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  1. Article ; Online: Impulse Control Disorders in Parkinson's Disease: Has COVID-19 Related Lockdown Been a Trigger?

    Rábano-Suárez, Pablo / Martínez-Fernández, Raúl / Natera-Villalba, Elena / Pareés, Isabel / Martínez-Castrillo, Juan Carlos / Alonso-Canovas, Araceli

    Movement disorders clinical practice

    2021  Volume 8, Issue 6, Page(s) 940–943

    Abstract: Background: Parkinson's disease (PD) patients, especially those on dopamine agonists (DA), are at risk of impulse control disorders (ICD). Little attention has been paid to the influence of environmental factors.: Cases: Retrospective analysis of ... ...

    Abstract Background: Parkinson's disease (PD) patients, especially those on dopamine agonists (DA), are at risk of impulse control disorders (ICD). Little attention has been paid to the influence of environmental factors.
    Cases: Retrospective analysis of consecutive PD patients seen in our outpatient Movement Disorders Clinic during 2 months (September-November 2020) to explore the frequency of ICD during the preceding 2-month lockdown period, and comparison with an equivalent control group (September-November 2019). Among 114 patients assessed, 15 (13%) presented ICD during the lockdown, versus 6 (4.5%,
    Conclusion: During COVID-19 lockdown, the occurrence of ICD in PD patients taking DA was higher than expected, and with increased severity. Environmental stressors may play a role in ICD presentation in vulnerable patients.
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13276
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  2. Article ; Online: Autoimmune Septin-5 Disease Presenting as Spinocerebellar Ataxia and Nystagmus.

    Herrero San Martin, Alejandro / Amarante Cuadrado, Carla / Gonzalez Arbizu, Maialen / Rábano-Suárez, Pablo / Ostos-Moliz, Fernando / Naranjo, Laura / Sabater, Lidia / Martinez Hernandez, Eugenia / Ruiz Garcia, Raquel / Toledo Alfocea, Daniel

    Neurology

    2021  Volume 97, Issue 6, Page(s) 291–292

    MeSH term(s) Autoimmune Diseases of the Nervous System/complications ; Autoimmune Diseases of the Nervous System/diagnosis ; Cell Cycle Proteins/immunology ; Humans ; Male ; Middle Aged ; Nystagmus, Pathologic/etiology ; Septins/immunology ; Spinocerebellar Ataxias/etiology
    Chemical Substances Cell Cycle Proteins ; SEPTIN5 protein, human (EC 3.6.1.-) ; Septins (EC 3.6.1.-)
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000012240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Generalized myoclonus in COVID-19.

    Rábano-Suárez, Pablo / Bermejo-Guerrero, Laura / Méndez-Guerrero, Antonio / Parra-Serrano, Javier / Toledo-Alfocea, Daniel / Sánchez-Tejerina, Daniel / Santos-Fernández, Teresa / Folgueira-López, María Dolores / Gutiérrez-Gutiérrez, Judit / Ayuso-García, Blanca / González de la Aleja, Jesús / Benito-León, Julián

    Neurology

    2020  Volume 95, Issue 6, Page(s) e767–e772

    Abstract: Objective: To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus.: Methods: Patient data were obtained from medical records from the University Hospital "12 de Octubre," ... ...

    Abstract Objective: To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus.
    Methods: Patient data were obtained from medical records from the University Hospital "12 de Octubre," Madrid, Spain.
    Results: Three patients (2 men and 1 woman, aged 63-88 years) presented with mild hypersomnia and generalized myoclonus following the onset of the so-called inflammatory phase of coronavirus disease 2019 (COVID-19). All of them had presented previously with anosmia. Myoclonus was generalized with both positive and negative jerks, predominantly involving the facial, trapezius, sternocleidomastoid, and upper extremities muscles. These myoclonic jerks occurred spontaneously and were extremely sensitive to multisensory stimuli (auditive and tactile) or voluntary movements, with an exaggerated startle response. Other causes of myoclonus were ruled out, and none of the patients had undergone respiratory arrest or significant prolonged hypoxia. All of them improved, at least partially, with immunotherapy.
    Conclusions: Our 3 cases highlight the occurrence of myoclonus during the COVID-19 pandemic as a post- or para-infectious immune-mediated disorder. However, we cannot rule out that SARS-CoV-2 may spread transneuronally to first- and second-order structures connected with the olfactory bulb. Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and optimal treatment.
    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Female ; Glucocorticoids/administration & dosage ; Humans ; Male ; Methylprednisolone/administration & dosage ; Middle Aged ; Myoclonus/diagnostic imaging ; Myoclonus/drug therapy ; Myoclonus/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023)
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Vega Pérez, Diana / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Sayas Catalán, Javier / Ramos-González, Ana / González de la Aleja, Jesús

    Neurology

    2020  Volume 95, Issue 15, Page(s) e2109–e2118

    Abstract: Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.: Methods: Patient data were obtained from medical records from the Hospital ... ...

    Abstract Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.
    Methods: Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [
    Results: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment.
    Conclusion: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.
    MeSH term(s) Betacoronavirus ; Brain/diagnostic imaging ; Brain/metabolism ; COVID-19 ; Consciousness Disorders ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/physiopathology ; Disease Progression ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Electroencephalography ; Humans ; Hypokinesia/diagnostic imaging ; Hypokinesia/etiology ; Hypokinesia/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscle Rigidity/diagnostic imaging ; Muscle Rigidity/etiology ; Muscle Rigidity/physiopathology ; Nortropanes ; Ocular Motility Disorders ; Pandemics ; Parkinson Disease, Postencephalitic/diagnostic imaging ; Parkinson Disease, Postencephalitic/etiology ; Parkinson Disease, Postencephalitic/physiopathology ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/physiopathology ; Putamen/diagnostic imaging ; Putamen/metabolism ; SARS-CoV-2 ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Dopamine Plasma Membrane Transport Proteins ; Nortropanes ; ioflupane (VF232WE742)
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010282
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  5. Article: Generalized myoclonus in COVID-19

    Rábano-Suárez, Pablo / Bermejo-Guerrero, Laura / Méndez-Guerrero, Antonio / Parra-Serrano, Javier / Toledo-Alfocea, Daniel / Sánchez-Tejerina, Daniel / Santos-Fernández, Teresa / Folgueira-López, María Dolores / Gutiérrez-Gutiérrez, Judit / Ayuso-García, Blanca / González de la Aleja, Jesús / Benito-León, Julián

    Neurology

    Abstract: OBJECTIVE: To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus. METHODS: Patient data were obtained from medical records from the University Hospital "12 de Octubre," Madrid, ...

    Abstract OBJECTIVE: To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus. METHODS: Patient data were obtained from medical records from the University Hospital "12 de Octubre," Madrid, Spain. RESULTS: Three patients (2 men and 1 woman, aged 63-88 years) presented with mild hypersomnia and generalized myoclonus following the onset of the so-called inflammatory phase of coronavirus disease 2019 (COVID-19). All of them had presented previously with anosmia. Myoclonus was generalized with both positive and negative jerks, predominantly involving the facial, trapezius, sternocleidomastoid, and upper extremities muscles. These myoclonic jerks occurred spontaneously and were extremely sensitive to multisensory stimuli (auditive and tactile) or voluntary movements, with an exaggerated startle response. Other causes of myoclonus were ruled out, and none of the patients had undergone respiratory arrest or significant prolonged hypoxia. All of them improved, at least partially, with immunotherapy. CONCLUSIONS: Our 3 cases highlight the occurrence of myoclonus during the COVID-19 pandemic as a post- or para-infectious immune-mediated disorder. However, we cannot rule out that SARS-CoV-2 may spread transneuronally to first- and second-order structures connected with the olfactory bulb. Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and optimal treatment.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #348218
    Database COVID19

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  6. Article ; Online: Generalized myoclonus in COVID-19

    Rábano-Suárez, Pablo / Bermejo-Guerrero, Laura / Méndez-Guerrero, Antonio / Parra-Serrano, Javier / Toledo-Alfocea, Daniel / Sánchez-Tejerina, Daniel / Santos-Fernández, Teresa / Folgueira-López, María Dolores / Gutiérrez-Gutiérrez, Judit / Ayuso-García, Blanca / González de la Aleja, Jesús / Benito-León, Julián

    Neurology

    2020  Volume 95, Issue 6, Page(s) e767–e772

    Abstract: Objective To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus. Methods Patient data were obtained from medical records from the University Hospital “12 de Octubre,” Madrid, ... ...

    Abstract Objective To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus. Methods Patient data were obtained from medical records from the University Hospital “12 de Octubre,” Madrid, Spain. Results Three patients (2 men and 1 woman, aged 63–88 years) presented with mild hypersomnia and generalized myoclonus following the onset of the so-called inflammatory phase of coronavirus disease 2019 (COVID-19). All of them had presented previously with anosmia. Myoclonus was generalized with both positive and negative jerks, predominantly involving the facial, trapezius, sternocleidomastoid, and upper extremities muscles. These myoclonic jerks occurred spontaneously and were extremely sensitive to multisensory stimuli (auditive and tactile) or voluntary movements, with an exaggerated startle response. Other causes of myoclonus were ruled out, and none of the patients had undergone respiratory arrest or significant prolonged hypoxia. All of them improved, at least partially, with immunotherapy. Conclusions Our 3 cases highlight the occurrence of myoclonus during the COVID-19 pandemic as a post- or para-infectious immune-mediated disorder. However, we cannot rule out that SARS-CoV-2 may spread transneuronally to first- and second-order structures connected with the olfactory bulb. Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and optimal treatment.
    Keywords Clinical Neurology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.0000000000009829
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  7. Article: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Vega Pérez, Diana / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Sayas Catalán, Javier / Ramos-González, Ana / González de la Aleja, Jesús

    Neurology

    Abstract: OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the Hospital ... ...

    Abstract OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [123I]-ioflupane dopamine transporter (DaT) SPECT images were acquired 4 hours after a single dose of 185 MBq of 123I-FP-CIT. Quantitative analysis was performed with DaTQUANT software providing the specific binding ratio and z score values of the striatum. RESULTS: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. CONCLUSION: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #638341
    Database COVID19

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  8. Article ; Online: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Pérez, Diana Vega / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Catalán, Javier Sayas / González, Ana Ramos- / González de la Aleja, Jesús

    Neurology

    2020  , Page(s) 10.1212/WNL.0000000000010282

    Abstract: OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the “Hospital ... ...

    Abstract OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the “Hospital Universitario 12 de Octubre” in Madrid, Spain. [ 123 I]-ioflupane dopamine transporter single-photon emission CT (DaT-SPECT) images were acquired 4 hours after a single dose of 185 MBq of 123 I-FP-CIT. Quantitative analysis was performed using DaTQUANT TM software providing the specific binding ratio (SBR) and z-score values of the striatum. RESULTS: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. CONCLUSION: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the central nervous system, affecting midbrain structures and leading to neurological signs and symptoms.
    Keywords Clinical Neurology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.0000000000010282
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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