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Article: The Evaluation of Winter Wheat Adaptation to Climate Change in the Central Non-Black Region of Russia: Study of the Gene Pool Resistance of Wheat from the N.I. Vavilov Institute of Plant Industry (VIR) World Collection to Abiotic Stress Factors.

Temirbekova, Sulukhan K / Kulikov, Ivan M / Afanasyeva, Yuliya V / Beloshapkina, Olga O / Kalashnikova, Elena A / Kirakosyan, Rima N / Dokukin, Peter A / Kucher, Dmitry E / Latati, Mourad / Rebouh, Nazih Y

Plants (Basel, Switzerland)

2021 Volume 10, Issue 11

Abstract: ... from the world's largest wheat collection of N.I. Vavilov Institute of Plant Industry (VIR) to investigate ... of a wheat ideotype as postulated by N.I. Vavilov in 1935. The critical years in studying the wheat's winter ...

Abstract	The paper presents the results of a 50-year research of the genepool of the winter wheat from the world's largest wheat collection of N.I. Vavilov Institute of Plant Industry (VIR) to investigate its resistance to the abiotic stress factors of the Moscow region and see how closely it matches the attributes of a wheat ideotype as postulated by N.I. Vavilov in 1935. The critical years in studying the wheat's winter resistance were 10 years out of 50: excessive water saturation during the year 2013; soil drought in 1988; and atmospheric drought in 1972 and 2010. During the investigation, the following gene pool features were analyzed: frost characterized by the cultivar Sojuz 50 (Russia), rapid temperature change, thawing, ice, and rotting resistance characterized by the cultivars Zarya 2 (Russia), Sv 75268, (Sweden), Caristerm and Tukan (Germany), PP 114-74 and Liwilla (Poland), Maris Ploughman and Granta (Great Britain), Titan (USA), Zdar (Czech), and Zenta (Switzerland); regeneration capacity in spring after poor wintering expressed by the cultivars Pamyati Fedina (Russia), TAW 3668.71 (Germany) and Rmo (Poland); resistance to excessive soil and air saturation exhibited by the cultivars Moskovskaya 39 (Russia), Tukan, Compal, Obelisk, Orestis, and Bussard (Germany); solid standing culm that is resistant to lodging characterized by the cultivars Tukan, Kronjuwel, Compal (Germany), Zenta (Switzerland), Moskovskaya 56 (Russia), and Hvede Sarah (Denmark); resistance to enzyme-mycotic depletion of seeds characterized by the cultivars Tukan, Compal, Obelisk, Orestis, Bussard (Germany), Sv 75268, Helge, VG 73394, Salut, Sv 75355 (Sweden), Zenta (Switzerland), Moskovskaya 39, and Ferrugineum 737.76 (Russia); and resistance to soil and atmospheric drought demonstrated by the cultivars Liessau, Heine Stamm, Severin, Neuzucht 14/4, Haynes, Rus 991, Halle 1020 (Germany), Gama (Poland), Sv 71536 (Sweden), and Moskovskaya 39 (Russia). Moreover, the cultivar Mironovskaya 808 (Ukraine) showed resistance to almost all abiotic stress factors studied. The performed study contributes towards the provision of potential sources of resistance to abiotic stress factors prevalent in the Moscow region that can be incorporated in advanced breeding programs.
Language	English
Publishing date	2021-10-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10112337
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Article: The Evaluation of Winter Wheat Adaptation to Climate Change in the Central Non-Black Region of Russia: Study of the Gene Pool Resistance of Wheat from the N.I. Vavilov Institute of Plant Industry (VIR) World Collection to Abiotic Stress Factors

Temirbekova, Sulukhan K. / Kulikov, Ivan M. / Afanasyeva, Yuliya V. / Beloshapkina, Olga O. / Kalashnikova, Elena A. / Kirakosyan, Rima N. / Dokukin, Peter A. / Kucher, Dmitry E. / Latati, Mourad / Rebouh, Nazih Y.

Plants. 2021 Oct. 29, v. 10, no. 11

2021

Abstract: ... from the world’s largest wheat collection of N.I. Vavilov Institute of Plant Industry (VIR) to investigate ... of a wheat ideotype as postulated by N.I. Vavilov in 1935. The critical years in studying the wheat’s winter ...

Abstract	The paper presents the results of a 50-year research of the genepool of the winter wheat from the world’s largest wheat collection of N.I. Vavilov Institute of Plant Industry (VIR) to investigate its resistance to the abiotic stress factors of the Moscow region and see how closely it matches the attributes of a wheat ideotype as postulated by N.I. Vavilov in 1935. The critical years in studying the wheat’s winter resistance were 10 years out of 50: excessive water saturation during the year 2013; soil drought in 1988; and atmospheric drought in 1972 and 2010. During the investigation, the following gene pool features were analyzed: frost characterized by the cultivar Sojuz 50 (Russia), rapid temperature change, thawing, ice, and rotting resistance characterized by the cultivars Zarya 2 (Russia), Sv 75268, (Sweden), Caristerm and Tukan (Germany), PP 114-74 and Liwilla (Poland), Maris Ploughman and Granta (Great Britain), Titan (USA), Zdar (Czech), and Zenta (Switzerland); regeneration capacity in spring after poor wintering expressed by the cultivars Pamyati Fedina (Russia), TAW 3668.71 (Germany) and Rmo (Poland); resistance to excessive soil and air saturation exhibited by the cultivars Moskovskaya 39 (Russia), Tukan, Compal, Obelisk, Orestis, and Bussard (Germany); solid standing culm that is resistant to lodging characterized by the cultivars Tukan, Kronjuwel, Compal (Germany), Zenta (Switzerland), Moskovskaya 56 (Russia), and Hvede Sarah (Denmark); resistance to enzyme-mycotic depletion of seeds characterized by the cultivars Tukan, Compal, Obelisk, Orestis, Bussard (Germany), Sv 75268, Helge, VG 73394, Salut, Sv 75355 (Sweden), Zenta (Switzerland), Moskovskaya 39, and Ferrugineum 737.76 (Russia); and resistance to soil and atmospheric drought demonstrated by the cultivars Liessau, Heine Stamm, Severin, Neuzucht 14/4, Haynes, Rus 991, Halle 1020 (Germany), Gama (Poland), Sv 71536 (Sweden), and Moskovskaya 39 (Russia). Moreover, the cultivar Mironovskaya 808 (Ukraine) showed resistance to almost all abiotic stress factors studied. The performed study contributes towards the provision of potential sources of resistance to abiotic stress factors prevalent in the Moscow region that can be incorporated in advanced breeding programs.
Keywords	Russia ; abiotic stress ; air ; climate change ; culms ; cultivars ; drought ; frost ; gene pool ; ice ; ideotypes ; soil ; spring ; temperature ; winter wheat ; Denmark ; Germany ; Great Britain ; Poland ; Sweden ; Switzerland ; Ukraine
Language	English
Dates of publication	2021-1029
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10112337
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Formation of neutral In(m)C(n) clusters under C60 ion bombardment of indium.

Breuer, Lars / Kucher, Andrew / Herder, Matthias / Wucher, Andreas / Winograd, Nicholas

The journal of physical chemistry. A

2014 Volume 118, Issue 37, Page(s) 8542–8552

Abstract: ... The resulting size distributions of neutral In(m)C(n) clusters are compared with those of the corresponding ...

Abstract	The formation of neutral gas phase indium carbide clusters under C60(+) ion bombardment of solid indium was investigated using laser based postionization prior to mass spectrometric detection. Two different postionization methods were used and shown to provide saturated photoionization efficiency, thereby delivering nearly the same information about the composition of the sputtered material. The resulting size distributions of neutral In(m)C(n) clusters are compared with those of the corresponding cationic secondary cluster ions and discussed in terms of calculated cluster properties. Investigating the dependence on C60(+) ion fluence, we demonstrate that clusters containing only one carbon atom are formed in single impact events, whereas the formation of more carbon-rich clusters results from carbon accumulation at the bombarded surface.
Language	English
Publishing date	2014-09-18
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp5024247
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Article: [Regulatory Potential of SNP Markers in Genes of DNA Repair Systems].

Babushkina, N P / Kucher, A N

Molekuliarnaia biologiia

2023 Volume 57, Issue 1, Page(s) 24–46

Abstract: A broad range of SNP markers associated with diseases and pathogenically significant features were identified in noncoding regions of the human genome. The mechanisms that underlie their associations are a pressing problem. A number of associations was ... ...

Abstract	A broad range of SNP markers associated with diseases and pathogenically significant features were identified in noncoding regions of the human genome. The mechanisms that underlie their associations are a pressing problem. A number of associations was previously observed between polymorphic variants of DNA repair proteins genes and common diseases. To clarify the possible mechanisms of the associations, a detailed annotation of the regulatory potential of the markers was carried out using online resources (GTX-Portal, VannoPortal, Ensemble, RegulomeDB, Polympact, UCSC, GnomAD, ENCODE, GeneHancer, EpiMap Epigenomics 2021, HaploReg, GWAS4D, JASPAR, ORegAnno, DisGeNet, and OMIM). The review characterizes the regulatory potential for the polymorphisms rs560191 (of the TP53BP1 gene), rs1805800, rs709816 (NBN), rs473297 (MRE11), rs189037, rs1801516 (ATM), rs1799977 (MLH1), rs1805321 (PMS2), and rs20579 (LIG1). General characteristics of the markers are considered, and data are summarized to describe their influence on expression of their own and co-regulated genes and binding affinity of transcription factors. The review additionally considers the data on adaptogenic and pathogenic potentials of the SNPs and co-localized histone modifications. A possible involvement in regulating the functions of both their own and nearby genes may explain the associations of the SNPs with diseases and their clinical phenotypes.
MeSH term(s)	Humans ; Polymorphism, Single Nucleotide ; DNA Repair/genetics ; Transcription Factors/genetics ; Genome, Human
Chemical Substances	Transcription Factors
Language	Russian
Publishing date	2023-03-28
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	213542-5
ISSN	0026-8984
ISSN	0026-8984
DOI	10.31857/S0026898423010032
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Article ; Online: FIGURATIVE THEORY BY N.ELIAS IN CONTEMPORARY SOCIOLOGICAL DISCOURSE

Kucher Galina Olegovna

Sovremennye Issledovaniâ Socialʹnyh Problem, Iss

2013 Volume 2

Abstract: This paper presents the figurative theory under German sociologist N.Elias - one of the first ... synthetic sociological theories. With the concept of "figuration" of N.Elias there was performed synthesis ... The purpose of this article is to show the impact of sociology of N.Elias on modern sociological theories ...

Abstract	This paper presents the figurative theory under German sociologist N.Elias - one of the first synthetic sociological theories. With the concept of "figuration" of N.Elias there was performed synthesis of micro and macro approaches in sociology, which is distinctive for present sociological discourse. The purpose of this article is to show the impact of sociology of N.Elias on modern sociological theories, to detect complex connection with other synthetic theories. The comparison of key theoretical concepts of figurative sociology and structuration theory ("figuration" and "structuration", "affects" and "unconscious", "habit" and "routinization") supports system-influenced by the work of Elias on the formation of the initial theoretical premise by A.Giddens. However comparison of figurative and dramatic sociology shows more parallelism of theoretical constructs by N.Elias and I.Hoffmann. Both authors are working on stories of etiquette rules, rituals and ceremonies, but use different perspectives (diachronic or synchronic), the different interpretations of continuous changes (as the interaction inside and between figurations or as a chain effect or a trace of the events), focusing on the analysis of the influence changes at different levels (social structures or structures of individual experience). These comparisons make it possible to estimate theoretical potential of the basic concepts of sociology figurative, the possibility of their use of context proposed by Elias, particularly in synchronic perspective but for the social structures.
Keywords	Social Sciences ; H
Subject code	300
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Science and Innovation Center Publishing House
Document type	Article ; Online
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Article: BIOMECHANICAL COMPARISON OF THREE POSTERIOR MALLEOLUS FRACTURE FIXATION METHODS IN RELATION TO DIFFERENT FRACTURE MORPHOLOGY: A FINITE ELEMENT ANALYSIS.

Kucher, I / Liabakh, A

Georgian medical news

2023 , Issue 338, Page(s) 33–40

Abstract: ... under vertical loading 700 N. PP showed the highest level of VMS in the elements of the metal implants ...

Abstract	The objective of this study was to compare the biomechanical behavior of three fixation methods for posterior malleolar fracture (PMF) in relation to different fracture morphology and to evaluate the corresponding changes of the stress distribution on the articular surface of the tibia plafond by finite element analysis (FEA). Three internal fixation techniques: two lag screws in antero-posterior direction (AP lag screws), two lag screws in postero-anterior direction (PA lag screws) and posterior plate (PP) were analyzed for posteromedial (PM) and posterolateral (PL) fragment of PMF using the FEA. The values of relative deformations, total displacements, and von Mises stress (VMS) in the model elements were estimated under vertical loading 700 N. PP showed the highest level of VMS in the elements of the metal implants (from 97.1 to 106.15 MPa), than PA (44.77 MPa and 39.2 MPa) and AP (23.99 MPa and 25.53 MPa) lag screws group, regardless morphology of PMF. The presence of the PM and PL fragment of PMF causes displacement contact stress distribution to the anterior part of the tibia plafond surface. PP is biomechanically the most efficient technique for the fixation of PMF regardless of the fragment morphology. The distribution of loads on the articular surface of the tibia plateau depends on the morphology of the injury and the type of osteosynthesis of the PMF.
MeSH term(s)	Humans ; Ankle Fractures/diagnostic imaging ; Ankle Fractures/surgery ; Finite Element Analysis ; Bone Screws ; Biomechanical Phenomena ; Fracture Fixation, Internal/methods
Language	English
Publishing date	2023-07-05
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
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Article ; Online: Pathogenetic Significance of Long Non-Coding RNAs in the Development of Thoracic and Abdominal Aortic Aneurysms.

Kucher, Aksana N / Koroleva, Iuliia A / Nazarenko, Maria S

Biochemistry. Biokhimiia

2023 Volume 89, Issue 1, Page(s) 130–147

Abstract: Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. ... ...

Abstract	Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. Within less than a decade of studies on the role of lncRNAs in AA, using experimental and bioinformatic approaches, scientists have obtained the data confirming the involvement of these molecules in metabolic pathways and pathogenetic mechanisms critical for the aneurysm development. Regardless of the location of pathological process (thoracic or abdominal aorta), AA was found to be associated with changes in the expression of various lncRNAs in the tissue of the affected vessels. The consistency of changes in the expression level of lncRNA, mRNA and microRNA in aortic tissues during AA development has been recordedand regulatory networks implicated in the AA pathogenesis in which lncRNAs act as competing endogenous RNAs (ceRNA networks) have been identified. It was found that the same lncRNA can be involved in different ceRNA networks and regulate different biochemical and cellular events; on the other hand, the same pathological process can be controlled by different lncRNAs. Despite some similarities in pathogenesis and overlapping of involved lncRNAs, the ceRNA networks described for abdominal and thoracic AA are different. Interactions between lncRNAs and other molecules, including those participating in epigenetic processes, have also been identified as potentially relevant to the AA pathogenesis. The expression levels of some lncRNAs were found to correlate with clinically significant aortic features and biochemical parameters. Identification of regulatory RNAs functionally significant in the aneurysm development is important for clarification of disease pathogenesis and will provide a basis for early diagnostics and development of new preventive and therapeutic drugs.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Aortic Aneurysm, Abdominal/genetics ; RNA, Messenger/metabolism ; RNA, Competitive Endogenous
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; RNA, Messenger ; RNA, Competitive Endogenous
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297924010085
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Article: The FTO Gene and Diseases: The Role of Genetic Polymorphism, Epigenetic Modifications, and Environmental Factors

Kucher, A. N

Russian journal of genetics. 2020 Sept., v. 56, no. 9

2020

Abstract: The review provides information on the function of the FTO gene (known as the fat mass and obesity-associated gene) and the encoded enzyme, on the functional role of single nucleotide polymorphisms (SNPs) in coding and noncoding gene regions and the ... ...

Abstract	The review provides information on the function of the FTO gene (known as the fat mass and obesity-associated gene) and the encoded enzyme, on the functional role of single nucleotide polymorphisms (SNPs) in coding and noncoding gene regions and the range of their competences, and on association of the FTO polymorphisms with diseases and traits. Factors that have modifying effect on the contribution of polymorphisms to the risk of disease development and trait variability are discussed. The FTO gene encodes alpha-ketoglutarate-dependent dioxygenase, which has a wide range of competences (including demethylation of RNA and single-stranded DNA), which are important for the functioning of the body. Nonsynonymous substitutions in the FTO gene lead to the development of orphan autosomal recessive disease (OMIM 612938). In the FTO noncoding regions, a wide range of variants has been detected, including those of regulatory importance (eQTL, sQTL, etc.). The competence of these variants extends to both FTO and neighboring genes (IRX3, IRX5, RPGRIP1L). Intronic polymorphisms of the FTO gene have been found to be associated with a wide range of multifactorial diseases and traits (obesity and related anthropometric traits, lipid metabolism markers, diabetes mellitus (type 2), coronary heart disease, metabolic syndrome, and other diseases). In the overwhelming majority of studies, the same allele variants are classified as risk ones; however, previously established associations of the FTO polymorphisms with diseases (traits) are demonstrated not in all populations. It is demonstrated that the effects of the FTO gene SNPs can be modified by exogenous and endogenous environmental factors, as well as lifestyle (including the type of diet, consumption of certain nutrients and medications, physical activity, etc.). Epigenetic factors (DNA methylation at CpG sites) are also important for regulating the level of FTO expression and the effects of individual SNPs. The accumulated data on the FTO structure and function, as well as the functional role of the encoded enzyme, make this gene attractive from the point of view of developing personalized approaches to healthcare.
Keywords	DNA methylation ; RNA ; alleles ; coronary disease ; demethylation ; diabetes mellitus ; diet ; enzymes ; epigenetics ; health services ; lifestyle ; lipid metabolism ; metabolic syndrome ; obesity ; physical activity ; risk ; single-stranded DNA
Language	English
Dates of publication	2020-09
Size	p. 1025-1043.
Publishing place	Pleiades Publishing
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1195858-3
ISSN	1608-3369 ; 1022-7954
ISSN (online)	1608-3369
ISSN	1022-7954
DOI	10.1134/S1022795420090136
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Article: PRE-SURGICAL DIAGNOSTIC PARALLELS IN BASAL CELL CARCINOMA OF THE SKIN.

Zaychenko, Y / Kucher, A / Mota, I / Kiladze, N

Georgian medical news

2022 , Issue 322, Page(s) 90–94

Abstract: The aim of the study was to determine the basic dermatoscopic principles for diagnosis of nonpigmented basal cell carcinoma in young patients, to analyze the volume of preoperative high-resolution ultrasound, to compare indicators and to justify the ... ...

Abstract	The aim of the study was to determine the basic dermatoscopic principles for diagnosis of nonpigmented basal cell carcinoma in young patients, to analyze the volume of preoperative high-resolution ultrasound, to compare indicators and to justify the expediency of using a double diagnostic test "Dermatoscopy + ultrasound" to determine the indications for surgery. The paper presents 15 cases of basal cell carcinoma in young patients, all cases studied by dermatoscopy (Kittler's algorithm) and high-frequency ultrasonography. In cases of the superficial type of BCC, hypoechoic formations with uneven growth in the dermis to a depth of 0.5-0.8 mm with a uniform structure and enhanced vascularization were observed. Dermatoscopically, this variety is characterized by a varied pattern of vessels - serpentine, branched, monomorphic. Erosive surfaces are represented by structureless areas. Irregular white lines, perpendicular in places, are also characteristic. In the nodular form, the lesions were hypoechoic, with clear, even symmetrical contours, regular oval or round shape, with a germination depth of 1.3-1.5 mm. When measuring blood flow, increased vascularization was observed. Dermatoscopically was fixed monomorphic branched vascular pattern, structureless areas and serpentine white lines Both ultrasound and dermatoscopic indices fully confirm the diagnosis of basal cell carcinomas, establish penetration depth, the documented dimensions make possible to resolve the issue of optimal surgical intervention.
MeSH term(s)	Carcinoma, Basal Cell/diagnostic imaging ; Carcinoma, Basal Cell/surgery ; Dermoscopy ; Humans ; Neovascularization, Pathologic ; Skin Neoplasms/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2022-02-05
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
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Article ; Online: Neurogenic inflammation

A. N. Kucher

Бюллетень сибирской медицины, Vol 19, Iss 2, Pp 171-

biochemical markers, genetic control and diseases

2020 Volume 181

Abstract: Neurogenic inflammation is a pathological process based on bidirectional interactions between cells of the nervous and immune systems as well as on a wide range of biologically active substances.Aim. Basing on scientific publications and information ... ...

Abstract	Neurogenic inflammation is a pathological process based on bidirectional interactions between cells of the nervous and immune systems as well as on a wide range of biologically active substances.Aim. Basing on scientific publications and information provided in databases, to analyze markers of neurogenic inflammation (biochemical, genetic) and characterize their involvement in the pathogenesis of diseases of various organ systems.Results. Neurogenic inflammation that occurs during the development of various diseases (asthma, urticaria, atopic dermatitis, psoriasis, rheumatoid arthritis, pain syndrome, interstitial cystitis, colitis, etc.) is characterized by common stages and pathophysiologically active substances. Mediators released by nerve cells (substance P, calcitonin gene-related peptide, vasoactive peptide), acting on specific receptors, contribute to mast cell degranulation with the release of a complex of biologically active substances (histamine, tryptase, nerve growth factor, etc.), which activate inflammatory processes. Biologically active substances and receptors significant for the development of neurogenic inflammation are under genetic control. At the same time, there are overlaps of the spectrum of diseases for which importance in the pathogenesis of neurogenic inflammation is proved and an association between variants of neurogenic inflammation genes. This makes it possible to conclude that the course of neurogenic inflammation will depend not only on the etiological factors, but also on the genetic features of key molecules involved in neurogenic inflammation processes. The similarity of the pathogenetic links of neurogenic inflammation (at the genetic and biochemical levels) in various pathologies may underlie the formation of comorbid conditions.Conclusion. Understanding the biochemical and genetic components of the development of neurogenic inflammation is of interest for prevention and treatment of diseases (including comorbid ones) based on this pathological process.
Keywords	нейрогенное воспаление ; генетика ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Siberian State Medical University (Tomsk)
Document type	Article ; Online
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