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  1. Article: Perspectives: modelling the vasculitis and granulomatous tissue destruction of granulomatosis with polyangiitis (GPA).

    Gadola, Stephan D

    Clinical and experimental rheumatology

    2012  Volume 30, Issue 1 Suppl 70, Page(s) S1–2

    MeSH term(s) Animals ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Cartilage/immunology ; Cartilage/pathology ; Dexamethasone/pharmacology ; Disease Models, Animal ; Fibroblasts/immunology ; Fibroblasts/pathology ; Glucocorticoids/pharmacology ; Granulomatosis with Polyangiitis/drug therapy ; Granulomatosis with Polyangiitis/immunology ; Granulomatosis with Polyangiitis/pathology ; Humans ; Kidney/immunology ; Kidney/pathology ; Lung/immunology ; Lung/pathology ; Mice ; Myeloblastin/immunology
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Glucocorticoids ; Dexamethasone (7S5I7G3JQL) ; Myeloblastin (EC 3.4.21.76)
    Language English
    Publishing date 2012-01
    Publishing country Italy
    Document type Editorial
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
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  2. Article ; Online: An open-label phase 2a study investigating the efficacy and safety of a cathepsin S inhibitor in patients with moderate-to-severe psoriasis.

    Gadola, Stephan D / Färber, Petra / Posch, Maximilian G / Nagel, Sandra / Canducci, Filippo

    Journal of the American Academy of Dermatology

    2021  Volume 87, Issue 5, Page(s) 1089–1091

    MeSH term(s) Humans ; Cathepsins/adverse effects ; Cathepsins/antagonists & inhibitors ; Psoriasis/drug therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances cathepsin S (EC 3.4.22.27) ; Cathepsins (EC 3.4.-)
    Language English
    Publishing date 2021-12-11
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.09.074
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  3. Article ; Online: The versatility of the CD1 lipid antigen presentation pathway.

    Chancellor, Andrew / Gadola, Stephan D / Mansour, Salah

    Immunology

    2018  Volume 154, Issue 2, Page(s) 196–203

    Abstract: The family of non-classical major histocompatibility complex (MHC) class-I like CD1 molecules has an emerging role in human disease. Group 1 CD1 includes CD1a, CD1b and CD1c, which function to display lipids on the cell surface of antigen-presenting ... ...

    Abstract The family of non-classical major histocompatibility complex (MHC) class-I like CD1 molecules has an emerging role in human disease. Group 1 CD1 includes CD1a, CD1b and CD1c, which function to display lipids on the cell surface of antigen-presenting cells for direct recognition by T-cells. The recent advent of CD1 tetramers and the identification of novel lipid ligands has contributed towards the increasing number of CD1-restricted T-cell clones captured. These advances have helped to identify novel donor unrestricted and semi-invariant T-cell populations in humans and new mechanisms of T-cell recognition. However, although there is an opportunity to design broadly acting lipids and harness the therapeutic potential of conserved T-cells, knowledge of their role in health and disease is lacking. We briefly summarize the current evidence implicating group 1 CD1 molecules in infection, cancer and autoimmunity and show that although CD1 are not as diverse as MHC, recent discoveries highlight their versatility as they exhibit intricate mechanisms of antigen presentation.
    MeSH term(s) Animals ; Antigen Presentation/immunology ; Antigens, CD1/chemistry ; Antigens, CD1/immunology ; Antigens, CD1/metabolism ; Autoimmunity ; Disease Susceptibility ; Humans ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Lipids/immunology ; Signal Transduction ; Structure-Activity Relationship ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances Antigens, CD1 ; Ligands ; Lipids
    Language English
    Publishing date 2018-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.12912
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  4. Article ; Online: Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: A randomized, controlled, open-label, parallel group trial (DOXPREVENT.ICU).

    Dhar, Raja / Kirkpatrick, John / Gilbert, Laura / Khanna, Arjun / Modi, Mahavir Madhavdas / Chawla, Rakesh K / Dalal, Sonia / Maturu, Venkata Nagarjuna / Stern, Marcel / Keppler, Oliver T / Djukanovic, Ratko / Gadola, Stephan D

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0280745

    Abstract: Background: After admission to hospital, COVID-19 progresses in a substantial proportion of patients to critical disease that requires intensive care unit (ICU) admission.: Methods: In a pragmatic, non-blinded trial, 387 patients aged 40-90 years ... ...

    Abstract Background: After admission to hospital, COVID-19 progresses in a substantial proportion of patients to critical disease that requires intensive care unit (ICU) admission.
    Methods: In a pragmatic, non-blinded trial, 387 patients aged 40-90 years were randomised to receive treatment with SoC plus doxycycline (n = 192) or SoC only (n = 195). The primary outcome was the need for ICU admission as judged by the attending physicians. Three types of analyses were carried out for the primary outcome: "Intention to treat" (ITT) based on randomisation; "Per protocol" (PP), excluding patients not treated according to randomisation; and "As treated" (AT), based on actual treatment received. The trial was undertaken in six hospitals in India with high-quality ICU facilities. An online application serving as the electronic case report form was developed to enable screening, randomisation and collection of outcomes data.
    Results: Adherence to treatment per protocol was 95.1%. Among all 387 participants, 77 (19.9%) developed critical disease needing ICU admission. In all three primary outcome analyses, doxycycline was associated with a relative risk reduction (RRR) and absolute risk reduction (ARR): ITT 31.6% RRR, 7.4% ARR (P = 0.063); PP 40.7% RRR, 9.6% ARR (P = 0.017); AT 43.2% RRR, 10.8% ARR (P = 0.007), with numbers needed to treat (NTT) of 13.4 (ITT), 10.4 (PP), and 9.3 (AT), respectively. Doxycycline was well tolerated with not a single patient stopping treatment due to adverse events.
    Conclusions: In hospitalized COVID-19 patients, doxycycline, a safe, inexpensive, and widely available antibiotic with anti-inflammatory properties, reduces the need for ICU admission when added to SoC.
    MeSH term(s) Humans ; COVID-19 ; Doxycycline ; SARS-CoV-2 ; Hospitalization ; Intensive Care Units ; Treatment Outcome
    Chemical Substances Doxycycline (N12000U13O)
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280745
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  5. Article ; Online: Vasculitis in 2011: the renaissance of granulomatous inflammation in AAV.

    Gadola, Stephan D / Gross, Wolfgang L

    Nature reviews. Rheumatology

    2012  Volume 8, Issue 2, Page(s) 74–76

    Abstract: In 2011, the year that subtypes of ANCA-associated vasculitis (AAV) were officially renamed according to key pathological characteristics, important progress was made not only in differentiating these subtypes, but also in understanding—and treating— ... ...

    Abstract In 2011, the year that subtypes of ANCA-associated vasculitis (AAV) were officially renamed according to key pathological characteristics, important progress was made not only in differentiating these subtypes, but also in understanding—and treating—their eponymous manifestations.
    MeSH term(s) Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Granulomatosis with Polyangiitis/blood ; Granulomatosis with Polyangiitis/classification ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Humans ; Immunologic Factors/therapeutic use ; Neural Networks, Computer ; Rituximab ; Terminology as Topic ; Vasculitis/blood ; Vasculitis/classification ; Vasculitis/diagnosis ; Vasculitis/drug therapy
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Monoclonal, Murine-Derived ; Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2012-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2011.218
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  6. Article ; Online: Virus infection, asthma, and chronic obstructive pulmonary disease.

    Djukanovic, Ratko / Gadola, Stephan D

    The New England journal of medicine

    2008  Volume 359, Issue 19, Page(s) 2062–2064

    MeSH term(s) Animals ; Asthma/immunology ; Asthma/virology ; CD4-Positive T-Lymphocytes/physiology ; Disease Models, Animal ; Humans ; Inflammation ; Mice ; Natural Killer T-Cells/physiology ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/virology ; Virus Diseases/complications
    Language English
    Publishing date 2008-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr0806978
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    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: a randomized, controlled, open-label, parallel group trial (DOXPREVENT.ICU)

    Dhar, Raja / Kirkpatrick, John / Gilbert, Laura / Khanna, Arjun / Modi, Mahavir Madhavdas / Chawla, Rakesh K / Dalal, Sonia / Maturu, Venkata Nagarjuna / Stern, Marcel / Keppler, Oliver T / Djukanovic, Ratko / Gadola, Stephan D

    medRxiv

    Abstract: ... Background: ... After admission to hospital, COVID-19 progresses in a substantial proportion of patients to critical disease that requires intensive care unit (ICU) admission. ... Methods: ... In a pragmatic, non-blinded trial, 387 patients aged 40-90 ... ...

    Abstract Background: After admission to hospital, COVID-19 progresses in a substantial proportion of patients to critical disease that requires intensive care unit (ICU) admission. Methods: In a pragmatic, non-blinded trial, 387 patients aged 40-90 years were randomised to receive treatment with SoC plus doxycycline (n=192) or SoC only (n=195). The primary outcome was the need for ICU admission as judged by the attending physicians. Three types of analyses were carried out for the primary outcome: Intention to treat (ITT) based on randomisation; Per protocol (PP), excluding patients not treated according to randomisation; and As treated (AT), based on actual treatment received. The trial was undertaken in six hospitals in India with high-quality ICU facilities. An online application serving as the electronic case report form was developed to enable screening, randomisation and collection of outcomes data. Results: Adherence to treatment per protocol was 95.1%. Among all 387 participants, 77 (19.9%) developed critical disease needing ICU admission. In all three primary outcome analyses, doxycycline was associated with a relative risk reduction (RRR) and absolute risk reduction (ARR): ITT 31.6% RRR, 7.4% ARR (P=0.063); PP 40.7% RRR, 9.6% ARR (P=0.017); AT 43.2% RRR, 10.8% ARR (P=0.007), with numbers needed to treat (NTT) of 13.4 (ITT), 10.4 (PP), and 9.3 (AT), respectively. Doxycycline was well tolerated with not a single patient stopping treatment due to adverse events. Conclusions: In hospitalized COVID-19 patients, doxycycline, a safe, inexpensive, and widely available antibiotic with anti-inflammatory properties, reduces the need for ICU admission when added to SoC.
    Keywords covid19
    Language English
    Publishing date 2022-02-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.01.30.22269685
    Database COVID19

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  8. Article ; Online: T-cell populations in chronic pancreatitis.

    Jupp, James / Mansour, Salah / Johnson, Colin D / Sanderson, Joseph / Fine, David / Gadola, Stephan

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2015  Volume 15, Issue 4, Page(s) 311–312

    MeSH term(s) Adult ; Aged ; Female ; Humans ; Lymphocyte Count ; Male ; Middle Aged ; Monocytes/chemistry ; Pancreatitis, Chronic/immunology ; Pancreatitis, Chronic/pathology ; Receptors, Antigen, T-Cell/biosynthesis ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta/biosynthesis ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; T-Lymphocytes, Helper-Inducer ; Th1 Cells
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2015-07
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2015.04.009
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  9. Article ; Online: Clinical and immunological remarks about TAP deficiency.

    Zimmer, Jacques / Sleiman, Marwan / Hentges, François / Gadola, Stephan D

    The Journal of biological chemistry

    2012  Volume 287, Issue 32, Page(s) 27047; author reply 27048

    MeSH term(s) Animals ; Antigen Presentation ; Antigens, Ly/immunology ; CD8-Positive T-Lymphocytes/immunology ; Epitopes/immunology ; HLA-B7 Antigen/immunology ; Humans ; Membrane Proteins/immunology ; Metalloproteases/immunology ; Vaccinia/immunology ; Vaccinia virus/immunology
    Chemical Substances Antigens, Ly ; Epitopes ; HLA-B7 Antigen ; Membrane Proteins ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2012-08-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.L112.379578
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  10. Article ; Online: Intestinal ischaemia and mesenteric necrosis in a heavy smoker.

    Darshan, Jagannath / Shaw, Emily / Green, Bryan / Gallagher, Patrick J / Gadola, Stephan D

    QJM : monthly journal of the Association of Physicians

    2013  Volume 106, Issue 2, Page(s) 183–186

    MeSH term(s) Abdominal Pain/etiology ; Aspirin/therapeutic use ; Diarrhea/etiology ; Humans ; Jejunal Diseases/complications ; Jejunal Diseases/diagnosis ; Jejunal Diseases/drug therapy ; Male ; Mesenteric Arteries/pathology ; Middle Aged ; Necrosis ; Simvastatin/therapeutic use ; Smoking Cessation ; Thromboangiitis Obliterans/complications ; Thromboangiitis Obliterans/diagnosis ; Thromboangiitis Obliterans/drug therapy ; Treatment Outcome ; Weight Loss
    Chemical Substances Simvastatin (AGG2FN16EV) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcs178
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