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  1. Book: Histone deacetylase inhibitors as cancer therapeutics

    Grant, Steven

    (Advances in cancer research ; 116)

    2012  

    Author's details ed. by Steven Grant
    Series title Advances in cancer research ; 116
    Collection
    Language English
    Size XII, 270 S. : Ill.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017507169
    ISBN 978-0-12-394387-3 ; 0-12-394387-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 178 -116- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Disrupting autophagy in

    Grant, Steven

    Haematologica

    2023  Volume 108, Issue 6, Page(s) 1458–1460

    MeSH term(s) Humans ; Cell Line, Tumor ; Protein Kinase Inhibitors ; Leukemia, Myeloid, Acute/genetics ; Autophagy/genetics ; fms-Like Tyrosine Kinase 3/genetics ; Mutation
    Chemical Substances Protein Kinase Inhibitors ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; FLT3 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-01
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.282054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.76: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online: HIV and Cancer Immunotherapy: Similar Challenges and Converging Approaches

    Paiardini, Mirko / Ahmed, Rafi / Grant Deeks, Steven / Dhodapkar, Kavita M.

    2020  

    Keywords Medicine ; Immunology ; HIV ; cancer ; ART ; immunotherapy ; immune surveillance ; immune checkpoint blockade ; inflammation ; CAR T cells
    Size 1 electronic resource (157 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231291
    ISBN 9782889637164 ; 2889637166
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Targeting cereblon in AML.

    Grant, Steven

    Blood

    2021  Volume 137, Issue 5, Page(s) 584–586

    MeSH term(s) Humans ; Lenalidomide ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Stem Cells ; Thalidomide ; Ubiquitin-Protein Ligases
    Chemical Substances Thalidomide (4Z8R6ORS6L) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020009827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  5. Article ; Online: Recruiting TP53 to target chronic myeloid leukemia stem cells.

    Grant, Steven

    Haematologica

    2020  Volume 105, Issue 5, Page(s) 1172–1174

    MeSH term(s) Animals ; Disease Models, Animal ; Fusion Proteins, bcr-abl ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mice ; Stem Cells
    Chemical Substances Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2020-04-25
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2019.246306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diet's Role in Modifying Risk of Alzheimer's Disease: History and Present Understanding.

    Grant, William B / Blake, Steven M

    Journal of Alzheimer's disease : JAD

    2023  Volume 96, Issue 4, Page(s) 1353–1382

    Abstract: Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD). The approaches used here to assess diet's role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational studies, ... ...

    Abstract Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD). The approaches used here to assess diet's role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational studies, and laboratory studies. Ecological studies have identified fat, meat, and obesity from high-energy diets as important risk factors for AD and reported that AD rates peak about 15-20 years after national dietary changes. Observational studies have compared the Western dietary pattern with those of the Dietary Approaches to Stop Hypertension (DASH), Mediterranean (MedDi), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets. Those studies identified AD risk factors including higher consumption of saturated and total fats, meat, and ultraprocessed foods and a lower risk of AD with higher consumption of fruits, legumes, nuts, omega-3 fatty acids, vegetables, and whole grains. Diet-induced factors associated with a significant risk of AD include inflammation, insulin resistance, oxidative stress, elevated homocysteine, dietary advanced glycation end products, and trimethylamine N-oxide. The molecular mechanisms by which dietary bioactive components and specific foods affect risk of AD are discussed. Given most countries' entrenched food supply systems, the upward trends of AD rates would be hard to reverse. However, for people willing and able, a low-animal product diet with plenty of anti-inflammatory, low-glycemic load foods may be helpful.
    MeSH term(s) Humans ; Alzheimer Disease/epidemiology ; Alzheimer Disease/prevention & control ; Alzheimer Disease/etiology ; Cross-Sectional Studies ; Prospective Studies ; Diet ; Risk Factors
    Language English
    Publishing date 2023-11-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The ethics of facility fees for dermatology clinics.

    Sharp, Kelley / Sloan, Steven Brett / Grant-Kels, Jane M

    Clinics in dermatology

    2023  Volume 42, Issue 1, Page(s) 82–83

    MeSH term(s) Humans ; Dermatology ; Fees and Charges
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Letter
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2023.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Se 972: Show issues Location:
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  8. Article: Limitations of track and trigger systems and the National Early Warning Score. Part 3: cultural and behavioural factors.

    Grant, Steven

    British journal of nursing (Mark Allen Publishing)

    2019  Volume 28, Issue 4, Page(s) 234–241

    Abstract: This article discusses the evidence in relation to preventable deaths and a reported culture of suboptimal care. It warns of the dangers of over-relying on track and trigger systems (TTS) in place of clinical judgement. The article explores cultural and ... ...

    Abstract This article discusses the evidence in relation to preventable deaths and a reported culture of suboptimal care. It warns of the dangers of over-relying on track and trigger systems (TTS) in place of clinical judgement. The article explores cultural and behavioural factors, the effects of short staffing and inappropriate skill mix, which all increase the risk of human error. It emphasises a key message that registered nurses must reflect on the need to change their individual and team approaches to the recognition and assessment of the deteriorating patient.
    MeSH term(s) Clinical Deterioration ; Critical Illness/mortality ; Critical Illness/nursing ; Humans ; Monitoring, Physiologic/methods ; Nursing Staff/psychology ; Organizational Culture ; Risk Factors ; State Medicine/organization & administration ; United Kingdom/epidemiology
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2019.28.4.234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3449: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: R-spondin(g) to syndecan-1 in myeloma.

    Grant, Steven

    Blood

    2018  Volume 131, Issue 9, Page(s) 946–947

    MeSH term(s) Humans ; Membrane Glycoproteins ; Multiple Myeloma ; Proteoglycans ; Syndecan-1 ; beta Catenin
    Chemical Substances Membrane Glycoproteins ; Proteoglycans ; Syndecan-1 ; beta Catenin
    Language English
    Publishing date 2018-03-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-12-821504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Limitations of track and trigger systems and the National Early Warning Score. Part 1: areas of contention.

    Grant, Steven

    British journal of nursing (Mark Allen Publishing)

    2018  Volume 27, Issue 11, Page(s) 624–631

    Abstract: Evidence suggests that the identification and response to the deteriorating patient continues to be an ongoing concern, despite the widespread use of track and trigger score (TTS) systems. This article discusses the variations in the parameters included ... ...

    Abstract Evidence suggests that the identification and response to the deteriorating patient continues to be an ongoing concern, despite the widespread use of track and trigger score (TTS) systems. This article discusses the variations in the parameters included in the different TTS systems in use across the NHS and their sensitivity. Clinical guidelines and physiological theory are used to appraise the parameters allocated in the National Early Warning Score (NEWS 1 and 2), highlighting potential limitations of the tool. The findings lead to the conclusion that registered nurses should not rely solely on NEWS, but should use it to support their clinical judgement.
    MeSH term(s) Clinical Deterioration ; Confounding Factors (Epidemiology) ; Critical Illness ; Humans ; Monitoring, Physiologic ; Practice Guidelines as Topic ; Severity of Illness Index ; State Medicine ; United Kingdom ; Vital Signs
    Language English
    Publishing date 2018-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2018.27.11.624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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