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Article ; Online: Gene therapy avenues and COVID-19 vaccines.

Abu Abed, Omar S

2021 Volume 22, Issue 2, Page(s) 120–124

MeSH term(s)	COVID-19/prevention & control ; COVID-19/therapy ; COVID-19 Vaccines/therapeutic use ; Genetic Therapy ; Humans ; Pharmaceutical Vehicles ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; Pharmaceutical Vehicles ; RNA, Messenger ; Vaccines, Synthetic
Language	English
Publishing date	2021-06-02
Publishing country	England
Document type	Letter
ZDB-ID	2060566-3
ISSN	1476-5470 ; 1466-4879
ISSN (online)	1476-5470
ISSN	1466-4879
DOI	10.1038/s41435-021-00136-6
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Article: Acute Severe Hyponatremia following Hysteroscopic Procedure in a Young Patient: A Case Report and Review of the Literature.

Atieh, Anwar S / Abu Shamma, Omar K / Abdelhafez, Mohammad O / Baniowda, Muath A / Abed, Samia / Babaa, Basheer H / Hamadah, Abdurrahman / Gharaibeh, Kamel A

Case reports in nephrology

2021 Volume 2021, Page(s) 7195660

Abstract: Background: Hysteroscopic surgery is a minimally invasive procedure used to diagnose and treat intrauterine pathologies. It requires distension of the uterine cavity for the adequate visualization of the operative field. Glycine (1.5%) is one of the ... ...

Abstract	Background: Hysteroscopic surgery is a minimally invasive procedure used to diagnose and treat intrauterine pathologies. It requires distension of the uterine cavity for the adequate visualization of the operative field. Glycine (1.5%) is one of the most commonly used solutions because it is nonconductive and also has good optical properties. However, acute hyponatremia is a critical complication that can develop after the absorption of a sufficient amount of the irrigation medium. Conclusion: Multiple strategies can be taken to reduce the risk of fluid absorption and subsequent hyponatremia. Moreover, attention should be paid to the treatment approach for patients with acute hyponatremia following hysteroscopic procedures; rapid correction of acute hyponatremia for such patients might be safe, although there is no consensus in the literature, and further trials are needed.
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627652-5
ISSN	2090-665X ; 2090-6641
ISSN (online)	2090-665X
ISSN	2090-6641
DOI	10.1155/2021/7195660
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Article ; Online: PEGylated polymeric nanocapsules for oral delivery of trypsin targeted to the small intestines.

Abu Abed, Omar S / Chaw, Cheng Shu / Williams, Lee / Elkordy, Amal A

International journal of pharmaceutics

2020 Volume 592, Page(s) 120094

Abstract: ... emulsion/evaporation method as w/o/w and s/o/w. Particle size, encapsulation efficiencies, drug release ... prepared as s/o/w or w/o/w (P < 0.05). Most of the encapsulated protein was released sustainedly ...

Abstract	The lack of trypsin in the intestines may end up with malnutrition; thus, trypsin replacement therapy is required in such cases. The main objective of this study is to formulate and evaluate polymeric nanocapsule (PNC) systems able to deliver trypsin to the small intestines with the minimal release in the stomach with the maximum biological activity. Four nanocapsule formulations were prepared by double emulsion/evaporation method as w/o/w and s/o/w. Particle size, encapsulation efficiencies, drug release in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF), morphology, the biological activity of encapsulated trypsin and shelf-life stability were investigated for all formulations. All formulations had a spherical shape with submicron size, and encapsulation efficiency more than 80%. The biological activity of encapsulated trypsin was significantly affected by the amount of trehalose and whether the formulations were prepared as s/o/w or w/o/w (P < 0.05). Most of the encapsulated protein was released sustainedly at the target site (SIF) over 24 h with minimum amount release in the gastric fluids. Also, more than 90% of physical integrity trypsin encapsulated in all formulations was retained after storage under chilled conditions for six months. However, the enzymatic assay results show that with low trehalose content, the biological activity was low, while increasing the trehalose amount increased the shelf stability to reach around 100% after six months of the study. The results obtained in this research work clearly indicated a promising potential of controlled release polymeric nanocapsules containing trypsin to target the small intestine and protect trypsin from the harsh condition facing the proteins during the process of preparation or the period of storage.
MeSH term(s)	Intestine, Small ; Nanocapsules ; Particle Size ; Polyethylene Glycols ; Polymers ; Trypsin
Chemical Substances	Nanocapsules ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Trypsin (EC 3.4.21.4)
Language	English
Publishing date	2020-11-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2020.120094
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Article ; Online: Lysozyme and DNase I loaded poly (D, L lactide-co-caprolactone) nanocapsules as an oral delivery system.

Abu Abed, Omar S / Chaw, Cheng / Williams, Lee / Elkordy, Amal A

Scientific reports

2018 Volume 8, Issue 1, Page(s) 13158

Abstract: Clinical applications of oral protein therapy for the treatment of various chronic diseases are limited due to the harsh conditions encounter the proteins during their journey in the Gastrointestinal Tract. Although nanotechnology forms a platform for ... ...

Abstract	Clinical applications of oral protein therapy for the treatment of various chronic diseases are limited due to the harsh conditions encounter the proteins during their journey in the Gastrointestinal Tract. Although nanotechnology forms a platform for the development of oral protein formulations, obtaining physiochemically stable formulations able to deliver active proteins is still challenging because of harsh preparation conditions. This study proposes the use of poly (D, L-lactic-co-caprolactone)-based polymeric nanocapsules at different monomers' ratios for protein loading and oral delivery. All formulations had a spherical shape and nano-scale size, and lysozyme encapsulation efficiency reached 80% and significantly affected by monomers' ratio. Trehalose and physical state of lysozyme had a significant effect on its biological activity (P < 0.05). Less than 10% of the protein was released in simulated gastric fluid, and 73% was the highest recorded accumulative release percentage in simulated intestinal fluid (SIF) over 24 h. The higher caprolactone content, the higher encapsulation efficiency (EE) and the lower SIF release recorded. Therefore, the formulation factors were optimised and the obtained system was PEGylated wisely to attain EE 80%, 81% SIF release within 24 h, and 98% lysozyme biological activity. The optimum formulation was prepared to deliver DNase, and similar attributes were obtained.
MeSH term(s)	Administration, Oral ; Animals ; Biomimetic Materials/chemistry ; Cattle ; Chickens ; Deoxyribonuclease I/chemistry ; Deoxyribonuclease I/metabolism ; Drug Compounding/methods ; Drug Delivery Systems ; Drug Liberation ; Factor Analysis, Statistical ; Gastric Juice/chemistry ; Kinetics ; Muramidase/chemistry ; Muramidase/metabolism ; Nanocapsules/chemistry ; Nanocapsules/ultrastructure ; Particle Size ; Polyesters/chemistry
Chemical Substances	Nanocapsules ; Polyesters ; lactide-caprolactone copolymer (70524-20-8) ; Deoxyribonuclease I (EC 3.1.21.1) ; Muramidase (EC 3.2.1.17)
Language	English
Publishing date	2018-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-31303-x
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Article ; Online: Synthesis of new pyrazolone and pyrazole-based adamantyl chalcones and antimicrobial activity.

Al-Saheb, Rawan / Makharza, Sami / Al-Battah, Feras / Abu-El-Halawa, Rajab / Kaimari, Tawfeq / Abu Abed, Omar S

Bioscience reports

2020 Volume 40, Issue 9

Abstract: Chalcones and their derivatives are becoming increasingly popular due to their various pharmacological effects. Chalcone molecules may be extracted from natural resources, entirely synthesised, or biosynthesised by modifying the natural ones. In the ... ...

Abstract	Chalcones and their derivatives are becoming increasingly popular due to their various pharmacological effects. Chalcone molecules may be extracted from natural resources, entirely synthesised, or biosynthesised by modifying the natural ones. In the present study, five pyrazole-based adamantyl heterocyclic compounds were synthesised by condensation of 1-adamantyl chalcone with substituted phenylhydrazine. The products were characterised by using ¹H NMR, ¹³C NMR and FT-IR spectroscopy. The microbiological activity of these compounds was investigated against bacteria and fungi. The new compounds showed good to moderate activity against the microbial species used for screening. All developed molecules showed antibacterial activity against Gram-negative and Gram-positive. These molecules showed antifungal activities against Fusarium oxysporum fungus and in a dose-dependent manner, apart from RS-1 molecules which showed compromised antifungal activity and even at a high dose.
MeSH term(s)	Adamantane/analogs & derivatives ; Adamantane/chemical synthesis ; Adamantane/pharmacology ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/pharmacology ; Chalcones/chemical synthesis ; Chalcones/pharmacology ; Microbial Sensitivity Tests ; Molecular Structure ; Pyrazoles/chemistry ; Pyrazolones/chemistry ; Structure-Activity Relationship
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents ; Chalcones ; Pyrazoles ; Pyrazolones ; Adamantane (PJY633525U)
Language	English
Publishing date	2020-09-10
Publishing country	England
Document type	Journal Article
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20201950
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Article ; Online: Characteristics, fates and complications of long-term silicone oil tamponade after pars plana vitrectomy.

Abu-Yaghi, Nakhleh E / Abu Gharbieh, Yazan A / Al-Amer, Ahmad M / AlRyalat, Saif Aldeen S / Nawaiseh, Mohammed B / Darweesh, Mohammad J / Alkukhun, Leen R / Abed, Alaa M / Saleh, Omar A / Ababneh, Osama H

BMC ophthalmology

2020 Volume 20, Issue 1, Page(s) 336

Abstract: Background: Silicone oil tamponade has become a mainstay in treatment of advanced retinal detachment due to multiple etiologies. The aim of this study is to assess the characteristics, fates and complications of long-term silicone oil tamponade after ... ...

Abstract	Background: Silicone oil tamponade has become a mainstay in treatment of advanced retinal detachment due to multiple etiologies. The aim of this study is to assess the characteristics, fates and complications of long-term silicone oil tamponade after par plana vitrectomy (PPV), and to compare the outcomes of different silicone oil viscosities used in a cohort of consecutive patients. Methods: This is a retrospective comparative case series of eyes undergoing vitrectomy with silicone oil tamponade for retinal detachment by a single surgeon using different oil viscosities that were followed for one year with the silicone oil in situ. Visual acuity (VA), intraocular pressure (IOP) and complications associated with the follow up period were analyzed and compared. Results: Eighty-five eyes of 85 patients were included in this study. Forty three patients had 1000 centistoke (cs) oil injected and 42 patients had 5000cs oil utilized. Demographic, cause of retinal detachment and preoperative ocular characteristics were similar in both groups. Long term complications in both groups included ocular hypertension (67.4% vs 66.7%), keratopathy due to silicone oil emulsification and migration to the anterior chamber (7.0% vs 11.9%), recurrent retinal detachment (4.7% vs 19%) and epiretinal membrane formation (7% vs 19%). In the 1000cs oil group, there was no significant difference between baseline IOP and any subsequent visit. There was a significant difference between baseline IOP and visits at day 1 (with IOP difference of 2.61 mmHg (±6.5)) (p = 0.028), 1 month (with IOP difference of 3.52 mmHg (±8.1)) (p = 0.026), 4 months (with IOP difference of 6.38 mmHg (±9.3)) (p = 0.005), and one year (with IOP difference of 4.24 mmHg (±11.1)) (p = 0.048), all higher in the post-operative period in the 5000cs oil group. Excluding the first post-operative day, no significant difference was found for VA between baseline visits and subsequent visits for either silicone oil groups. Conclusion: In this cohort of patients with long-term silicone oil tamponade after PPV to treat retinal detachment, IOP increased significantly in patients who received 5000cs silicone oil. There was no significant difference between other complication rates in patients receiving either oil viscosities. Long term silicone oil tamponade remains a viable option in certain cases, and a vigilant follow up for complications is necessary to limit any adverse effects and improve visual and surgical outcomes.
MeSH term(s)	Endotamponade ; Humans ; Retinal Detachment/surgery ; Retrospective Studies ; Silicone Oils/adverse effects ; Vitrectomy
Chemical Substances	Silicone Oils
Language	English
Publishing date	2020-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-020-01608-5
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Article ; Online: Lysozyme and DNase I loaded poly (D, L lactide-co-caprolactone) nanocapsules as an oral delivery system

Omar S. Abu Abed / Cheng Chaw / Lee Williams / Amal A. Elkordy

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 10

Abstract: Abstract Clinical applications of oral protein therapy for the treatment of various chronic diseases are limited due to the harsh conditions encounter the proteins during their journey in the Gastrointestinal Tract. Although nanotechnology forms a ... ...

Abstract	Abstract Clinical applications of oral protein therapy for the treatment of various chronic diseases are limited due to the harsh conditions encounter the proteins during their journey in the Gastrointestinal Tract. Although nanotechnology forms a platform for the development of oral protein formulations, obtaining physiochemically stable formulations able to deliver active proteins is still challenging because of harsh preparation conditions. This study proposes the use of poly (D, L-lactic-co-caprolactone)-based polymeric nanocapsules at different monomers’ ratios for protein loading and oral delivery. All formulations had a spherical shape and nano-scale size, and lysozyme encapsulation efficiency reached 80% and significantly affected by monomers’ ratio. Trehalose and physical state of lysozyme had a significant effect on its biological activity (P < 0.05). Less than 10% of the protein was released in simulated gastric fluid, and 73% was the highest recorded accumulative release percentage in simulated intestinal fluid (SIF) over 24 h. The higher caprolactone content, the higher encapsulation efficiency (EE) and the lower SIF release recorded. Therefore, the formulation factors were optimised and the obtained system was PEGylated wisely to attain EE 80%, 81% SIF release within 24 h, and 98% lysozyme biological activity. The optimum formulation was prepared to deliver DNase, and similar attributes were obtained.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Rare Case of Nasal Sarcoma with BCOR Internal Tandem Duplication Showing Complete Pathologic Response to the VDC-IE Chemotherapy Protocol.

Salah, Samer / Sughayer, Maher A / Jaber, Omar / Abu Abed, Nebras / Ajlouni, Fatena / Al Gargaz, Wisam / Abu Hijlih, Ramiz / Abuhijla, Fawzi / Al-Ibraheem, Akram / Alul, Farah / Naser, Walid

Case reports in oncological medicine

2023 Volume 2023, Page(s) 5546323

Abstract: ... Sarcoma ... ...

Abstract	Sarcoma with
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2629911-2
ISSN	2090-6714 ; 2090-6706
ISSN (online)	2090-6714
ISSN	2090-6706
DOI	10.1155/2023/5546323
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Article: Unexpected and Rare Sites of Metastasis in Oncologic Patients.

Shalata, Walid / Abu Jama, Ashraf / Abu Salman, Amjad / Golosky, Mitchell / Solomon, Adam / Abu Saleh, Omar / Michlin, Regina / Shalata, Sondos / Agbarya, Abed / Yakobson, Alexander

Journal of clinical medicine

2023 Volume 12, Issue 20

Abstract: Case studies of rare oncologic metastases are an important source of clinical data for health care professionals and researchers. While infrequent, the knowledge base and clinical recommendations derived from such cases aid in advancements in the field. ... ...

Abstract	Case studies of rare oncologic metastases are an important source of clinical data for health care professionals and researchers. While infrequent, the knowledge base and clinical recommendations derived from such cases aid in advancements in the field. As such, we aim to add five cases to the growing body of literature. The first two male patients, aged 69 and 73, were diagnosed with colon adenocarcinoma, suspected to be a second primary prostate carcinoma, following positron emission tomography-computer tomography (PET-CT). This suspicion was ruled out by prostatectomy and histopathological investigations, which instead found adenocarcinoma of colonic origin. The next two male patients, ages 63 and 68, were diagnosed, respectively, with metastatic pancreatic adenocarcinoma with cardiac metastases and metastatic melanoma with distant metastases to the pancreas. The final patient was a 73-year-old male diagnosed with metastatic breast cancer after a radiological investigation of suspected renal cell carcinoma.
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206447
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Article: Association of

Abdelhafez, Mohammad / Nasereddin, Abedelmajeed / Shamma, Omar Abu / Abed, Rajaa / Sinnokrot, Raghida / Marof, Omar / Heif, Tariq / Erekat, Zaid / Al-Jawabreh, Amer / Ereqat, Suheir

Interdisciplinary perspectives on infectious diseases

2023 Volume 2023, Page(s) 9551163

Abstract: The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor ( ...

Abstract	The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor (
Language	English
Publishing date	2023-09-16
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2478373-0
ISSN	1687-7098 ; 1687-708X
ISSN (online)	1687-7098
ISSN	1687-708X
DOI	10.1155/2023/9551163
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