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Article ; Online: Candida albicans increases the aerobic glycolysis and activates MAPK-dependent inflammatory response of liver sinusoidal endothelial cells.

Aparicio-Fernandez, Leire / Antoran, Aitziber / Areitio, Maialen / Rodriguez-Erenaga, Oier / Martin-Souto, Leire / Buldain, Idoia / Márquez, Joana / Benedicto, Aitor / Arteta, Beatriz / Pellon, Aize / Moyes, David L / Rementeria, Aitor / Ramirez-Garcia, Andoni

Microbes and infection

2024 , Page(s) 105305

Abstract: The liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms ... ...

Abstract	The liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms involved in the interaction between these cells and C. albicans. Transcriptomics-based analysis showed an increase in the expression of genes related to the immune response (including receptors, cytokines, and adhesion molecules), as well as to aerobic glycolysis. Further in vitro analyses showed that IL-6 production in response to C. albicans is controlled by MyD88- and SYK-pathways, suggesting an involvement of Toll-like and C-type lectin receptors and the subsequent activation of the MAP-kinases and c-Fos/AP-1 transcription factor. In addition, liver sinusoidal endothelial cells undergo metabolic reprogramming towards aerobic glycolysis induced by C. albicans, as confirmed by the increased Extracellular Acidification Rate and the overexpression of enolase (Eno2), hexonikase (Hk2) and glucose transporter 1 (Slc2a1). In conclusion, these results indicate that the hepatic endothelium responds to C. albicans by increasing aerobic glycolysis and promoting an inflammatory environment.
Language	English
Publishing date	2024-01-29
Publishing country	France
Document type	Journal Article
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2024.105305
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Article ; Online: The

Guruceaga, Xabier / Perez-Cuesta, Uxue / Martin-Vicente, Adela / Pelegri-Martinez, Eduardo / Thorn, Harrison I / Cendon-Sanchez, Saioa / Xie, Jinhong / Nywening, Ashley V / Ramirez-Garcia, Andoni / Fortwendel, Jarrod R / Rementeria, Aitor

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1327299

Abstract: In this study, two ... ...

Abstract	In this study, two distinct
MeSH term(s)	Humans ; Animals ; Mice ; Aspergillus fumigatus ; Virulence/genetics ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Homeostasis ; Cell Wall/metabolism
Chemical Substances	Fungal Proteins
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1327299
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Article ; Online: Identification of the Most Immunoreactive Antigens of

Areitio, Maialen / Antoran, Aitziber / Rodriguez-Erenaga, Oier / Aparicio-Fernandez, Leire / Martin-Souto, Leire / Buldain, Idoia / Zaldibar, Beñat / Ruiz-Gaitan, Alba / Pemán, Javier / Rementeria, Aitor / Ramirez-Garcia, Andoni

Journal of proteome research

2024 Volume 23, Issue 5, Page(s) 1634–1648

Abstract: The delay in making a correct diagnosis ... ...

Abstract	The delay in making a correct diagnosis of
MeSH term(s)	Animals ; Mice ; Candida/immunology ; Candida/pathogenicity ; Humans ; Candidiasis/immunology ; Candidiasis/microbiology ; Candidiasis/blood ; Immunoglobulin G/blood ; Antigens, Fungal/immunology ; Antigens, Fungal/blood ; Proteomics/methods ; Candida albicans/immunology ; Candida albicans/pathogenicity ; Fungal Proteins/immunology ; Phosphoglycerate Mutase/immunology ; Phosphoglycerate Kinase/immunology ; Glyceraldehyde-3-Phosphate Dehydrogenases/immunology ; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism ; Antibodies, Fungal/blood ; Antibodies, Fungal/immunology ; Female ; Virulence
Chemical Substances	Immunoglobulin G ; Antigens, Fungal ; Fungal Proteins ; Phosphoglycerate Mutase (EC 5.4.2.11) ; Phosphoglycerate Kinase (EC 2.7.2.3) ; Glyceraldehyde-3-Phosphate Dehydrogenases (EC 1.2.1.-) ; Antibodies, Fungal
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00752
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Article ; Online: The Host Immune Response to

Buldain, Idoia / Martin-Souto, Leire / Antoran, Aitziber / Areitio, Maialen / Aparicio-Fernandez, Leire / Rementeria, Aitor / Hernando, Fernando L / Ramirez-Garcia, Andoni

Journal of fungi (Basel, Switzerland)

2021 Volume 7, Issue 2

Abstract: Infections caused by the opportunistic ... ...

Abstract	Infections caused by the opportunistic pathogens
Language	English
Publishing date	2021-01-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof7020075
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Article ; Online: Dot Immunobinding Assay for the Rapid Serodetection of

Martin-Souto, Leire / Antoran, Aitziber / Areitio, Maialen / Aparicio-Fernandez, Leire / Martín-Gómez, María Teresa / Fernandez, Roberto / Astigarraga, Egoitz / Barreda-Gómez, Gabriel / Schwarz, Carsten / Rickerts, Volker / Hernando, Fernando L / Rementeria, Aitor / Buldain, Idoia / Ramirez-Garcia, Andoni

Journal of fungi (Basel, Switzerland)

2023 Volume 9, Issue 2

Abstract: The detection ... ...

Abstract	The detection of
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9020158
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Article ; Online: Microbiota and fungal-bacterial interactions in the cystic fibrosis lung.

Santos-Fernandez, Eneko / Martin-Souto, Leire / Antoran, Aitziber / Areitio, Maialen / Aparicio-Fernandez, Leire / Bouchara, Jean-Philippe / Schwarz, Carsten / Rementeria, Aitor / Buldain, Idoia / Ramirez-Garcia, Andoni

FEMS microbiology reviews

2023 Volume 47, Issue 3

Abstract: The most common genetic hereditary disease affecting Caucasians is cystic fibrosis (CF), which is caused by autosomal recessive mutations in the CFTR gene. The most serious consequence is the production of a thick and sticky mucus in the respiratory ... ...

Abstract	The most common genetic hereditary disease affecting Caucasians is cystic fibrosis (CF), which is caused by autosomal recessive mutations in the CFTR gene. The most serious consequence is the production of a thick and sticky mucus in the respiratory tract, which entraps airborne microorganisms and facilitates colonization, inflammation and infection. Therefore, the present article compiles the information about the microbiota and, particularly, the inter-kingdom fungal-bacterial interactions in the CF lung, the molecules involved and the potential effects that these interactions may have on the course of the disease. Among the bacterial compounds, quorum sensing-regulated molecules such as homoserine lactones, phenazines, rhamnolipids, quinolones and siderophores (pyoverdine and pyochelin) stand out, but volatile organic compounds, maltophilin and CF-related bacteriophages are also explained. These molecules exhibit diverse antifungal mechanisms, including iron starvation and induction of reactive oxygen and nitrogen species production. The fungal compounds are less studied, but they include cell wall components, siderophores, patulin and farnesol. Despite the apparent competition between microorganisms, the persistence of significant rates of bacterial-fungal co-colonization in CF suggests that numerous variables influence it. In conclusion, it is crucial to increase scientific and economic efforts to intensify studies on the bacterial-fungal inter-kingdom interactions in the CF lung.
MeSH term(s)	Humans ; Cystic Fibrosis/genetics ; Cystic Fibrosis/microbiology ; Siderophores ; Bacteria ; Microbiota ; Lung/microbiology
Chemical Substances	Siderophores
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	283740-7
ISSN	1574-6976 ; 0168-6445
ISSN (online)	1574-6976
ISSN	0168-6445
DOI	10.1093/femsre/fuad029
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Zs.A 2165: Show issues

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Article ; Online: Nitrogen, Iron and Zinc Acquisition: Key Nutrients to

Perez-Cuesta, Uxue / Guruceaga, Xabier / Cendon-Sanchez, Saioa / Pelegri-Martinez, Eduardo / Hernando, Fernando L / Ramirez-Garcia, Andoni / Abad-Diaz-de-Cerio, Ana / Rementeria, Aitor

Journal of fungi (Basel, Switzerland)

2021 Volume 7, Issue 7

Abstract: Aspergillus ... ...

Abstract	Aspergillus fumigatus
Language	English
Publishing date	2021-06-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof7070518
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Article ; Online: Aspergillus fumigatus

Guruceaga, Xabier / Perez-Cuesta, Uxue / Pellon, Aize / Cendon-Sanchez, Saioa / Pelegri-Martinez, Eduardo / Gonzalez, Oskar / Hernando, Fernando Luis / Mayayo, Emilio / Anguita, Juan / Alonso, Rosa M / Keller, Nancy P / Ramirez-Garcia, Andoni / Rementeria, Aitor

Journal of fungi (Basel, Switzerland)

2021 Volume 7, Issue 11

Abstract: The activity of fumagillin, a mycotoxin produced ... ...

Abstract	The activity of fumagillin, a mycotoxin produced by
Language	English
Publishing date	2021-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof7110936
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Article ; Online: Flexible multiplex PCR to detect SARS-CoV-2, coronavirus OC43 and influenza A virus in nasopharyngeal swab samples.

Pelegri-Martinez, Eduardo / Guruceaga, Xabier / Martin-Souto, Leire / Abad-Diaz-de-Cerio, Ana / Rementeria, Aitor / Dominguez-Monedero, Alazne / Gallego, Mikel / Martinez, Oscar / Arana-Arri, Eunate / Aranzamendi, Maitane / Ramirez-Garcia, Andoni

Journal of applied microbiology

2022 Volume 133, Issue 6, Page(s) 3534–3545

Abstract: Introduction: Quantitative reverse transcription PCR (RT-qPCR) is the leading tool to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given that it will almost certainly continue to coexist with other respiratory viruses in the ... ...

Abstract	Introduction: Quantitative reverse transcription PCR (RT-qPCR) is the leading tool to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given that it will almost certainly continue to coexist with other respiratory viruses in the coming years, our study aimed to design a multiplex PCR system not affected by supplier outages and with reduced cost compared to the existing commercially available kits. Methods and results: In this study, combinations of four primers/probe sets were used to construct a flexible RT-qPCR assay which is capable of discriminating between SARS-CoV-2 and the seasonal human coronavirus HCoV-OC43, or even influenza A virus. Additionally, the human RPP30 gene was used as an internal control. To demonstrate the robustness of the assay, it was applied to a collection of 150 clinical samples. The results showed 100% sensitivity and specificity compared to the automatized system used at the hospital and were better when indeterminate samples were analysed. Conclusions: This study provides an efficient method for the simultaneous detection of SARS-CoV-2, HCoV-OC43 and influenza A virus, and its efficacy has been tested on clinical samples showing outstanding results. Significance and impact of the study: The multiplex RT-qPCR design offers an accessible and economical alternative to commercial detection kits for hospitals and laboratories with limited economic resources or facing situations of supply shortage.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; Multiplex Polymerase Chain Reaction/methods ; Influenza A virus/genetics ; COVID-19/diagnosis ; Sensitivity and Specificity ; Nasopharynx
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15788
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Article ; Online: The Host Immune Response to Scedosporium / Lomentospora

Idoia Buldain / Leire Martin-Souto / Aitziber Antoran / Maialen Areitio / Leire Aparicio-Fernandez / Aitor Rementeria / Fernando L. Hernando / Andoni Ramirez-Garcia

Journal of Fungi, Vol 7, Iss 2, p

2021 Volume 75

Abstract: Infections caused by the opportunistic pathogens Scedosporium / Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against ... ...

Abstract	Infections caused by the opportunistic pathogens Scedosporium / Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. Scedosporium / Lomentospora cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dectin-1 and through receptors that are yet unknown. After recognition, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells is species-specific, highlighting the poor response by microglial cells against L. prolificans . Moreover, a great number of Scedosporium / Lomentospora antigens have been identified, most notably catalase, PRM and Hsp70 for their potential medical applicability. Against host immune response, these fungi contain evasion mechanisms, inducing host non-protective response, masking fungal molecular patterns, destructing host defense proteins and decreasing oxidative killing. In conclusion, although many advances have been made, many aspects remain to be elucidated and more research is necessary to shed light on the immune response to Scedosporium / Lomentospora .
Keywords	Scedosporium ; Lomentospora ; immune response ; cytokine ; macrophage ; lymphocyte ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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