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Article ; Online: Post-operative antibiotic prophylaxis in spine surgery patients with thoracolumbar drains: A meta analysis.

Xia, Terry C / Rainone, Gersham J / Woodhouse, Cody J / Kramer, Dallas E / Whiting, Alexander C

World neurosurgery: X

2024 Volume 23, Page(s) 100373

Abstract: Objective: Closed-suction drains are commonly placed after thoracolumbar surgery to reduce the risk of post-operative hematoma and neurologic deterioration, and may stay in place for a longer period of time if output remains high. Prolonged maintenance ... ...

Abstract	Objective: Closed-suction drains are commonly placed after thoracolumbar surgery to reduce the risk of post-operative hematoma and neurologic deterioration, and may stay in place for a longer period of time if output remains high. Prolonged maintenance of surgical site drains, however, is associated with an increased risk of surgical site infection (SSI). The present study aims to examine the literature regarding extended duration (≥24 h) prophylactic antibiotic use in patients undergoing posterior thoracolumbar surgery with closed-suction drainage. Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Relevant studies reporting the use of 24-h post-operative antibiotics compared with extended duration post-operative antibiotics in patients undergoing posterior thoracolumbar surgery with closed-suction drainage were identified from a PubMed database query. Results: Six studies were included for statistical analysis, encompassing 1003 patients that received 24 h of post-operative antibiotics and 984 patients that received ≥24 h of post-operative antibiotics. The SSI rate was 5.16 % for the shorter duration group (24 h) and 4.44 % ( Conclusions: There is no significant difference in rates of SSI in patients receiving 24 h of post-operative antibiotics compared with patients receiving ≥24 h of post-operative antibiotics. Shorter durations of post-operative antibiotics in patients with thoracolumbar drains have similar outcomes compared to patients receiving longer courses of antibiotics. Shorter durations of antibiotics could potentially help lead to lower overall cost and length of stay for these patients.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ISSN	2590-1397
ISSN (online)	2590-1397
DOI	10.1016/j.wnsx.2024.100373
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Article: Alternative COVID-19 mitigation measures in school classrooms: analysis using an agent-based model of SARS-CoV-2 transmission.

Woodhouse, M J / Aspinall, W P / Sparks, R S J / Brooks-Pollock, E / Relton, C

Royal Society open science

2022 Volume 9, Issue 8, Page(s) 211985

Abstract: The SARS-CoV-2 epidemic has impacted children's education, with schools required to implement infection control measures that have led to periods of absence and classroom closures. We developed an agent-based epidemiological model of SARS-CoV-2 ... ...

Abstract	The SARS-CoV-2 epidemic has impacted children's education, with schools required to implement infection control measures that have led to periods of absence and classroom closures. We developed an agent-based epidemiological model of SARS-CoV-2 transmission in a school classroom that allows us to quantify projected infection patterns within primary school classrooms, and related uncertainties. Our approach is based on a contact model constructed using random networks, informed by structured expert judgement. The effectiveness of mitigation strategies in suppressing infection outbreaks and limiting pupil absence are considered. COVID-19 infections in primary schools in England in autumn 2020 were re-examined and the model was then used to estimate infection levels in autumn 2021, as the Delta variant was emerging and it was thought likely that school transmission would play a major role in an incipient new wave of the epidemic. Our results were in good agreement with available data. These findings indicate that testing-based surveillance is more effective than bubble quarantine, both for reducing transmission and avoiding pupil absence, even accounting for insensitivity of self-administered tests. Bubble quarantine entails large numbers of absences, with only modest impact on classroom infections. However, maintaining reduced contact rates within the classroom can have a major benefit for managing COVID-19 in school settings.
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.211985
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Article ; Online: Lumbar plexus safe working zones with lateral lumbar interbody fusion: a systematic review and meta-analysis.

Kramer, Dallas E / Woodhouse, Cody / Kerolus, Mena G / Yu, Alexander

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2022 Volume 31, Issue 10, Page(s) 2527–2535

Abstract: Purpose: Significant risk of injury to the lumbar plexus and its departing motor and sensory nerves exists with lateral lumbar interbody fusion (LLIF). Several cadaveric and imaging studies have investigated the lumbar plexus position with respect to ... ...

Abstract	Purpose: Significant risk of injury to the lumbar plexus and its departing motor and sensory nerves exists with lateral lumbar interbody fusion (LLIF). Several cadaveric and imaging studies have investigated the lumbar plexus position with respect to the vertebral body anteroposterior plane. To date, no systematic review and meta-analysis of the lumbar plexus safe working zones for LLIF has been performed. Methods: This systematic review was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Relevant studies reporting on the position of the lumbar plexus with relation to the vertebral body in the anteroposterior plane were identified from a PubMed database query. Quantitative analysis was performed using Welch's t test. Results: Eighteen studies were included, encompassing 1005 subjects and 2472 intervertebral levels. Eleven studies used supine magnetic resonance imaging (MRI) with in vivo subjects. Seven studies used cadavers, five of which performed dissection in the left lateral decubitus position. A significant correlation (p < 0.001) existed between anterior lumbar plexus displacement and evaluation with in vivo MRI at all levels between L1-L5 compared with cadaveric measurement. Supine position was also associated with significant (p < 0.001) anterior shift of the lumbar plexus at all levels between L1-L5. Conclusions: This is the first comprehensive systematic review and meta-analysis of the lumbar neural components and safe working zones for LLIF. Our analysis suggests that the lumbar plexus is significantly displaced ventrally with the supine compared to lateral decubitus position, and that MRI may overestimate ventral encroachment of lumbar plexus.
MeSH term(s)	Cadaver ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/innervation ; Lumbar Vertebrae/surgery ; Lumbosacral Plexus/anatomy & histology ; Psoas Muscles ; Spinal Fusion/methods
Language	English
Publishing date	2022-08-19
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-022-07352-2
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Zs.A 3437: Show issues

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Article ; Online: Palliative radiotherapy is effective for both well- and poorly differentiated neuroendocrine neoplasms.

O'Reilly, Eileen / Lao, Louis / Woodhouse, Braden / Sharples, Katrina / Print, Cris / Lawrence, Ben

Journal of medical imaging and radiation oncology

2023 Volume 68, Issue 1, Page(s) 94–102

Abstract: Introduction: The outcomes of palliative radiation therapy (RT) for neuroendocrine neoplasms (NEN) are seldom reported. We investigated outcomes following palliative radiotherapy in a cohort of patients with NENs. We hypothesised that well- ... ...

Abstract	Introduction: The outcomes of palliative radiation therapy (RT) for neuroendocrine neoplasms (NEN) are seldom reported. We investigated outcomes following palliative radiotherapy in a cohort of patients with NENs. We hypothesised that well-differentiated NEN will be less likely to have a clinical response than poorly differentiated NEN. Methods: Patients who received at least one course of palliative RT were identified using the New Zealand NETwork! Registry. Patients with Merkel cell carcinoma, pulmonary small cell carcinoma or asymptomatic patients were excluded. Clinical response to RT within 90 days and overall survival were analysed alongside clinical variables (fractionation, RT site, tumour differentiation and tumour primary site). Results: The cohort comprised 79 patients, with 147 courses of palliative RT delivered. Clinical response was measurable for 100 courses, with clinical response rate of 76%. A course delivered to a well-differentiated NEN was associated with 2.02-fold (95% CI 0.67, 6.12; P = 0.21) increase in odds of a clinical response compared to a poorly differentiated NEN. Median overall survival from the first fraction of RT was 94 days (95% CI 80, 138 days). Overall survival was higher in well-differentiated NEN than in poorly differentiated NEN (HR 0.2, 95% CI 0.10-0.40, P-value < 0.001); 30-day mortality was 7%. There were significantly reduced odds of clinical response for non-bone sites, and for courses >10 fractions compared to a single fraction. Conclusion: Palliative RT is an appropriate option for management of symptoms in patients with both well- and poorly differentiated metastatic NEN.
MeSH term(s)	Humans ; Neuroendocrine Tumors/radiotherapy ; Dose Fractionation, Radiation ; Small Cell Lung Carcinoma ; Lung Neoplasms/radiotherapy ; New Zealand ; Retrospective Studies
Language	English
Publishing date	2023-10-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2389687-5
ISSN	1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
ISSN (online)	1754-9485 ; 1440-1673
ISSN	1754-9477 ; 0004-8461
DOI	10.1111/1754-9485.13597
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Zs.B 66: Show issues

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Article ; Online: Experimental laboratory models as tools for understanding modifiable dementia risk.

Sinclair, Duncan / Canty, Alison J / Ziebell, Jenna M / Woodhouse, Adele / Collins, Jessica M / Perry, Sharn / Roccati, Eddy / Kuruvilla, Maneesh / Leung, Jacqueline / Atkinson, Rachel / Vickers, James C / Cook, Anthony L / King, Anna E

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024

Abstract: Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to ... ...

Abstract	Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia. This review provides an overview of experimental research into 15 established and putative modifiable dementia risk factors: less early-life education, hearing loss, depression, social isolation, life stress, hypertension, obesity, diabetes, physical inactivity, heavy alcohol use, smoking, air pollution, anesthetic exposure, traumatic brain injury, and disordered sleep. It explores how experimental models have been, and can be, used to address questions about modifiable dementia risk and prevention that cannot readily be addressed in human studies. HIGHLIGHTS: Modifiable dementia risk factors are promising targets for dementia prevention. Interrogation of mechanisms underlying dementia risk is difficult in human populations. Studies using diverse experimental models are revealing modifiable dementia risk mechanisms. We review experimental research into 15 modifiable dementia risk factors. Laboratory science can contribute uniquely to dementia prevention.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13834
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Zs.A 6316: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 540: Show issues

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Article ; Online: Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system.

Reale, Laura A / Dyer, Marcus S / Perry, Sharn E / Young, Kaylene M / Dickson, Tracey C / Woodhouse, Adele / Blizzard, Catherine A

Progress in neurobiology

2023 Volume 226, Page(s) 102449

Abstract: Alterations in upper motor neuron excitability are one of the earliest phenomena clinically detected in ALS, and in 97 % of cases, the RNA/DNA binding protein, TDP-43, is mislocalised in upper and lower motor neurons. While these are two major ... ...

Abstract	Alterations in upper motor neuron excitability are one of the earliest phenomena clinically detected in ALS, and in 97 % of cases, the RNA/DNA binding protein, TDP-43, is mislocalised in upper and lower motor neurons. While these are two major pathological hallmarks in disease, our understanding of where disease pathology begins, and how it spreads through the corticomotor system, is incomplete. This project used a model where mislocalised TDP-43 was expressed in the motor cortex, to determine if localised cortical pathology could result in widespread corticomotor system degeneration. Mislocalised TDP-43 caused layer V excitatory neurons in the motor cortex to become hyperexcitable after 20 days of expression. Following cortical hyperexcitability, a spread of pathogenic changes through the corticomotor system was observed. By 30 days expression, there was a significant decrease in lower motor neuron number in the lumbar spinal cord. However, cell loss occurred selectively, with a significant loss in lumbar regions 1-3, and not lumbar regions 4-6. This regional vulnerability was associated with alterations in pre-synaptic excitatory and inhibitory proteins. Excitatory inputs (VGluT2) were increased in all lumbar regions, while inhibitory inputs (GAD65/67) were increased in lumbar regions 4-6 only. This data indicates that mislocalised TDP-43 in upper motor neurons can cause lower motor neuron degeneration. Furthermore, cortical pathology increased excitatory inputs to the spinal cord, to which local circuitry compensated with an upregulation of inhibition. These findings reveal how TDP-43 mediated pathology may spread through corticofugal tracts in ALS and identify a potential pathway for therapeutic intervention.
MeSH term(s)	Mice ; Animals ; Amyotrophic Lateral Sclerosis/genetics ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Spinal Cord/metabolism ; DNA-Binding Proteins/metabolism
Chemical Substances	DNA-Binding Proteins ; TDP-43 protein, mouse
Language	English
Publishing date	2023-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	185535-9
ISSN	1873-5118 ; 0301-0082
ISSN (online)	1873-5118
ISSN	0301-0082
DOI	10.1016/j.pneurobio.2023.102449
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Article ; Online: Pre-slaughter factors linked to variation in responses to carbon dioxide gas stunning in pig abattoirs.

Jongman, E C / Woodhouse, R / Rice, M / Rault, J-L

Animal : an international journal of animal bioscience

2020 Volume 15, Issue 2, Page(s) 100134

Abstract: The stunning process is an important component of slaughter with implications for animal welfare due to the potential distress and pain in the case of a sub-effective or lengthy stun. This study examined the factors correlated with variation in responses ...

Abstract	The stunning process is an important component of slaughter with implications for animal welfare due to the potential distress and pain in the case of a sub-effective or lengthy stun. This study examined the factors correlated with variation in responses to carbon dioxide (CO
MeSH term(s)	Abattoirs ; Animal Welfare ; Animals ; Australia ; Carbon Dioxide ; Female ; Hydrocortisone ; Male ; Swine
Chemical Substances	Carbon Dioxide (142M471B3J) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2020-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2020.100134
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Article ; Online: Pathological Links between Traumatic Brain Injury and Dementia: Australian Pre-Clinical Research.

Collins, Jessica M / Woodhouse, Adele / Bye, Nicole / Vickers, James C / King, Anna E / Ziebell, Jenna M

Journal of neurotrauma

2020 Volume 37, Issue 5, Page(s) 782–791

Abstract: Traumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease, the most common cause of ... ...

Abstract	Traumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease, the most common cause of dementia. Further, the TBI-induced form of dementia, called chronic traumatic encephalopathy, shares many pathological hallmarks present in multiple different diseases which cause dementia. The inflammatory and neuritic responses to TBI and dementia overlap, indicating that they may share common pathological mechanisms and that TBI may ultimately cause a pathological cascade culminating in the development of dementia. This review explores Australian pre-clinical research investigating the pathological links between TBI and dementia.
MeSH term(s)	Animals ; Australia ; Brain/metabolism ; Brain/pathology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/metabolism ; Brain Injuries, Traumatic/pathology ; Dementia/etiology ; Dementia/metabolism ; Dementia/pathology ; Humans ; Microglia/metabolism ; Microglia/pathology ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; tau Proteins/metabolism
Chemical Substances	tau Proteins
Language	English
Publishing date	2020-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2019.6906
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Zs.A 2016: Show issues

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Article ; Online: Correction to: A Scoping Review of HIV Pre-exposure Prophylaxis Stigma and Implications for Stigma-Reduction Interventions for Men and Transwomen Who Have Sex with Men.

Rosengren, A Lina / Lelutiu-Weinberger, Corina / Woodhouse, E Wilbur / Sandanapitchai, Priyadharshiny / Hightow-Weidman, Lisa B

AIDS and behavior

2021 Volume 25, Issue 9, Page(s) 3046

Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-021-03163-6
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Zs.A 6451: Show issues

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Article ; Online: A Scoping Review of HIV Pre-exposure Prophylaxis Stigma and Implications for Stigma-Reduction Interventions for Men and Transwomen Who Have Sex with Men.

Rosengren, A Lina / Lelutiu-Weinberger, Corina / Woodhouse, E Wilbur / Sandanapitchai, Priyadharshiny / Hightow-Weidman, Lisa B

AIDS and behavior

2021 Volume 25, Issue 7, Page(s) 2054–2070

Abstract: HIV remains a public health concern in the United States. Although pre-exposure prophylaxis (PrEP) can be expected to reduce HIV incidence, its uptake, adherence, and persistence remain limited, particularly among highest priority groups such as men who ... ...

Abstract	HIV remains a public health concern in the United States. Although pre-exposure prophylaxis (PrEP) can be expected to reduce HIV incidence, its uptake, adherence, and persistence remain limited, particularly among highest priority groups such as men who have sex with men and transwomen (MSMTW). Using a socioecological framework, we conducted a scoping review to examine PrEP-related stigma to inform future research, policy, and programmatic planning. Using the PRISMA extension for scoping reviews, we conducted database searches from August 2018 to April 2020 for articles addressing PrEP stigma. Studies were independently screened and coded by three authors, resulting in thematic categorization of several types of PrEP stigma on four socioecological levels. Of 557 references, a final sample of 23 studies was coded, 61% qualitative, and 87% focusing exclusively on MSMTW. Most instances of PrEP-related stigma occurred on the interpersonal level and included associations of PrEP with risk promotion, HIV-related stigma, and promiscuity. Other frequent themes across socioecological levels included provider distrust and discrimination, government and pharmaceutical industry distrust, internalized homonegativity, PrEP efficacy distrust, and anticipated homonegativity. Notably, PrEP was also framed positively as having physical and psychological benefits, and assuming responsibility for protecting one's community via PrEP awareness-raising. PrEP-related stigma persists, demanding interventions to modify its impact. Leveraging PrEP-positive discourses to challenge PrEP stigma is an emerging avenue, alongside efforts to increase provider willingness to promote PrEP routinely by reducing provider bias, aligning with the national strategy to End the HIV Epidemic.
MeSH term(s)	Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Homosexuality, Male ; Humans ; Male ; Pre-Exposure Prophylaxis ; Sexual and Gender Minorities ; United States
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2021-01-02
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-020-03135-2
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