Article ; Online: Phylodynamic analysis of foot-and-mouth disease virus evolution in Mar Chiquita, Argentina.
2024 Volume 169, Issue 5, Page(s) 101
Abstract: ... from 21 farms located in the Mar Chiquita district. Whole FMDV genome sequences were obtained by PCR ...
Abstract | Foot-and-mouth disease is a highly contagious disease affecting cloven-hoofed animals, resulting in considerable economic losses. Its causal agent is foot-and-mouth disease virus (FMDV), a picornavirus. Due to its error-prone replication and rapid evolution, the transmission and evolutionary dynamics of FMDV can be studied using genomic epidemiological approaches. To analyze FMDV evolution and identify possible transmission routes in an Argentinean region, field samples that tested positive for FMDV by PCR were obtained from 21 farms located in the Mar Chiquita district. Whole FMDV genome sequences were obtained by PCR amplification in seven fragments and sequencing using the Sanger technique. The genome sequences obtained from these samples were then analyzed using phylogenetic, phylogeographic, and evolutionary approaches. Three local transmission clusters were detected among the sampled viruses. The dataset was analyzed using Bayesian phylodynamic methods with appropriate coalescent and relaxed molecular clock models. The estimated mean viral evolutionary rate was 1.17 × 10 |
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MeSH term(s) | Animals ; Foot-and-Mouth Disease Virus/genetics ; Argentina/epidemiology ; Bayes Theorem ; Phylogeny ; Picornaviridae |
Language | English |
Publishing date | 2024-04-17 |
Publishing country | Austria |
Document type | Journal Article |
ZDB-ID | 7491-3 |
ISSN | 1432-8798 ; 0304-8608 |
ISSN (online) | 1432-8798 |
ISSN | 0304-8608 |
DOI | 10.1007/s00705-024-06028-0 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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