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Article ; Online: Prescription retinoid and contraception use in women in Australia: A population-based study.

Gerhardy, Laura / Nassar, Natasha / Litchfield, Melisa / Kennedy, Debra / Smith, Annika / Gillies, Malcolm B / Pearson, Sallie-Anne / Zoega, Helga / Shand, Antonia

The Australasian journal of dermatology

2024

Abstract: Background/obectives: Oral retinoids are teratogenic, and pregnancy avoidance is an important part of retinoid prescribing. Australia does not have a standardised pregnancy prevention programme for women using oral retinoids, and the contraception ... ...

Abstract	Background/obectives: Oral retinoids are teratogenic, and pregnancy avoidance is an important part of retinoid prescribing. Australia does not have a standardised pregnancy prevention programme for women using oral retinoids, and the contraception strategies for women who use oral retinoids are not well understood. The objectives were to determine trends in the use of prescription retinoids among Australian reproductive-aged women and whether women dispensed oral retinoids used contraception concomitantly. Methods: This was a population-based study using Australian Pharmaceutical Benefits (PBS) dispensing claims for a random 10% sample of 15-44-year-old Australian women, 2013 - 2021. We described rates and annual trends in dispensing claims for PBS-listed retinoids and contraceptives. We also estimated concomitant oral retinoid and contraceptive use on the day of each retinoid dispensing and determined if there was a period of contraceptive treatment that overlapped. Estimates were then extrapolated to the national level. Results: There were 1,545,800 retinoid dispensings to reproductive-aged women; 57.1% were oral retinoids. The rate of retinoid dispensing to reproductive-aged women increased annually, from 28 dispensings per 1000 population in 2013 to 41 per 1000 in 2021. The rate of oral retinoid dispensing doubled over the study period, from 14 dispensings per 1000 population in 2013 to 28 per 1000 in 2021, while topical retinoid dispensing did not change. Only 25% of oral retinoid dispensings had evidence of concomitant contraceptive use in 2021. Conclusions: Rates of oral retinoid dispensing have doubled among reproductive-aged women over the past decade. A large percentage of oral retinoid use does not appear to have concomitant contraception use, posing a risk of teratogenic effects in pregnancies.
Language	English
Publishing date	2024-05-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.14294
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Zs.A 236: Show issues

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Article ; Online: Aging in 10 Minutes: Do Age Simulation Suits Mimic Physical Decline in Old Age? Comparing Experimental Data with Established Reference Data.

Gerhardy, Thomas H / Schlomann, Anna / Wahl, Hans-Werner / Mombaur, Katja / Sloot, Lizeth H / Schmidt, Laura I

Experimental aging research

2023 , Page(s) 1–13

Abstract: Introduction: Age simulation suits are increasingly used in health care education. However, empirical evidence that quantifies the simulated performance losses in established geriatric tests and compares those declines with reference data of older ... ...

Abstract	Introduction: Age simulation suits are increasingly used in health care education. However, empirical evidence that quantifies the simulated performance losses in established geriatric tests and compares those declines with reference data of older adults is scarce. Methods: In a standardized lab setting, we compared performance of Results: Reduced performance was observed in both groups when wearing the suit, yet to different degrees dependent on the assessment and user age. For one, larger declines were observed in more challenging and complex tasks across age groups. In addition, comparisons with reference values revealed age-differential "instant aging" effects. Discussion: A simulated "fourth age," where frailty and impairments are accumulating, was not reached in the majority of assessments, especially not among younger participants. In conclusion, existing age simulation suits may have some educational and empathy potential, but so far, they fail in simulating the age period with most serious functional loss.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	753202-7
ISSN	1096-4657 ; 0361-073X
ISSN (online)	1096-4657
ISSN	0361-073X
DOI	10.1080/0361073X.2023.2256630
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Zs.A 1405: Show issues

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Article: "Aging Means to Me… That I Feel Lonely More Often"? An Experimental Study on the Effects of Age Simulation Regarding Views on Aging.

Schmidt, Laura I / Schlomann, Anna / Gerhardy, Thomas / Wahl, Hans-Werner

Frontiers in psychology

2022 Volume 13, Page(s) 806233

Abstract: Over the last decades, educational programs involving age simulation suits (ASS) emerged with the ambition to further the understanding of age-related loss experiences, enhance empathy and reduce negative attitudes toward older adults in healthcare ... ...

Abstract	Over the last decades, educational programs involving age simulation suits (ASS) emerged with the ambition to further the understanding of age-related loss experiences, enhance empathy and reduce negative attitudes toward older adults in healthcare settings and in younger age groups at large. However, the impact of such "instant aging" interventions on individuals' personal views on aging have not been studied yet. The aim of the current study is to address possible effects of ASS interventions on multiple outcomes related to views on aging, i.e., aging-related cognitions (i.e., expectations regarding social losses), awareness of age-related change (AARC) and age stereotypes. Moreover, we explore effects on broader constructs with relevance to aging, i.e., perceived obsolescence, risk perceptions, as well as desired support through technology. In a within-subjects design, N = 40 participants (
Language	English
Publishing date	2022-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.806233
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Article: Effects of age simulation suits on psychological and physical outcomes: a systematic review.

Gerhardy, Thomas H / Schlomann, Anna / Wahl, Hans-Werner / Schmidt, Laura I

European journal of ageing

2022 Volume 19, Issue 4, Page(s) 953–976

Abstract: Age simulation suits (ASS) are widely used to simulate sensory and physical restrictions that typically occur as people age. This review has two objectives: first, we synthesize the current research on ASS in terms of the observed psychological and ... ...

Abstract	Age simulation suits (ASS) are widely used to simulate sensory and physical restrictions that typically occur as people age. This review has two objectives: first, we synthesize the current research on ASS in terms of the observed psychological and physical effects associated with ASS. Second, we analyze indicators able to estimate the validity of ASS in simulating "true" ageing processes. Following the PRISMA guidelines, eight electronic databases were searched (BASE, Cinhal, Cochrane, Google Scholar, ProQuest, PsychINFO, Pubmed, and Web of Science). Qualitative and quantitative studies addressing effects of ASS interventions regarding psychological outcomes (i.e., empathy, attitudes) or physical parameters (i.e., gait, balance) were included. The Mixed Methods Appraisal Tool was applied for quality assessment. Of 1890 identified citations, we included 94 for full-text screening and finally 26 studies were examined. Publication years ranged from 2001 to 2021. Study populations were predominantly based on students in health-related disciplines. Results suggest that ASS can initiate positive effects on attitudes toward ( Supplementary information: The online version contains supplementary material available at 10.1007/s10433-022-00722-1.
Language	English
Publishing date	2022-09-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2190233-1
ISSN	1613-9372
ISSN	1613-9372
DOI	10.1007/s10433-022-00722-1
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Zs.A 6097: Show issues

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Article ; Online: Large Cecal Varices as Cause of Lower Gastrointestinal Bleeding.

Büchter, Matthias / Gerhardy, Nicola / Wetter, Axel

Deutsches Arzteblatt international

2019 Volume 116, Issue 41, Page(s) 690

MeSH term(s)	Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/diagnosis ; Female ; Gastrointestinal Hemorrhage/etiology ; Humans ; Middle Aged
Language	English
Publishing date	2019-11-08
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.2019.0690
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Article ; Online: The first Australian experience with ward-based continuous positive airway pressure for COVID-19 respiratory failure: a retrospective cohort study.

Gerhardy, Benjamin / Comsa, Monica / Tahir, Ali / Lynch, Dalton / Polkinghorne, Adam / Orde, Sam / Branley, James / Morgan, Lucy

Internal medicine journal

2022 Volume 52, Issue 11, Page(s) 1986–1990

Abstract: We present the first Australian cohort of patients with COVID-19 respiratory failure managed with escalating respiratory support including continuous positive airway pressure (CPAP) on a standard medical ward at a tertiary Sydney hospital during the 2021 ...

Abstract	We present the first Australian cohort of patients with COVID-19 respiratory failure managed with escalating respiratory support including continuous positive airway pressure (CPAP) on a standard medical ward at a tertiary Sydney hospital during the 2021 COVID-19 Delta variant outbreak. We demonstrate an equivalent mortality to CPAP delivered in intensive care unit and outline our ward structure and management during the pandemic.
MeSH term(s)	Humans ; Continuous Positive Airway Pressure ; COVID-19 ; Retrospective Studies ; Australia/epidemiology ; SARS-CoV-2 ; Tertiary Care Centers ; Respiratory Insufficiency/therapy
Language	English
Publishing date	2022-11-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.15911
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 424: Show issues

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Article ; Online: RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing.

Moursy, Ahmed / Cléry, Antoine / Gerhardy, Stefan / Betz, Katharina M / Rao, Sanjana / Mazur, Jarosław / Campagne, Sébastien / Beusch, Irene / Duszczyk, Malgorzata M / Robinson, Mark D / Panse, Vikram Govind / Allain, Frédéric H-T

Nature communications

2023 Volume 14, Issue 1, Page(s) 7166

Abstract: The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach ... ...

Abstract	The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in yeast to uncover the consensus sequence bound to each RRM. High-resolution NMR structures show that RRM2 recognizes a 5´-GNGG-3´ motif leading to an unusual mille-feuille topology. These structures also reveal how RRM1 preferentially interacts with a CC-dinucleotide upstream of this motif, and how the inter-RRM linker and the region C-terminal to RRM2 contribute to cooperative RNA-binding. Structure-guided functional studies show that Npl3 genetically interacts with U2 snRNP specific factors and we provide evidence that Npl3 melts U2 snRNA stem-loop I, a prerequisite for U2/U6 duplex formation within the catalytic center of the B
MeSH term(s)	Nucleic Acid Conformation ; Ribonucleoprotein, U2 Small Nuclear/metabolism ; RNA/metabolism ; RNA Splicing ; RNA, Small Nuclear/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Spliceosomes/metabolism
Chemical Substances	Ribonucleoprotein, U2 Small Nuclear ; RNA (63231-63-0) ; RNA, Small Nuclear ; U2 small nuclear RNA ; NPL3 protein, S cerevisiae
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42962-4
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Article: Klinischer Schnappschuss. Große Zökumvarizen als Ursache einer unteren gastrointestinalen Blutung. Large Cecal Varices as Cause of Lower Gastrointestinal Bleeding

Büchter, Matthias / Gerhardy, Nicola / Wetter, Axel

Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

2019 Volume 116, Issue 41, Page(s) 690

Language	German
Document type	Article
ZDB-ID	1453475-7
ISSN	0012-1207
Database	Current Contents Medicine

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Ua VI Zs.103/2: Show issues

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Article ; Online: Nocturnal blood pressure and nocturnal blood pressure fluctuations: the effect of short-term CPAP therapy and their association with the severity of obstructive sleep apnea.

Picard, Frauke / Panagiotidou, Petroula / Tammen, Anne-Beke / Wolf-Pütz, Anamaria / Steffen, Maximilian / Gerhardy, Hanno Julian / Waßenberg, Sebastian / Klein, Rolf Michael

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2021 Volume 18, Issue 2, Page(s) 361–371

Abstract: Study objectives: We determined the relationship of cardiovascular risk factors, cardiovascular diseases, nocturnal blood pressure (NBP), and NBP fluctuations (NBPFs) with the severity of obstructive sleep apnea (OSA). We also investigated the effect of ...

Abstract	Study objectives: We determined the relationship of cardiovascular risk factors, cardiovascular diseases, nocturnal blood pressure (NBP), and NBP fluctuations (NBPFs) with the severity of obstructive sleep apnea (OSA). We also investigated the effect of short-term continuous positive airway pressure therapy on NBP parameters. Methods: This retrospective study included 548 patients from our cardiac clinic with suspected OSA. Patients underwent polysomnography and continuous NBP measurement using the pulse transit time. According to their apnea-hypopnea index (AHI), patients were subclassified as controls (AHI < 5 events/h), mild (AHI 5 to < 15 events/h), moderate (AHI 15 to < 30 events/h), and severe OSA (AHI ≥ 30 events/h); 294 patients received continuous positive airway pressure therapy. Results: Analysis of covariance showed that NBP and the frequency of NBPFs were the highest in severe followed by moderate and mild OSA (all Conclusions: The severity of OSA is associated with an increase in NBP and NBPFs. Continuous positive airway pressure reduces NBP parameters already after the first night. In addition to BP, the diagnosis and therapy of NBPFs should be considered in patients with OSA. Clinical trial registration: Registry: German Clinical Trials Register; Name: Nocturnal blood pressure and nocturnal blood pressure fluctuations associated with the severity of obstructive sleep apnea; URL: https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00024087; Identifier: DRKS00024087. Citation: Picard F, Panagiotidou P, Tammen A-B, et al. Nocturnal blood pressure and nocturnal blood pressure fluctuations: the effect of short-term CPAP therapy and their association with the severity of obstructive sleep apnea.
MeSH term(s)	Blood Pressure ; Continuous Positive Airway Pressure ; Humans ; Polysomnography ; Retrospective Studies ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.9564
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Zs.A 6590: Show issues

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Article ; Online: A randomised controlled trial assessing the potential of palmitoylethanolamide (PEA) to act as an adjuvant to resistance training in healthy adults: a study protocol.

Huschtscha, Zoya / Fyfe, Jackson J / Feros, Simon A / Betik, Andrew C / Shaw, Christopher S / Main, Luana C / Abbott, Gavin / Tan, Sze-Yen / Refalo, Martin C / Gerhardy, Michael / Grunwald, Emma / May, Anthony / Silver, Jessica / Smith, Craig M / White, Matthew / Hamilton, D Lee

Trials

2023 Volume 24, Issue 1, Page(s) 245

Abstract: Background: Non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics are used frequently by athletes either prophylactically for the prevention of pain, or to accelerate recovery following an injury. However, these types of pain management ... ...

Abstract	Background: Non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics are used frequently by athletes either prophylactically for the prevention of pain, or to accelerate recovery following an injury. However, these types of pain management strategies have been shown to inhibit signalling pathways (e.g., cyclooxygenase-2) that may hinder muscular adaptations such as hypertrophy and strength. Nutraceuticals such as palmitoylethanolamide (PEA) have analgesic properties that act via different mechanisms to NSAIDS/analgesics. Furthermore, PEA has been shown to have a positive effect on sleep and may contribute positively to muscle hypertrophy via PKB activation. Although PEA has not been widely studied in the athletic or recreationally active population, it may provide an alternative solution for pain management if it is found not to interfere with, or enhance training adaptations. Therefore, the study aim is to investigate the effects of daily PEA supplementation (Levagen + ®) with resistance training on lean body mass, strength, power and physical performance and outcomes of recovery (e.g., sleep) compared to placebo. Methods: This double-blind, randomised controlled study will take place over an 11-week period (including 8-weeks of progressive resistance training). Participants for this study will be 18-35 years old, healthy active adults that are not resistance trained. Participants will attend a familiarisation (week 0), pre-testing (week 1) and final-testing (week 11). At the pre-testing and final-testing weeks, total lean body mass (dual-energy X-ray absorptiometry; DXA), total mid-thigh cross sectional area (pQCT), maximal muscular strength (1 repetition maximum bench press, isometric mid-thigh pull) and power (countermovement jump and bench throw) will be assessed. Additionally, circulating inflammatory cytokines and anabolic hormones, sleep quality and quantity (ActiGraph), pain and subjective wellbeing (questionnaires) will also be examined. Discussion: This study is designed to investigate the effects that PEA may have on pre-to post intervention changes in total body and regional lean muscle mass, strength, power, sleep, subjective wellbeing, and pain associated with resistance training and menstruation compared with the placebo condition. Unlike other NSAIDs and analgesics, which may inhibit muscle protein synthesis and training adaptations, PEA which provides analgesia via alternative mechanisms may provide an alternative pain management solution. It is therefore important to determine if this analgesic compound interferes with or enhances training adaptations so that athletes and active individuals can make an informed decision on their pain management strategies. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR: ACTRN12621001726842p).
MeSH term(s)	Female ; Humans ; Adult ; Adolescent ; Young Adult ; Resistance Training/methods ; Pisum sativum ; Australia ; Muscle Strength ; Analgesics/pharmacology ; Pain ; Dietary Supplements/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Muscle, Skeletal ; Randomized Controlled Trials as Topic
Chemical Substances	palmidrol (6R8T1UDM3V) ; Analgesics ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07199-y
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