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Article ; Online: Adverse childhood experiences, dental insurance, and developmental disability: Association with unmet dental needs in Ohio.

Horter, Lili / Richardson, Carson / Paul, Marika / Meyer, Beau D

2024

Abstract: Objective: This study investigated whether insurance status and/or developmental disability moderated the association between adverse childhood experiences (ACE) and unmet dental needs among children aged 0 to 17 in Ohio.: Methods: We utilized cross- ... ...

Abstract	Objective: This study investigated whether insurance status and/or developmental disability moderated the association between adverse childhood experiences (ACE) and unmet dental needs among children aged 0 to 17 in Ohio. Methods: We utilized cross-sectional data from the 2021 Ohio Medicaid Assessment Survey to assess the dental needs of children. ACE scores, dental insurance status, and developmental disability status were analyzed using multivariable logistic regression to identify their potential association with parental-reported unmet dental needs. Results: The weighted sample represented 2,752,222 children in Ohio. Over half reported zero ACEs (55.8%) and no dental needs (56.1%). Approximately 1 in 9 lacked dental insurance (11.1%), and 1 in 10 had a developmental disability (9.9%). Children with one to three ACEs had three times the odds of unmet dental needs compared to children with zero ACEs (OR = 3.20; 95%CI [2.10, 4.89]), and children with four or more ACEs had eight times the odds of unmet dental needs (OR = 8.78; 95%CI [5.26, 14.67]). Children lacking dental insurance had over six times higher odds of unmet dental needs compared to children with dental insurance (OR = 6.10; 95%CI [3.92, 9.49]). The presence of developmental disability status did not moderate the presence of unmet dental needs; however, the lack of dental insurance status significantly moderated the association between ACEs and unmet dental needs. Conclusion: Insurance status, not developmental disability, moderated the association between ACEs and unmet dental needs among children in Ohio. Efforts to ensure continuous access to dental insurance are warranted.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	410719-6
ISSN	1752-7325 ; 0022-4006
ISSN (online)	1752-7325
ISSN	0022-4006
DOI	10.1111/jphd.12605
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Article: Bayesian profile regression for clustering analysis involving a longitudinal response and explanatory variables.

Rouanet, Anaïs / Johnson, Rob / Strauss, Magdalena / Richardson, Sylvia / Tom, Brian D / White, Simon R / Kirk, Paul D W

Methodology : European journal of research methods for the behavioral & social sciences

2023 Volume 73, Issue 2, Page(s) 314–339

Abstract: The identification of sets of co-regulated genes that share a common function is a key question of modern genomics. Bayesian profile regression is a semi-supervised mixture modelling approach that makes use of a response to guide inference toward ... ...

Abstract	The identification of sets of co-regulated genes that share a common function is a key question of modern genomics. Bayesian profile regression is a semi-supervised mixture modelling approach that makes use of a response to guide inference toward relevant clusterings. Previous applications of profile regression have considered univariate continuous, categorical, and count outcomes. In this work, we extend Bayesian profile regression to cases where the outcome is longitudinal (or multivariate continuous) and provide PReMiuMlongi, an updated version of PReMiuM, the R package for profile regression. We consider multivariate normal and Gaussian process regression response models and provide proof of principle applications to four simulation studies. The model is applied on budding yeast data to identify groups of genes co-regulated during the
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2190957-X
ISSN	1614-2241 ; 1614-1881
ISSN (online)	1614-2241
ISSN	1614-1881
DOI	10.1093/jrsssc/qlad097
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Article ; Online: Obesity does not alter vascular function and handgrip exercise hemodynamics in middle-aged patients with hypertension.

Ratchford, Stephen M / Broxterman, Ryan M / La Salle, D Taylor / Kwon, Oh Sung / Hopkins, Paul N / Richardson, Russell S / Trinity, Joel D

American journal of physiology. Regulatory, integrative and comparative physiology

2023 Volume 326, Issue 1, Page(s) R1–R9

Abstract: Lifestyle modification including exercise training is often the first line of defense in the treatment of obesity and hypertension (HTN), however, little is known regarding how these potentially compounding disease states impact vasodilatory and ... ...

Abstract	Lifestyle modification including exercise training is often the first line of defense in the treatment of obesity and hypertension (HTN), however, little is known regarding how these potentially compounding disease states impact vasodilatory and hemodynamic responses at baseline and exercise. Therefore, this study sought to compare the impact of obesity on vascular function and hemodynamics at baseline and during handgrip (HG) exercise among individuals with HTN. Non-obese (13M/7F, 56 ± 16 yr, 25 ± 4 kg/m
MeSH term(s)	Adult ; Middle Aged ; Humans ; Hand Strength ; Hemodynamics ; Hypertension ; Exercise/physiology ; Blood Pressure ; Obesity ; Vasodilation/physiology ; Hypotension ; Brachial Artery ; Regional Blood Flow
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00105.2023
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Article ; Online: Author Correction: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.

McMillin, Douglas W / Delmore, Jake / Weisberg, Ellen / Negri, Joseph M / Geer, Corey D / Klippel, Steffen / Mitsiades, Nicholas / Schlossman, Robert L / Munshi, Nikhil C / Kung, Andrew L / Griffin, James D / Richardson, Paul G / Anderson, Kenneth C / Mitsiades, Constantine S

Nature medicine

2024 Volume 30, Issue 4, Page(s) 1214

Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02847-5
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Article ; Online: Straightforward Mechanosynthesis of a Phase-Pure Interpenetrated MOF-5 Bearing a Size-Matching Tetrazine-Based Linker.

do Pim, Walace D / Marcotte, Sébastien / Kitos, Alexandros A / Richardson, Paul / Pallister, Peter / Murugesu, Muralee

Inorganic chemistry

2022 Volume 61, Issue 30, Page(s) 11695–11701

Abstract: The archetypal metal-organic framework-5 (MOF-5 or IRMOF-1) has been explored as a benchmark sorbent material with untapped potential to be studied in the capture and storage of gases and chemical confinement. Several derivatives of this framework have ... ...

Abstract	The archetypal metal-organic framework-5 (MOF-5 or IRMOF-1) has been explored as a benchmark sorbent material with untapped potential to be studied in the capture and storage of gases and chemical confinement. Several derivatives of this framework have been prepared using the multivariate (MTV) strategy through mixing size-matching linkers to isolate, for example, MIXMOFs that outperform same-linker congeners when employed as gas reservoirs. Herein, we describe a straightforward protocol that uses mechanosynthesis (solvent-free grinding) followed by mild activation in dimethylformamide (DMF)/CHCl
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.2c01285
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Article ; Online: Using long-term data from a whole ecosystem warming experiment to identify best spring and autumn phenology models.

Schädel, Christina / Seyednasrollah, Bijan / Hanson, Paul J / Hufkens, Koen / Pearson, Kyle J / Warren, Jeffrey M / Richardson, Andrew D

Plant-environment interactions (Hoboken, N.J.)

2023 Volume 4, Issue 4, Page(s) 188–200

Abstract: Predicting vegetation phenology in response to changing environmental factors is key in understanding feedbacks between the biosphere and the climate system. Experimental approaches extending the temperature range beyond historic climate variability ... ...

Abstract	Predicting vegetation phenology in response to changing environmental factors is key in understanding feedbacks between the biosphere and the climate system. Experimental approaches extending the temperature range beyond historic climate variability provide a unique opportunity to identify model structures that are best suited to predicting phenological changes under future climate scenarios. Here, we model spring and autumn phenological transition dates obtained from digital repeat photography in a boreal
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ISSN	2575-6265
ISSN (online)	2575-6265
DOI	10.1002/pei3.10118
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Article ; Online: Video meeting signals: Experimental evidence for a technique to improve the experience of video conferencing.

Hills, Paul D / Clavin, Mackenzie V Q / Tufft, Miles R A / Gobel, Matthias S / Richardson, Daniel C

PloS one

2022 Volume 17, Issue 8, Page(s) e0270399

Abstract: We found evidence from two experiments that a simple set of gestural techniques can improve the experience of online meetings. Video conferencing technology has practical benefits, but psychological costs. It has allowed industry, education and social ... ...

Abstract	We found evidence from two experiments that a simple set of gestural techniques can improve the experience of online meetings. Video conferencing technology has practical benefits, but psychological costs. It has allowed industry, education and social interactions to continue in some form during the covid-19 lockdowns. But it has left many users feeling fatigued and socially isolated, perhaps because the limitations of video conferencing disrupt users' ability to coordinate interactions and foster social affiliation. Video Meeting Signals (VMS™) is a simple technique that uses gestures to overcome some of these limitations. First, we carried out a randomised controlled trial with over 100 students, in which half underwent a short training session in VMS. All participants rated their subjective experience of two weekly seminars, and transcripts were objectively coded for the valence of language used. Compared to controls, students with VMS training rated their personal experience, their feelings toward their seminar group, and their perceived learning outcomes as significantly higher. Also, they were more likely to use positive language and less likely to use negative language. A second, larger experiment replicated the first, and added a condition where groups were given a version of the VMS training but taught to use emoji response buttons rather than gestures to signal the same information. The emoji-trained groups did not experience the same improvement as the VMS groups. By exploiting the specific benefits of gestural communication, VMS has great potential to overcome the psychological problems of group video meetings.
MeSH term(s)	COVID-19 ; Communicable Disease Control ; Communications Media ; Gestures ; Humans ; Videoconferencing
Language	English
Publishing date	2022-08-03
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0270399
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Article ; Online: Fetoplacental vascular effects of maternal adrenergic antihypertensive and cardioprotective medications in pregnancy.

Tropea, Teresa / Mavichak, Weerawaroon / Evangelinos, Angelos / Brennan-Richardson, Charlotte / Cottrell, Elizabeth C / Myers, Jenny E / Johnstone, Edward D / Brownbill, Paul

Journal of hypertension

2023 Volume 41, Issue 11, Page(s) 1675–1687

Abstract: Maternal cardiovascular diseases, including hypertension and cardiac conditions, are associated with poor fetal outcomes. A range of adrenergic antihypertensive and cardioprotective medications are often prescribed to pregnant women to reduce major ... ...

Abstract	Maternal cardiovascular diseases, including hypertension and cardiac conditions, are associated with poor fetal outcomes. A range of adrenergic antihypertensive and cardioprotective medications are often prescribed to pregnant women to reduce major maternal complications during pregnancy. Although these treatments are not considered teratogenic, they may have detrimental effects on fetal growth and development, as they cross the fetoplacental barrier, and may contribute to placental vascular dysregulation. Medication risk assessment sheets do not include specific advice to clinicians and women regarding the safety of these therapies for use in pregnancy and the potential off-target effects of adrenergic medications on fetal growth have not been rigorously conducted. Little is known of their effects on the fetoplacental vasculature. There is also a dearth of knowledge on adrenergic receptor activation and signalling within the endothelium and vascular smooth muscle cells of the human placenta, a vital organ in the maintenance of adequate blood flow to satisfy fetal growth and development. The fetoplacental circulation, absent of sympathetic innervation, and unique in its reliance on endocrine, paracrine and autocrine influence in the regulation of vascular tone, appears vulnerable to dysregulation by adrenergic antihypertensive and cardioprotective medications compared with the adult peripheral circulation. This semi-systematic review focuses on fetoplacental vascular expression of adrenergic receptors, associated cell signalling mechanisms and predictive consequences of receptor activation/deactivation by antihypertensive and cardioprotective medications.
MeSH term(s)	Adult ; Female ; Humans ; Pregnancy ; Adrenergic Agents/metabolism ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Fetus ; Placenta/metabolism ; Placental Circulation/physiology
Chemical Substances	Adrenergic Agents ; Antihypertensive Agents
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003532
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Article ; Online: Histological and Radiological Assessment of Endogenously Generated Repair Tissue

McCarthy, Helen S / Tins, Bernhard / Gallacher, Peter D / Jermin, Paul / Richardson, James B / Kuiper, Jan Herman / Roberts, Sally

Cartilage

2023 Volume 14, Issue 1, Page(s) 48–58

Abstract: Objective: To examine repair tissue formed approximately 15 months after a chondral harvest in the human knee.: Design: Sixteen individuals (12 males, 4 females, mean age 36 ± 9 years) underwent a chondral harvest in the trochlea as a pre-requisite ... ...

Abstract	Objective: To examine repair tissue formed approximately 15 months after a chondral harvest in the human knee. Design: Sixteen individuals (12 males, 4 females, mean age 36 ± 9 years) underwent a chondral harvest in the trochlea as a pre-requisite for autologous chondrocyte implantation (ACI) treatment. The harvest site was assessed via MRI at 14.3 ± 3.2 months and arthroscopy at 15 ± 3.5 months (using the Oswestry Arthroscopy Score [O-AS] and the International Cartilage Repair Society Arthroscopy Score [ICRS-AS]). Core biopsies (1.8 mm diameter, Results: The mean O-AS and ICRS-AS of the repaired harvest sites were 7.2 ± 3.2 and 10.1 ± 3.5, respectively, with 80.3% ± 26% repair fill depth on MRI. The histological quality of the repair tissue formed was variable, with some hyaline cartilage present in 50% of the biopsies; where this occurred, it was associated with a significantly higher ICRS-AS than those with no hyaline cartilage present (median 11 vs. 7.5, Conclusions: We demonstrate good-quality structural repair tissue formed following cartilage harvest in ACI, suggesting this site can be useful to study endogenous cartilage repair in humans. The trochlea is less commonly affected by osteoarthritis; therefore, location may be critical for spontaneous repair. Understanding the mechanisms and factors influencing this could improve future treatments for cartilage defects.
MeSH term(s)	Male ; Female ; Humans ; Adult ; Middle Aged ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/surgery ; Cartilage, Articular/pathology ; Chondrocytes ; Cartilage Diseases/pathology ; Hyaline Cartilage/surgery ; Collagen
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035221149523
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Article ; Online: Insights into the pathological basis of dementia from population-based neuropathology studies.

Wharton, Stephen B / Simpson, Julie E / Ince, Paul G / Richardson, Connor D / Merrick, Richard / Matthews, Fiona E / Brayne, Carol

Neuropathology and applied neurobiology

2023 Volume 49, Issue 4, Page(s) e12923

Abstract: The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complementary ... ...

Abstract	The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complementary insights to conventional case-control studies, which tend to be more representative of a younger clinical cohort. The Cognitive Function and Ageing Study (CFAS) is a longitudinal study of cognitive impairment and frailty in the general United Kingdom population. In this review, we provide an overview of the major findings from CFAS, alongside other studies, which have demonstrated a high prevalence of pathology in the ageing brain, particularly Alzheimer's disease neuropathological change and vascular pathology. Increasing burdens of these pathologies are the major correlates of dementia, especially neurofibrillary tangles, but there is substantial overlap in pathology between those with and without dementia, particularly at intermediate burdens of pathology and also at the oldest ages. Furthermore, additional pathologies such as limbic-predominant age-related TDP-43 encephalopathy, ageing-related tau astrogliopathy and primary age-related tauopathies contribute to late-life dementia. Findings from ageing population-representative studies have implications for the understanding of dementia pathology in the community. The high prevalence of pathology and variable relationship to dementia status has implications for disease definition and indicate a role for modulating factors on cognitive outcome. The complexity of late-life dementia, with mixed pathologies, indicates a need for a better understanding of these processes across the life-course to direct the best research for reducing risk in later life of avoidable clinical dementia syndromes.
MeSH term(s)	Humans ; Longitudinal Studies ; Alzheimer Disease/epidemiology ; Alzheimer Disease/pathology ; Brain/pathology ; Tauopathies/pathology
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80371-6
ISSN	1365-2990 ; 0305-1846
ISSN (online)	1365-2990
ISSN	0305-1846
DOI	10.1111/nan.12923
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