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  1. Article ; Online: Gene of the month:

    Thunders, Michelle / Delahunt, Brett

    Journal of clinical pathology

    2020  Volume 73, Issue 12, Page(s) 773–776

    Abstract: Transmembrane serine protease 2 is encoded by ... ...

    Abstract Transmembrane serine protease 2 is encoded by the
    MeSH term(s) COVID-19/virology ; Genetic Markers ; Humans ; Male ; Prostatic Neoplasms/genetics ; SARS-CoV-2/pathogenicity ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Virus Internalization
    Chemical Substances Genetic Markers ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2020-206987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Epigenetics: Its Understanding Is Crucial to a Sustainable Healthcare System.

    Thunders, Michelle

    Healthcare (Basel, Switzerland)

    2015  Volume 3, Issue 2, Page(s) 194–204

    Abstract: Understanding the molecular impact of lifestyle factors has never been so important; a period in time where there are so many adults above retirement age has been previously unknown. As a species, our life expectancy is increasing yet the period of our ... ...

    Abstract Understanding the molecular impact of lifestyle factors has never been so important; a period in time where there are so many adults above retirement age has been previously unknown. As a species, our life expectancy is increasing yet the period of our lives where we enjoy good health is not expanding proportionately. Over the next 50 years we will need to almost double the percentage of GDP spent on health care, largely due to the increasing incidence of obesity related chronic diseases. A greater understanding and implementation of an integrated approach to health is required. Research exploring the impact of nutritional and exercise intervention on the epigenetically flexible genome is up front in terms of addressing healthy aging. Alongside this, we need a greater understanding of the interaction with our immune and nervous systems in preserving and maintaining health and cognition.
    Language English
    Publishing date 2015-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare3020194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gene of the month:

    Thunders, Michelle / Delahunt, Brett

    Journal of clinical pathology

    2020  Volume 74, Issue 2, Page(s) 69–72

    Abstract: DICER1 is a highly conserved RNaseIII endoribonuclease that has a critical role in the biogenesis of microRNAs (miRNAs). miRNAs are small regulatory RNAs responsible for post-transcriptional gene silencing, controlling more than half of human protein- ... ...

    Abstract DICER1 is a highly conserved RNaseIII endoribonuclease that has a critical role in the biogenesis of microRNAs (miRNAs). miRNAs are small regulatory RNAs responsible for post-transcriptional gene silencing, controlling more than half of human protein-coding genes. This is achieved through the targeting and regulation of complementary RNA transcripts and has a well-documented role in post-transcriptional gene regulation and transposon repression. DICER1 deficiency results in dysregulation of miRNAs, changing the expression of many genes. DICER1 syndrome represents a collection of benign and malignant tumours arising from an autosomally inherited germline mutation leading to an inherited predisposition to cancer. The syndrome represents an unusual form of Knudson's two-hit hypothesis, where individuals with a pathogenic germline
    MeSH term(s) DEAD-box RNA Helicases/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Predisposition to Disease/genetics ; Germ-Line Mutation ; Humans ; Mutation ; Neoplastic Syndromes, Hereditary/genetics ; Ribonuclease III/genetics
    Chemical Substances DICER1 protein, human (EC 3.1.26.3) ; Ribonuclease III (EC 3.1.26.3) ; DEAD-box RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2020-12-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2020-207203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Discovery and Mechanism of Action of a Novel Antimicrobial Peptide from an Earthworm.

    Wu, Yizhao / Deng, Songge / Wang, Xiuhong / Thunders, Michelle / Qiu, Jiangping / Li, Yinsheng

    Microbiology spectrum

    2023  Volume 11, Issue 1, Page(s) e0320622

    Abstract: The robust innate immune system of the earthworm provides a potential source of natural antimicrobial peptides (AMPs). However, the cost and high rediscovery rate of direct separation and purification limits their discovery. Genome sequencing of numerous ...

    Abstract The robust innate immune system of the earthworm provides a potential source of natural antimicrobial peptides (AMPs). However, the cost and high rediscovery rate of direct separation and purification limits their discovery. Genome sequencing of numerous earthworm species facilitates the discovery of new antimicrobial peptides. Through predicting potential antimicrobial peptides in the open reading frames of the Eisenia andrei genome and sequence optimization, a novel antimicrobial peptide, named EWAMP-R (RIWWSGGWRRWRW), was identified. EWAMP-R demonstrated good activity against various bacteria, including drug-resistant strains. The antibacterial mechanisms of EWAMP-R were explored through molecular simulation and wet-laboratory experiments. These experiments demonstrated that the bacterial membrane may be one of the targets of EWAMP-R but that there may be different interactions with Gram-negative and Gram-positive bacterial membranes. EWAMP-R can disrupt bacterial membrane integrity; however, at low concentrations, it appears that EWAMP-R may get through the membrane of Escherichia coli instead of damaging it directly, implying the existence of a secondary response. Gene expression studies identified that in E. coli, only the apoptosis-like cell death (ALD) pathway was activated, while in Staphylococcus aureus, the MazEF pathway was also upregulated, limiting the influence of the ALD pathway. The different antimicrobial actions against Gram-positive and -negative bacteria can provide important information on the structure-activity relationship of AMPs and facilitate AMP design with higher specificity. This study identified a new source of antibacterial agents that has the potential to address the increasingly serious issue of antibiotic resistance.
    MeSH term(s) Animals ; Oligochaeta ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Peptides ; Staphylococcus aureus ; Escherichia coli/genetics ; Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests
    Chemical Substances Antimicrobial Cationic Peptides ; Antimicrobial Peptides ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03206-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Epigenetics

    Michelle Thunders

    Healthcare, Vol 3, Iss 2, Pp 194-

    Its Understanding Is Crucial to a Sustainable Healthcare System

    2015  Volume 204

    Abstract: Understanding the molecular impact of lifestyle factors has never been so important; a period in time where there are so many adults above retirement age has been previously unknown. As a species, our life expectancy is increasing yet the period of our ... ...

    Abstract Understanding the molecular impact of lifestyle factors has never been so important; a period in time where there are so many adults above retirement age has been previously unknown. As a species, our life expectancy is increasing yet the period of our lives where we enjoy good health is not expanding proportionately. Over the next 50 years we will need to almost double the percentage of GDP spent on health care, largely due to the increasing incidence of obesity related chronic diseases. A greater understanding and implementation of an integrated approach to health is required. Research exploring the impact of nutritional and exercise intervention on the epigenetically flexible genome is up front in terms of addressing healthy aging. Alongside this, we need a greater understanding of the interaction with our immune and nervous systems in preserving and maintaining health and cognition.
    Keywords epigenetics ; health ; disease ; Medicine ; R
    Subject code 306
    Language English
    Publishing date 2015-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The epigenome: key to understanding and predicting gout flares.

    Wolyncewicz, Ben / Major, Tanya J / Delahunt, Brett / Thunders, Michelle

    Pathology

    2021  Volume 53, Issue 7, Page(s) 824–829

    Abstract: Gout is a form of arthritis, resulting from an inflammatory reaction to the deposition of monosodium urate (MSU) crystals in the synovial fluid of the joint space. It is characterised by periods of acute inflammation in the affected joint, or joints ( ... ...

    Abstract Gout is a form of arthritis, resulting from an inflammatory reaction to the deposition of monosodium urate (MSU) crystals in the synovial fluid of the joint space. It is characterised by periods of acute inflammation in the affected joint, or joints (known as gout flares), separated by asymptomatic periods. There seems to be substantial overlap between environmental triggers of gout flares and common environmental modifiers (diet, pharmaceuticals, and stress) of epigenetic markers (DNA methylation, histone modifications, and ncRNA). Very few studies have looked at whether environment is influencing gout through epigenetic mechanisms. The pathogenesis of gouty inflammation is well understood but understanding the variation of response to hyperuricaemia in terms of gout flare initiation is less well known. In this review, we will examine the potential of epigenomics in understanding how gout flares may occur, both in terms of development of hyperuricaemia and the inflammatory response. Looking at the epigenome and its intersection with lifestyle could help identify new targets and strategies for effective management of gout flares.
    MeSH term(s) Epigenome ; Epigenomics ; Gout/genetics ; Gout/immunology ; Gout/pathology ; Humans ; Hyperuricemia ; Inflammation ; Life Style ; Symptom Flare Up
    Language English
    Publishing date 2021-10-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2021.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Gene of the month: TMPRSS2 (transmembrane serine protease 2)

    Thunders, Michelle / Delahunt, Brett

    J. clin. pathol

    Abstract: Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast- ... ...

    Abstract Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast-specific-related gene), an oncogenic transcription factor, is the most common chromosomal aberration detected in prostate cancer, responsible for driving carcinogenesis. The other key role of TMPRSS2 is in priming the viral spike protein which facilitates viral entry essential for viral infectivity. The protease activates a diverse range of viruses. Both SARS-CoV and SARS-CoV-2 (COVID-19) use angiotensin-converting enzyme 2 (ACE2) and TMPRSS2 to facilitate entry to cells, but with SARS-CoV-2 human-to-human transmission is much higher than SARS-CoV. As TMPRSS2 is expressed outside of the lung, and can therefore contribute to extrapulmonary spread of viruses, it warrants further exploration as a potential target for limiting viral spread and infectivity.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #740294
    Database COVID19

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  8. Article ; Online: Gene of the month

    Thunders, Michelle / Delahunt, Brett

    Journal of Clinical Pathology

    TMPRSS2 (transmembrane serine protease 2)

    2020  , Page(s) jclinpath–2020–206987

    Abstract: Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast- ... ...

    Abstract Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast-specific-related gene), an oncogenic transcription factor, is the most common chromosomal aberration detected in prostate cancer, responsible for driving carcinogenesis. The other key role of TMPRSS2 is in priming the viral spike protein which facilitates viral entry essential for viral infectivity. The protease activates a diverse range of viruses. Both SARS-CoV and SARS-CoV-2 (COVID-19) use angiotensin-converting enzyme 2 (ACE2) and TMPRSS2 to facilitate entry to cells, but with SARS-CoV-2 human-to-human transmission is much higher than SARS-CoV. As TMPRSS2 is expressed outside of the lung, and can therefore contribute to extrapulmonary spread of viruses, it warrants further exploration as a potential target for limiting viral spread and infectivity.
    Keywords Pathology and Forensic Medicine ; General Medicine ; covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2020-206987
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Chromosomal instability and its effect on cell lines.

    He, Zichen / Wilson, Andrew / Rich, Fenella / Kenwright, Diane / Stevens, Aaron / Low, Yee Syuen / Thunders, Michelle

    Cancer reports (Hoboken, N.J.)

    2023  Volume 6, Issue 6, Page(s) e1822

    Abstract: Background: Cancer cell lines are invaluable model systems for biomedical research because they provide an almost unlimited supply of biological materials. However, there is considerable skepticism regarding the reproducibility of data derived from ... ...

    Abstract Background: Cancer cell lines are invaluable model systems for biomedical research because they provide an almost unlimited supply of biological materials. However, there is considerable skepticism regarding the reproducibility of data derived from these in vitro models.
    Recent findings: Chromosomal instability (CIN) is one of the primary issues associated with cell lines, which can cause genetic heterogeneity and unstable cell properties within a cell population. Many of these problems can be avoided with some precautions. Here we review the underlying causes of CIN, including merotelic attachment, telomere dysfunction, DNA damage response defects, mitotic checkpoint defects and cell cycle disturbances.
    Conclusion: In this review we summarize studies highlighting the consequences of CIN in various cell lines and provide suggestions on monitoring and controlling CIN during cell culture.
    MeSH term(s) Humans ; Mitosis/genetics ; Reproducibility of Results ; Chromosomal Instability ; Cell Line ; Neoplasms/genetics
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Molecular Profiling of Endometrial Cancer: An Exploratory Study in Aotearoa, New Zealand.

    Henry, Claire E / Phan, Khoi / Orsman, Elena J / Kenwright, Diane / Thunders, Michelle C / Filoche, Sara K

    Cancers

    2021  Volume 13, Issue 22

    Abstract: Background: Aotearoa, New Zealand, has one of the fastest-rising rates of endometrial cancer (EC) worldwide, increasing particularly in younger Māori and Pasifika women. There is a move towards using molecular profiling to direct treatment for each EC ... ...

    Abstract Background: Aotearoa, New Zealand, has one of the fastest-rising rates of endometrial cancer (EC) worldwide, increasing particularly in younger Māori and Pasifika women. There is a move towards using molecular profiling to direct treatment for each EC subtype.
    Aim: This study aimed to explore the molecular profiling of primary EC tissue in Aotearoa.
    Methods: We used the PORTEC guidelines for the molecular subtyping of 90 patients' samples into four categories:
    Results: In total, 15 samples were MMRd, 9 were p53 abnormal, 8 were
    Conclusion: Surrogate markers for
    Language English
    Publishing date 2021-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13225641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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