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Article: Genes & cells: Drug candidate may stop MERS: Chemical disrupts assembly centers of coronaviruses.

Rosen, Meghan

2014 Volume 185, Issue 13, Page(s) 10–11

Keywords	covid19
Language	English
Publishing date	2014-06-17
Publishing country	United States
Document type	News
ZDB-ID	2023570-7
ISSN	1943-0930 ; 0036-8423
ISSN (online)	1943-0930
ISSN	0036-8423
DOI	10.1002/scin.5591851308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Perceived financial burden is indirectly linked to sexual well-being

Allsop, David B / Péloquin, Katherine / Saxey, Matthew T / Rossi, Meghan A / Rosen, Natalie O

Frontiers in psychology

2023 Volume 14, Page(s) 1063268

Abstract: Introduction: Medically assisted reproduction is a difficult treatment process for couples both financially and sexually. Yet, these two domains have not been examined together among couples seeking treatment, leaving couples and practitioners without ... ...

Abstract	Introduction: Medically assisted reproduction is a difficult treatment process for couples both financially and sexually. Yet, these two domains have not been examined together among couples seeking treatment, leaving couples and practitioners without guidance on how to address these domains together. Methods: In line with Couples and Finance Theory, we tested the hypothesis that perceived financial burden and couple income would predict quality of life during medically assisted reproduction, which would then predict four domains of sexual well-being (i.e., sexual satisfaction, desire, distress, and frequency). We also examined if the results differed by treatment status-that is, between partners who were receiving treatment and those who were not. Cross-sectional data from 120 couples who had undergone medically assisted reproduction in the past six months were analyzed Results: An individual's greater perceived financial burden predicted their own lower quality of life during medically assisted reproduction, which in turn predicted their lower sexual satisfaction, desire and distress, as well as their partner's lower sexual satisfaction. Household income did not indirectly predict any sexual well-being domains, and results regarding treatment status were inconclusive. Discussion: Clinicians can discuss with couples how perceived financial strain of medically assisted reproduction affects their quality of life and what ramifications that may have for their sexual well-being.
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1063268
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Article ; Online: Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice.

Rosen, Anne L / Lint, Michael A / Voelker, Dayne H / Gilbert, Nicole M / Tomera, Christopher P / Santiago-Borges, Jesús / Wallace, Meghan A / Hannan, Thomas J / Burnham, Carey-Ann D / Hultgren, Scott J / Kau, Andrew L

mBio

2024 Volume 15, Issue 2, Page(s) e0255423

Abstract: Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. ... ...

Abstract	Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic
MeSH term(s)	Adolescent ; Adult ; Animals ; Female ; Humans ; Mice ; Middle Aged ; Young Adult ; Anti-Infective Agents ; Cystitis ; Escherichia coli Infections/microbiology ; Secretory Leukocyte Peptidase Inhibitor/genetics ; Urinary Tract Infections/microbiology ; Uropathogenic Escherichia coli/genetics
Chemical Substances	Anti-Infective Agents ; Secretory Leukocyte Peptidase Inhibitor ; Slpi protein, mouse
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02554-23
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Article: Prior Fc Receptor activation primes macrophages for increased sensitivity to IgG via long term and short term mechanisms.

Bond, Annalise / Fiaz, Sareen / Rollins, Kirstin R / Nario, Jazz Elaiza Q / Rosen, Samuel J / Granados, Alyssa / Wilson, Maxwell Z / Morrissey, Meghan A

bioRxiv : the preprint server for biology

2023

Abstract: Macrophages measure the 'eat-me' signal IgG to identify targets for phagocytosis. We wondered if prior encounters with IgG influence macrophage appetite. IgG is recognized by the Fc Receptor. To temporally control Fc Receptor activation, we engineered an ...

Abstract	Macrophages measure the 'eat-me' signal IgG to identify targets for phagocytosis. We wondered if prior encounters with IgG influence macrophage appetite. IgG is recognized by the Fc Receptor. To temporally control Fc Receptor activation, we engineered an Fc Receptor that is activated by light-induced oligomerization of Cry2, triggering phagocytosis. Using this tool, we demonstrate that Fc Receptor activation primes macrophages to be more sensitive to IgG in future encounters. Macrophages that have previously experienced Fc Receptor activation eat more IgG-bound cancer cells. Increased phagocytosis occurs by two discrete mechanisms - a short- and long-term priming. Long term priming requires new protein synthesis and Erk activity. Short term priming does not require new protein synthesis and correlates with an increase in Fc Receptor mobility. Our work demonstrates that IgG primes macrophages for increased phagocytosis, suggesting that therapeutic antibodies may become more effective after initial priming doses.
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.14.567059
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Article ; Online: Biased Partner Perceptions of Women's Pain Self-Efficacy in Postpartum Pain During Intercourse: A Dyadic Longitudinal Examination.

Rossi, Meghan A / Maxwell, Jessica A / Rosen, Natalie O

The journal of pain

2020 Volume 21, Issue 9-10, Page(s) 1047–1059

Abstract: Postpartum pain during intercourse is a prevalent and distressing problem that has substantial consequences for affected couples. Partner perceptions-such as how partners perceive women's pain self-efficacy-contribute to an individual's pain experience. ... ...

Abstract	Postpartum pain during intercourse is a prevalent and distressing problem that has substantial consequences for affected couples. Partner perceptions-such as how partners perceive women's pain self-efficacy-contribute to an individual's pain experience. This study examined whether partners under- or over-estimate women's intercourse pain self-efficacy at 3-months postpartum and the implications of this bias for women's pain and couples' sexual functioning at 3- and 6-months postpartum. Women who reported pain during intercourse and their partners (N = 89 couples) completed online measures assessing pain self-efficacy (own or partner perceptions), pain intensity, and sexual functioning at 3- and 6-months postpartum. Analyses were based on the Truth and Bias Model of Judgement and Response Surface Analysis. Partners were accurate in their estimates of women's pain self-efficacy (ie, their estimates were positively correlated with women's), but they also underestimated it by perceiving women to be less efficacious than women themselves reported. When couples showed greater agreement for lower levels of pain self-efficacy at 3 months, women reported greater pain intensity and both partners reported poorer sexual functioning at 3- and 6-months postpartum. Findings may inform interventions that promote pain self-efficacy to improve partner support and couples' sexual functioning. PERSPECTIVE: When women report-and their partners perceive-low levels of women's self-efficacy for managing painful intercourse, women report greater postpartum pain during intercourse and couples indicate poorer sexual functioning. These findings suggest that interventions aimed at promoting couples' agreement at high pain self-efficacy may improve their adjustment to postpartum pain.
MeSH term(s)	Adaptation, Psychological/physiology ; Adolescent ; Adult ; Coitus/physiology ; Coitus/psychology ; Dyspareunia/diagnosis ; Dyspareunia/epidemiology ; Dyspareunia/psychology ; Female ; Humans ; Longitudinal Studies ; Male ; Pain/diagnosis ; Pain/epidemiology ; Pain/psychology ; Pain Measurement/methods ; Pain Measurement/psychology ; Perception/physiology ; Postpartum Period/physiology ; Postpartum Period/psychology ; Self Efficacy ; Sexual Partners/psychology ; Young Adult
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2018789-0
ISSN	1528-8447 ; 1526-5900
ISSN (online)	1528-8447
ISSN	1526-5900
DOI	10.1016/j.jpain.2020.01.006
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Article: Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice.

bioRxiv : the preprint server for biology

2023

Abstract: Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. ... ...

Abstract	Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.10.561753
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Article ; Online: A Longitudinal Investigation of Couples' Sexual Growth and Destiny Beliefs in the Transition to Parenthood.

Rossi, Meghan A / Impett, Emily A / Dawson, Samantha J / Vannier, Sarah / Kim, James / Rosen, Natalie O

Archives of sexual behavior

2022 Volume 51, Issue 3, Page(s) 1559–1575

Abstract: Beliefs about sexuality tend to become more salient during sexual challenges and are associated with how individuals respond to these difficulties and, in turn, their sexual well-being. The transition to parenthood is marked by significant changes to ... ...

Abstract	Beliefs about sexuality tend to become more salient during sexual challenges and are associated with how individuals respond to these difficulties and, in turn, their sexual well-being. The transition to parenthood is marked by significant changes to couples' sexuality. As such, this period of vulnerability may be an important context in which these beliefs impact how couples manage sexual stressors and may have implications for their sexual well-being. In a longitudinal dyadic study, we examined whether couples' sexual growth beliefs (e.g., beliefs that sexual problems can be resolved through effort) and sexual destiny beliefs (e.g., beliefs that sexual problems reflect incompatibility with their partner) correspond with changes to various facets of couples' sexual well-being over time. First-time parent couples (N = 203) completed online surveys assessing these beliefs in pregnancy (32 weeks) and measures of sexual well-being (satisfaction, desire, and distress) in pregnancy (20 and 32 weeks) and across the postpartum period (3, 6, 9, 12 months). Dyadic latent growth curve models showed that expectant mothers who reported stronger sexual destiny beliefs in pregnancy reported higher sexual distress and lower sexual satisfaction at 3 months postpartum. When partners reported stronger sexual destiny beliefs in pregnancy, both they and new mothers reported greater sexual desire at 3 months postpartum. Unexpectedly, partners' higher sexual growth beliefs in pregnancy predicted mothers' lower sexual desire at 3 months postpartum. Sexual growth and destiny beliefs were not associated with change in couples' sexual well-being beyond 3 months postpartum. Findings shed light on the potential benefits and costs of sexual growth and destiny beliefs for couples' sexual well-being early in the postpartum period, but not over time.
MeSH term(s)	Female ; Humans ; Libido ; Orgasm ; Postpartum Period ; Pregnancy ; Sexual Behavior ; Sexual Partners
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184221-3
ISSN	1573-2800 ; 0004-0002
ISSN (online)	1573-2800
ISSN	0004-0002
DOI	10.1007/s10508-021-02267-3
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Article ; Online: Sexual growth and destiny beliefs: Longitudinal associations with dyadic coping among couples seeking medically assisted reproduction.

Rossi, Meghan A / Péloquin, Katherine / Allsop, David B / El Amiri, Sawsane / Bouzayen, Renda / Brassard, Audrey / Bergeron, Sophie / Rosen, Natalie O

The journal of sexual medicine

2023 Volume 20, Issue 10, Page(s) 1241–1251

Abstract: Background: Medically assisted reproduction is a vulnerable time for couples' sexual health. Believing that sexual challenges can be worked through (i.e., sexual growth beliefs) or that these challenges indicate incompatibility (i.e., sexual destiny ... ...

Abstract	Background: Medically assisted reproduction is a vulnerable time for couples' sexual health. Believing that sexual challenges can be worked through (i.e., sexual growth beliefs) or that these challenges indicate incompatibility (i.e., sexual destiny beliefs) may be related to dyadic coping-the strategies couples use to cope-with the physical and psychological stressors of medically assisted reproduction. Aim: In the current study we aimed to examine the longitudinal associations between typical (i.e., average) levels of sexual growth and destiny beliefs and positive and negative facets of dyadic coping and how greater than typical levels of these constructs predicted each other across time. Methods: Couples (n = 219) seeking medically assisted reproduction were recruited for an online longitudinal, dyadic study. Outcomes: Couples completed online measures of sexual growth and destiny beliefs and positive and negative dyadic coping at baseline, 6-and 12-months. Results: Random intercept cross-lagged panel models demonstrated that at the within-person level, reporting higher sexual growth beliefs at baseline, relative to their average across time points, was associated with lower negative dyadic coping at 6 months. Higher negative dyadic coping at 6 months, relative to their average, was linked to lower sexual growth beliefs at 12-months. When individuals reported higher sexual destiny beliefs at 6-months, relative to their average, they and their partners reported higher negative dyadic coping at 12 -months. At the between-person level, higher overall levels of sexual destiny beliefs were related to higher overall levels of negative dyadic coping. No associations with positive dyadic coping were identified. Clinical implications: Couples may benefit from identifying and reducing unhelpful beliefs about sex and negative dyadic coping. Strengths and limitations: Strengths of this study include our large, inclusive sample, engagement of community partners, and novel analytical approach to assess change over time. However, following couples in 6-month increments and not using questionnaires specific to medically assisted reproduction may have limited our ability to detect nuanced changes that couples experience during this time. Conclusion: Lower sexual growth and higher sexual destiny beliefs may promote couples' engagement in less adaptive coping behaviors as they seek medically assisted reproduction.
MeSH term(s)	Humans ; Sexual Behavior/psychology ; Adaptation, Psychological ; Stress, Psychological/psychology ; Reproduction ; Surveys and Questionnaires ; Sexual Partners/psychology
Language	English
Publishing date	2023-08-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1093/jsxmed/qdad098
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Article: Reduction in Antibiotic Delivery Time Following Improving Pediatric Sepsis Outcomes Quality Improvement Initiative at a Major Children's Hospital.

Gill, Meghan / Raghu, Vikram / Ferguson, Elizabeth / Marcinick, Adrienne / Rosen, Johanna / Butler, Gabriella / Horvat, Christopher / Crowley, Kelli

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2023 Volume 28, Issue 1, Page(s) 55–62

Abstract: Objective: Sepsis causes morbidity and mortality in pediatric patients, but timely antibiotic administration can improve sepsis outcomes. The pharmacy department can affect the time from order to delivery of antibiotics. By evaluating the pharmacy ... ...

Abstract	Objective: Sepsis causes morbidity and mortality in pediatric patients, but timely antibiotic administration can improve sepsis outcomes. The pharmacy department can affect the time from order to delivery of antibiotics. By evaluating the pharmacy process, this study aimed to decrease the time from antibiotic order to delivery to within 45 minutes. Methods: All antibiotic orders placed following a positive sepsis screen for acute care patients at a freestanding children's hospital from April 1, 2019, to December 31, 2019, were reviewed. Lean Six Sigma methodology including process mapping was used to identify and implement improvements, including educational interventions for providers. Outcome measures included time from antibiotic order placement to delivery and to administration. Additional assessment of process measures included evaluation of order priority, PowerPlan (an internally created order set) use, and delivery method. Results: Ninety-eight antibiotic orders for 85 patients were evaluated. In an individual chart of antibiotic delivery time, a trend towards faster delivery time was observed after interventions. Stat orders (40.5 minutes [IQR, 19.5-48]) were delivered more quickly than routine orders (51 minutes [IQR, 45-65]; p < 0.001). Orders using the PowerPlan (20.5 minutes [IQR, 18.5-38]) were delivered more quickly than those that did not (47 minutes [IQR, 34-64]; p < 0.01). Shorter time to administration was observed with pneumatic tube delivery (41 minutes [IQR, 20-50]) than with direct delivery to a health care provider (51 minutes [IQR, 31-83]; p < 0.05) or to the automated dispensing cabinet's refrigerator (47 minutes [IQR, 41-62]; p < 0.0001). Conclusions: Multifactorial coordinated interventions within the pharmacy department improve medication delivery time for pediatric sepsis antibiotic orders.
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-28.1.55
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Article ; Online: Probing entanglement in a 2D hard-core Bose-Hubbard lattice.

Karamlou, Amir H / Rosen, Ilan T / Muschinske, Sarah E / Barrett, Cora N / Di Paolo, Agustin / Ding, Leon / Harrington, Patrick M / Hays, Max / Das, Rabindra / Kim, David K / Niedzielski, Bethany M / Schuldt, Meghan / Serniak, Kyle / Schwartz, Mollie E / Yoder, Jonilyn L / Gustavsson, Simon / Yanay, Yariv / Grover, Jeffrey A / Oliver, William D

Nature

2024

Abstract: Entanglement and its propagation are central to understanding many physical properties of quantum ... ...

Abstract	Entanglement and its propagation are central to understanding many physical properties of quantum systems
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07325-z
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