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  1. Article ; Online: Patient-Oriented Tools for Communicating Lung Cancer Screening Results: The First of Many Critical Components.

    Rendle, Katharine A / Vachani, Anil

    Chest

    2023  Volume 163, Issue 3, Page(s) 477–478

    MeSH term(s) Humans ; Early Detection of Cancer ; Lung Neoplasms/diagnosis ; Lung Neoplasms/prevention & control ; Tomography, X-Ray Computed ; Mass Screening
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.11.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Web Exclusive. Annals On Call - Real-World Complications of Lung Cancer Screening.

    Centor, Robert M / Rendle, Katharine A / Vachani, Anil

    Annals of internal medicine

    2024  Volume 177, Issue 3, Page(s) eA230006

    MeSH term(s) Humans ; Early Detection of Cancer ; Lung Neoplasms/diagnosis
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Webcast ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/A23-0006
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  3. Article ; Online: Could DNA Fragments Be the Key to Early Detection of Lung Cancer?

    Thompson, Jeffrey C / Vachani, Anil

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 9, Page(s) 1120–1122

    MeSH term(s) Humans ; Cell-Free Nucleic Acids ; Early Detection of Cancer/methods ; Lung Neoplasms/diagnosis ; Lung ; DNA
    Chemical Substances Cell-Free Nucleic Acids ; DNA (9007-49-2)
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202303-0387ED
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  4. Article ; Online: Impact of low-dose computed tomography screening on lung cancer incidence and outcomes.

    Vachani, Anil / Caruso, Christopher

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 4, Page(s) 232–238

    Abstract: Purpose of review: To review findings from clinical trials of lung cancer screening (LCS), assess contemporary issues with implementation in clinical practice, and review emerging strategies to increase the uptake and efficiency of LCS.: Recent ... ...

    Abstract Purpose of review: To review findings from clinical trials of lung cancer screening (LCS), assess contemporary issues with implementation in clinical practice, and review emerging strategies to increase the uptake and efficiency of LCS.
    Recent findings: In 2013, the USPSTF recommended annual screening for individuals aged 55-80 years and currently smoke or quit within the past 15 years based on reduced mortality from lung cancer with annual low-dose computed tomography (LDCT) screening in the National Lung Screening Trial. Subsequent trials have demonstrated similar mortality outcomes in individuals with lower pack-year smoking histories. These findings, coupled with evidence for disparities in screening eligibility by race, resulted in updated guidelines by USPSTF to broaden eligibility criteria for screening. Despite this body of evidence, implementation in the United States has been suboptimal with fewer than 20% of eligible individuals receiving a screen. Barriers to efficient implementation are multifactorial and include patient, clinician, and system-level factors.
    Summary: Multiple randomized trials have established that annual LCS reduces mortality from lung cancer; however, several areas of uncertainty exist on the effectiveness of annual LDCT. Ongoing research is examining approaches to improve the uptake and efficiency of LCS, such as the use of risk-prediction models and biomarkers for identification of high-risk individuals.
    MeSH term(s) Humans ; United States/epidemiology ; Early Detection of Cancer/methods ; Incidence ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/epidemiology ; Tomography, X-Ray Computed/methods ; Mass Screening/methods
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4900: Show issues Location:
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  5. Article ; Online: Expanding the Reach of Lung Cancer Screening: Risk Models for Individuals Who Never Smoked.

    Vachani, Anil / Nana-Sinkam, Patrick

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 1, Page(s) 13–15

    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Smokers ; Smoke ; Early Detection of Cancer ; Prospective Studies ; Nicotiana ; China
    Chemical Substances Smoke
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202208-1521ED
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  6. Article ; Online: Reply.

    Vachani, Anil / Zhou, Meijia / Ghosh, Sudip / Zhang, Shumin / Szapary, Philippe / Gaurav, Dheeraj / Kalsekar, Iftekhar

    Journal of the American College of Radiology : JACR

    2023  Volume 21, Issue 4, Page(s) 546–547

    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2023.04.009
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  7. Article ; Online: Photodynamic therapy for stage I and II non-small cell lung cancer: A SEER-Medicare analysis 2000-2016.

    Chhatre, Sumedha / Murgu, Septimiu / Vachani, Anil / Jayadevappa, Ravishankar

    Medicine

    2022  Volume 101, Issue 11

    Abstract: Abstract: We analyzed mortality (all-cause and lung cancer-specific) and time to follow-up treatment in stage I and II non-small cell lung cancer (NSCLC) patients treated with photodynamic therapy (PDT) compared with ablation therapy and radiation ... ...

    Abstract Abstract: We analyzed mortality (all-cause and lung cancer-specific) and time to follow-up treatment in stage I and II non-small cell lung cancer (NSCLC) patients treated with photodynamic therapy (PDT) compared with ablation therapy and radiation therapy.From Surveillance, Epidemiology, and End Results-Medicare linked data, patients diagnosed with stage I and II NSCLC between 2000 and 2015 were identified. Outcomes were mortality (overall and lung cancer-specific) and time to follow-up treatment. We analyzed mortality using Cox proportional hazard models. We used generalized linear model to assess time to follow-up treatment (PDT and ablation groups). Models were adjusted for inverse probability weighted propensity score.Of 495,441 NSCLC patients, 56 with stage I and II disease received PDT (mono or multi-modal), 477 received ablation (mono or multi-modal), and 14,178 received radiation therapy alone. None from PDT group had metastatic disease (M0) and 70% had no nodal involvement (N0). Compared with radiation therapy alone, PDT therapy was associated with lower hazard of overall (hazard ratio = 0.56, 95% CI = 0.39-0.80), and lung cancer-specific mortality (hazard ratio = 0.64, 95% CI = 0.43-0.97). Unadjusted mean time to follow-up treatment was 70days (standard deviation = 146) for PDT group and 67 days (standard deviation = 174) for ablation group. Compared with ablation, PDT was associated with an average increase of 125days to follow-up treatment (P = .11).Among stage I and II NSCLC patients, PDT was associated with improved survival, compared with radiation alone; and longer time to follow-up treatment compared with ablation. Currently, PDT is offered in various combinations with surgery and radiation. Larger studies can investigate the efficacy and effectiveness of these combinations.
    MeSH term(s) Aged ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Medicare ; Neoplasm Staging ; Photochemotherapy ; SEER Program ; Treatment Outcome ; United States/epidemiology
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029053
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  8. Article ; Online: Effect of an artificial intelligence tool on management decisions for indeterminate pulmonary nodules.

    Kim, Roger Y / Oke, Jason L / Dotson, Travis L / Bellinger, Christina R / Vachani, Anil

    Respirology (Carlton, Vic.)

    2023  Volume 28, Issue 6, Page(s) 582–584

    MeSH term(s) Humans ; Artificial Intelligence ; Multiple Pulmonary Nodules/diagnostic imaging ; Multiple Pulmonary Nodules/therapy ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy
    Language English
    Publishing date 2023-04-05
    Publishing country Australia
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14502
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    Zs.A 4957: Show issues Location:
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  9. Article ; Online: Quantifying the Value of Reduced Health Disparities: Low-Dose Computed Tomography Lung Cancer Screening of High-Risk Individuals Within the United States.

    Shafrin, Jason / Kim, Jaehong / Marin, Moises / Ramsagar, Sangeetha / Davies, Mark Lloyd / Stewart, Kyana / Kalsekar, Iftekhar / Vachani, Anil

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2024  Volume 27, Issue 3, Page(s) 313–321

    Abstract: Objective: This study aimed to measure the value of increasing lung cancer screening rates for high-risk individuals and its impact on health disparities.: Methods: The model estimated changes in health economic outcomes if low-dose computed ... ...

    Abstract Objective: This study aimed to measure the value of increasing lung cancer screening rates for high-risk individuals and its impact on health disparities.
    Methods: The model estimated changes in health economic outcomes if low-dose computed tomography screening increased from current to 100% compliance, following clinical guidelines. Current low-dose computed tomography screening rates were estimated by income, education, and race, using 2017-2019 Behavioral Risk Factor Surveillance System data. The model contained a decision tree module to segment the population by screening outcomes and a Markov chain module to estimate cancer progression over time. Model parameters included information on survival, quality of life, and costs related to cancer diagnosis, treatment, and adverse events. Distributional cost-effectiveness analysis estimated the net monetary value from reduced health disparities-measured using quality-adjusted life expectancy-across income, education, and race groups. Outcomes were assessed over 30 years.
    Results: Lung cancer screening eligibility using US Preventive Services Task Force guidelines was higher for individuals with income <$15 000 (47.2%) and without a high-school education (46.1%) than individuals with income >$50 000 (16.6%) and with a college degree (13.5%), respectively. Increasing lung cancer screening to 100% compliance was cost-effective ($64 654 per quality-adjusted life-year) and produced economic value by up to $560 per person ($182.1 billion for United States overall). Up to 32.2% of the value was due to reductions in health disparities.
    Conclusions: Significant value in increasing lung cancer screening rates derived from reducing health disparities. Policy makers and clinicians may not be appropriately prioritizing cancer screening if value from reducing health disparities is unconsidered.
    MeSH term(s) Humans ; United States ; Early Detection of Cancer ; Quality of Life ; Mass Screening ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/epidemiology ; Cost-Benefit Analysis ; Tomography, X-Ray Computed/methods ; Health Inequities
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2023.12.014
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    Zs.A 5904: Show issues Location:
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  10. Article ; Online: Air pollution and lung cancer survival in Pennsylvania.

    McKeon, Thomas P / Anil Vachani / Penning, Trevor M / Hwang, Wei-Ting

    Lung cancer (Amsterdam, Netherlands)

    2022  Volume 170, Page(s) 65–73

    Abstract: Objective: Lung cancer is a leading cause of cancer death in the United States. Exposure to outdoor air pollution (OAP) is associated with increased lung cancer incidence, however little is known about the association of OAP and survival after diagnosis. ...

    Abstract Objective: Lung cancer is a leading cause of cancer death in the United States. Exposure to outdoor air pollution (OAP) is associated with increased lung cancer incidence, however little is known about the association of OAP and survival after diagnosis.
    Methods: We investigated the effects of OAP and lung cancer survival in Pennsylvania using data from Pennsylvania Cancer Registry. The study population consisted of 252,123 patients diagnosed between 1990 and 2017. The Environmental Protection Agency's ambient air monitoring network provided information on OAP exposure of NO
    Results: Median survival time was 0.76 [CIs: 0.75, 0.77] years for the study population and for localized, regional, and distant site diagnosis were 2.2 [CIs: 2.17, 2.23], 1.13 [CIs: 1.12, 1.15], and 0.42 [CIs: 0.41, 0.43] years, respectively. NO
    Conclusion: These findings supported the hypotheses that OAP can influence the carcinogenic process, impairing chemotherapy treatment, and provide important public health implications since environmental factors are not often considered in prognosis of survival after diagnosis.
    MeSH term(s) Air Pollutants/adverse effects ; Air Pollution/adverse effects ; Air Pollution/analysis ; Environmental Exposure/adverse effects ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/etiology ; Nitrogen Dioxide/analysis ; Particulate Matter/analysis ; Pennsylvania/epidemiology
    Chemical Substances Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2022-06-10
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2022.06.004
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