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Article ; Online: International conference on "Photosynthesis research for sustainability-2015" in honor of George C. Papageorgiou", September 21-26, 2015, Crete, Greece.

Allakhverdiev, Suleyman I / Tomo, Tatsuya / Stamatakis, Kostas / Govindjee

2015 Volume 130, Issue 1-3, Page(s) 1–10

Abstract: ... for Sustainability-2015'' was held in honor of George C. Papageorgiou at the Conference Center of the Orthodox ... introduction and key contributions of George C. Papageorgiou, the honored scientist, and then information ...

Abstract	During September 21-26, 2015, an international conference entitled ''Photosynthesis Research for Sustainability-2015'' was held in honor of George C. Papageorgiou at the Conference Center of the Orthodox Academy of Crete, an exceptionally beautiful location right on the Mediterranean Sea coast, Kolymvari, Chania, Crete, (Greece) (see http://photosynthesis2015.cellreg.org/ ). The meeting was held under the auspices of the Greek "General Secretariat for Research and Technology" (GSRT). We first provide a brief introduction and key contributions of George C. Papageorgiou, the honored scientist, and then information on the conference, on the speakers, and the program. A special feature of this conference was awards given to 13 young investigators, who are recognized in this Report. Several photographs are also included; they show the pleasant ambience at this conference. We invite the readers to the next conference on "Photosynthesis Research for Sustainability-2016," which will honor Nathan Nelson and T. Nejat Veziroglu; it will be held during June 19-25, 2016, in Pushchino, Moscow Region, Russia (see http://photosynthesis2016.cellreg.org/ ).
MeSH term(s)	Conservation of Natural Resources ; History, 20th Century ; History, 21st Century ; Photosynthesis ; Research/history
Language	English
Publishing date	2015-12-09
Publishing country	Netherlands
Document type	Biography ; Historical Article ; Introductory Journal Article
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-015-0207-9
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Article ; Conference proceedings: International conference on âPhotosynthesis research for sustainability-2015â in honor of George C. Papageorgiouâ, September 21â26, 2015, Crete, Greece

Allakhverdiev, Suleyman I / Govindjee / Kostas Stamatakis / Tatsuya Tomo

Photosynthesis research. 2016 Dec., v. 130, no. 1-3

2016

Abstract: ... for Sustainability-2015ââ was held in honor of George C. Papageorgiou at the Conference Center of the Orthodox ... a brief introduction and key contributions of George C. Papageorgiou, the honored scientist, and ...

Abstract	During September 21â26, 2015, an international conference entitled ââPhotosynthesis Research for Sustainability-2015ââ was held in honor of George C. Papageorgiou at the Conference Center of the Orthodox Academy of Crete, an exceptionally beautiful location right on the Mediterranean Sea coast, Kolymvari, Chania, Crete, (Greece) (see http://photosynthesis2015.cellreg.org/). The meeting was held under the auspices of the Greek âGeneral Secretariat for Research and Technologyâ (GSRT). We first provide a brief introduction and key contributions of George C. Papageorgiou, the honored scientist, and then information on the conference, on the speakers, and the program. A special feature of this conference was awards given to 13 young investigators, who are recognized in this Report. Several photographs are also included; they show the pleasant ambience at this conference. We invite the readers to the next conference on âPhotosynthesis Research for Sustainability-2016,â which will honor Nathan Nelson and T. Nejat Veziroglu; it will be held during June 19â25, 2016, in Pushchino, Moscow Region, Russia (see http://photosynthesis2016.cellreg.org/).
Keywords	coasts ; honors and awards ; photographs ; photosynthesis ; scientists ; Crete ; Greece ; Mediterranean Sea ; Russia
Language	English
Dates of publication	2016-12
Size	p. 1-10.
Publishing place	Springer Netherlands
Document type	Article ; Conference proceedings
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-015-0207-9
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Article ; Online: Salt and heat stress enhances hydrogen production in cyanobacteria.

Broussos, Panayiotis-Ilias / Romanos, George E / Stamatakis, Kostas

Photosynthesis research

2024

Abstract: Cyanobacteria are among the most suitable organisms for the capture of excessive amounts of ... ...

Abstract	Cyanobacteria are among the most suitable organisms for the capture of excessive amounts of CO
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-024-01098-2
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Book ; Online: Optimizing Information Freshness over a Channel that Wears Out

Stamatakis, George J. / Simeone, Osvaldo / Pappas, Nikolaos

2023

Abstract: A sensor samples and transmits status updates to a destination through a wireless channel that wears out over time and with every use. At each time slot, the sensor can decide to sample and transmit a fresh status update, restore the initial quality of ... ...

Abstract	A sensor samples and transmits status updates to a destination through a wireless channel that wears out over time and with every use. At each time slot, the sensor can decide to sample and transmit a fresh status update, restore the initial quality of the channel, or remain silent. The actions impose different costs on the operation of the system, and we study the problem of optimally selecting the actions at the transmitter so as to maximize the freshness of the information at the receiver, while minimizing the communication cost. Freshness is measured by the age of information (AoI). The problem is addressed using dynamic programming, and numerical results are presented to provide insights into the optimal transmission policy. Comment: Asilomar 2023
Keywords	Computer Science - Information Theory ; Computer Science - Networking and Internet Architecture
Publishing date	2023-12-01
Publishing country	us
Document type	Book ; Online
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Article ; Online: Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein.

Stamatakis, George / Samiotaki, Martina / Temponeras, Ioannis / Panayotou, George / Stratikos, Efstratios

The Journal of biological chemistry

2021 Volume 297, Issue 5, Page(s) 101329

Abstract: Population genetic variability in immune system genes can often underlie variability in immune responses to pathogens. Cytotoxic T-lymphocytes are emerging as critical determinants of both severe acute respiratory syndrome coronavirus 2 infection ... ...

Abstract	Population genetic variability in immune system genes can often underlie variability in immune responses to pathogens. Cytotoxic T-lymphocytes are emerging as critical determinants of both severe acute respiratory syndrome coronavirus 2 infection severity and long-term immunity, after either recovery or vaccination. A hallmark of coronavirus disease 2019 is its highly variable severity and breadth of immune responses between individuals. To address the underlying mechanisms behind this phenomenon, we analyzed the proteolytic processing of S1 spike glycoprotein precursor antigenic peptides across ten common allotypes of endoplasmic reticulum aminopeptidase 1 (ERAP1), a polymorphic intracellular enzyme that can regulate cytotoxic T-lymphocyte responses by generating or destroying antigenic peptides. We utilized a systematic proteomic approach that allows the concurrent analysis of hundreds of trimming reactions in parallel, thus better emulating antigen processing in the cell. While all ERAP1 allotypes were capable of producing optimal ligands for major histocompatibility complex class I molecules, including known severe acute respiratory syndrome coronavirus 2 epitopes, they presented significant differences in peptide sequences produced, suggesting allotype-dependent sequence biases. Allotype 10, previously suggested to be enzymatically deficient, was rather found to be functionally distinct from other allotypes. Our findings suggest that common ERAP1 allotypes can be a major source of heterogeneity in antigen processing and through this mechanism contribute to variable immune responses in coronavirus disease 2019.
MeSH term(s)	Aminopeptidases/chemistry ; Aminopeptidases/immunology ; Antigen Presentation/immunology ; Antigens, Viral/immunology ; Humans ; Immunoglobulin Allotypes/immunology ; Minor Histocompatibility Antigens/chemistry ; Minor Histocompatibility Antigens/immunology ; Peptides/genetics ; Peptides/immunology ; Recombinant Proteins/chemistry ; Recombinant Proteins/immunology ; SARS-CoV-2/chemistry ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Antigens, Viral ; Immunoglobulin Allotypes ; Minor Histocompatibility Antigens ; Peptides ; Recombinant Proteins ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Aminopeptidases (EC 3.4.11.-) ; ERAP1 protein, human (EC 3.4.11.-)
Language	English
Publishing date	2021-10-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.101329
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Article ; Online: ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides.

Temponeras, Ioannis / Stamatakis, George / Samiotaki, Martina / Georgiadis, Dimitris / Pratsinis, Harris / Panayotou, George / Stratikos, Efstratios

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased efficacy of immune-checkpoint inhibitor cancer immunotherapy, suggesting that pharmacological inhibition of ERAP2 could have important therapeutic implications. To ... ...

Abstract	Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased efficacy of immune-checkpoint inhibitor cancer immunotherapy, suggesting that pharmacological inhibition of ERAP2 could have important therapeutic implications. To explore the effects of ERAP2 inhibition on the immunopeptidome of cancer cells, we treated MOLT-4 T lymphoblast leukemia cells with a recently developed selective ERAP2 inhibitor, isolated Major Histocompatibility class I molecules (MHCI), and sequenced bound peptides by liquid chromatography tandem mass spectrometry. Inhibitor treatment induced significant shifts on the immunopeptidome so that more than 20% of detected peptides were either novel or significantly upregulated. Most of the inhibitor-induced peptides were 9mers and had sequence motifs and predicted affinity consistent with being optimal ligands for at least one of the MHCI alleles carried by MOLT-4 cells. Such inhibitor-induced peptides could serve as triggers for novel cytotoxic responses against cancer cells and synergize with the therapeutic effect of immune-checkpoint inhibitors.
MeSH term(s)	Aminopeptidases ; Antigen Presentation ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Histocompatibility Antigens Class I/chemistry ; Humans ; Peptides/immunology ; Phosphinic Acids/chemistry ; Phosphinic Acids/pharmacology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Tandem Mass Spectrometry
Chemical Substances	Histocompatibility Antigens Class I ; Peptides ; Phosphinic Acids ; Aminopeptidases (EC 3.4.11.-) ; ERAP2 protein, human (EC 3.4.11.-)
Language	English
Publishing date	2022-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031913
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Article ; Online: Synechococcus elongatus PCC7942: a cyanobacterium cell factory for producing useful chemicals and fuels under abiotic stress conditions.

Vayenos, Dimitrios / Romanos, George Em / Papageorgiou, George C / Stamatakis, Kostas

Photosynthesis research

2020 Volume 146, Issue 1-3, Page(s) 235–245

Abstract: Sucrose, a compatible osmolyte in cyanobacteria, functions both as an energy reserve and as osmoprotectant. Sugars are the most common substrates used by microorganisms to produce hydrogen ( ... ...

Abstract	Sucrose, a compatible osmolyte in cyanobacteria, functions both as an energy reserve and as osmoprotectant. Sugars are the most common substrates used by microorganisms to produce hydrogen (H
MeSH term(s)	Carbohydrate Metabolism ; Fermentation ; Hydrogen/metabolism ; Photosynthesis/physiology ; Salt Tolerance ; Stress, Physiological ; Sucrose/metabolism ; Synechococcus/chemistry ; Synechococcus/physiology
Chemical Substances	Sucrose (57-50-1) ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2020-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-020-00747-6
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Article ; Online: ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides

Ioannis Temponeras / George Stamatakis / Martina Samiotaki / Dimitris Georgiadis / Harris Pratsinis / George Panayotou / Efstratios Stratikos

International Journal of Molecular Sciences, Vol 23, Iss 1913, p

2022 Volume 1913

Abstract	Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased efficacy of immune-checkpoint inhibitor cancer immunotherapy, suggesting that pharmacological inhibition of ERAP2 could have important therapeutic implications. To explore the effects of ERAP2 inhibition on the immunopeptidome of cancer cells, we treated MOLT-4 T lymphoblast leukemia cells with a recently developed selective ERAP2 inhibitor, isolated Major Histocompatibility class I molecules (MHCI), and sequenced bound peptides by liquid chromatography tandem mass spectrometry. Inhibitor treatment induced significant shifts on the immunopeptidome so that more than 20% of detected peptides were either novel or significantly upregulated. Most of the inhibitor-induced peptides were 9mers and had sequence motifs and predicted affinity consistent with being optimal ligands for at least one of the MHCI alleles carried by MOLT-4 cells. Such inhibitor-induced peptides could serve as triggers for novel cytotoxic responses against cancer cells and synergize with the therapeutic effect of immune-checkpoint inhibitors.
Keywords	aminopeptidase ; antigenic peptide ; antigen presentation ; adaptive immunity ; major histocompatibility molecules ; proteomics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generation of SARS-CoV-2 S1 Spike Glycoprotein Putative Antigenic Epitopes in Vitro by Intracellular Aminopeptidases.

Stamatakis, George / Samiotaki, Martina / Mpakali, Anastasia / Panayotou, George / Stratikos, Efstratios

Journal of proteome research

2020 Volume 19, Issue 11, Page(s) 4398–4406

Abstract: Presentation of antigenic peptides by MHCI is central to cellular immune responses against viral pathogens. While adaptive immune responses versus SARS-CoV-2 can be of critical importance to both recovery and vaccine efficacy, how protein antigens from ... ...

Abstract	Presentation of antigenic peptides by MHCI is central to cellular immune responses against viral pathogens. While adaptive immune responses versus SARS-CoV-2 can be of critical importance to both recovery and vaccine efficacy, how protein antigens from this pathogen are processed to generate antigenic peptides is largely unknown. Here, we analyzed the proteolytic processing of overlapping precursor peptides spanning the entire sequence of the S1 spike glycoprotein of SARS-CoV-2, by three key enzymes that generate antigenic peptides, aminopeptidases ERAP1, ERAP2, and IRAP. All enzymes generated shorter peptides with sequences suitable for binding onto HLA alleles, but with distinct specificity fingerprints. ERAP1 was the most efficient in generating peptides 8-11 residues long, the optimal length for HLA binding, while IRAP was the least efficient. The combination of ERAP1 with ERAP2 greatly limited the variability of peptide sequences produced. Less than 7% of computationally predicted epitopes were found to be produced experimentally, suggesting that aminopeptidase processing may constitute a significant filter to epitope presentation. These experimentally generated putative epitopes could be prioritized for SARS-CoV-2 immunogenicity studies and vaccine design. We furthermore propose that this in vitro trimming approach could constitute a general filtering method to enhance the prediction robustness for viral antigenic epitopes.
MeSH term(s)	Aminopeptidases/metabolism ; Antigens, Viral/chemistry ; Antigens, Viral/metabolism ; Chromatography, Liquid ; Epitopes/chemistry ; Epitopes/metabolism ; HEK293 Cells ; HLA Antigens/chemistry ; HLA Antigens/metabolism ; Humans ; Peptides/analysis ; Peptides/chemistry ; Peptides/metabolism ; Proteomics/methods ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Tandem Mass Spectrometry
Chemical Substances	Antigens, Viral ; Epitopes ; HLA Antigens ; Peptides ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Aminopeptidases (EC 3.4.11.-)
Keywords	covid19
Language	English
Publishing date	2020-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.0c00457
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Article ; Online: Proteomic Identification of the SLC25A46 Interactome in Transgenic Mice Expressing SLC25A46-FLAG.

Perivolidi, Vasiliki-Iris / Violitzi, Foteini / Ioannidou, Elisavet / Rinotas, Vagelis / Stamatakis, George / Samiotaki, Martina / Panayotou, George / Douni, Eleni

Journal of proteome research

2022 Volume 21, Issue 2, Page(s) 375–394

Abstract: The outer mitochondrial membrane protein SLC25A46 has been recently identified as a novel genetic cause of a wide spectrum of neurological diseases. The aim of the present work was to elucidate the physiological role of SLC25A46 through the ... ...

Abstract	The outer mitochondrial membrane protein SLC25A46 has been recently identified as a novel genetic cause of a wide spectrum of neurological diseases. The aim of the present work was to elucidate the physiological role of SLC25A46 through the identification of its interactome with immunoprecipitation and proteomic analysis in whole cell extracts from the cerebellum, cerebrum, heart, and thymus of transgenic mice expressing ubiquitously SLC25A46-FLAG. Our analysis identified 371 novel putative interactors of SLC25A46 and confirmed 17 known ones. A total of 79 co-immunoprecipitated proteins were common in two or more tissues, mainly participating in mitochondrial activities such as oxidative phosphorylation (OXPHOS) and ATP production, active transport of ions or molecules, and the metabolism. Tissue-specific co-immunoprecipitated proteins were enriched for synapse annotated proteins in the cerebellum and cerebrum for metabolic processes in the heart and for nuclear processes and proteasome in the thymus. Our proteomic approach confirmed known mitochondrial interactors of SLC25A46 including MICOS complex subunits and also OPA1 and VDACs, while we identified novel interactors including the ADP/ATP translocases SLC25A4 and SLC25A5, subunits of the OXPHOS complexes and F
MeSH term(s)	Animals ; Mice ; Mice, Transgenic ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Phosphate Transport Proteins/genetics ; Phosphate Transport Proteins/metabolism ; Proteomics
Chemical Substances	Mitochondrial Proteins ; Phosphate Transport Proteins
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.1c00728
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