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  1. Article: Authors' Response.

    Bountziouka, Vasiliki / Nelson, Christopher P / Codd, Veryan / Samani, Nilesh J

    Journal of the Academy of Nutrition and Dietetics

    2023  Volume 124, Issue 2, Page(s) 166–167

    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2646718-5
    ISSN 2212-2672
    ISSN 2212-2672
    DOI 10.1016/j.jand.2023.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2828: Show issues

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  2. Article ; Online: Meetings - An American viewpoint.

    Cooper, Christopher S / Nelson, Caleb P

    Journal of pediatric urology

    2020  Volume 16, Issue 3, Page(s) 275

    MeSH term(s) Congresses as Topic ; Humans ; Societies, Medical ; United States
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2020.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6387: Show issues Location:
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  3. Article ; Online: Notes from the Field: Cluster of Severe Illness from Neptune's Fix Tianeptine Linked to Synthetic Cannabinoids - New Jersey, June-November 2023.

    Counts, Christopher J / Spadaro, Anthony V / Cerbini, Trevor A / Krotulski, Alex J / Greller, Howard A / Nelson, Lewis S / Ruck, Bruce E / Calello, Diane P

    MMWR. Morbidity and mortality weekly report

    2024  Volume 73, Issue 4, Page(s) 89–90

    MeSH term(s) Humans ; Neptune ; New Jersey/epidemiology ; Thiazepines ; Cannabinoids
    Chemical Substances tianeptine (0T493YFU8O) ; Thiazepines ; Cannabinoids
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7304a5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1827: Show issues Location:
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  4. Article ; Online: Large-Scale Analysis of the Association between Air Pollutants and Leucocyte Telomere Length in the UK Biobank.

    Bountziouka, Vasiliki / Hansell, Anna L / Nelson, Christopher P / Codd, Veryan / Samani, Nilesh J

    Environmental health perspectives

    2023  Volume 131, Issue 2, Page(s) 27701

    MeSH term(s) Air Pollutants ; Biological Specimen Banks ; Telomere ; United Kingdom ; Leukocytes
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP11745
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    Zs.B 1360: Show issues Location:
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    Zs.MO 379: Show issues

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  5. Article ; Online: Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp

    Okolo, Ephraim A / Pahl, Axel / Sievers, Sonja / Pask, Christopher M / Nelson, Adam / Marsden, Stephen P

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 26, Page(s) e202203992

    Abstract: A 'top down' scaffold remodelling approach to library synthesis was applied to spirotricyclic ureas prepared by a complexity-generating oxidative dearomatisation. Eighteen structurally-distinct, ... ...

    Abstract A 'top down' scaffold remodelling approach to library synthesis was applied to spirotricyclic ureas prepared by a complexity-generating oxidative dearomatisation. Eighteen structurally-distinct, sp
    MeSH term(s) Small Molecule Libraries/chemistry ; Gene Library
    Chemical Substances Small Molecule Libraries
    Language English
    Publishing date 2023-03-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203992
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  6. Article ; Online: Genetic determinants of telomere length and cancer risk.

    Nelson, Christopher P / Codd, Veryan

    Current opinion in genetics & development

    2020  Volume 60, Page(s) 63–68

    Abstract: The relationship of telomere length with cancer risk has been the source of much debate within epidemiological studies, which have produced inconsistent finding both between and within different cancer types. Over recent years, genome-wide association ... ...

    Abstract The relationship of telomere length with cancer risk has been the source of much debate within epidemiological studies, which have produced inconsistent finding both between and within different cancer types. Over recent years, genome-wide association studies of increasing size have identified variants that determine human telomere length. These variants have subsequently been utilised as instrumental variables in Mendelian randomisation based studies, allowing the investigation of potential causal relationships between telomere length and cancer. Here we discuss recent advances in both genomic discovery, studies that give increasing evidence towards a causal role for telomere length in cancer risk and considerations for future studies.
    MeSH term(s) Biomarkers, Tumor/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Polymorphism, Single Nucleotide ; Risk Factors ; Telomere ; Telomere Homeostasis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2020.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3240: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres.

    Lu, Robert / Nelson, Christopher B / Rogers, Samuel / Cesare, Anthony J / Sobinoff, Alexander P / Pickett, Hilda A

    iScience

    2023  Volume 27, Issue 1, Page(s) 108655

    Abstract: Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length. One of the defining features of ALT cells is the prevalence of extrachromosomal telomeric repeat ...

    Abstract Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length. One of the defining features of ALT cells is the prevalence of extrachromosomal telomeric repeat (ECTR) DNA. Here, we identify that ALT cells engage in two modes of telomere synthesis. Non-productive telomere synthesis occurs during the G2 phase of the cell cycle and is characterized by newly synthesized internal telomeric regions that are not retained in the subsequent G1, coinciding with an induction of ECTR DNA. Productive telomere synthesis occurs specifically during the transition from G2 to mitosis and is defined as the extension of the telomere termini. While many proteins associated with break-induced telomere synthesis function in both non-productive and productive telomere synthesis, POLH specifically promotes productive telomere lengthening and suppresses non-productive telomere synthesis. These findings delineate the mechanism and cell cycle regulation of ALT-mediated telomere synthesis and extension.
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108655
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  8. Article ; Online: Product Formulation Controls the Impact of Biofouling on Consumer Plastic Photochemical Fate in the Ocean.

    Nelson, Taylor F / Reddy, Christopher M / Ward, Collin P

    Environmental science & technology

    2021  Volume 55, Issue 13, Page(s) 8898–8907

    Abstract: The photodegradation rates of floating marine plastics govern their environmental lifetimes, but the controls on this process remain poorly understood. Photodegradation of these materials has so far been studied under ideal conditions in the absence of ... ...

    Abstract The photodegradation rates of floating marine plastics govern their environmental lifetimes, but the controls on this process remain poorly understood. Photodegradation of these materials has so far been studied under ideal conditions in the absence of environmental factors such as biofouling, which may slow photochemical transformation rates through light screening. To investigate this interaction, we incubated different plastics in continuous flow seawater mesocosms to follow (i) the extent of biofilm growth on the samples and (ii) decreases in light transmittance through the samples over time. We used consumer products with high relevance (e.g., shopping bags, water bottles, and packaging materials) and with different formulations, referring to primary polymers (polyethylene (PE) and polyethylene terephthalate (PET)) and inorganic additives (titanium dioxide (TiO
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.1c02079
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  9. Article: Dietary Patterns and Practices and Leucocyte Telomere Length: Findings from the UK Biobank.

    Bountziouka, Vasiliki / Nelson, Christopher P / Wang, Qingning / Musicha, Crispin / Codd, Veryan / Samani, Nilesh J

    Journal of the Academy of Nutrition and Dietetics

    2023  Volume 123, Issue 6, Page(s) 912–922.e26

    Abstract: ... to the pattern (both P values < 0.05). Conversely, a reversed association between quintile of the "Meat" pattern ... and LTL was observed, with z-LTL being on average shorter by 0.025 SD (P = 6.12×10: Conclusions ...

    Abstract Background: Shorter telomere length (TL) is associated with risk of several age-related diseases and decreased life span, but the extent to which dietary patterns and practices associate with TL is uncertain.
    Objective: This study aimed to investigate the association of dietary patterns and practices and leucocyte TL (LTL).
    Design: This was a cross-sectional study.
    Participants and setting: Data collected voluntarily from up to 422,797 UK Biobank participants, during 2006-2010.
    Main outcome measures: LTL was measured as a ratio of the telomere repeat number to a single-copy gene and was log
    Statistical analyses performed: Adherence a priori to a Mediterranean-style diet was assessed through the MedDietScore. Principal component analysis was used to a posteriori extract the "Meat" and "Prudent" dietary patterns. Additional dietary practices considered were the self-reported adherence to "Vegetarian" diet, "Eating 5-a-day of fruit and vegetables" and "Abstaining from eggs/dairy/wheat/sugar." Associations between quintiles of dietary patterns or adherence to dietary practices with z-LTL were investigated through multivariable linear regression models (adjusted for demographic, lifestyle, and clinical characteristics).
    Results: Adherence to the "Mediterranean" and the "Prudent" patterns, was positively associated with LTL, with an effect magnitude in z-LTL of 0.020 SD and 0.014 SD, respectively, for the highest vs the lowest quintile of adherence to the pattern (both P values < 0.05). Conversely, a reversed association between quintile of the "Meat" pattern and LTL was observed, with z-LTL being on average shorter by 0.025 SD (P = 6.12×10
    Conclusions: Several dietary patterns and practices associated with beneficial health effects are significantly associated with longer LTL. However, the magnitude of the association was small, and any clinical relevance is uncertain.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Biological Specimen Banks ; Diet, Mediterranean ; Telomere ; United Kingdom
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2646718-5
    ISSN 2212-2672
    ISSN 2212-2672
    DOI 10.1016/j.jand.2023.01.008
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Toward Anticipatory Governance of Human Genome Editing: A Critical Review of Scholarly Governance Discourse.

    Nelson, John P / Selin, Cynthia L / Scott, Christopher T

    Journal of responsible innovation

    2021  Volume 8, Issue 3, Page(s) 382–420

    Abstract: The rapid development of human genome editing (HGE) techniques evokes an urgent need for forward-looking deliberation regarding the aims, processes, and governance of research. The framework of anticipatory governance (AG) may serve this need. This ... ...

    Abstract The rapid development of human genome editing (HGE) techniques evokes an urgent need for forward-looking deliberation regarding the aims, processes, and governance of research. The framework of anticipatory governance (AG) may serve this need. This article reviews scholarly discourse about HGE through an AG lens, aiming to identify gaps in discussion and practice and suggest how AG efforts may fill them. Discourse on HGE has insufficiently reckoned with the institutional and systemic contexts, inputs, and implications of HGE work, to the detriment of its ability to prepare for a variety of possible futures and pursue socially desirable ones. More broadly framed and inclusive efforts in foresight and public engagement, focused not only upon the in-principle permissibility of HGE activities but upon the contexts of such work, may permit improved identification of public values relevant to HGE and of actions by which researchers, funders, policymakers, and publics may promote them.
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2755439-9
    ISSN 2329-9037 ; 2329-9037
    ISSN (online) 2329-9037
    ISSN 2329-9037
    DOI 10.1080/23299460.2021.1957579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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