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Article ; Online: Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism.

Tachibana, Shizuko / Yu, Nam-Kyung / Li, Ruixia / Fernandez-Costa, Carolina / Liang, Alex / Choi, Janet / Jung, Dayoen / Xiao, Changchun / Kralli, Anastasia / Yates, John R / Ross, Robert S / Cho, Yoshitake

Circulation

2023 Volume 147, Issue 11, Page(s) 916–919

MeSH term(s)	Animals ; Mice ; Cell Respiration ; Heart ; Heart Failure ; Mice, Inbred C57BL ; Muscle Proteins/metabolism ; Myocardium/metabolism ; Oxidative Stress
Chemical Substances	Muscle Proteins ; PERM1 protein, mouse
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.122.060173
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Article: A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects.

Jiang, Xu / Yu, Kyung-Sang / Nam, Dong Hyuk / Oh, Jaeseong

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is commonly used for the treatment of type 2 diabetes mellitus (T2DM). CKD-370 was newly developed as a cocrystal formulation of empagliflozin with co-former L-proline, which has ... ...

Abstract	Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is commonly used for the treatment of type 2 diabetes mellitus (T2DM). CKD-370 was newly developed as a cocrystal formulation of empagliflozin with co-former L-proline, which has been confirmed to be bioequivalent in South Korea. This study aimed to quantify the differences in the absorption phase and pharmacokinetic (PK) parameters of two empagliflozin formulations in healthy subjects by using population PK analysis. The plasma concentration data of empagliflozin were obtained from two randomized, open-label, crossover, phase 1 clinical studies in healthy Korean subjects after a single-dose administration. A population PK model was constructed by using a nonlinear mixed-effects (NLME) approach (Monolix Suite 2021R1). Interindividual variability (IIV) and interoccasion variability (IOV) were investigated. The final model was evaluated by goodness-of-fit (GOF) diagnostic plots, visual predictive checks (VPCs), prediction errors, and bootstrapping. The PK of empagliflozin was adequately described with a two-compartment combined transit compartment model with first-order absorption and elimination. Log-transformed body weight significantly influenced systemic clearance (CL) and the volume of distribution in the peripheral compartment (V2) of empagliflozin. GOF plots, VPCs, prediction errors, and the bootstrapping of the final model suggested that the proposed model was adequate and robust, with good precision at different dose strengths. The cocrystal form did not affect the absorption phase of the drug, and the PK parameters were not affected by the different treatments.
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17040522
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Article ; Online: Long-term effectiveness and safety of cilostazol versus clopidogrel in secondary prevention of noncardioembolic ischemic stroke.

Lee, Yu Jeong / Je, Nam Kyung

European journal of clinical pharmacology

2023 Volume 79, Issue 8, Page(s) 1107–1116

Abstract: Purpose: Cilostazol is a widely used antiplatelet drug for secondary stroke prevention in Asia, but its comparison with clopidogrel is not well understood. This study aims to investigate the effectiveness and safety of cilostazol compared to clopidogrel ...

Abstract	Purpose: Cilostazol is a widely used antiplatelet drug for secondary stroke prevention in Asia, but its comparison with clopidogrel is not well understood. This study aims to investigate the effectiveness and safety of cilostazol compared to clopidogrel for the secondary prevention of noncardioembolic ischemic stroke. Methods: This retrospective comparative effectiveness research analyzed 1:1 propensity scorematched data from insured individuals between 2012 and 2019, using administrative claims data in Health Insurance Review and Assessment in Korea. Patients with diagnosis codes for ischemic stroke without cardiac disease were included and divided into two groups, those receiving cilostazol and those receiving clopidogrel. The primary outcome was a recurrent ischemic stroke. Secondary outcomes included all-cause death, myocardial infarction, hemorrhagic stroke, and a composite of these outcomes. The safety outcome was major gastrointestinal bleeding. Results: The study analyzed 4,754 patients in the propensity scorematched population and found no statistically significant difference in recurrent ischemic stroke (cilostazol group vs clopidogrel group, 2.7% vs 3.2%; 95% CI, 0.62-1.21), the composite outcome of recurrent ischemic stroke, all-cause death, myocardial infarction, and hemorrhagic stroke (5.1% vs 5.5%; 0.75-1.22), and major gastrointestinal bleeding (1.3% vs 1.5%; 0.57-1.47) between patients receiving cilostazol and those receiving clopidogrel. In subgroup analysis, cilostazol was associated with a lower incidence of recurrent ischemic stroke compared to clopidogrel in hypertensive patients (2.5% vs 3.9%; interaction P = 0.041). Conclusions: This real-world study suggests that cilostazol is effective and safe for noncardioembolic ischemic stroke and may be associated with better effectiveness in hypertensive patients compared to clopidogrel.
MeSH term(s)	Humans ; Clopidogrel/adverse effects ; Cilostazol/adverse effects ; Aspirin/adverse effects ; Ischemic Stroke/drug therapy ; Retrospective Studies ; Hemorrhagic Stroke/drug therapy ; Secondary Prevention ; Drug Therapy, Combination ; Platelet Aggregation Inhibitors/adverse effects ; Stroke/drug therapy ; Myocardial Infarction/drug therapy ; Myocardial Infarction/epidemiology ; Myocardial Infarction/prevention & control ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/prevention & control ; Treatment Outcome
Chemical Substances	Clopidogrel (A74586SNO7) ; Cilostazol (N7Z035406B) ; Aspirin (R16CO5Y76E) ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2023-06-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-023-03522-3
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Article ; Online: Gene repressive mechanisms in the mouse brain involved in memory formation.

Yu, Nam-Kyung / Kaang, Bong-Kiun

BMB reports

2015 Volume 49, Issue 4, Page(s) 199–200

Abstract: Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes ... ...

Abstract	Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exploited ribosome profiling using the mouse hippocampal tissues at multiple time points after a learning event. Analysis of the resulting database revealed novel types of gene regulation after learning. First, the translation of a group of genes was rapidly suppressed without change in mRNA levels. At later time points, the expression of another group of genes was downregulated through reduction in mRNA levels. This reduction was predicted to be downstream of inhibition of ESR1 (Estrogen Receptor 1) signaling. Overexpressing Nrsn1, one of the genes whose translation was suppressed, or activating ESR1 by injecting an agonist interfered with memory formation, suggesting the functional importance of these findings. Moreover, the translation of genes encoding the translational machineries was found to be suppressed, among other genes in the mouse hippocampus. Together, this unbiased approach has revealed previously unidentified characteristics of gene regulation in the brain and highlighted the importance of repressive controls. [BMB Reports 2016; 49(4): 199-200].
MeSH term(s)	Animals ; Brain/physiology ; Conditioning (Psychology) ; Gene Expression Regulation ; Hippocampus/physiology ; Learning ; Memory/physiology ; Mice ; Repressor Proteins/metabolism
Chemical Substances	Repressor Proteins
Language	English
Publishing date	2015-12-02
Publishing country	Korea (South)
Document type	News
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
DOI	10.5483/bmbrep.2016.49.4.044
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Article ; Online: Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency.

Choi, Dong Il / Kim, Myeongwon / Kim, Somi / Yu, Nam-Kyung / Kwak, Chuljung / Seo, Hyunhyo / Lee, Kyungmin / Kaang, Bong-Kiun

Molecular brain

2021 Volume 14, Issue 1, Page(s) 1

Abstract: CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive ... ...

Abstract	CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits.
MeSH term(s)	Animals ; Behavior, Animal ; CCCTC-Binding Factor/deficiency ; CCCTC-Binding Factor/metabolism ; Cognition Disorders/metabolism ; Mice, Knockout ; Neurons/metabolism ; Phenotype ; Mice
Chemical Substances	CCCTC-Binding Factor ; Ctcf protein, mouse
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/s13041-020-00716-z
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Article ; Online: Quantification and Validation of an HPLC Method for Low Concentrations of Apigenin-7-

Lee, Jin Seok / Nam, Yu Ran / Kim, Hyun Jong / Kim, Woo Kyung

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 2

Abstract: In this study, we aimed to develop and validate a pretreatment method for separating and analyzing the small amounts of biomarkers contained in topical cream formulations. Analyzing semisolid formulations that contain low concentrations of active ... ...

Abstract	In this study, we aimed to develop and validate a pretreatment method for separating and analyzing the small amounts of biomarkers contained in topical cream formulations. Analyzing semisolid formulations that contain low concentrations of active ingredients is difficult. Cream formulations containing an aqueous ethanol extract of 0.1% Agrimonia pilosa is an example. Approximately 0.0013% of apigenin-7-
MeSH term(s)	Plant Extracts ; Agrimonia ; Chromatography, High Pressure Liquid ; Water ; Ethanol ; Liquid-Liquid Extraction
Chemical Substances	Plant Extracts ; apigenin-7-O-glucuronide ; Water (059QF0KO0R) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28020713
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Article: Chaenomelin, a New Phenolic Glycoside, and Anti-

Kim, Kyung Ah / Kang, Dong-Min / Ko, Yoon-Joo / Ra, Moon-Jin / Jung, Sang-Mi / Yu, Jeong-Nam / Ahn, Mi-Jeong / Kim, Ki Hyun

Plants (Basel, Switzerland)

2024 Volume 13, Issue 5

Abstract: ... Salix ... ...

Abstract	Salix chaenomeloides
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13050701
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Article: A Study on the Retrospective Reinterpretation of BRCA1 and BRCA2 Variants.

Kim, Jin Ju / Kim, Dong Ja / Nam, Eon Jeong / Song, Kyung Eun / Ham, Ji Yeon / Kim, Yu Kyung / Lee, Nan Young

Clinical laboratory

2024 Volume 70, Issue 4

Abstract: Background: Hereditary breast/ovarian cancer is associated with BRCA gene mutations. As large volumes of clinical data on BRCA variants are continuously updated, their clinical interpretation may change, leading to their reclassification. This study ... ...

Abstract	Background: Hereditary breast/ovarian cancer is associated with BRCA gene mutations. As large volumes of clinical data on BRCA variants are continuously updated, their clinical interpretation may change, leading to their reclassification. This study analyzed the class and proportion of the changed clinical interpretations of BRCA variants to validate the need for periodic reviews of these variants. Methods: This retrospective study reinterpreted previously reported BRCA1 and BRCA2 exon variants according to the 2015 American College of Medical Genetics and Genomics guidelines and the clinical significance of the recent public genomic database. Reanalyzed results were obtained for patients tested for BRCA genetic mutation for 10 years and 4 months. Results: We included data from 4,058 patients, with 595 having at least one pathogenic variant (P), likely pathogenic variant (LP), or variant of uncertain significance (VUS) at a detection rate of 14.66%. The numbers of exon and intron variants were 562 (87.81%) and 78 (12.19%), respectively. BRCA1 exhibited a significantly higher P/LP detection rate of 6.96% compared to that of BRCA2 at 6.89% (p < 0.001). Conversely, BRCA2 demonstrated a significantly higher VUS rate of 10.38% compared to that of BRCA1 at 5.08% (p < 0.001). Among BRCA1 mutations, substitutions were the most prevalent in P/LP and VUS. Among BRCA2 mutations, deletions were most prevalent in P/LP, and substitutions were most prevalent in VUS. Among the 131 patients with P/LP in BRCA1 exons, the clinical interpretation was reclassified in two cases (1.53%), one VUS and one benign/likely benign (B/LB), and 48 cases (48.00%) with VUS were reclassified; one to P/LP and 47 to B/LB. Among the 138 patients with P/LP in BRCA2 exons, the clinical interpretation was reclassified in six (4.35%), five to VUS, and one to B/LB, and all 74 with VUS were reclassified to B/LB. Conclusions: We determined the class and proportion of reclassified BRCA variants. In conclusion, reviews are required to provide clinical guidance, such as determining treatment direction and preventive measures in the future.
MeSH term(s)	Female ; Humans ; Retrospective Studies ; Genetic Predisposition to Disease ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Mutation ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Genetic Testing/methods ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2024-04-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230911
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Article ; Online: Synaptic ensembles between raphe and D

Choi, Ja Eun / Choi, Dong Il / Lee, Jisu / Kim, Jooyoung / Kim, Min Jung / Hong, Ilgang / Jung, Hyunsu / Sung, Yongmin / Kim, Ji-Il / Kim, TaeHyun / Yu, Nam-Kyung / Lee, Seung-Hee / Choe, Han Kyoung / Koo, Ja Wook / Kim, Joung-Hun / Kaang, Bong-Kiun

Science advances

2022 Volume 8, Issue 41, Page(s) eabo7527

Abstract: Social animals expend considerable energy to maintain social bonds throughout their life. Male and female mice show sexually dimorphic behaviors, yet the underlying neural mechanisms of sociability and their dysregulation during social disconnection ... ...

Abstract	Social animals expend considerable energy to maintain social bonds throughout their life. Male and female mice show sexually dimorphic behaviors, yet the underlying neural mechanisms of sociability and their dysregulation during social disconnection remain unknown. Dopaminergic neurons in dorsal raphe nucleus (DRN
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abo7527
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Article ; Online: CTCF as a multifunctional protein in genome regulation and gene expression.

Kim, Somi / Yu, Nam-Kyung / Kaang, Bong-Kiun

Experimental & molecular medicine

2015 Volume 47, Page(s) e166

Abstract: CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and ... ...

Abstract	CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters. CTCF can also recruit other transcription factors while bound to chromatin domain boundaries. The three-dimensional organization of the eukaryotic genome dictates its function, and CTCF serves as one of the core architectural proteins that help establish this organization. The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. Here we briefly describe the diverse roles of CTCF that contribute to genome organization and gene expression.
MeSH term(s)	Animals ; CCCTC-Binding Factor ; Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Gene Expression Regulation ; Genome ; Humans ; Protein Binding ; Protein Interaction Maps ; Repressor Proteins/analysis ; Repressor Proteins/metabolism ; Cohesins
Chemical Substances	CCCTC-Binding Factor ; CTCF protein, human ; Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; Repressor Proteins
Language	English
Publishing date	2015-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/emm.2015.33
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