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Article ; Online: The cancer secretome and secreted biomarkers.

Donadelli, Massimo

Seminars in cell & developmental biology

2017 Volume 78, Page(s) 1–2

MeSH term(s)	Biomarkers, Tumor/analysis ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Neoplasms/pathology ; Proteome/analysis ; Tumor Microenvironment/physiology
Chemical Substances	Biomarkers, Tumor ; Proteome
Language	English
Publishing date	2017-09-06
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2017.09.004
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Article ; Online: Metastatic outgrowth via the two-way interplay of autophagy and metabolism.

Behrooz, Amir Barzegar / Cordani, Marco / Donadelli, Massimo / Ghavami, Saeid

Biochimica et biophysica acta. Molecular basis of disease

2023 Volume 1870, Issue 3, Page(s) 166824

Abstract: Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, ...

Abstract	Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, engage in dynamic dialogues with stromal cells and undertake epithelial-mesenchymal transition (EMT) phenoconversion. To ensure survival, tumor cells employ several strategies such as restructuring their metabolic needs to adapt to the alterations of the microenvironmental resources via different mechanisms including macroautophagy (autophagy) and to circumvent anoikis-a form of cell death induced upon detachment from the extracellular matrix (ECM). This review focuses on the puzzling connections of autophagy and energetic metabolism within the context of cancer metastasis.
MeSH term(s)	Humans ; Neoplasms/pathology ; Proteins ; Autophagy
Chemical Substances	Proteins
Language	English
Publishing date	2023-11-09
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2023.166824
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Article ; Online: HUS and TTP: traversing the disease and the age spectrum.

Donadelli, Roberta / Sinha, Aditi / Bagga, Arvind / Noris, Marina / Remuzzi, Giuseppe

Seminars in nephrology

2023 Volume 43, Issue 4, Page(s) 151436

Abstract: Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is characterized by microvascular thrombosis with consequent thrombocytopenia, ... ...

Abstract	Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is characterized by microvascular thrombosis with consequent thrombocytopenia, microangiopathic hemolytic anemia and/or multiorgan dysfunction. In the past, the distinction between HUS and TTP was predominantly based on clinical grounds. However, clinical presentation of the two syndromes often overlaps and, the differential diagnosis is broad. Identification of underlying pathogenic mechanisms has enabled the classification of these syndromes on a molecular basis: typical HUS caused by Shiga toxin-producing Escherichia coli (STEC-HUS); atypical HUS or complement-mediated TMA (aHUS/CM-TMA) associated with genetic or acquired defects leading to dysregulation of the alternative pathway (AP) of complement; and TTP that results from a severe deficiency of the von Willebrand Factor (VWF)-cleaving protease, ADAMTS13. The etiology of TMA differs between pediatric and adult patients. Childhood TMA is chiefly caused by STEC-HUS, followed by CM-TMA and pneumococcal HUS (Sp-HUS). Rare conditions such as congenital TTP (cTTP), vitamin B12 metabolism defects, and coagulation disorders (diacylglycerol epsilon mutation) present as TMA chiefly in children under 2 years of age. In contrast secondary causes and acquired ADAMT13 deficiency are more common in adults. In adults, compared to children, diagnostic delays are more frequent due to the wide range of differential diagnoses. In this review we focus on the three major forms of TMA, STEC-HUS, aHUS and TTP, outlining the clinical presentation, diagnosis and management of the affected patients, to help highlight the salient features and the differences between adult and pediatric patients which are relevant for management.
MeSH term(s)	Adult ; Humans ; Child ; Infant ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/etiology ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Diagnosis, Differential ; Mutation
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604652-6
ISSN	1558-4488 ; 0270-9295
ISSN (online)	1558-4488
ISSN	0270-9295
DOI	10.1016/j.semnephrol.2023.151436
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Article: Global risks, the macroeconomy, and asset prices.

Costola, Michele / Donadelli, Michael / Gerotto, Luca / Gufler, Ivan

Empirical economics

2022 Volume 63, Issue 5, Page(s) 2357–2388

Abstract: We propose a novel index of global risks awareness (GRAI) based on the most concerning risks-classified in five categories (economic, environmental, geopolitical, societal, and technological)-reported by the World Economic Forum (WEF) according to the ... ...

Abstract	We propose a novel index of global risks awareness (GRAI) based on the most concerning risks-classified in five categories (economic, environmental, geopolitical, societal, and technological)-reported by the World Economic Forum (WEF) according to the potential impact and likelihood occurrence. The degree of public concern toward these risks is captured by Google search volumes on topics having the same or similar wording of that one of the WEF Global Risk Report. The dynamics of our GRAI exhibits several spillover episodes and indicates that concerns on the five different categories of global risks are-on average-highly interconnected. We further examine the interconnection between global risks perceptions and the macroeconomy and find that concerns on economic-, geopolitical-, and societal-related risks are net shock transmitters, whereas the macroeconomic variables are largely net receivers. Finally, we perform standard cross-sectional asset pricing tests and provide evidence that rising interconnection among global risks awareness commands a positive and statistically significant risk premium.
Language	English
Publishing date	2022-02-14
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1462176-9
ISSN	1435-8921 ; 0377-7332
ISSN (online)	1435-8921
ISSN	0377-7332
DOI	10.1007/s00181-022-02205-9
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Article: Temperature Variability and the Macroeconomy: A World Tour

Donadelli, Michael / Jüppner, Marcus / Vergalli, Sergio

Environmental and resource economics. 2022 Sept., v. 83, no. 1

2022

Abstract: This paper uses historical monthly temperature level data for a panel of 114 countries to identify the effects of within year temperature level variability on productivity growth in five different macro regions, i.e., (1) Africa, (2) Asia, (3) Europe, (4) ...

Abstract	This paper uses historical monthly temperature level data for a panel of 114 countries to identify the effects of within year temperature level variability on productivity growth in five different macro regions, i.e., (1) Africa, (2) Asia, (3) Europe, (4) North America and (5) South America. We find two primary results. First, higher intra-annual temperature variability reduces (increases) productivity in Europe and North America (Asia). Second, higher intra-annual temperature variability has no significant effects on productivity in Africa and South America. Additional empirical tests indicate also the following: (1) rising intra-annual temperature variability reduces productivity (even thought less significantly)in both tropical and non-tropical regions, (2) inter-annual temperature variability reduces (increases) productivity in North America (Europe) and (3) winter and summer inter-annual temperature variability generates a drop in productivity in both Europe and North America. Taken together, these findings indicate that temperature variability shocks tend to have stronger adverse economic effects among richer economies. In a production economy featuring long-run productivity and temperature volatility shocks, we quantify these negative impacts and find welfare losses of 2.9% (1%) in Europe (North America).
Keywords	economics ; temperature ; winter ; Africa ; Asia ; Europe ; North America ; South America
Language	English
Dates of publication	2022-09
Size	p. 221-259.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1479788-4
ISSN	1573-1502 ; 0924-6460
ISSN (online)	1573-1502
ISSN	0924-6460
DOI	10.1007/s10640-021-00579-5
Database	NAL-Catalogue (AGRICOLA)

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Article: Sex and "the City": Financial stress and online pornography consumption.

Donadelli, Michael / Lalanne, Marie

Journal of behavioral and experimental finance

2020 Volume 27, Page(s) 100379

Abstract: We examine the effects of financial stress on online pornography consumption. We use novel data on daily accesses to one of the most popular porn website (xHamster) for 43 different cities belonging to 10 countries for the year 2016. In financial cities, ...

Abstract	We examine the effects of financial stress on online pornography consumption. We use novel data on daily accesses to one of the most popular porn website (xHamster) for 43 different cities belonging to 10 countries for the year 2016. In financial cities, in which people are more likely to be affected by financial stress, we observe that on average online porn viewing decreases as financial stress increases. We present some evidence suggesting the causing channel to be altered mood.
Keywords	covid19
Language	English
Publishing date	2020-08-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2214-6350
ISSN	2214-6350
DOI	10.1016/j.jbef.2020.100379
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Article ; Online: The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives.

Behrooz, Amir Barzegar / Cordani, Marco / Fiore, Alessandra / Donadelli, Massimo / Gordon, Joseph W / Klionsky, Daniel J / Ghavami, Saeid

Seminars in cancer biology

2024 Volume 99, Page(s) 24–44

Abstract: Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, and cancer development, with a ... ...

Abstract	Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, and cancer development, with a specific emphasis on how obesity-driven changes affect the regulation of autophagy and subsequent implications for cancer risk. The burgeoning epidemic of obesity underscores the relevance of this research, particularly given the established links between obesity, autophagy, and various cancers. Our exploration delves into hormonal influence, notably INS (insulin) and LEP (leptin), on obesity and autophagy interactions. Further, we draw attention to the latest findings on molecular factors linking obesity to cancer, including hormonal changes, altered metabolism, and secretory autophagy. We posit that targeting autophagy modulation may offer a potent therapeutic approach for obesity-associated cancer, pointing to promising advancements in nanocarrier-based targeted therapies for autophagy modulation. However, we also recognize the challenges inherent to these approaches, particularly concerning their precision, control, and the dual roles autophagy can play in cancer. Future research directions include identifying novel biomarkers, refining targeted therapies, and harmonizing these approaches with precision medicine principles, thereby contributing to a more personalized, effective treatment paradigm for obesity-mediated cancer.
MeSH term(s)	Humans ; Obesity/complications ; Obesity/metabolism ; Adipose Tissue/metabolism ; Treatment Outcome ; Autophagy/physiology ; Neoplasms/etiology ; Neoplasms/metabolism
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2024.01.003
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Article ; Online: Using past epidemics to estimate the macroeconomic implications of COVID-19: A bad idea!

Donadelli, Michael / Ferranna, Licia / Gufler, Ivan / Paradiso, Antonio

Structural change and economic dynamics

2021 Volume 57, Page(s) 214–224

Abstract: This work is intended to show that past epidemic scenarios are not suitable to estimate the macroeconomic impact of the new 2019 coronavirus. Using five centuries of macroeconomic data for England and a unique dataset on epidemics and other significant ... ...

Abstract	This work is intended to show that past epidemic scenarios are not suitable to estimate the macroeconomic impact of the new 2019 coronavirus. Using five centuries of macroeconomic data for England and a unique dataset on epidemics and other significant events (i.e., wars and natural disasters), we show that the macroeconomic effect of epidemics reflects the socio-economic features characterizing different eras. A mapping between past epidemic scenarios and the COVID-19-induced environment can thus lead to misleading outcomes. We believe our evidence to be of general interest and key for policymakers forced to implement rapid and effective policies.
Language	English
Publishing date	2021-03-20
Publishing country	England
Document type	Journal Article
ISSN	1873-6017
ISSN (online)	1873-6017
DOI	10.1016/j.strueco.2021.03.002
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Article ; Online: From COVID-19 herd immunity to investor herding in international stock markets: The role of government and regulatory restrictions.

Kizys, Renatas / Tzouvanas, Panagiotis / Donadelli, Michael

International review of financial analysis

2021 Volume 74, Page(s) 101663

Abstract: We study if government response to the novel coronavirus COVID-19 pandemic can mitigate investor herding behaviour in international stock markets. Our empirical analysis is informed by daily stock market data from 72 countries from both developed and ... ...

Abstract	We study if government response to the novel coronavirus COVID-19 pandemic can mitigate investor herding behaviour in international stock markets. Our empirical analysis is informed by daily stock market data from 72 countries from both developed and emerging economies in the first quarter of 2020. The government response to the COVID-19 outbreak is measured by means of the Oxford COVID-19 Government Response Tracker, where higher scores are associated with greater stringency. Three main findings are in order. First, results show evidence of investor herding in international stock markets. Second, we document that the Oxford Government Response Stringency Index mitigates investor herding behaviour, by way of reducing multidimensional uncertainty. Third, short-selling restrictions, temporarily imposed by the national and supranational regulatory authorities of the European Union, appear to exert a mitigating effect on herding. Finally, our results are robust to a range of model specifications.
Language	English
Publishing date	2021-01-12
Publishing country	United States
Document type	Journal Article
ISSN	1873-8079
ISSN (online)	1873-8079
DOI	10.1016/j.irfa.2021.101663
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Article ; Online: Mitochondrial metabolic alterations in cancer cells and related therapeutic targets.

Riganti, Chiara / Donadelli, Massimo

Seminars in cell & developmental biology

2019 Volume 98, Page(s) 1–3

MeSH term(s)	Antineoplastic Agents/pharmacology ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2019-10-24
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2019.10.005
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