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  1. Article: Upper Gastrointestinal Bleeding With Hemobilia Caused by Gallstones.

    Chang, Chia-Wen / Wu, Yen-Hung / Liu, Hsin-Liang

    The Journal of emergency medicine

    2020  Volume 58, Issue 5, Page(s) e227–e229

    Abstract: Background: Hemobilia refers to bleeding in the biliary tract, commonly due to iatrogenic, traumatic, and neoplastic causes. It is a rare source of upper gastrointestinal hemorrhage, but it can be severe and fatal. However, gallstones account for 5%-15% ...

    Abstract Background: Hemobilia refers to bleeding in the biliary tract, commonly due to iatrogenic, traumatic, and neoplastic causes. It is a rare source of upper gastrointestinal hemorrhage, but it can be severe and fatal. However, gallstones account for 5%-15% of hemobilia cases.
    Case report: A 60-year-old woman with diabetes mellitus and chronic kidney disease visited the emergency department with complaints of epigastric pain and vomiting of coffee ground-like content for 2 days. Physical examination revealed epigastric tenderness and hyperactive bowel sounds. Laboratory tests showed anemia with a hemoglobin count of 10.7 mg/dL and elevated liver function tests with total and direct bilirubin levels of 3.6 mg/dL and 2.5 mg/dL, respectively. Panendoscopy showed oozing of coffee ground-like material at the orifice of the ampulla of Vater and second portion of the duodenum, leading to suspicion of hemobilia. After admission, endoscopic retrograde cholangiopancreatography revealed common bile duct (CBD) dilatation with choledocholithiasis, biliary sludge, and filling defect at the middle section of the CBD. Endoscopic sphincterotomy with balloon lithotripsy was performed. After biliary decompression and broad-spectrum antibiotic administration, abdominal pain was relieved, and liver enzyme and total bilirubin levels improved. Symptoms of hemobilia depend on the bleeding rate and presence of bile duct obstructions due to clots. Minor and slow bleeding tend to form clots and cause biliary obstruction. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Although minor hemobilia may remain asymptomatic and tends to resolve spontaneously, the cause of hemobilia must be corrected to prevent recurrent bleeding or obstruction.
    MeSH term(s) Abdominal Pain/etiology ; Cholangiopancreatography, Endoscopic Retrograde ; Female ; Gallstones/complications ; Gastrointestinal Hemorrhage/etiology ; Hemobilia/etiology ; Humans ; Middle Aged
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2020.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison of Effects of N95 Respirators and Surgical Masks to Physiological and Psychological Health among Healthcare Workers: A Randomized Controlled Trial.

    Su, Che-Yu / Peng, Chiung-Yu / Liu, Hsin-Liang / Yeh, I-Jeng / Lee, Chi-Wei

    International journal of environmental research and public health

    2021  Volume 18, Issue 24

    Abstract: Since the onset of the coronavirus disease 2019 pandemic, wearing facemasks has become more important for healthcare workers. This study aimed to investigate and compare the influence of wearing N95 respirators and surgical masks for 8 h on physiological ...

    Abstract Since the onset of the coronavirus disease 2019 pandemic, wearing facemasks has become more important for healthcare workers. This study aimed to investigate and compare the influence of wearing N95 respirators and surgical masks for 8 h on physiological and psychological health. Sixty-eight healthcare workers were randomly assigned to the N95 respirator or surgical mask groups. Physiological parameters of participants were measured by Tensor Tip MTX at baseline and at the 2nd, 4th, 6th and 8th h of wearing the facemasks. The symptoms after wearing facemasks were also determined via the questionnaire. There were no significant changes in physiological parameters at most time checkpoints in both groups. Significant differences were observed in terms of heart rate at the 8th h, time trends (adjusted difference of least squares means were -8.53 and -2.01), and interaction of time and mask type between the two groups (
    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Masks ; N95 Respirators ; Occupational Exposure ; Respiratory Protective Devices ; SARS-CoV-2
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182413308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparison of Effects of N95 Respirators and Surgical Masks to Physiological and Psychological Health among Healthcare Workers

    Che-Yu Su / Chiung-Yu Peng / Hsin-Liang Liu / I-Jeng Yeh / Chi-Wei Lee

    International Journal of Environmental Research and Public Health, Vol 18, Iss 13308, p

    A Randomized Controlled Trial

    2021  Volume 13308

    Abstract: Since the onset of the coronavirus disease 2019 pandemic, wearing facemasks has become more important for healthcare workers. This study aimed to investigate and compare the influence of wearing N95 respirators and surgical masks for 8 h on physiological ...

    Abstract Since the onset of the coronavirus disease 2019 pandemic, wearing facemasks has become more important for healthcare workers. This study aimed to investigate and compare the influence of wearing N95 respirators and surgical masks for 8 h on physiological and psychological health. Sixty-eight healthcare workers were randomly assigned to the N95 respirator or surgical mask groups. Physiological parameters of participants were measured by Tensor Tip MTX at baseline and at the 2nd, 4th, 6th and 8th h of wearing the facemasks. The symptoms after wearing facemasks were also determined via the questionnaire. There were no significant changes in physiological parameters at most time checkpoints in both groups. Significant differences were observed in terms of heart rate at the 8th h, time trends (adjusted difference of least squares means were −8.53 and −2.01), and interaction of time and mask type between the two groups ( p -value for interaction was 0.0146). The values of these physiological parameters were within normal ranges. The N95 respirator group had significantly higher incidences of shortness of breath, headache, dizziness, difficulty talking and fatigue that spontaneously resolved. In conclusion, healthcare workers who wore either N95 respirators or surgical masks during an 8 h shift had no obvious harmful effects on physiological and psychological health. Additionally, the N95 respirator group did not show a higher risk than the surgical mask group.
    Keywords N95 respirator ; physiological parameters ; psychological health ; healthcare workers ; Tensor Tip MTX device ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Gallium nitride-based geometric and propagation metasurfaces for vortex beam emissions.

    Chen, Meng-Hsin / Liu, Yan-Liang / Su, Vin-Cent

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25436

    Abstract: This work experimentally demonstrates the highly-efficient geometric and propagation metasurfaces for vortex beam emissions. These metasurfaces are respectively composed of high-aspect-ratio fin-like and cylindrical gallium nitride (GaN) meta-atoms. ... ...

    Abstract This work experimentally demonstrates the highly-efficient geometric and propagation metasurfaces for vortex beam emissions. These metasurfaces are respectively composed of high-aspect-ratio fin-like and cylindrical gallium nitride (GaN) meta-atoms. Remarkably, the optimized configuration of the fin-like GaN meta-atoms achieves a cross-polarization transmission efficiency of up to 99 %. Similarly, the cylindrical GaN meta-atoms exhibit an average co-polarization transmission efficiency of 97 %. Both metasurfaces, designed for vortex beam emission, exhibit annular intensity converging capabilities at distinct wavelengths in the visible. Notably, the geometric metasurface shows achromatic annular intensity distributions over a continuous wavelength range up to 100 nm, in sharp contrast to the propagation metasurface, which is subject to inherent wavelength dispersion limitations.
    Language English
    Publishing date 2024-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity:

    Wu, Yen-Hung / Yeh, I-Jeng / Phan, Nam Nhut / Yen, Meng-Chi / Liu, Hsin-Liang / Wang, Chih-Yang / Hsu, Hui-Ping

    International journal of medical sciences

    2021  Volume 18, Issue 5, Page(s) 1143–1152

    Abstract: Highly pathogenic coronaviruses (CoVs) induce acute respiratory distress syndrome, and the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused a pandemic since late 2019. The diversity of clinical manifestations after SARS-CoV-2 ... ...

    Abstract Highly pathogenic coronaviruses (CoVs) induce acute respiratory distress syndrome, and the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused a pandemic since late 2019. The diversity of clinical manifestations after SARS-CoV-2 infection results in great challenges to diagnose CoV disease 2019 (COVID-19). There is a growing body of published research on this topic; however, effective medications are still undergoing a long process of being assessed. In the search for potential genetic targets for this infection, we applied a holistic bioinformatics approach to study alterations of gene signatures between SARS-CoV-2-infected cells and mock-infected controls. Two different kinds of lung epithelial cells, A549 with angiotensin-converting enzyme 2 (ACE2) overexpression and normal human bronchial epithelial (NHBE) cells, were infected with SARS-CoV-2. We performed bioinformatics analyses of RNA-sequencing in this study. Through a Venn diagram, Database for Annotation, Visualization and Integrated Discovery, Gene Ontology, Ingenuity Pathway Analysis, and Gene Set Enrichment Analysis, the pathways and networks were constructed from commonly upregulated genes in SARS-CoV-2-infected lung epithelial cells. Genes associated with immune-related pathways, responses of host cells after intracellular infection, steroid hormone biosynthesis, receptor signaling, and the complement system were enriched. Dysregulation of the immune system and malfunction of interferon contribute to a failure to kill SARS-CoV-2 and exacerbate respiratory distress in severely ill patients. Current findings from this study provide a comprehensive investigation of SARS-CoV-2 infection using high-throughput technology.
    MeSH term(s) A549 Cells ; COVID-19/genetics ; COVID-19/immunology ; Computer Simulation ; Gene Regulatory Networks ; Host-Pathogen Interactions/immunology ; Humans ; SARS-CoV-2/physiology
    Language English
    Publishing date 2021-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.52256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer.

    Ku, Su-Chi / Liu, Hsin-Liang / Su, Che-Yu / Yeh, I-Jeng / Yen, Meng-Chi / Anuraga, Gangga / Ta, Hoang Dang Khoa / Chiao, Chung-Chieh / Xuan, Do Thi Minh / Prayugo, Fidelia Berenice / Wang, Wei-Jan / Wang, Chih-Yang

    Aging

    2022  Volume 14, Issue 20, Page(s) 8498–8567

    Abstract: Breast cancer is one of the leading deaths in all kinds of malignancies; therefore, it is important for early detection. At the primary tumor site, tumor cells could take on mesenchymal properties, termed the epithelial-to-mesenchymal transition (EMT). ... ...

    Abstract Breast cancer is one of the leading deaths in all kinds of malignancies; therefore, it is important for early detection. At the primary tumor site, tumor cells could take on mesenchymal properties, termed the epithelial-to-mesenchymal transition (EMT). This process is partly regulated by members of the cadherin (
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Prognosis ; Gene Expression Regulation, Neoplastic ; Cadherins/genetics ; Cadherins/metabolism ; Epithelial-Mesenchymal Transition/genetics
    Chemical Substances Cadherins
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emerging Success Against the COVID-19 Pandemic: Hospital Surge Capacity in Taiwan.

    Wang, Tzu-Yi / Liu, Hsin-Liang / Lin, Chun-Yu / Kuo, Fang-Li / Yang, Pei-Hsuan / Yeh, I-Jeng

    Annals of emergency medicine

    2020  Volume 76, Issue 3, Page(s) 374–376

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Management ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Surge Capacity/statistics & numerical data ; Taiwan/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2020.05.001
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  8. Article ; Online: Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers

    Hsin-Liang Liu / Hung-Yi Chuang / Chien-Ning Hsu / Su-Shin Lee / Chen-Cheng Yang / Kuan-Ting Liu

    International Journal of Environmental Research and Public Health, Vol 17, Iss 2909, p

    2020  Volume 2909

    Abstract: Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D receptor (VDR) genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of a ... ...

    Abstract Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D receptor (VDR) genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of a relationship between lead neurotoxicity and polymorphisms has previously been presented. In this study, we investigated the relationship between the polymorphisms of VDR , MT1A , and MT2A genes and lead toxicity following chronic occupational lead exposure. We measured vibration perception thresholds (VPT) and current perception thresholds (CPT) in 181 workers annually for five years. The outcome variables were correlated to the subject’s index of long-term lead exposure. Polymorphisms of VDR , MT1A , and MT2A were defined. The potential confounders, including age, sex, height, smoking, alcohol consumption, and working life span, were also collected and analyzed using linear regression. The regression coefficients of some gene polymorphisms were at least 20 times larger than regression coefficients of time-weighted index of cumulative blood lead (TWICL) measures. All regression coefficients of TWICL increased slightly. MT1A rs11640851 (AA/CC) was associated with a statistically significant difference in all neurological outcomes except hand and foot VPT. MT1A rs8052394 was associated with statistically significant differences in hand and foot CPT 2000 Hz. In MT2A rs10636, those with the C allele showed a greater effect on hand CPT than those with the G allele. Among the VDR gene polymorphisms, the Apa rs7975232 (CC/AA) single nucleotide polymorphism was associated with the greatest difference in hand CPT. MT2A rs28366003 appeared to have a neural protective effect, whereas Apa (rs7975232) of VDR and MT2A rs10636 increased the neurotoxicity as measured by CPT in the hands. MT1A rs8052394 had a protective effect on large myelinated nerves. MT1A rs11640851 was associated with susceptibility to neurotoxicity.
    Keywords vitamin D receptor ; metallothionein 1A and 2A ; gene polymorphisms ; lead toxicity ; sensory nervous system ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers.

    Liu, Hsin-Liang / Chuang, Hung-Yi / Hsu, Chien-Ning / Lee, Su-Shin / Yang, Chen-Cheng / Liu, Kuan-Ting

    International journal of environmental research and public health

    2020  Volume 17, Issue 8

    Abstract: Chronic exposure to lead is neurotoxic to the human peripheral sensory system. ... ...

    Abstract Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant
    MeSH term(s) Biomarkers/metabolism ; Chemical Industry ; Environmental Exposure ; Female ; Genotype ; Humans ; Lead/blood ; Lead/toxicity ; Lead Poisoning, Nervous System/blood ; Lead Poisoning, Nervous System/diagnosis ; Male ; Metallothionein/genetics ; Occupational Diseases/chemically induced ; Occupational Diseases/genetics ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control ; Occupational Exposure/statistics & numerical data ; Polymorphism, Single Nucleotide ; Receptors, Calcitriol/genetics
    Chemical Substances Biomarkers ; MT1A protein, human ; MT2A protein, human ; Receptors, Calcitriol ; Lead (2P299V784P) ; Metallothionein (9038-94-2)
    Language English
    Publishing date 2020-04-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17082909
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  10. Article ; Online: Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines.

    Xuan, Do Thi Minh / Yeh, I-Jeng / Wu, Chung-Che / Su, Che-Yu / Liu, Hsin-Liang / Chiao, Chung-Chieh / Ku, Su-Chi / Jiang, Jia-Zhen / Sun, Zhengda / Ta, Hoang Dang Khoa / Anuraga, Gangga / Wang, Chih-Yang / Yen, Meng-Chi

    Journal of immunology research

    2022  Volume 2022, Page(s) 3883822

    Abstract: Monkeypox virus (MPV) is a smallpox-like virus belonging to the ... ...

    Abstract Monkeypox virus (MPV) is a smallpox-like virus belonging to the genus
    MeSH term(s) Animals ; Disease Progression ; HeLa Cells ; Humans ; Macaca mulatta ; Mpox (monkeypox)/pathology ; Monkeypox virus/genetics ; Smallpox ; Transcriptome
    Language English
    Publishing date 2022-09-01
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2022/3883822
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