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  1. Article ; Online: Reply to G. Yu et al.

    Wu, Hao-Xiang / Pan, Yi-Qian / Wang, Zi-Xian / Wang, Feng

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 15, Page(s) 2864–2865

    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  2. Article: Correction: Yu et al. Rare-Earth-Metal (Nd

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Correction: Yu et al. Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: There was an error in the original publication [ ... ]. ...

    Abstract There was an error in the original publication [...].
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Yu et al. Comparison of Physical and Biochemical Characterizations of SARS-CoV-2 Inactivated by Different Treatments.

    Yu, Shouzhi / Wei, Yangyang / Liang, Hongyang / Ji, Wenheng / Chang, Zhen / Xie, Siman / Wang, Yichuan / Li, Wanli / Liu, Yingwei / Wu, Hao / Li, Jie / Wang, Hui / Yang, Xiaoming

    Viruses

    2023  Volume 15, Issue 5

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2023-04-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.

    Xie, Linbi / Song, Xu / Lei, Ling / Chen, Chu / Zhao, Huan / Hu, Jingyi / Yu, Yue / Bai, Xiaolu / Wu, Xia / Li, Xiangfeng / Yang, Xiao / Yuan, Bo / Li, Dongxiao / Zhu, Xiangdong / Zhang, Xingdong

    Journal of ethnopharmacology

    2023  Volume 321, Page(s) 117480

    Abstract: Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula ...

    Abstract Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula for fracture therapy. In clinic, OK is effective in treating fractures while alleviating osteoporosis (OP) symptoms. However, active components of OK and the associated molecular mechanisms remain not fully elucidated.
    Aim of the study: This study aims to systematically evaluate the anti-osteoporosis efficacy of OK and for the first time combine network pharmacology with high-throughput whole gene transcriptome sequencing to study its underlying mechanism.
    Materials and methods: In this study, the osteoporosis model was established by the castration of both ovaries. The level of serum bone turnover factor was detected by enzyme-linked immunosorbent assay. Micro-CT and HE staining were used to observe the changes of bone histopathology, and nano-indentation technique was used to detect the biomechanical properties of rat bone. The main active Chemical components of OK were identified using UPLC-DAD. Efficacy verification and mechanism exploration were conducted by network pharmacology, molecular docking, whole gene transcriptomics and in vivo experiments.
    Results: In our study, OK significantly improved bone microarchitecture and bone biomechanical parameters in OVX rats, reduced osteoclast indexes such as C-telopeptide of type I collage (CTX-I) and increased Osteoprotegerin (OPG)/Receptor activator of NF-κB ligand (RANKL) levels. Mechanistically, PI3K/AKT pathway was a common pathway for genome enrichment analysis (KEGG) of both network pharmacology and RNA-seq studies. G protein-β-like protein (GβL), Ribosomal-protein S6 kinase homolog 2 (S6K2), and Phosphoinositide 3-kinase (PI3K) appeared differentially expression in the PI3K-AKT signaling pathway. These results were also confirmed by qRT-PCR and immunohistochemistry.
    Conclusions: OK may be used to treat osteoporosis, at least partly by activating PI3K/AKT/mTORC1 signaling pathway.
    MeSH term(s) Rats ; Animals ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Network Pharmacology ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoporosis/metabolism ; Gene Expression Profiling ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Osteoprotegerin ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-11-22
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  6. Article ; Online: The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis.

    Zhao, Yi / Zhao, Linan / Wang, Tao / Liu, Zhenghao / Tang, Suyuan / Huang, Hongxia / Wu, Li / Sun, Youzhi

    Integrative cancer therapies

    2024  Volume 23, Page(s) 15347354241233258

    Abstract: ... levels of SNCG, ER-α, : Results: SGJY significantly reduced the tumor weight and volume, and the level ... The protein expression of SNCG, ER-α, : Conclusion: The results demonstrate that SGJY ... suppressing the protein expression in the SNCG/ER-α/AKT-ERK pathway. ...

    Abstract Background: Soothing the liver (called
    The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms.
    Materials and methods: SGJY herbal combination was extracted using water. A breast cancer rat model was developed by chemical DMBA by gavage, then treated with SGJY for 11 weeks. The tumor tissue was preserved for RNA sequencing and analyzed by IPA software. The inhibition effects of SGJY on MCF-7 and T47D breast cancer cells were investigated by SRB assay and cell apoptosis analysis, and the protein expression levels of SNCG, ER-α,
    Results: SGJY significantly reduced the tumor weight and volume, and the level of estradiol in serum. The results of IPA analysis reveal SGJY upregulated 7 canonical pathways and downregulated 16 canonical pathways. Estrogen receptor signaling was the key canonical pathway with 9 genes downregulated. The results of upstream regulator analysis reveal beta-estradiol was the central target; the upstream regulator network scheme showed that 86 genes could affect the expression of the beta-estradiol, including SNCG, CCL21 and MB. Additionally, SGJY was verified to significantly alter the expression of SNCG mRNA, CCL21 mRNA and MB mRNA which was consistent with the data of RNA-Seq. The inhibition effects of SGJY exhibited a dose-dependent response. The apoptosis rates of MCF7 and T47D cells were upregulated. The protein expression of SNCG, ER-α,
    Conclusion: The results demonstrate that SGJY may inhibit the growth of breast cancer. The mechanism might involve downregulating the level of serum estradiol, and suppressing the protein expression in the SNCG/ER-α/AKT-ERK pathway.
    MeSH term(s) Animals ; Female ; Humans ; Rats ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Estradiol ; gamma-Synuclein/genetics ; gamma-Synuclein/metabolism ; MAP Kinase Signaling System ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Estrogen/metabolism ; RNA, Messenger/metabolism ; RNA-Seq
    Chemical Substances Estradiol (4TI98Z838E) ; gamma-Synuclein ; Neoplasm Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Estrogen ; RNA, Messenger ; SNCG protein, human
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182320-0
    ISSN 1552-695X ; 1534-7354
    ISSN (online) 1552-695X
    ISSN 1534-7354
    DOI 10.1177/15347354241233258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6026: Show issues Location:
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  7. Article: Prescription characteristics of Xue-Fu-Zhu-Yu-Tang in pain management: a population-based study using the National Health Insurance Research Database in Taiwan.

    Kuo, Chun-En / Hsu, Sheng-Feng / Chen, Ching-Chih / Wu, Szu-Ying / Hung, Yu-Chiang / Hsu, Chung Y / Tsai, I-Ju / Hu, Wen-Long

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1233156

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1233156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical Efficacy of the Huo Xue Hua Yu Method Combined with Aspirin in the Treatment of Acute Cerebral Infarction: A Systematic Evaluation and Meta-analysis.

    Chen, Chu / Ma, Fang / Wen, Xinli / Liu, Xing / Tang, Qing / Wu, Yilun

    Current pharmaceutical design

    2023  Volume 29, Issue 25, Page(s) 2009–2017

    Abstract: Objective: The study aimed to evaluate the clinical efficacy of the Huo Xue Hua Yu method combined ... of them, the Huo Xue Hua Yu method combined with aspirin has been administered, while 597 have only been ... 2.90 to 5.84, : Conclusion: The combination of the Huo Xue Hua Yu method and aspirin represents ...

    Abstract Objective: The study aimed to evaluate the clinical efficacy of the Huo Xue Hua Yu method combined with aspirin in the treatment of patients with acute cerebral infarction (ACI).
    Methods: By searching electronic databases, such as the Chinese Biomedical Literature Database (CBM), the China National Knowledge Infrastructure Database (CNKI), the China Science and Technology Journal Database, Wanfang, PubMed, Embase, and the Cochrane Library, all randomized controlled trials (RCTs) published before 14 July, 2022, and published in Chinese or English languages were selected. Statistical analysis was performed using Review Manager 5.4 calculation software to calculate the odds ratio (OR), mean difference (MD), 95% confidence interval (CI), and p values.
    Results: 13 articles that included 1,243 patients were identified; in 646 of them, the Huo Xue Hua Yu method combined with aspirin has been administered, while 597 have only been administered aspirin therapy. The combined treatment significantly improved clinical efficacy (OR: 4.41, 95% CI: 2.90 to 5.84,
    Conclusion: The combination of the Huo Xue Hua Yu method and aspirin represents a beneficial adjunctive therapy for ACI.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/therapeutic use ; Aspirin/therapeutic use ; Stroke/drug therapy ; Treatment Outcome ; Brain Ischemia/drug therapy ; Acute Disease ; Cerebral Infarction/drug therapy
    Chemical Substances Drugs, Chinese Herbal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2023-06-22
    Publishing country United Arab Emirates
    Document type Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612829666230622110753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
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  9. Article ; Online: In reply of the comment "Is oral lichen planus potentially malignant: A reply to Yu-Wei Chiu et al".

    Chiu, Yu-Wei / Su, Yee-Fun / Yang, Cheng-Chieh / Liu, Chung-Ji / Chen, Yi-Ju / Cheng, Han-Chieh / Wu, Cheng-Hsien / Chen, Pei-Yin / Lee, Yu-Hsien / Chen, Yen-Lin / Chen, Yi-Tzu / Peng, Chih-Yu / Lu, Ming-Yi / Yu, Chuan-Hang / Kao, Shou-Yen / Fwu, Chyng-Wen / Huang, Yu-Feng

    Oral diseases

    2022  Volume 29, Issue 5, Page(s) 2317–2318

    MeSH term(s) Humans ; Lichen Planus, Oral/complications ; Cell Transformation, Neoplastic ; Mouth Neoplasms
    Language English
    Publishing date 2022-05-04
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14214
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    Zs.A 4427: Show issues Location:
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  10. Article ; Online: The dynamic metabolic profile of Qi-Yu-San-Long decoction in rat urine using UPLC-QTOF-MS

    Zheng, Ting / Zhao, Yue / Li, Ruijuan / Huang, Mengwen / Zhou, An / Li, Zegeng / Wu, Huan

    Journal of pharmaceutical analysis

    2022  Volume 12, Issue 5, Page(s) 755–765

    Abstract: Qi-Yu-San-Long decoction (QYSLD) is a traditional Chinese medicine that has been clinically used ...

    Abstract Qi-Yu-San-Long decoction (QYSLD) is a traditional Chinese medicine that has been clinically used in the treatment of non-small-cell lung cancer (NSCLC) for more than 20 years. However, to date, metabolic-related studies on QYSLD have not been performed. In this study, a post-targeted screening strategy based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight full information tandem mass spectrometry (UPLC-QTOF-MS
    Language English
    Publishing date 2022-05-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2022.05.005
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