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  1. Book ; Online: Étude grammaticale et stylistique de textes de langue française

    Bertucci, Marie-Madeleine

    Capes et agrégation de lettres modernes

    (Didaskein)

    2020  

    Series title Didaskein
    Keywords linguistics ; Language teaching & learning (other than ELT) ; linguistique ; littérature ; grammaire ; didactique ; langue française ; sciences du langage ; stylistique ; FLE (français langue étrangère) ; enseignement du français ; capes ; enseignement des lettres ; enseignement de la grammaire ; lettres modernes ; agrégation de Lettres Modernes ; Master MEEF PLC Lettres
    Language fra
    Size 1 electronic resource (254 pages)
    Publisher UGA Éditions
    Publishing place Grenoble
    Document type Book ; Online
    Note French
    HBZ-ID HT030380671
    ISBN 9782377471935 ; 2377471935
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Phosphoinositide 3-Kinase (PI3K) Inhibitors and Breast Cancer: An Overview of Current Achievements.

    Bertucci, Alexandre / Bertucci, François / Gonçalves, Anthony

    Cancers

    2023  Volume 15, Issue 5

    Abstract: The phosphatidylinositol 3-kinase (PI3K) pathway is one of the most altered pathways in human cancers, and it plays a central role in cellular growth, survival, metabolism, and cellular mobility, making it a particularly interesting therapeutic target. ... ...

    Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is one of the most altered pathways in human cancers, and it plays a central role in cellular growth, survival, metabolism, and cellular mobility, making it a particularly interesting therapeutic target. Recently, pan-inhibitors and then selective p110α subunit inhibitors of PI3K were developed. Breast cancer is the most frequent cancer in women and, despite therapeutic progress in recent years, advanced breast cancers remain incurable and early breast cancers are at risk of relapse. Breast cancer is divided in three molecular subtypes, each with its own molecular biology. However, PI3K mutations are found in all breast cancer subtypes in three main "hotspots". In this review, we report the results of the most recent and main ongoing studies evaluating pan-PI3K inhibitors and selective PI3K inhibitors in each breast cancer subtype. In addition, we discuss the future of their development, the various potential mechanisms of resistance to these inhibitors and the ways to circumvent them.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The MonarchE trial: improving the clinical outcome in HR

    Bertucci, François / Finetti, Pascal / Mamessier, Emilie / De Nonneville, Alexandre

    Cancer communications (London, England)

    2023  Volume 43, Issue 8, Page(s) 938–942

    MeSH term(s) Humans ; Female ; Breast Neoplasms/therapy ; Receptor, ErbB-2 ; Biomarkers, Tumor
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Biomarkers, Tumor
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Évolution et facteurs associés à la publication des travaux de thèse d’exercice par les internes d’oncologie médicale en France.

    de Nonneville, Alexandre / Bertucci, François / Lambaudie, Éric / Houvenaeghel, Gilles / Sabatier, Renaud / Gonçalves, Anthony / Viens, Patrice

    Bulletin du cancer

    2022  Volume 109, Issue 4, Page(s) 409–423

    Abstract: ... appointed to the medical oncology specialty in France in order to identify ways of improving ... Medical students who obtained a medical oncology appointment in France between 2010 and 2015 were retrospectively ...

    Title translation Medical thesis publication of medical oncology residents in France: Trends and associated factors.
    Abstract Introduction: The French medical residency system requires the completion and subsequent defense of a thesis. Only a minority of this work is eventually published in an peer-reviewed journal. The main objective of this study was to evaluate the publication rate and associated patterns among residents appointed to the medical oncology specialty in France in order to identify ways of improving their educational framework and to promote the dissemination of their results. The secondary objective was to describe the characteristics associated with a publication in a high impact journal.
    Methodology: Medical students who obtained a medical oncology appointment in France between 2010 and 2015 were retrospectively identified. Records of medical theses listed in the SUDOC University Documentation System catalog were used and cross-referenced with a Medline search.
    Results: Of the one hundred and eighty-five students included in the analysis, a publication indexed in Medline was found for 55 of them (29.7%). The average impact-factor was 5.71. The main factor independently associated with publication was a delay of ≤5 years between appointment and thesis defense dates. Among the published works, the time between appointment and defense, language of publication, study design, number of centers and patients included, and the fact that the thesis reported a clinical trial, were associated with publication in a journal with a high impact factor.
    Conclusion: These results show an approximative thesis work publication rate of 70% by medical oncology residents, and suggest the importance of starting the thesis project early during the residency in order to be published.
    MeSH term(s) Abstracting and Indexing ; France ; Humans ; Internship and Residency ; Medical Oncology ; Publishing ; Retrospective Studies
    Language French
    Publishing date 2022-02-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2022.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.15: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2-negative breast cancer.

    Bertucci, François / De Nonneville, Alexandre / Finetti, Pascal / Mamessier, Emilie

    Cancer communications (London, England)

    2023  Volume 43, Issue 8, Page(s) 943–946

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Neoadjuvant Therapy ; Tertiary Lymphoid Structures ; Treatment Outcome ; Receptor, ErbB-2
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: RE: HER2DX ERBB2 mRNA expression in advanced HER2-positive breast cancer treated with T-DM1.

    Bertucci, François / de Nonneville, Alexandre / Finetti, Pascal / Mamessier, Emilie

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 6, Page(s) 762–763

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Ado-Trastuzumab Emtansine ; Receptor, ErbB-2/metabolism ; RNA, Messenger/genetics ; Trastuzumab/therapeutic use ; Maytansine/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Ado-Trastuzumab Emtansine (SE2KH7T06F) ; Receptor, ErbB-2 (EC 2.7.10.1) ; RNA, Messenger ; Trastuzumab (P188ANX8CK) ; Maytansine (14083FR882) ; ERBB2 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Training load and intensity distribution for sprinting among world-class track cyclists.

    Desgorces, François-Denis / Slawinski, Jean / Bertucci, William / Rousseau, Florian / Toussaint, Jean-François / Noirez, Philippe

    The Journal of sports medicine and physical fitness

    2023  Volume 63, Issue 4, Page(s) 513–520

    Abstract: Background: Only few studies analyzed real training programs of sprinters while that should be a valuable step in the understanding of sprint training. The present study aimed at characterizing track cycling sprinter training by training load and ... ...

    Abstract Background: Only few studies analyzed real training programs of sprinters while that should be a valuable step in the understanding of sprint training. The present study aimed at characterizing track cycling sprinter training by training load and intensity distribution.
    Methods: Twenty-nine weeks of prechampionship training data were retrospectively analyzed for 6 world-class athletes. Training load was measured by the ratio of volume completed to maximal volume and categorized by five intensity zones (endurance: zones1-2; sprinting: zones3-5) and exercise type (on-bike or resistance). Intra-week (training monotony) and inter-week (acute-chronic workload ratio) variation was also studied.
    Results: On-bike training represented 77.4±15.3% of total training load; resistance training, 22.6±15.2% (note high standard deviation). Total weekly training load significantly varied (P=0.0002) with high acute-chronic workload ratio (12.0±3.2 weeks >1.5 or <0.8), but low intra-week variations (training monotony, 1.81±0.20). Zone4 and zone5 made up 74.4±16.9% of total training load; zone1, 15.8±11%. Training load was seldom in zone2 (6.4±5.3%) or zone3 (3.3±4.2%). From the first to the second half of the period, zone3-4 training load decreased (39.3±3.3 to 27.4±1.7%; P=0.01), while zone5 increased (34.9±2.4 to 50±3.7%; P=0.002).
    Conclusions: In this reduced group of elite athletes, training appeared to mainly consist of on-bike exercises within the highest intensity zones. As demonstrated by monotony and acute-chronic workload ratio overloading and unloading are based on high variations over weeks, not days. Essentially, this study describes a polarized intensity distribution on the highest intensities which increased with world championships approach.
    MeSH term(s) Humans ; Retrospective Studies ; Exercise ; Resistance Training ; Athletes ; Bicycling
    Language English
    Publishing date 2023-03-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 410823-1
    ISSN 1827-1928 ; 0022-4707
    ISSN (online) 1827-1928
    ISSN 0022-4707
    DOI 10.23736/S0022-4707.22.13685-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.B 326: Show issues Location:
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  8. Article: PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond?

    Gonçalves, Anthony / Bertucci, Alexandre / Bertucci, François

    Cancers

    2020  Volume 12, Issue 6

    Abstract: Exquisitely exploiting defects in homologous recombination process, poly(ADP-ribose) polymerase (PARP) inhibitors have recently emerged as a promising class of therapeutics in human epidermal growth factor receptor 2 (HER2)-negative advanced breast ... ...

    Abstract Exquisitely exploiting defects in homologous recombination process, poly(ADP-ribose) polymerase (PARP) inhibitors have recently emerged as a promising class of therapeutics in human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer with germline breast cancer 1 (BRCA1) or breast cancer 2 (BRCA2) mutations (gBRCA1/2m). In this setting, PARP inhibitors, either as single agent or in combination with platinum-based chemotherapy, significantly increased progression-free survival, as compared to conventional chemotherapy. Accordingly, further therapeutic advances are expected at an earlier stage of the disease. In the neoadjuvant setting, veliparib failed to increase the pathological complete response rate when added to a carboplatin-based regimen, in unselected triple-negative breast cancer patients. Similarly, when administered before anthracycline-cyclophosphamide, the neoadjuvant olaparib-paclitaxel combination was not superior to carboplatin-paclitaxel, in patients with HER2-negative breast cancer and BRCA1/2 mutation, or homologous recombination defect. Yet, neoadjuvant talazoparib, administered as a single-agent in patients with HER2-negative breast cancer and germline BRCA1/2 mutation, achieved an impressive pathological complete response rate of nearly 50%. In the adjuvant setting, the results from the OlympiA phase III study, evaluating adjuvant olaparib in HER2-negative early breast cancer and germline BRCA1/2 mutations, are eagerly awaited. Ongoing trials should clarify whether PARP inhibitors might improve outcome when administered in the adjuvant or neoadjuvant setting in early breast cancer patients with BRCA1/2 mutation or homologous recombination defect.
    Language English
    Publishing date 2020-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12061378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Sacituzumab govitecan in triple-negative breast cancer.

    de Nonneville, Alexandre / Goncalves, Anthony / Mamessier, Emilie / Bertucci, François

    Annals of translational medicine

    2022  Volume 10, Issue 11, Page(s) 647

    Language English
    Publishing date 2022-06-07
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A machine learning-based algorithm to eliminate breast and axillary surgery in patients with breast cancer and pathological complete response after neoadjuvant chemotherapy.

    de Nonneville, Alexandre / Boudin, Laurys / Houvenaeghel, Gilles / Gonçalves, Anthony / Bertucci, François

    Annals of translational medicine

    2023  Volume 11, Issue 11, Page(s) 397

    Language English
    Publishing date 2023-03-06
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-23-689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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