervention (AD-1507-31,473). CCR methodology was used in the MB study to control imbalance in, among other baseline variables, the percent minority (i.e., non-White) participants at each study site. Simulation schemes explored variation in degree of misspecification in the baseline covariate of interest, and include correct report, observed misspecification, and a range of simulated misspecification for intervals within and beyond that observed in the MB study. We also consider three within-site sample size scenarios: that observed in the MB study, small (mean 10) and large (mean 50). Simulations at every level of baseline covariate misspecification suggest that use of the CCR strategy provides between-arm imbalance that is simultaneously lower and less variable, on average, than that produced from the SR strategy. We find that the gains to using CCR over SR are nearly twice as high with accurate reporting (Δ = −5.33) compared to the observed study-level misspecification (Δ = −3.03). Although CCR still outperforms SR as the level of misspecification increases, the gains to using CCR over SR decrease; thus, every effort should still be made to obtain high-quality baseline data.
Keywords	Cluster-randomized trials ; Covariate-constrained randomization ; Simple randomization ; Medicine (General) ; R5-920
Subject code	310
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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