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  1. Article ; Online: IR and py/GC/MS examination of amber relics excavated from 6th century royal tomb in Korean Peninsula.

    Park, Jongseo / Yun, Eunyoung / Kang, Hyungtae / Ahn, Jooyoung / Kim, Gyuho

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2016  Volume 165, Page(s) 114–119

    Abstract: Relics of amber were excavated from King Muryeong's tomb constructed in the 6th century ... pyrolysis/gas chromatography/mass spectrometry) analysis were utilized. The reference Baltic amber sample ... was also analyzed with the same method for comparison. The relics were confirmed to be amber ...

    Abstract Relics of amber were excavated from King Muryeong's tomb constructed in the 6th century on the Korean peninsula. To estimate the provenance, FTIR (Fourier transform infrared spectroscopy) and py/GC/MS (pyrolysis/gas chromatography/mass spectrometry) analysis were utilized. The reference Baltic amber sample was also analyzed with the same method for comparison. The relics were confirmed to be amber from the FTIR analysis where an absorption band near 1150cm(-1), characteristic one in Baltic amber, was also observed. In py/GC/MS analysis, pyrolyzed products like butanedioic acid and dehydroabietic acid, known constituents of amber, were observed. In addition, d-fenchyl alcohol, camphor, borneol and butanedioic acid, typical constituents of Baltic amber, were observed in some samples. From this, it appears that some of relics were made from Baltic amber and that Baltic amber was transported to the Korean peninsula in the time of tomb construction.
    Language English
    Publishing date 2016-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2016.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case-control analysis of smoking and breast cancer in African American women: findings from the AMBER Consortium.

    Park, Song-Yi / Palmer, Julie R / Rosenberg, Lynn / Haiman, Christopher A / Bandera, Elisa V / Bethea, Traci N / Troester, Melissa A / Viscidi, Emma / Kolonel, Laurence N / Olshan, Andrew F / Ambrosone, Christine B

    Carcinogenesis

    2016  Volume 37, Issue 6, Page(s) 607–615

    Abstract: Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast ...

    Abstract Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast cancer risk by menopause and hormone receptor status [estrogen receptor-positive (ER+), ER-negative (ER-) and triple-negative (ER-, PR-, HER2-)]. The study included 5791 African American women with breast cancer and 17376 African American controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in multivariable logistic regression analysis with adjustment for study and risk factors. Results differed by menopausal status. Among postmenopausal women, positive associations were observed for long duration and greater pack-years of smoking: relative to never smoking, fully adjusted ORs were 1.14 (95% CI: 1.03-1.26) for duration ≥20 years and 1.16 (95% CI: 1.01-1.33) for ≥20 pack-years. By contrast, inverse associations were observed among premenopausal women, with ORs of 0.80 (95% CI: 0.68-95) for current smoking and 0.81 (95% CI: 0.69-0.96) for former smoking, without trends by duration. Associations among postmenopausal women were somewhat stronger for ER+ breast cancer. The findings suggest that the relation of cigarette smoking to breast cancer risk in African American women may vary by menopausal status and breast cancer subtype.
    MeSH term(s) Adult ; African Americans/statistics & numerical data ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Case-Control Studies ; Female ; Humans ; Logistic Models ; Menopause ; Middle Aged ; Receptors, Estrogen/metabolism ; Smoking/adverse effects ; Smoking/epidemiology ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/etiology ; Young Adult
    Chemical Substances Receptors, Estrogen
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgw040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium.

    Bandera, Elisa V / Chandran, Urmila / Hong, Chi-Chen / Troester, Melissa A / Bethea, Traci N / Adams-Campbell, Lucile L / Haiman, Christopher A / Park, Song-Yi / Olshan, Andrew F / Ambrosone, Christine B / Palmer, Julie R / Rosenberg, Lynn

    Breast cancer research and treatment

    2015  Volume 150, Issue 3, Page(s) 655–666

    Abstract: ... body fat distribution on breast cancer subtypes in AA women. We evaluated these associations in the AMBER Consortium ...

    Abstract African American (AA) women are more likely than white women to be obese and to be diagnosed with ER- and triple-negative (TN) breast cancer, but few studies have evaluated the impact of obesity and body fat distribution on breast cancer subtypes in AA women. We evaluated these associations in the AMBER Consortium by pooling data from four large studies. Cases were categorized according to hormone receptor status as ER+, ER-, and TN (ER-, PR-, and HER2-) based on pathology data. A total of 2104 ER+ cases, 1070 ER- cases (including 491 TN cases), and 12,060 controls were included. Odds ratios (OR) and 95 % confidence intervals (CI) were computed using logistic regression, taking into account breast cancer risk factors. In postmenopausal women, higher recent (most proximal value to diagnosis/index date) BMI was associated with increased risk of ER+ cancer (OR 1.31; 95 % CI 1.02-1.67 for BMI ≥ 35 vs. <25 kg/m(2)) and with decreased risk of TN tumors (OR 0.60; 95 % CI 0.39-0.93 for BMI ≥ 35 vs. <25). High young adult BMI was associated with decreased premenopausal ER+ cancer and all subtypes of postmenopausal cancer, and high recent waist-to-hip ratio with increased risk of premenopausal ER+ tumors (OR 1.35; 95 % CI 1.01-1.80) and all tumor subtypes combined in postmenopausal women (OR 1.26; 95 % CI 1.02-1.56). The impact of general and central obesity varies by menopausal status and hormone receptor subtype in AA women. Our findings imply different mechanisms for associations of adiposity with TN and ER+ breast cancers.
    MeSH term(s) Adult ; African Americans/statistics & numerical data ; Aged ; Aged, 80 and over ; Body Fat Distribution/adverse effects ; Breast Neoplasms/ethnology ; Breast Neoplasms/etiology ; Breast Neoplasms/pathology ; Female ; Humans ; Menopause ; Middle Aged ; Obesity/complications ; Obesity/epidemiology ; Obesity/ethnology ; Odds Ratio ; Receptor, ErbB-2/analysis ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis ; Risk Factors
    Chemical Substances Receptors, Estrogen ; Receptors, Progesterone ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2015-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-015-3353-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Full down-conversion of amber-emitting phosphor-converted light-emitting diodes with powder phosphors and a long-wave pass filter.

    Oh, Jeong Rok / Cho, Sang-Hwan / Park, Hoo Keun / Oh, Ji Hye / Lee, Yong-Hee / Do, Young Rag

    Optics express

    2010  Volume 18, Issue 11, Page(s) 11063–11072

    Abstract: ... monochromatic amber-emitting light-emitting diode (LED) using a powder-based phosphor-converted LED combined ... with a long-wave pass filter (LWPF). The capping of a blue-reflecting and amber-passing LWPF enhances ... both the amber emission from the silicate amber phosphor layer and the color purity due to the blocking and ...

    Abstract This paper reports the possibility of a facile optical structure to realize a highly efficient monochromatic amber-emitting light-emitting diode (LED) using a powder-based phosphor-converted LED combined with a long-wave pass filter (LWPF). The capping of a blue-reflecting and amber-passing LWPF enhances both the amber emission from the silicate amber phosphor layer and the color purity due to the blocking and recycling of the pumping blue light from the InGaN LED. The enhancement of the luminous efficacy of the amber pc-LED with a LWPF (phosphor concentration 20 wt%, 39.4 lm/W) is 34% over that of an amber pc-LED without a LWPF (phosphor concentration 55 wt%, 29.4 lm/W) at 100 mA and a high color purity (>96%) with Commission International d'Eclairage (CIE) color coordinates of x=0.57 and y=0.42.
    MeSH term(s) Color ; Equipment Design ; Equipment Failure Analysis ; Filtration/instrumentation ; Light ; Lighting/instrumentation ; Powders ; Semiconductors
    Chemical Substances Powders
    Language English
    Publishing date 2010-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.18.011063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Tetracycline-regulated suppression of amber codons in mammalian cells.

    Park, H J / RajBhandary, U L

    Molecular and cellular biology

    1998  Volume 18, Issue 8, Page(s) 4418–4425

    Abstract: ... recently an amber suppression system in mammalian cells dependent on coexpression of Escherichia coli ... glutaminyl-tRNA synthetase (GlnRS) along with the E. coli glutamine-inserting amber suppressor tRNA. Here ... gene and the E. coli glutamine-inserting amber suppressor tRNA gene resulted in suppression ...

    Abstract As an approach to inducible suppression of nonsense mutations in mammalian cells, we described recently an amber suppression system in mammalian cells dependent on coexpression of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) along with the E. coli glutamine-inserting amber suppressor tRNA. Here, we report on tetracycline-regulated expression of the E. coli GlnRS gene and, thereby, tetracycline-regulated suppression of amber codons in mammalian HeLa and COS-1 cells. The E. coli GlnRS coding sequence attached to a minimal mammalian cell promoter was placed downstream of seven tandem tetracycline operator sequences. Cotransfection of HeLa cell lines expressing a tetracycline transactivator protein, carrying a tetracycline repressor domain linked to part of a herpesvirus VP16 activation domain, with the E. coli GlnRS gene and the E. coli glutamine-inserting amber suppressor tRNA gene resulted in suppression of the amber codon in a reporter chloramphenicol acetyltransferase gene. The tetracycline transactivator-mediated expression of E. coli GlnRS was essentially completely blocked in HeLa or COS-1 cells grown in the presence of tetracycline. Concomitantly, both aminoacylation of the suppressor tRNA and suppression of the amber codon were reduced significantly in the presence of tetracycline.
    MeSH term(s) Acylation ; Amino Acyl-tRNA Synthetases/genetics ; Amino Acyl-tRNA Synthetases/metabolism ; Animals ; COS Cells ; Codon ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Gene Expression Regulation ; HeLa Cells ; Humans ; Nuclear Localization Signals ; RNA, Transfer/genetics ; Tetracycline/metabolism ; Trans-Activators/genetics
    Chemical Substances Codon ; Nuclear Localization Signals ; Trans-Activators ; RNA, Transfer (9014-25-9) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; glutaminyl-tRNA synthetase (EC 6.1.1.18) ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 1998-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.18.8.4418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: TRNA2Gln Su+2 mutants that increase amber suppression.

    Bradley, D / Park, J V / Soll, L

    Journal of bacteriology

    1981  Volume 145, Issue 2, Page(s) 704–712

    Abstract: ... trp B9601 amber mutation on translationally stringent rpsL594 streptomycin-resistant ribosomes ... amber mutants, which were almost identical to that of Su+2, the two mutant Su+ transfer ... ribonucleic acids inserted glutamine at amber sites. ...

    Abstract We selected mutants of lambda pSu+2 which had an increased ability to suppress on Escherichia coli trp B9601 amber mutation on translationally stringent rpsL594 streptomycin-resistant ribosomes. tRNA2Gin Su+2 molecules produced from eight independent mutants were purified, and their ribonucleic acid sequences were determined. Two types of mutations were mapped to the tRNA2Gin Su+2(glnV) gene by this method. Both altered the pseudouridine at position 37 of the tRNA anticodon loop. Seven of the isolates were transitions (pseudouridine to cytosine), and one was a transversion (pseudouridine to adenine). These mutations resulted in Su+ transfer ribonucleic acid molecules that exhibited higher transmission coefficients than their parent Su+2 transfer ribonucleic acids. As judged by their suppressor spectra on T4 amber mutants, which were almost identical to that of Su+2, the two mutant Su+ transfer ribonucleic acids inserted glutamine at amber sites.
    MeSH term(s) Amino Acyl-tRNA Synthetases/metabolism ; Base Sequence ; Escherichia coli/genetics ; Glutamine ; Mutation ; RNA, Transfer/genetics ; Substrate Specificity ; Suppression, Genetic
    Chemical Substances Glutamine (0RH81L854J) ; RNA, Transfer (9014-25-9) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-)
    Language English
    Publishing date 1981-02
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.145.2.704-712.1981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Amber suppression in mammalian cells dependent upon expression of an Escherichia coli aminoacyl-tRNA synthetase gene.

    Drabkin, H J / Park, H J / RajBhandary, U L

    Molecular and cellular biology

    1996  Volume 16, Issue 3, Page(s) 907–913

    Abstract: ... eukaryotic cells, we have analyzed the expression of an Escherichia coli glutamine-inserting amber suppressor tRNA ...

    Abstract As an approach to inducible suppression of nonsense mutations in mammalian and in higher eukaryotic cells, we have analyzed the expression of an Escherichia coli glutamine-inserting amber suppressor tRNA gene in COS-1 and CV-1 monkey kidney cells. The tRNA gene used has the suppressor tRNA coding sequence flanked by sequences derived from a human initiator methionine tRNA gene and has two changes in the coding sequence. This tRNA gene is transcribed, and the transcript is processed to yield the mature tRNA in COS-1 and CV-1 cells. We show that the tRNA is not aminoacylated in COS-1 cells by any of the endogenous aminoacyl-tRNA synthetases and is therefore not functional as a suppressor. Concomitant expression of the E. coli glutaminyl-tRNA synthetase gene results in aminoacylation of the suppressor tRNA and its functioning as a suppressor. These results open up the possibility of attempts at regulated suppression of nonsense codons in mammalian cells by regulating expression of the E. coli glutaminyl-tRNA synthetase gene in an inducible, cell-type specific, or developmentally regulated manner.
    MeSH term(s) Amino Acyl-tRNA Synthetases/genetics ; Animals ; Base Sequence ; Cell Line ; Codon, Nonsense/genetics ; Escherichia coli/genetics ; Gene Expression Regulation ; Haplorhini ; Molecular Sequence Data ; Mutation ; Plasmids/genetics ; RNA, Transfer/genetics
    Chemical Substances Codon, Nonsense ; RNA, Transfer (9014-25-9) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-)
    Language English
    Publishing date 1996-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.16.3.907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A systematic review of audit tools for evaluating the quality of green spaces in mental health research.

    Park, Hyunseo / Brown, Catherine D / Pearson, Amber L

    Health & place

    2024  Volume 86, Page(s) 103185

    Abstract: Research showing the relationship between exposure to green space and health has yielded conflicting results, possibly due to the oversight of green space quality in quantitative studies. This systematic review, guided by the PRISMA framework (registered ...

    Abstract Research showing the relationship between exposure to green space and health has yielded conflicting results, possibly due to the oversight of green space quality in quantitative studies. This systematic review, guided by the PRISMA framework (registered under Prospero ID CRD42023279720), focused on audit tools for green space quality in mental health research. From 4028 studies, 13 were reviewed, with 77 % linking better mental health outcomes to higher green space quality. Eight tools, especially Public Open Space and Dillen et al. tools demonstrated strong correlations with mental health. Certain green space qualities like grass, pathways, and water elements showed positive health associations. Future research should aim for standardized quality metrics and robust methodologies to support causal inferences and efficient assessments.
    MeSH term(s) Humans ; Mental Health ; Parks, Recreational ; Environment ; Water ; Benchmarking
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1262540-1
    ISSN 1873-2054 ; 1353-8292
    ISSN (online) 1873-2054
    ISSN 1353-8292
    DOI 10.1016/j.healthplace.2024.103185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Tibial Plateau Fracture With Use of Tibia Strut and Bone Filler in a 37-Year-Old Male: A Case Report.

    Ngo, Wayne / Craddock, Germain / Frangenberg, Alex / Park, Amber / Basu, Niladri

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52913

    Abstract: Tibial plateau fractures (TPFs) are orthopedic challenges with multiple injury modalities and clinical presentations. TPFs are often classified using the Schatzker classification system, which can dictate management. In our case, a 37-year-old male ... ...

    Abstract Tibial plateau fractures (TPFs) are orthopedic challenges with multiple injury modalities and clinical presentations. TPFs are often classified using the Schatzker classification system, which can dictate management. In our case, a 37-year-old male presented at an orthopedic specialty hospital with right knee pain after a fall from a truck ramp. X-rays and CT imaging demonstrated a comminuted bicondylar TPF in the emergency room with metaphyseal dissociation. The patient was placed in a knee immobilizer, made non-weight bearing, and scheduled for outpatient follow-up with a local orthopedic surgeon. The patient was lost to follow-up and referred to our clinic six months after the fall with the chief complaint of inability to ambulate with severe pain and instability in the knee. X-rays demonstrated a malunion of the bicondylar tibial plateau with fracture deformities of the medial femoral condyle and lateral tibial plateau. The patient's deformity was corrected with a medial opening wedge proximal tibial osteotomy with a fibula strut allograft and filled with beta-tricalcium bone filler. At the first month follow-up, the patient's pain was well controlled, fragments and the knee were appropriately aligned, and no significant soft tissue or joint effusion was appreciated on imaging. After failing nonoperative treatment, this patient with comminuted bicondylar TPF has received definitive treatment with open reduction and internal fixation. Higher rates of unacceptable results from nonoperative treatment are in line with the Schatzker series, in which operative treatment resulted in more acceptable outcomes. Because the fracture in this patient is consistent with a Schatzker VI classification with intra-articular depression, the patient should have initially been treated with an external fixator and not been sent home in a knee immobilizer. This led to a malunion that necessitated corrective surgery. Therefore, correctly classifying fracture severity is important for selecting the best treatment course and minimizing complications.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Examining the Theory of Motivated Information Management (TMIM) in the COVID-19 Pandemic.

    Ju, Ilwoo / Ohs, Jennifer / Park, Taehwan / Hinsley, Amber

    Journal of health communication

    2022  Volume 27, Issue 5, Page(s) 326–342

    Abstract: In order to inform understanding of the public's health information management during the COVID-19 pandemic, we applied a modification of TMIM from a serial mediation model to a conditional process model (moderated mediation). In doing so, the current ... ...

    Abstract In order to inform understanding of the public's health information management during the COVID-19 pandemic, we applied a modification of TMIM from a serial mediation model to a conditional process model (moderated mediation). In doing so, the current study attempted to refine some of the relational propositions of the original TMIM with a focus on efficacy while addressing the distinction between a mediator and a moderator in a behavioral decision model. Findings from an online survey of U.S. adults (n = 488) demonstrated that anxiety can positively motivate evaluation of information seeking during the COVID-19 pandemic context, a unique context of application for TMIM. Efficacy was found to be qualified as an individual difference variable that moderates the relationships of uncertainty perception and health decision. Our newly proposed conditional process framework of the TMIM opens research directions in health information-seeking and encourages researchers to continuously incorporate updated methodological thought and approach in applying and building communication theory.
    MeSH term(s) Adult ; COVID-19/epidemiology ; Communication ; Humans ; Information Management ; Pandemics ; Uncertainty
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427988-5
    ISSN 1087-0415 ; 1081-0730
    ISSN (online) 1087-0415
    ISSN 1081-0730
    DOI 10.1080/10810730.2022.2107737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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