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  1. Article ; Online: Why Is BMI Related to COPD? Is It All in the Genes?

    Hernández Cordero, Ana I / Sin, Don D

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202403-0601ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clotting in COVID-19: Is It All in the Genes?

    Hernandez Cordero, Ana I / Sin, Don D

    American journal of respiratory cell and molecular biology

    2021  Volume 64, Issue 6, Page(s) 647–649

    MeSH term(s) Blood Coagulation/genetics ; COVID-19 ; Epithelial Cells ; Humans ; Lung ; SARS-CoV-2
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0134ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cannabis smoking is associated with advanced epigenetic age.

    Hernandez Cordero, Ana I / Li, Xuan / Xi Yang, Chen / Ambalavanan, Amirtha / MacIsaac, Julia L / Kobor, Michael S / Doiron, Dany / Tan, Wan / Bourbeau, Jean / Sin, Don D / Duan, Qingling / Leung, Janice M

    The European respiratory journal

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00458-2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Systemic and Airway Epigenetic Disruptions Are Associated with Health Status in COPD.

    Hernandez Cordero, Ana I / Li, Xuan / Yang, Chen Xi / Yang, Julia / MacIsaac, Julia L / Dever, Kristy / Kobor, Michael S / Milne, Stephen / van Eeden, Stephan F / Shaipanich, Tawimas / Lam, Stephen / Leung, Janice M / Sin, Don D

    Biomedicines

    2023  Volume 11, Issue 1

    Abstract: Epigenetic modifications are common in chronic obstructive pulmonary disease (COPD); however, their clinical relevance is largely unknown. We hypothesized that epigenetic disruptions are associated with symptoms and health status in COPD. We profiled the ...

    Abstract Epigenetic modifications are common in chronic obstructive pulmonary disease (COPD); however, their clinical relevance is largely unknown. We hypothesized that epigenetic disruptions are associated with symptoms and health status in COPD. We profiled the blood (
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11010134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy.

    Lionikas, Arimantas / Hernandez Cordero, Ana I / Kilikevicius, Audrius / Carroll, Andrew M / Bewick, Guy S / Bunger, Lutz / Ratkevicius, Aivaras / Heisler, Lora K / Harboe, Mette / Oxvig, Claus

    Physiological reports

    2023  Volume 11, Issue 15, Page(s) e15793

    Abstract: Aims: Stanniocalcin-2 (STC2) has recently been implicated in human muscle mass variability by genetic analysis. Biochemically, STC2 inhibits the proteolytic activity of the metalloproteinase PAPP-A, which promotes muscle growth by upregulating the ... ...

    Abstract Aims: Stanniocalcin-2 (STC2) has recently been implicated in human muscle mass variability by genetic analysis. Biochemically, STC2 inhibits the proteolytic activity of the metalloproteinase PAPP-A, which promotes muscle growth by upregulating the insulin-like growth factor (IGF) axis. The aim was to examine if STC2 affects skeletal muscle mass and to assess how the IGF axis mediates muscle hypertrophy induced by functional overload.
    Methods: We compared muscle mass and muscle fiber morphology between Stc2
    Results: Stc2
    Conclusion: Here we provide evidence that STC2 is an inhibitor of muscle growth upregulated, along with other components of the IGF axis, during overload-induced muscle hypertrophy.
    MeSH term(s) Animals ; Mice ; Glycoproteins/genetics ; Glycoproteins/metabolism ; Hypertrophy ; Insulin-Like Growth Factor Binding Protein 4/metabolism ; Insulin-Like Growth Factor I/metabolism ; Muscle, Skeletal/metabolism ; Peptide Hormones/metabolism ; Pregnancy-Associated Plasma Protein-A/genetics
    Chemical Substances Glycoproteins ; Insulin-Like Growth Factor Binding Protein 4 ; Insulin-Like Growth Factor I (67763-96-6) ; Peptide Hormones ; Pregnancy-Associated Plasma Protein-A (EC 3.4.24.-) ; teleocalcin (76687-96-2) ; Stc2 protein, mouse
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Calpain Regulates Reactive Oxygen Species Production during Capacitation through the Activation of NOX2 and NOX4.

    Ortiz-García, César I / Salgado-Lucio, Monica L / Roa-Espitia, Ana L / Muñoz-Sánchez, Aidé A / Cordero-Martínez, Joaquín / Hernández-González, Enrique O

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Capacitation is a series of physiological, biochemical, and metabolic changes experienced by mammalian spermatozoa. These changes enable them to fertilize eggs. The capacitation prepares the spermatozoa to undergo the acrosomal reaction and ... ...

    Abstract Capacitation is a series of physiological, biochemical, and metabolic changes experienced by mammalian spermatozoa. These changes enable them to fertilize eggs. The capacitation prepares the spermatozoa to undergo the acrosomal reaction and hyperactivated motility. Several mechanisms that regulate capacitation are known, although they have not been fully disclosed; among them, reactive oxygen species (ROS) play an essential role in the normal development of capacitation. NADPH oxidases (NOXs) are a family of enzymes responsible for ROS production. Although their presence in mammalian sperm is known, little is known about their participation in sperm physiology. This work aimed to identify the NOXs related to the production of ROS in guinea pig and mouse spermatozoa and define their participation in capacitation, acrosomal reaction, and motility. Additionally, a mechanism for NOXs' activation during capacitation was established. The results show that guinea pig and mouse spermatozoa express NOX2 and NOX4, which initiate ROS production during capacitation. NOXs inhibition by VAS2870 led to an early increase in the capacitation and intracellular concentration of Ca
    MeSH term(s) Animals ; Guinea Pigs ; Male ; Mice ; Calpain/metabolism ; NADPH Oxidase 4/metabolism ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism ; Semen/metabolism ; Spermatozoa/metabolism ; Sperm Capacitation
    Chemical Substances Calpain (EC 3.4.22.-) ; NADPH Oxidase 4 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-) ; Nox4 protein, mouse (EC 1.6.3.-) ; Reactive Oxygen Species
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging.

    Hernandez Cordero, Ana I / Yang, Chen Xi / Li, Xuan / Yang, Julia / Shaipanich, Tawimas / MacIsaac, Julie L / Lin, David T S / Kobor, Michael S / Horvath, Steve / Man, Shu Fan Paul / Sin, Don D / Leung, Janice M

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose ... ...

    Abstract One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose outcomes in severe COPD. This study investigated which DNA methylation clock could best reflect airway epigenetic age when used in more accessible blood samples. Our analyses showed that out of six DNA methylation clocks investigated, DNAmGrimAge demonstrated the strongest correlation and the smallest difference between the airway epithelium and blood. Our findings suggests that blood DNAmGrimAge accurately reflects airway epigenetic age of individuals and that its elevation is highly associated with COPD.
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial.

    Milne, Stephen / Li, Xuan / Yang, Chen Xi / Leitao Filho, Fernando Sergio / Hernández Cordero, Ana I / Yang, Cheng Wei Tony / Shaipanich, Tawimas / van Eeden, Stephan F / Leung, Janice M / Lam, Stephen / Sin, Don D

    The European respiratory journal

    2021  Volume 58, Issue 1

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; COVID-19 ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/genetics ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00130-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Epigenetic blood biomarkers of ageing and mortality in COPD.

    Hernandez Cordero, Ana I / Yang, Chen Xi / Milne, Stephen / Li, Xuan / Hollander, Zsuzsanna / Chen, Virginia / Ng, Raymond / Tebbutt, Scott J / Leung, Janice M / Sin, Don D

    The European respiratory journal

    2021  Volume 58, Issue 6

    MeSH term(s) Aging ; Biomarkers ; Epigenesis, Genetic ; Epigenomics ; Humans ; Pulmonary Disease, Chronic Obstructive/genetics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01890-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.

    Hernández Cordero, Ana I / Yang, Chen Xi / Yang, Julia / Horvath, Steve / Shaipanich, Tawimas / MacIsaac, Julia / Lin, David T S / Kobor, Michael S / Guillemi, Silvia / Harris, Marianne / Lam, Wan / Lam, Stephen / Montaner, Julio / Man, S F Paul / Sin, Don D / Leung, Janice M

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 2, Page(s) 150–160

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Aging/genetics ; DNA Methylation/genetics ; Epigenomics ; HIV Infections/complications ; HIV Infections/genetics ; Humans ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/genetics
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202106-1440OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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