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  1. Article ; Online: Acute Treatment with the M-Channel (K

    Vigil, Fabio A / Belchior, Hindiael / Bugay, Vladislav / Bazaldua, Isabella I / Stoja, Aiola / Dantas, Denise C / Chun, Sang H / Farmer, Austin / Bozdemir, Eda / Holstein, Deborah M / Cavazos, Jose E / Lechleiter, James D / Brenner, Robert / Shapiro, Mark S

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2023  Volume 20, Issue 3, Page(s) 853–869

    Abstract: We investigated whether pharmacological increase of "M-type" (KCNQ, K ...

    Abstract We investigated whether pharmacological increase of "M-type" (KCNQ, K
    MeSH term(s) Mice ; Animals ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/drug therapy ; Epilepsy, Post-Traumatic ; Seizures/drug therapy ; Seizures/etiology ; Carbamates/pharmacology ; Carbamates/therapeutic use
    Chemical Substances ezogabine (12G01I6BBU) ; Carbamates
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-023-01361-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6156: Show issues Location:
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  2. Book: Brenner & Rector's the kidney / 2 / Barry M. Brenner

    Rector, Floyd C. / Brenner, Barry M.

    2008  

    Author's details ed. by Barry M. Brenner
    Collection Brenner & Rector's the kidney
    Language English
    Size XXII S., S. 1147 - 2241, LXIX S. : Ill., graph. Darst.
    Edition 8. ed.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015378123
    ISBN 978-1-416-03105-5 ; 1-416-03105-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 8396 order for loan Magazin
    2008 A 1267 order for loan Magazin

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  3. Book: Brenner & Rector's the kidney / 1 / Barry M. Brenner

    Rector, Floyd C. / Brenner, Barry M.

    2008  

    Author's details ed. by Barry M. Brenner
    Collection Brenner & Rector's the kidney
    Language English
    Size XXII, 1146, LIXI S. : Ill., graph. Darst.
    Edition 8. ed.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015378111
    ISBN 978-1-416-03105-5 ; 1-416-03105-7
    Database Catalogue ZB MED Medicine, Health

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    2008 A 1266 order for loan Magazin

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  4. Book: Brenner & Rector's the kidney / 1 / Barry M. Brenner

    Rector, Floyd C. / Brenner, Barry M.

    2004  

    Author's details ed. by Barry M. Brenner
    Collection Brenner & Rector's the kidney
    Language English
    Size XXI, 1481, LXXII S. : Ill., graph. Darst.
    Edition 7. ed.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013843212
    ISBN 0-7216-0164-2 ; 978-0-7216-0164-9
    Database Catalogue ZB MED Medicine, Health

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    2004 A 300 order for loan Magazin
    2008 A 3197 order for loan Magazin

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  5. Book: Brenner & Rector's the kidney / 2 / Barry M. Brenner

    Rector, Floyd C. / Brenner, Barry M.

    2004  

    Author's details ed. by Barry M. Brenner
    Collection Brenner & Rector's the kidney
    Language English
    Size XXI S., S. 1484 - 2870, LXXII S. : Ill., graph. Darst.
    Edition 7. ed.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Systemvoraussetzungen: Minimum system requirements: Windows: Windows 98, 2000, ME, NT4 (Service Pack 3 and above), or XP operating system; Microsoft Internet Explorer v5 (or later), or Netscape Navigator v4.8 (or later); Adobe Acrobat Reader 4.05 (or later); 800x600-pixel screen resolution; 16-bit color (65000 colors); 64 MB of RAM. Macintosh: MAC OS 9 (or later), or MAC OS X with classic Enviroments operating system; Microsoft Internet Explorer v5 (or later), or Netscape Navigator v4.8 (or later); Adobe Acrobat Reader 4.05 (or later); 800x600-pixel screen resolution; 16-bit color (65000 colors); 64 MB of RAM
    Accompanying material 1 CD-ROM (12 cm) + Begleith. (7 S.)
    HBZ-ID HT013843217
    ISBN 0-7216-0164-2 ; 978-0-7216-0164-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 301 order for loan Magazin
    2004 MO 49 <<[Begleitmaterial]>> order for loan Magazin
    2004 MO 50 <<[Begleitmaterial]>> order for loan Magazin
    2008 A 3198 order for loan Magazin

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  6. Article ; Online: Global-scale GWAS associates a subset of SNPs with animal-adapted variants in M. tuberculosis complex.

    Brenner, Evan P / Sreevatsan, Srinand

    BMC medical genomics

    2023  Volume 16, Issue 1, Page(s) 260

    Abstract: Background: While Mycobacterium tuberculosis complex (MTBC) variants are clonal, variant tuberculosis is a human-adapted pathogen, and variant bovis infects many hosts. Despite nucleotide identity between MTBC variants exceeding 99.95%, it remains ... ...

    Abstract Background: While Mycobacterium tuberculosis complex (MTBC) variants are clonal, variant tuberculosis is a human-adapted pathogen, and variant bovis infects many hosts. Despite nucleotide identity between MTBC variants exceeding 99.95%, it remains unclear what drives these differences. Markers of adaptation into variants were sought by bacterial genome-wide association study of single nucleotide polymorphisms extracted from 6,362 MTBC members from varied hosts and countries.
    Results: The search identified 120 genetic loci associated with MTBC variant classification and certain hosts. In many cases, these changes are uniformly fixed in certain variants while absent in others in this dataset, providing good discriminatory power in distinguishing variants by polymorphisms. Multiple changes were seen in genes for cholesterol and fatty acid metabolism, pathways previously proposed to be important for host adaptation, including Mce4F (part of the fundamental cholesterol intake Mce4 pathway), 4 FadD and FadE genes (playing roles in cholesterol and fatty acid utilization), and other targets like Rv3548c and PTPB, genes shown essential for growth on cholesterol by transposon studies.
    Conclusions: These findings provide a robust set of genetic loci associated with the split of variant bovis and variant tuberculosis, and suggest that adaptation to new hosts could involve adjustments in uptake and catabolism of cholesterol and fatty acids, like the proposed specialization to different populations in MTB lineages by alterations to host lipid composition. Future studies are required to elucidate how the associations between cholesterol profiles and pathogen utilization differences between hosts and MTBC variants, as well as the investigation of uncharacterized genes discovered in this study. This information will likely provide an understanding on the diversification of MBO away from humans and specialization towards a broad host range.
    MeSH term(s) Animals ; Humans ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study ; Mycobacterium tuberculosis/genetics ; Tuberculosis/genetics ; Tuberculosis/microbiology ; Cholesterol ; Fatty Acids
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Fatty Acids
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411865-5
    ISSN 1755-8794 ; 1755-8794
    ISSN (online) 1755-8794
    ISSN 1755-8794
    DOI 10.1186/s12920-023-01695-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 78/m mit Verwirrtheit nach Darmresektion : Vorbereitung auf die Facharztprüfung: Fall 24.

    Schmoch, T / Brenner, T / Weigand, M A

    Der Anaesthesist

    2019  Volume 68, Issue Suppl 2, Page(s) 189–193

    Title translation 78-year-old male with disorientation after intestinal resection : Preparation for the medical specialist examination: Part 24.
    MeSH term(s) Aged ; Confusion/etiology ; Confusion/psychology ; Digestive System Surgical Procedures/adverse effects ; Humans ; Male ; Postoperative Complications/psychology ; Postoperative Complications/therapy ; Sepsis/diagnosis ; Sepsis/psychology ; Shock, Septic/diagnosis ; Shock, Septic/psychology
    Language German
    Publishing date 2019-04-15
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 260-4
    ISSN 1432-055X ; 0003-2417
    ISSN (online) 1432-055X
    ISSN 0003-2417
    DOI 10.1007/s00101-019-0569-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 232: Show issues
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  8. Article ; Online: A rare PALB2 germline variant causing G2/M cell cycle arrest is associated with isolated myelosarcoma in infancy.

    Beer, Angelina / Beck, Ricardo / Schedel, Anne / von Bonin, Malte / Meinel, Jörn / Friedrich, Ulrike Anne / Menzel, Maria / Suttorp, Meinolf / Brenner, Sebastian / Fitze, Guido / Lange, Björn / Knöfler, Ralf / Hauer, Julia / Auer, Franziska

    Molecular genetics & genomic medicine

    2021  Volume 9, Issue 9, Page(s) e1746

    Abstract: Background: Isolated myelosarcoma of infancy is a rare presentation of acute myelogenous leukaemia (AML). Because of its rarity and early onset in infancy underlying genetic predisposition is potentially relevant in disease initiation.: Methods and ... ...

    Abstract Background: Isolated myelosarcoma of infancy is a rare presentation of acute myelogenous leukaemia (AML). Because of its rarity and early onset in infancy underlying genetic predisposition is potentially relevant in disease initiation.
    Methods and results: We report an oncologic emergency in an infant with thoracic and intraspinal aleukaemic myeloid sarcoma causing acute myelon compression and lower leg palsy. Whole-exome sequencing of the patient's germline DNA identified a rare PALB2 (OMIM 610355) variant (p.A1079S), which is located in a domain critical for the gene's proper function within the homology-directed repair pathway. In line with potential DNA damage repair defects mediated by the PALB2 deregulation, the patient's fibroblasts showed increased sensitivity towards radiation and DNA intercalating agents.
    Conclusion: Therefore, we suggest PALB2 p.A1079S as a pathogenic variant potentially contributing to the here observed patient phenotype.
    MeSH term(s) Cells, Cultured ; Fanconi Anemia Complementation Group N Protein/genetics ; Fanconi Anemia Complementation Group N Protein/metabolism ; Fibroblasts/metabolism ; Fibroblasts/physiology ; G2 Phase Cell Cycle Checkpoints ; Germ-Line Mutation ; Humans ; Infant ; Male ; Sarcoma, Myeloid/genetics ; Sarcoma, Myeloid/pathology ; Spinal Neoplasms/genetics ; Spinal Neoplasms/pathology
    Chemical Substances Fanconi Anemia Complementation Group N Protein ; PALB2 protein, human
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.1746
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  9. Book ; Thesis: Einfluss reduzierter Expression der Immunglobulin-m-schweren [Immunglobulin-my-schweren] Kette auf die Entwicklung und Selektion von B-Lymphozyten

    Brenner, Sven

    2010  

    Author's details vorgelegt von Sven Brenner
    Language German
    Size 126 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2010
    HBZ-ID HT016467187
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 D 671 order for loan Magazin

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  10. Article ; Online: 65/m mit Fieber, verminderter Vigilanz und zunehmender Dyspnoe : Vorbereitungskurs Anästhesiologische Intensivmedizin: Fall 16.

    Bartsch, Lorenz-Alexander / Brenner, Thorsten / Schmoch, Thomas

    Die Anaesthesiologie

    2022  Volume 71, Issue Suppl 1, Page(s) 88–92

    Title translation 65/m-Fever, reduced vigilance and increasing dyspnea : Preparation course anesthesiological intensive care medicine: case 16.
    MeSH term(s) Anesthesia ; Critical Care ; Dyspnea/etiology ; Fever ; Humans
    Language German
    Publishing date 2022-06-23
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-6866
    ISSN (online) 2731-6866
    DOI 10.1007/s00101-022-01137-4
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