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  1. Article: Nosocomial mucormycosis of the thigh.

    Boodman, Carl / Cheng, Matthew P

    IDCases

    2021  Volume 25, Page(s) e01225

    Abstract: We describe a case of nosocomial mucormycosis of the thigh in an immunocompromised patient admitted with COVID-19 acute respiratory distress syndrome. ...

    Abstract We describe a case of nosocomial mucormycosis of the thigh in an immunocompromised patient admitted with COVID-19 acute respiratory distress syndrome.
    Language English
    Publishing date 2021-07-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01225
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  2. Article ; Online: Optimizing cost as well as yield of blood cultures in sepsis.

    Akhter, Murtaza / Cheng, Matthew P

    The American journal of emergency medicine

    2021  Volume 47, Page(s) 294

    MeSH term(s) Bacteremia ; Blood Culture ; Humans ; Sepsis/diagnosis
    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.04.069
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  3. Article ; Online: The microbiological outcomes of culture-negative blood specimens using 16S rRNA broad-range PCR sequencing: a retrospective study in a Canadian province from 2018 to 2022.

    Lieu, Anthony / Harrison, Luke B / Harel, Josée / Lawandi, Alexander / Cheng, Matthew P / Domingo, Marc-Christian

    Journal of clinical microbiology

    2024  Volume 62, Issue 3, Page(s) e0151823

    Abstract: Broad-range 16S rRNA PCR and sequencing of 1,183 blood specimens from 853 unique patients yielded an interpretable sequence and bacterial identification in 29%, 16S rRNA amplification with uninterpretable sequences in 53%, and no amplification in 18%. ... ...

    Abstract Broad-range 16S rRNA PCR and sequencing of 1,183 blood specimens from 853 unique patients yielded an interpretable sequence and bacterial identification in 29%, 16S rRNA amplification with uninterpretable sequences in 53%, and no amplification in 18%. This study highlights the potential utility of this technique in identifying fastidious gram-negative and anaerobic bacteria but the frequent recovery of environmental and contaminant organisms argues for its judicious use.
    Importance: The existing literature focuses on its performance compared to blood cultures in patients with sepsis, leaving a gap in the literature regarding other blood specimens in suspected infectious syndrome across the severity spectrum. We aimed to characterize its microbiological outcomes and provide insight into its potential clinical utility.
    MeSH term(s) Humans ; RNA, Ribosomal, 16S/genetics ; Retrospective Studies ; DNA, Bacterial/genetics ; Polymerase Chain Reaction/methods ; Canada ; Sequence Analysis, DNA
    Chemical Substances RNA, Ribosomal, 16S ; DNA, Bacterial
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01518-23
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  4. Article: Walking the walk to include pregnant participants in non-obstetric clinical trials: Insights from the SNAP Trial.

    Malhamé, Isabelle / Hardy, Erica / Cheng, Matthew P / Tong, Steven Yc / Bowen, Asha C

    Obstetric medicine

    2023  Volume 16, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Editorial
    ZDB-ID 2612229-7
    ISSN 1753-4968 ; 1753-495X
    ISSN (online) 1753-4968
    ISSN 1753-495X
    DOI 10.1177/1753495X231163351
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  5. Article ; Online: Microbiological characterization of

    Lieu, Anthony / Lee, Todd C / Lawandi, Alexander / Tellier, Raymond / Cheng, Matthew P / Dufresne, Philippe J

    Journal of clinical microbiology

    2023  Volume 61, Issue 11, Page(s) e0091323

    Abstract: Bronchoalveolar lavage is usually employed for molecular diagnosis ... ...

    Abstract Bronchoalveolar lavage is usually employed for molecular diagnosis of
    MeSH term(s) Humans ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/microbiology ; Retrospective Studies ; Bronchoalveolar Lavage Fluid/microbiology ; Sensitivity and Specificity ; Canada ; Polymerase Chain Reaction/methods ; Pneumocystis carinii/genetics
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00913-23
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  6. Article ; Online: Serodiagnostics for SARS-CoV-2.

    Papenburg, Jesse / Yansouni, Cedric P / Caya, Chelsea / Cheng, Matthew P

    Annals of internal medicine

    2021  Volume 174, Issue 2, Page(s) 287–288

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Serologic Tests
    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-1396
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  7. Article ; Online: Retinal vein occlusion following COVID-19 vaccination.

    Peters, Matthew C / Cheng, Sean S H / Sharma, Abhishek / Moloney, Thomas P

    Clinical & experimental ophthalmology

    2022  Volume 50, Issue 4, Page(s) 459–461

    MeSH term(s) COVID-19 ; COVID-19 Vaccines/adverse effects ; Humans ; Retinal Hemorrhage ; Retinal Vein Occlusion/chemically induced ; Retinal Vein Occlusion/diagnosis ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-02-14
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14056
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  8. Article ; Online: Reply to Aronson et al.

    Cheng, Matthew P / Marty, Francisco M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 70, Issue 6, Page(s) 1262

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Latent Tuberculosis ; Mycobacterium tuberculosis ; Tuberculosis
    Language English
    Publishing date 2019-07-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz595
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  9. Article ; Online: Outcomes with severe pulmonary coccidioidomycosis and respiratory failure in the United States.

    Rush, Barret / Zeigler, Jennifer / Cheng, Matthew P / Hrymak, Carmen / Lother, Sylvain

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2023  Volume 8, Issue 1, Page(s) 40–48

    Abstract: Background: Coccidioidomycosis is a fungal infection with presentations ranging from asymptomatic illness to severe pneumonia and respiratory failure. The outcomes of patients with severe pulmonary coccidioidomycosis requiring mechanical ventilation (MV) ...

    Abstract Background: Coccidioidomycosis is a fungal infection with presentations ranging from asymptomatic illness to severe pneumonia and respiratory failure. The outcomes of patients with severe pulmonary coccidioidomycosis requiring mechanical ventilation (MV) are not well understood.
    Methods: We performed a retrospective cohort analysis utilizing the Nationwide Inpatient Sample (NIS) from 2006 to 2017. Patients >18 years of age with a diagnosis of pulmonary coccidioidomycosis were included in the cohort.
    Results: A total of 11,045 patients were hospitalized with a diagnosis of pulmonary coccidioidomycosis during the study period. Of these, 826 (7.5%) patients required MV during their hospitalization with a mortality rate of 33.5% compared to 1.3% (
    Conclusions: Approximately 7.5% of patients admitted with coccidioidomycosis in the United States require MV, and MV is associated with high mortality (33.5%).
    Language English
    Publishing date 2023-03-01
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2022-0028
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  10. Article ; Online: Expression and characterization of spore coat CotH kinases from the cellulosomes of anaerobic fungi (Neocallimastigomycetes).

    Lillington, Stephen P / Hamilton, Matthew / Cheng, Jan-Fang / Yoshikuni, Yasuo / O'Malley, Michelle A

    Protein expression and purification

    2023  Volume 210, Page(s) 106323

    Abstract: Anaerobic fungi (Neocallimastigomycetes) found in the guts of herbivores are biomass deconstruction specialists with a remarkable ability to extract sugars from recalcitrant plant material. Anaerobic fungi, as well as many species of anaerobic bacteria, ... ...

    Abstract Anaerobic fungi (Neocallimastigomycetes) found in the guts of herbivores are biomass deconstruction specialists with a remarkable ability to extract sugars from recalcitrant plant material. Anaerobic fungi, as well as many species of anaerobic bacteria, deploy multi-enzyme complexes called cellulosomes, which modularly tether together hydrolytic enzymes, to accelerate biomass hydrolysis. While the majority of genomically encoded cellulosomal genes in Neocallimastigomycetes are biomass degrading enzymes, the second largest family of cellulosomal genes encode spore coat CotH domains, whose contribution to fungal cellulosome and/or cellular function is unknown. Structural bioinformatics of CotH proteins from the anaerobic fungus Piromyces finnis shows anaerobic fungal CotH domains conserve key ATP and Mg
    MeSH term(s) Cellulosomes/genetics ; Cellulosomes/chemistry ; Cellulosomes/metabolism ; Escherichia coli/metabolism ; Anaerobiosis ; Bacterial Proteins/chemistry ; Spores/metabolism ; Adenosine Triphosphate/metabolism ; Fungi
    Chemical Substances Bacterial Proteins ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1055455-5
    ISSN 1096-0279 ; 1046-5928
    ISSN (online) 1096-0279
    ISSN 1046-5928
    DOI 10.1016/j.pep.2023.106323
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