LIVIVO - Search results -

Search results

Result 1 - 10 of total 51

Search options

Article ; Online: Inflammatory augmentation of the delayed type hypersensitivity arthritis mouse model.

Tønnessen, Theis Christian / Ueland, Thor / Ahmed, Muhammad Shakil / Attramadal, Håvard / Sjaastad, Ivar / Vinge, Leif Erik

Basic & clinical pharmacology & toxicology

2023 Volume 132, Issue 6, Page(s) 551–555

MeSH term(s)	Animals ; Mice ; Arthritis ; Disease Models, Animal ; Arthritis, Experimental ; Hypersensitivity, Delayed
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2134679-3
ISSN	1742-7843 ; 1742-7835
ISSN (online)	1742-7843
ISSN	1742-7835
DOI	10.1111/bcpt.13864
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.144: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cardiac sarcoma.

Hamre, Carl Fredrik Bonnevie / Kvammen, Eirik Magnus Hobbel / Vinge, Leif Erik / Skeie, Annette Torød / Hompland, Ivar

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2020 Volume 140, Issue 6

Abstract: Background: Although very rare, cardiac sarcoma is the most common malignant cardiac tumour. Cardiac tumours may present with constitutional symptoms and this can lead to delayed diagnosis.: Case presentation: A woman in her late twenties was ... ...

Title translation	Sarkom i hjertet.
Abstract	Background: Although very rare, cardiac sarcoma is the most common malignant cardiac tumour. Cardiac tumours may present with constitutional symptoms and this can lead to delayed diagnosis. Case presentation: A woman in her late twenties was admitted to the acute psychiatric ward with suspected depressive psychosis. Although she presented with insomnia, auditory hallucinosis and paranoid delusions, her main symptoms were dyspnoea, tachycardia and exhaustion. She was discharged after 17 days and admitted directly to the medical ward for further examination. A thorough somatic examination, including diagnostic imaging, revealed a tumour in the left atrium obstructing the mitral ostium in the diastole, resulting in orthopnoea. She had urgent cardiac surgery and the histology was consistent with an intimal sarcoma. Interpretation: This case illustrates a rare disease presenting with atypical symptoms. Her psychiatric symptoms resolved after surgery and oncologic treatment of her cardiac tumour.
MeSH term(s)	Female ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Hospitalization ; Humans ; Sarcoma/diagnostic imaging ; Sarcoma/surgery
Language	Norwegian
Publishing date	2020-04-20
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.19.0455
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 422: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 546: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice.

Tønnessen, Theis Christian / Melleby, Arne Olav / Hauge-Iversen, Ida Marie / Espe, Emil Knut Stenersen / Ahmed, Mohammed Shakil / Ueland, Thor / Haavardsholm, Espen Andre / Atkinson, Sara Marie / Melum, Espen / Attramadal, Håvard / Sjaastad, Ivar / Vinge, Leif Erik

PloS one

2022 Volume 17, Issue 1, Page(s) e0262821

Abstract: Aims: Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an ... ...

Abstract	Aims: Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an experimental model of RA in mice subjected to HF by constriction of the ascending aorta. Methods: Aorta was constricted via thoracotomy and placement of o-rings with inner diameter 0.55 mm or 0.66 mm, or sham operated. RA-like phenotype was instigated by delayed-type hypersensitivity arthritis (DTHA) two weeks after surgery and re-iterated after additional 18 days. Cardiac magnetic resonance imaging (MRI) was performed before surgery and at successive time points throughout the study. Six weeks after surgery the mice were euthanized, blood and tissue were collected, organ weights were documented, and expression levels of cardiac foetal genes were analysed. In a supplemental study, DTHA-mice were euthanized throughout 14 days after induction of arthritis, and blood was analysed for important markers and mediators of RA (SAP, TNF-α and IL-6). In order to put the latter findings into clinical context, the same molecules were analysed in serum from untreated RA patients and compared to healthy controls. Results: Significant elevations of inflammatory markers were found in both patient- and murine blood. Furthermore, the DTHA model appeared clinically relevant when compared to the inflammatory responses observed in three prespecified RA severity disease states. Two distinct trajectories of cardiac dysfunction and HF development were found using the two o-ring sizes. These differences were consistent by both MRI, organ weights and cardiac foetal gene expression levels. Still, no difference within the HF groups, nor within the sham groups, could be found when DTHA was induced. Conclusion: DTHA mediated systemic inflammation did not cause, nor modify HF caused by aortic constriction. This indicates other prerequisites for RA-induced cardiac dysfunction.
MeSH term(s)	Animals ; Aortic Valve Stenosis/etiology ; Aortic Valve Stenosis/physiopathology ; Arthritis, Experimental/complications ; Arthritis, Experimental/physiopathology ; Disease Models, Animal ; Heart Failure/etiology ; Heart Failure/physiopathology ; Humans ; Mice
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0262821
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice.

Theis Christian Tønnessen / Arne Olav Melleby / Ida Marie Hauge-Iversen / Emil Knut Stenersen Espe / Mohammed Shakil Ahmed / Thor Ueland / Espen Andre Haavardsholm / Sara Marie Atkinson / Espen Melum / Håvard Attramadal / Ivar Sjaastad / Leif Erik Vinge

PLoS ONE, Vol 17, Iss 1, p e

2022 Volume 0262821

Abstract: Aims Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an ... ...

Abstract	Aims Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an experimental model of RA in mice subjected to HF by constriction of the ascending aorta. Methods Aorta was constricted via thoracotomy and placement of o-rings with inner diameter 0.55 mm or 0.66 mm, or sham operated. RA-like phenotype was instigated by delayed-type hypersensitivity arthritis (DTHA) two weeks after surgery and re-iterated after additional 18 days. Cardiac magnetic resonance imaging (MRI) was performed before surgery and at successive time points throughout the study. Six weeks after surgery the mice were euthanized, blood and tissue were collected, organ weights were documented, and expression levels of cardiac foetal genes were analysed. In a supplemental study, DTHA-mice were euthanized throughout 14 days after induction of arthritis, and blood was analysed for important markers and mediators of RA (SAP, TNF-α and IL-6). In order to put the latter findings into clinical context, the same molecules were analysed in serum from untreated RA patients and compared to healthy controls. Results Significant elevations of inflammatory markers were found in both patient- and murine blood. Furthermore, the DTHA model appeared clinically relevant when compared to the inflammatory responses observed in three prespecified RA severity disease states. Two distinct trajectories of cardiac dysfunction and HF development were found using the two o-ring sizes. These differences were consistent by both MRI, organ weights and cardiac foetal gene expression levels. Still, no difference within the HF groups, nor within the sham groups, could be found when DTHA was induced. Conclusion DTHA mediated systemic inflammation did not cause, nor modify HF caused by aortic constriction. This indicates other prerequisites for RA-induced cardiac dysfunction.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Screening for symptoms of depression and anxiety in a cardiology department.

Berge, Torkil / Bull-Hansen, Bente / Solberg, Erik Ekker / Heyerdahl, Else Resser / Jørgensen, Kjetil Nordbø / Vinge, Leif Erik / Aarønæs, Marit / Øie, Erik / Hyldmo, Ingrid

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2019 Volume 139, Issue 14

Abstract: Background: Depression and anxiety are common in patients with cardiac disease and predict a poorer prognosis, increased mortality and reduced compliance with treatment. National and international guidelines recommend procedures for screening, but there ...

Title translation	Screening for symptomer på depresjon og angst ved en hjertemedisinsk avdeling.
Abstract	Background: Depression and anxiety are common in patients with cardiac disease and predict a poorer prognosis, increased mortality and reduced compliance with treatment. National and international guidelines recommend procedures for screening, but there is a lack of studies of such practices in Norwegian hospitals. The objective of this study was to implement a simple screening method for symptoms of depression and anxiety in patients with cardiac disease. Material and method: Patients in the Department of Cardiology at Diakonhjemmet Hospital who had valvular heart disease, tachyarrhythmia, myocardial infarction or heart failure were screened for symptoms of depression, anxiety and panic attacks with the aid of five questions from the Patient Health Questionnaire-2 (PHQ-2), Generalized Anxiety Disorder Scale-2 (GAD-2) and Patient Health Questionnaire - Somatic, Anxiety, and Depressive Symptom Scales (PHQ-SADS). The patients were recruited from the outpatient clinic or ward at least one month after acute heart disease. Results: A total of 57 of 232 patients reported symptoms of depression or anxiety when screened. The screening method was easy to implement, but time constraints and uncertainty regarding procedures for follow-up and the effect of following up the patients were reported. Interpretation: Good tools and methods are available for screening for symptoms of depression and anxiety and anxiety in patients with cardiac disease. More studies are needed regarding the benefits of screening, at what stage of the disease it should be performed, and whether it should be performed by the primary and/or the specialist health services.
MeSH term(s)	Aftercare ; Aged ; Aged, 80 and over ; Anxiety/diagnosis ; Cardiology Service, Hospital ; Depression/diagnosis ; Female ; Heart Diseases/psychology ; Heart Failure/psychology ; Heart Valve Diseases/psychology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/psychology ; Norway ; Panic Disorder/diagnosis ; Patient Health Questionnaire ; Tachycardia/psychology
Language	English
Publishing date	2019-10-07
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.18.0570
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 422: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 546: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis.

Arain, Fizza / Abraityte, Aurelija / Bogdanova, Mariia / Solberg, Ole G / Michelsen, Annika E / Lekva, Tove / Aakhus, Svend / Holm, Sverre / Halvorsen, Bente / Finsen, Alexandra V / Vinge, Leif-Erik / Nymo, Ståle / Espeland, Torvald / Ranheim, Trine / Aukrust, Pål / Vaage, Ingvar Jarle / Auensen, Andreas / Gullestad, Lars / Ueland, Thor

Circulation. Heart failure

2020 Volume 13, Issue 10, Page(s) e006643

Abstract: Background: Identification of novel biomarkers could provide prognostic information and improve risk stratification in patients with aortic stenosis (AS). YKL-40 (chitinase-3-like protein 1), a protein involved in atherogenesis, is upregulated in human ... ...

Abstract	Background: Identification of novel biomarkers could provide prognostic information and improve risk stratification in patients with aortic stenosis (AS). YKL-40 (chitinase-3-like protein 1), a protein involved in atherogenesis, is upregulated in human calcific aortic valves. We hypothesized that circulating YKL-40 would be elevated and associated with the degree of AS severity and outcome in patients with symptomatic AS. Methods: Plasma YKL-40 was analyzed in 2 AS populations, one severe AS (n=572) with outcome measures and one with mixed severity (n=67). YKL-40 expression in calcified valves and in an experimental pressure overload model was assessed. Results: We found (1) patients with AS had upregulated circulating YKL-40 compared with healthy controls (median 109 versus 34 ng/mL, Conclusions: YKL-40 levels were elevated in AS and associated with mortality but not with other metrics of disease severity including the degree of AS severity. Despite scientific rationale for its role in AS, the clinical utility of circulating YKL-40 as a biomarker is limited. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01794832.
MeSH term(s)	Aged ; Aged, 80 and over ; Animals ; Aortic Valve/metabolism ; Aortic Valve/pathology ; Aortic Valve Stenosis/blood ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/genetics ; Aortic Valve Stenosis/mortality ; Biomarkers/blood ; Case-Control Studies ; Chitinase-3-Like Protein 1/blood ; Chitinase-3-Like Protein 1/genetics ; Cross-Sectional Studies ; Denmark ; Disease Models, Animal ; Female ; Humans ; Interleukin-13 Receptor alpha2 Subunit/genetics ; Interleukin-13 Receptor alpha2 Subunit/metabolism ; Male ; Mice, Inbred C57BL ; Middle Aged ; Norway ; Prognosis ; Severity of Illness Index ; Up-Regulation
Chemical Substances	Biomarkers ; CHI3L1 protein, human ; Chil1 protein, mouse ; Chitinase-3-Like Protein 1 ; IL13RA2 protein, human ; Interleukin-13 Receptor alpha2 Subunit
Keywords	covid19
Language	English
Publishing date	2020-09-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.119.006643
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6745: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice.

Dhondup, Yangchen / Sjaastad, Ivar / Sandanger, Øystein / Aronsen, Jan Magnus / Ahmed, Muhammad Shakil / Attramadal, Håvard / Finsen, Alexandra Vanessa / Zhang, Lili / Ranheim, Trine / Alfsnes, Katrine / Aukrust, Pål / Christensen, Geir / Yndestad, Arne / Vinge, Leif Erik

Mediators of inflammation

2017 Volume 2017, Page(s) 9450439

Abstract: ... ...

Abstract	Aim
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2017/9450439
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3575: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction.

Fosshaug, Linn E / Colas, Romain A / Anstensrud, Anne K / Gregersen, Ida / Nymo, Ståle / Sagen, Ellen L / Michelsen, Annika / Vinge, Leif E / Øie, Erik / Gullestad, Lars / Halvorsen, Bente / Hansen, Trond V / Aukrust, Pål / Dalli, Jesmond / Yndestad, Arne

EBioMedicine

2019 Volume 46, Page(s) 264–273

Abstract: Background: Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic ... ...

Abstract	Background: Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating inflammatory disease. However, the regulation of these molecules following acute myocardial infarction (MI) remains of interest. Methods: In this prospective observational study we aimed to profile plasma levels of SPMs in ST-elevation MI (STEMI) patients during the first week following MI. Plasma LM concentrations were measured in patients with STEMI (n = 15) at three time points and compared with stable coronary artery disease (CAD; n = 10) and healthy controls (n = 10). Findings: Our main findings were: (i) Immediately after onset of MI and before peak troponin T levels, STEMI patients had markedly increased levels of SPMs as compared with healthy controls and stable CAD patients, with levels of these mediators declining during follow-up. (ii) The increase in SPMs primarily reflected an increase in docosapentaenoic acid- and docosahexaenoic acid-derived protectins. (iii) Several individual protectins were correlated with the rapid increase in neutrophil counts, but not with CRP. (iv) A shift in 5-LOX activity from the leukotriene B Interpretation: The temporal regulation of SPMs indicates that resolution mechanisms are activated early during STEMI as part of an endogenous mechanism to initiate repair. Thus strategies to boost the activity and/or efficacy of these endogenous mechanisms may represent novel therapeutic opportunities for treatment of patients with MI. FUND: This work was supported by grants from the South-Eastern Norwegian regional health authority, the European Research Council under the European Union's Horizon 2020 research and innovation program, a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society, and the Barts Charity.
MeSH term(s)	Aged ; Biomarkers ; Case-Control Studies ; Cytokines/blood ; Female ; Humans ; Inflammation Mediators/blood ; Lipids/blood ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Prospective Studies ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/etiology
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators ; Lipids
Language	English
Publishing date	2019-07-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2019.07.024
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7090: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Gene therapy in heart failure.

Vinge, Leif Erik / Raake, Philip W / Koch, Walter J

Circulation research

2008 Volume 102, Issue 12, Page(s) 1458–1470

Abstract: With increasing knowledge of basic molecular mechanisms governing the development of heart failure (HF), the possibility of specifically targeting key pathological players is evolving. Technology allowing for efficient in vivo transduction of myocardial ... ...

Abstract	With increasing knowledge of basic molecular mechanisms governing the development of heart failure (HF), the possibility of specifically targeting key pathological players is evolving. Technology allowing for efficient in vivo transduction of myocardial tissue with long-term expression of a transgene enables translation of basic mechanistic knowledge into potential gene therapy approaches. Gene therapy in HF is in its infancy clinically with the predominant amount of experience being from animal models. Nevertheless, this challenging and promising field is gaining momentum as recent preclinical studies in larger animals have been carried out and, importantly, there are 2 newly initiated phase I clinical trials for HF gene therapy. To put it simply, 2 parameters are needed for achieving success with HF gene therapy: (1) clearly identified detrimental/beneficial molecular targets; and (2) the means to manipulate these targets at a molecular level in a sufficient number of cardiac cells. However, several obstacles do exist on our way to efficient and safe gene transfer to human myocardium. Some of these obstacles are discussed in this review; however, it primarily focuses on the molecular target systems that have been subjected to intense investigation over the last decade in an attempt to make gene therapy for human HF a reality.
MeSH term(s)	Adenylyl Cyclases/genetics ; Adenylyl Cyclases/physiology ; Animals ; Animals, Genetically Modified ; Calcium Signaling/drug effects ; Calcium Signaling/genetics ; Calcium-Binding Proteins/antagonists & inhibitors ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/physiology ; Clinical Trials, Phase I as Topic ; Cricetinae ; G-Protein-Coupled Receptor Kinase 2/antagonists & inhibitors ; Genetic Therapy/adverse effects ; Genetic Therapy/methods ; Genetic Vectors/administration & dosage ; Genetic Vectors/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/genetics ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Mice ; Myocytes, Cardiac/physiology ; Organ Specificity ; Parvalbumins/genetics ; Parvalbumins/physiology ; Protein Phosphatase 1/physiology ; Rabbits ; Rats ; Receptors, Adrenergic, beta/classification ; Receptors, Adrenergic, beta/genetics ; Receptors, Adrenergic, beta/physiology ; S100 Proteins/genetics ; S100 Proteins/physiology ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/physiology
Chemical Substances	Calcium-Binding Proteins ; Parvalbumins ; Receptors, Adrenergic, beta ; S100 Proteins ; S100A1 protein ; phospholamban ; GRK2 protein, human (EC 2.7.11.15) ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16) ; Protein Phosphatase 1 (EC 3.1.3.16) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Adenylyl Cyclases (EC 4.6.1.1) ; adenylyl cyclase 6 (EC 4.6.1.1)
Language	English
Publishing date	2008-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.108.173195
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure.

Dhondup, Yangchen / Ueland, Thor / Dahl, Christen Peder / Askevold, Erik Tandberg / Sandanger, Øystein / Fiane, Arnt / Ohm, Ingrid Kristine / Sjaastad, Ivar / Finsen, Alexandra Vanessa / Wæhre, Anne / Gullestad, Lars / Aukrust, Pål / Yndestad, Arne / Vinge, Leif Erik

Journal of cardiac failure

2016 Volume 22, Issue 10, Page(s) 823–828

Abstract: Background: Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are released as danger-associated molecular patterns during cardiac stress, and may activate several innate immune receptors. The purpose of this study was to investigate the ... ...

Abstract	Background: Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are released as danger-associated molecular patterns during cardiac stress, and may activate several innate immune receptors. The purpose of this study was to investigate the regulation of these danger-associated molecular patterns during human heart failure (HF). Methods and results: Plasma levels of mtDNA and nDNA from HF patients (n = 84) were analyzed by reverse transcriptase-polymerase chain reaction and compared with controls (n = 72). Increased levels of mtDNA were found in New York Heart Association (NYHA) I-II and NYHA III-IV. There was evidence of increased nDNA in NYHA III-IV compared with controls and NYHA I-II. Kaplan-Meier analysis revealed higher mortality in patients with high nDNA levels, whereas high levels of mtDNA were associated with survival. Conclusions: Plasma levels of mtDNA and nDNA are elevated in human HF associated with increased and decreased mortality, respectively. This study may suggest a rationale for exploring interventions within inflammatory signaling pathways activated by nucleic acids as novel targets in treatment of HF.
MeSH term(s)	Aged ; Biomarkers/blood ; Case-Control Studies ; Co-Repressor Proteins/metabolism ; Female ; Heart Failure/blood ; Heart Failure/mortality ; Heart Failure/physiopathology ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mitochondria/metabolism ; Predictive Value of Tests ; Prognosis ; Reference Values ; Severity of Illness Index ; Statistics, Nonparametric ; Survival Analysis
Chemical Substances	Biomarkers ; C1D protein, human ; Co-Repressor Proteins
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2016.06.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4340: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito