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  1. Article ; Online: The challenges and prospects of smooth muscle tissue engineering.

    Baldwin, Christofer S / Iyer, Shilpa / Rao, Raj R

    Regenerative medicine

    2024  Volume 19, Issue 3, Page(s) 135–143

    Abstract: Many vascular disorders arise as a result of dysfunctional smooth muscle cells. Tissue engineering strategies have evolved as key approaches to generate functional vascular smooth muscle cells for use in cell-based precision and personalized regenerative ...

    Abstract Many vascular disorders arise as a result of dysfunctional smooth muscle cells. Tissue engineering strategies have evolved as key approaches to generate functional vascular smooth muscle cells for use in cell-based precision and personalized regenerative medicine approaches. This article highlights some of the challenges that exist in the field and presents some of the prospects for translating research advancements into therapeutic modalities. The article emphasizes the need for better developing synergetic intracellular and extracellular cues in the processes to generate functional vascular smooth muscle cells from different stem cell sources for use in tissue engineering strategies.
    MeSH term(s) Tissue Engineering ; Muscle, Smooth ; Stem Cells ; Myocytes, Smooth Muscle ; Regenerative Medicine
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2023-0230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Phasing out fossil fuels would save millions of lives worldwide.

    Lehtomäki, Heli / Rao, Shilpa / Hänninen, Otto

    BMJ (Clinical research ed.)

    2023  Volume 383, Page(s) 2774

    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Integrated multiplexed assays of variant effect reveal determinants of catechol-O-methyltransferase gene expression.

    Hoskins, Ian / Rao, Shilpa / Tante, Charisma / Cenik, Can

    Molecular systems biology

    2024  

    Abstract: Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expression in ... ...

    Abstract Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expression in coding sequences. Here, we pioneered a multiplexed assay based on polysome profiling to measure variant effects on translation at scale, uncovering single-nucleotide variants that increase or decrease ribosome load. By combining high-throughput ribosome load data with multiplexed mRNA and protein abundance readouts, we mapped the cis-regulatory landscape of thousands of catechol-O-methyltransferase (COMT) variants from RNA to protein and found numerous coding variants that alter COMT expression. Finally, we trained machine learning models to map signatures of variant effects on COMT gene expression and uncovered both directional and divergent impacts across expression layers. Our analyses reveal expression phenotypes for thousands of variants in COMT and highlight variant effects on both single and multiple layers of expression. Our findings prompt future studies that integrate several multiplexed assays for the readout of gene expression.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.1038/s44320-024-00018-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Linking climate change adaptation and public health: perspectives of Norwegian policymakers.

    Budin-Ljøsne, Isabelle / Nordeng, Zuzana / Schwarze, Per Everhard / Rao-Skirbekk, Shilpa

    Scandinavian journal of public health

    2024  , Page(s) 14034948241229486

    Language English
    Publishing date 2024-02-21
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1475054-5
    ISSN 1651-1905 ; 1403-4948
    ISSN (online) 1651-1905
    ISSN 1403-4948
    DOI 10.1177/14034948241229486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Breaking Barriers: Modeling the Blood-Brain Barrier in Parkinson's Disease Using a Human-Brain-Chip.

    Rao, Shilpa C / Sanyaolu, Arinola O

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 4, Page(s) 699

    MeSH term(s) Blood-Brain Barrier ; Brain ; Humans ; Parkinson Disease
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28968
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  6. Article ; Online: Awake on Twitter.

    Rajan, Shobana / Rao, Shilpa

    Journal of neurosurgical anesthesiology

    2021  Volume 34, Issue 3, Page(s) 339–340

    MeSH term(s) Humans ; Social Media ; Wakefulness
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1018119-2
    ISSN 1537-1921 ; 0898-4921
    ISSN (online) 1537-1921
    ISSN 0898-4921
    DOI 10.1097/ANA.0000000000000763
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  7. Article: Synchronous Metastatic Follicular Carcinoma and

    Fonseca, Daphne / Arya, Sahithi Shilpa / Rao, Chandrasekhara

    Indian journal of surgical oncology

    2022  Volume 14, Issue 1, Page(s) 249–251

    Language English
    Publishing date 2022-12-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-022-01688-3
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  8. Article ; Online: Delineating the Spectrum of Pituitary Adenoma Based on the WHO 2017 Classification.

    Paramita, Paul / Shilpa, Rao / Nandeesh, B N / Yasha, T C / Vani, Santosh

    Neurology India

    2024  Volume 72, Issue 1, Page(s) 96–101

    Abstract: Background: The WHO 2017 classification of endocrine tumors incorporates lineage-specific transcription factors (TF) and hormone expression for the classification of pituitary adenoma (PA). There is paucity of reports describing the spectrum of PA based ...

    Abstract Background: The WHO 2017 classification of endocrine tumors incorporates lineage-specific transcription factors (TF) and hormone expression for the classification of pituitary adenoma (PA). There is paucity of reports describing the spectrum of PA based on this classification.
    Objective: The aim of this study was to delineate the spectrum of PA based on WHO 2017 classification of endocrine tumors.
    Materials and methods: PA diagnosed in the year 2018 were studied. H and E and hormonal immunohistochemistry (IHC) for GH, PRL, ACTH, TSH, FSH, LH, CK, T-Pit and MIB-1 were performed and the results were analyzed.
    Results: The cohort included 88 cases. M: F ratio was 2:1. Clinically, 22 (25%) were functional and 66 (75%) were non-functional adenomas. Amongst the clinically functional adenomas, GH secreting adenomas were the commonest (68%). Majority (83%) of non-functional adenomas were hormone positive with gonadotroph adenomas being the commonest (72.7%). Eleven (12.5%) PA were clinically and hormonally silent. Three of these showed intense nuclear T-Pit positivity, classifying them under silent corticotroph adenoma. Lineage of the remaining eight adenomas remained undetermined, since, IHC for Pit-1 and SF-1 was not performed. The aggressive adenomas identified by IHC included sparsely granulated somatotroph adenoma, Crooke cell adenoma, silent corticotroph adenoma, densely granulated lactotroph adenoma in men and constituted 17% of the PA. Four (4/88) cases were clinically invasive.
    Conclusion: A large majority of PA including aggressive adenomas can be identified by IHC. Addition of T-Pit helped to identify silent corticotroph adenoma. Pit -1 and SF-1 TF would help identify plurihormonal Pit-1 PA and null cell adenomas.
    MeSH term(s) Male ; Humans ; Pituitary Neoplasms/diagnosis ; ACTH-Secreting Pituitary Adenoma ; Adenoma/diagnosis ; Hormones ; Organic Chemicals
    Chemical Substances OMS 2017 ; Hormones ; Organic Chemicals
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/neuroindia.NI_913_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 698: Show issues Location:
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  9. Article: Integrated multiplexed assays of variant effect reveal

    Hoskins, Ian / Rao, Shilpa / Tante, Charisma / Cenik, Can

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expression in ... ...

    Abstract Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expression in coding sequences. Here, we pioneered a multiplexed assay based on polysome profiling to measure variant effects on translation at scale, uncovering single-nucleotide variants that increase and decrease ribosome load. By combining high-throughput ribosome load data with multiplexed mRNA and protein abundance readouts, we mapped the
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.02.551517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A review of adult-type diffuse gliomas in the WHO CNS5 classification with special reference to Astrocytoma, IDH-mutant and Oligodendroglioma, IDH-mutant and 1p/19q codeleted.

    Santosh, Vani / Rao, Shilpa

    Indian journal of pathology & microbiology

    2022  Volume 65, Issue Supplement, Page(s) S14–S23

    Abstract: The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) features several changes in the classification, diagnostic criteria, nomenclature, and grading of diffuse gliomas. Adult-type ... ...

    Abstract The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) features several changes in the classification, diagnostic criteria, nomenclature, and grading of diffuse gliomas. Adult-type diffuse gliomas are genetically defined and include astrocytoma, isocitrate dehydrogenase (IDH)-mutant, oligodendroglioma, IDH-mutant and 1p/19q codeleted, and glioblastoma, IDH-wildtype. This review briefly discusses two tumor types: astrocytoma, IDH-mutant, and oligodendroglioma, IDH-mutant and 1p/19q codeleted, with emphasis on relevant changes in their classification and defining molecular genetic alterations. A simplified approach to the diagnosis of these tumors is provided.
    MeSH term(s) Adult ; Astrocytoma/diagnosis ; Astrocytoma/genetics ; Astrocytoma/pathology ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Glioma/diagnosis ; Glioma/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Mutation ; Oligodendroglioma/diagnosis ; Oligodendroglioma/genetics ; Oligodendroglioma/pathology ; World Health Organization
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2022-05-13
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_34_22
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