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  1. Article ; Online: Gene Expression Networks in the Murine Pulmonary Myocardium Provide Insight into the Pathobiology of Atrial Fibrillation.

    Boutilier, Jordan K / Taylor, Rhonda L / Mann, Tracy / McNamara, Elyshia / Hoffman, Gary J / Kenny, Jacob / Dilley, Rodney J / Henry, Peter / Morahan, Grant / Laing, Nigel G / Nowak, Kristen J

    G3 (Bethesda, Md.)

    2017  Volume 7, Issue 9, Page(s) 2999–3017

    Abstract: The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the ... ...

    Abstract The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the pulmonary myocardium gains pacemaker function is not clearly defined, although recent evidence indicates that changed transcriptional gene expression networks are at fault. The gene expression profile of this distinct cell type
    MeSH term(s) Animals ; Atrial Fibrillation/genetics ; Atrial Fibrillation/metabolism ; Atrial Fibrillation/physiopathology ; Biomarkers ; Calcium/metabolism ; Chromosome Mapping ; Computational Biology/methods ; Databases, Genetic ; Gene Expression Profiling ; Gene Regulatory Networks ; Genetic Association Studies ; Genetic Predisposition to Disease ; MAP Kinase Kinase Kinases/genetics ; Mice ; Molecular Sequence Annotation ; Phenotype ; Quantitative Trait Loci ; Transcriptome
    Chemical Substances Biomarkers ; TNNI3K protein, human (EC 2.7.11.1) ; MAP Kinase Kinase Kinases (EC 2.7.11.25) ; Calcium (SY7Q814VUP)
    Keywords covid19
    Language English
    Publishing date 2017--07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.117.044651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Variable cardiac α-actin (Actc1) expression in early adult skeletal muscle correlates with promoter methylation.

    Boutilier, Jordan K / Taylor, Rhonda L / Ram, Ramesh / McNamara, Elyshia / Nguyen, Quang / Goullée, Hayley / Chandler, David / Mehta, Munish / Balmer, Lois / Laing, Nigel G / Morahan, Grant / Nowak, Kristen J

    Biochimica et biophysica acta. Gene regulatory mechanisms

    2017  Volume 1860, Issue 10, Page(s) 1025–1036

    Abstract: Different genes encode the α-actin isoforms that are predominantly expressed in heart and skeletal muscle. Mutations in the skeletal muscle α-actin gene (ACTA1) cause muscle diseases that are mostly lethal in the early postnatal period. We previously ... ...

    Abstract Different genes encode the α-actin isoforms that are predominantly expressed in heart and skeletal muscle. Mutations in the skeletal muscle α-actin gene (ACTA1) cause muscle diseases that are mostly lethal in the early postnatal period. We previously demonstrated that the disease phenotype of ACTA1 mouse models could be rescued by transgenic over-expression of cardiac α-actin (ACTC1). ACTC1 is the predominant striated α-actin isoform in the heart but is also expressed in developing skeletal muscle. To develop a translatable therapy, we investigated the genetic regulation of Actc1 expression. Using strains from The Collaborative Cross (CC) genetic resource, we found that Actc1 varies in expression by up to 24-fold in skeletal muscle. We defined significant expression quantitative trait loci (eQTL) associated with early adult Actc1 expression in soleus and heart. eQTL in both heart and soleus mapped to the Actc1 locus and replicate an eQTL mapped for Actc1 in BXD heart and quadriceps. We built on this previous work by analysing genes within the eQTL peak regions to prioritise likely candidates for modifying Actc1 expression. Additionally we interrogated the CC founder haplotype contributions to enable prioritisation of genetic variants for functional analyses. Methylation around the Actc1 transcriptional start site in early adult skeletal muscle negatively correlated with Actc1 expression in a strain-dependent manner, while other marks of regulatory potential (histone modification and chromatin accessibility) were unaltered. This study provides novel insights into the complex genetic regulation of Actc1 expression in early adult skeletal muscles.
    MeSH term(s) Actins/biosynthesis ; Actins/genetics ; Animals ; DNA Methylation/physiology ; Gene Expression Regulation/physiology ; Mice ; Muscle, Skeletal/metabolism ; Promoter Regions, Genetic/physiology ; Quantitative Trait Loci
    Chemical Substances Actins
    Language English
    Publishing date 2017-08-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 1874-9399 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 1874-9399 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439
    DOI 10.1016/j.bbagrm.2017.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.

    Burgeson, James R / Moore, Amy L / Boutilier, Jordan K / Cerruti, Natasha R / Gharaibeh, Dima N / Lovejoy, Candace E / Amberg, Sean M / Hruby, Dennis E / Tyavanagimatt, Shanthakumar R / Allen, Robert D / Dai, Dongcheng

    Bioorganic & medicinal chemistry letters

    2012  Volume 22, Issue 13, Page(s) 4263–4272

    Abstract: A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La ... ...

    Abstract A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Crosse viruses). A compound selected from a library screen, compound 1, displayed submicromolar antiviral activity against both vaccinia virus (EC(50)=0.25 μM) and La Crosse virus (EC(50)=0.27 μM) in cytopathic effect (CPE) assays. SAR analysis was performed to further improve antiviral potency and to optimize drug-like properties of the initial hits. During our analysis, we identified 26, which was found to be nearly fourfold more potent than 1 against both vaccinia and La Crosse viruses. Selected compounds were further tested to more fully characterize the spectrum of antiviral activity. Many of these possessed single digit micromolar and sub-micromolar antiviral activity against a diverse array of targets, including influenza virus (Orthomyxoviridae), Tacaribe virus (Arenaviridae), and dengue virus (Flaviviridae).
    MeSH term(s) Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Arenavirus/drug effects ; Dengue Virus/drug effects ; La Crosse virus/drug effects ; Orthomyxoviridae/drug effects ; Structure-Activity Relationship ; Thiourea/chemical synthesis ; Thiourea/chemistry ; Thiourea/pharmacology ; Vaccinia virus/drug effects
    Chemical Substances Antiviral Agents ; Thiourea (GYV9AM2QAG)
    Language English
    Publishing date 2012-07-01
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2012.05.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity

    Burgeson, James R / Moore, Amy L / Boutilier, Jordan K / Cerruti, Natasha R / Gharaibeh, Dima N / Lovejoy, Candace E / Amberg, Sean M / Hruby, Dennis E / Tyavanagimatt, Shanthakumar R / Allen, Robert D., III / Dai, Dongcheng

    Bioorganic & medicinal chemistry letters. 2012 July 1, v. 22, no. 13

    2012  

    Abstract: A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La ... ...

    Abstract A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Crosse viruses). A compound selected from a library screen, compound 1, displayed submicromolar antiviral activity against both vaccinia virus (EC₅₀=0.25μM) and La Crosse virus (EC₅₀=0.27μM) in cytopathic effect (CPE) assays. SAR analysis was performed to further improve antiviral potency and to optimize drug-like properties of the initial hits. During our analysis, we identified 26, which was found to be nearly fourfold more potent than 1 against both vaccinia and La Crosse viruses. Selected compounds were further tested to more fully characterize the spectrum of antiviral activity. Many of these possessed single digit micromolar and sub-micromolar antiviral activity against a diverse array of targets, including influenza virus (Orthomyxoviridae), Tacaribe virus (Arenaviridae), and dengue virus (Flaviviridae).
    Keywords California encephalitis virus ; Dengue virus ; Orthomyxoviridae ; Rift Valley fever ; Tacaribe virus ; Vaccinia virus ; antiviral properties ; chemistry ; cytopathogenicity ; viruses
    Language English
    Dates of publication 2012-0701
    Size p. 4263-4272.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2012.05.035
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity

    Burgeson, James R. / Moore, Amy L. / Boutilier, Jordan K. / Cerruti, Natasha R. / Gharaibeh, Dima N. / Lovejoy, Candace E. / Amberg, Sean M. / Hruby, Dennis E. / Tyavanagimatt, Shanthakumar R. / Allen, Robert D., III / Dai, Dongcheng

    Bioorganic & medicinal chemistry letters

    Volume v. 22,, Issue no. 1

    Abstract: A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La ... ...

    Abstract A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Crosse viruses). A compound selected from a library screen, compound 1, displayed submicromolar antiviral activity against both vaccinia virus (EC₅₀=0.25μM) and La Crosse virus (EC₅₀=0.27μM) in cytopathic effect (CPE) assays. SAR analysis was performed to further improve antiviral potency and to optimize drug-like properties of the initial hits. During our analysis, we identified 26, which was found to be nearly fourfold more potent than 1 against both vaccinia and La Crosse viruses. Selected compounds were further tested to more fully characterize the spectrum of antiviral activity. Many of these possessed single digit micromolar and sub-micromolar antiviral activity against a diverse array of targets, including influenza virus (Orthomyxoviridae), Tacaribe virus (Arenaviridae), and dengue virus (Flaviviridae).
    Keywords Dengue virus ; Vaccinia virus ; antiviral properties ; Tacaribe virus ; chemistry ; viruses ; Rift Valley fever ; California encephalitis virus ; Orthomyxoviridae ; cytopathogenicity
    Language English
    Document type Article
    ISSN 0960-894X
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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