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  1. Article: Genetic Engineering Systems to Study Human Viral Pathogens from the Coronaviridae Family.

    Galkin, S O / Anisenko, A N / Shadrina, O A / Gottikh, M B

    Molecular biology

    2022  Volume 56, Issue 1, Page(s) 72–89

    Abstract: The COVID-19 pandemic caused by the previously unknown SARS-CoV- ... ...

    Abstract The COVID-19 pandemic caused by the previously unknown SARS-CoV-2
    Language English
    Publishing date 2022-02-12
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 213541-3
    ISSN 1608-3245 ; 0026-8933
    ISSN (online) 1608-3245
    ISSN 0026-8933
    DOI 10.1134/S0026893322010022
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  2. Article: [Genetic Engineering Systems to Study Human Viral Pathogens from the Coronaviridae Family].

    Galkin, S O / Anisenko, A N / Shadrina, O A / Gottikh, M B

    Molekuliarnaia biologiia

    2022  Volume 56, Issue 1, Page(s) 83–102

    Abstract: The COVID-19 pandemic caused by the previously unknown SARS-CoV-2 Betacoronavirus made it extremely important to develop simple and safe cellular systems which allow manipulation of the viral genome and high-throughput screening of its potential ... ...

    Abstract The COVID-19 pandemic caused by the previously unknown SARS-CoV-2 Betacoronavirus made it extremely important to develop simple and safe cellular systems which allow manipulation of the viral genome and high-throughput screening of its potential inhibitors. In this review, we made an attempt at summarizing the currently existing data on genetic engineering systems used to study not only SARS-CoV-2, but also other viruses from the Coronaviridae family. In addition, the review covers the basic knowledge about the structure and the life cycle of coronaviruses.
    MeSH term(s) COVID-19 ; Coronaviridae/genetics ; Genetic Engineering ; Humans ; Pandemics ; SARS-CoV-2
    Language Russian
    Publishing date 2022-01-27
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 213542-5
    ISSN 0026-8984
    ISSN 0026-8984
    DOI 10.31857/S0026898422010025
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1796: Show issues Location:
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  3. Article: Molekulyarno-geneticheskie osobennosti meningiom.

    Makashova, E S / Lasunin, N V / Galkin, M V / Zolotova, S V / Karandasheva, K O / Golanov, A V

    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

    2023  Volume 87, Issue 4, Page(s) 101–106

    Abstract: Meningioma is the most common primary tumor of the central nervous system. Traditional classification is based on histological properties of tumors and distinguishes different grades of meningioma malignancy. However, knowledge about different molecular ... ...

    Title translation Molecular genetic features of meningiomas.
    Abstract Meningioma is the most common primary tumor of the central nervous system. Traditional classification is based on histological properties of tumors and distinguishes different grades of meningioma malignancy. However, knowledge about different molecular mechanisms of tumor provided new data on genetic features of meningiomas. The authors analyze current available data on the main driver mutations, new classifications based on molecular genetic characteristics and potential targets for therapy.
    MeSH term(s) Humans ; Meningioma/genetics ; Meningioma/therapy ; Meningeal Neoplasms/genetics ; Meningeal Neoplasms/therapy ; Molecular Biology
    Language Russian
    Publishing date 2023-08-31
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 603458-5
    ISSN 0042-8817
    ISSN 0042-8817
    DOI 10.17116/neiro202387041101
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  4. Article: Novaya klassifikatsiya i podkhody k terapii shvannomatozov.

    Makashova, E S / Zolotova, S V / Absalyamova, O V / Galkin, M V / Petrokovskaya, A V / Kozlov, A V / Golanov, A V

    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

    2023  Volume 87, Issue 5, Page(s) 104–109

    Abstract: Schwannomatoses is a new classification unit for all the hereditary diseases caused by chromosome 22 damage followed by multiple benign neoplasms of the peripheral and central nervous system. Schwannomatosis occurs as a result of damage to different ... ...

    Title translation New classification and approaches to the treatment of schwannomatosis.
    Abstract Schwannomatoses is a new classification unit for all the hereditary diseases caused by chromosome 22 damage followed by multiple benign neoplasms of the peripheral and central nervous system. Schwannomatosis occurs as a result of damage to different genes: NF2, SMARCB1, LZRT1, loss of heterozygosity of the long arm of chromosome 22. Nevertheless, clinical manifestations are similar. Molecular diagnostics not only confirms the diagnosis, but also predicts the course of disease. Thus, the most severe clinical manifestations are observed in patients with violation of semantic sequences and reading frame shift in exons 2-13 of the NF2 gene. A more favorable course with less number of tumors is observed in patients with somatic mosaicism. Stereotactic irradiation and surgery are the main treatment options for schwannomatosis. However, there is evidence of effective targeted therapy with bevacizumab (inhibitor of vascular endothelial growth factor). Bevacizumab is used in patients with bilateral vestibular schwannomas and high risk of hearing loss, as well as for intramedullary tumor growth control.
    MeSH term(s) Humans ; Bevacizumab ; Vascular Endothelial Growth Factor A ; Neurilemmoma/genetics ; Neurilemmoma/therapy ; Neurofibromatoses/genetics ; Neurofibromatoses/therapy ; Neurofibromatoses/diagnosis ; Neurofibromatosis 2/genetics ; Neurofibromatosis 2/therapy ; Neurofibromatosis 2/diagnosis
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Vascular Endothelial Growth Factor A
    Language Russian
    Publishing date 2023-10-13
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 603458-5
    ISSN 0042-8817
    ISSN 0042-8817
    DOI 10.17116/neiro202387051104
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  5. Article ; Online: Stromal-vascular fraction of adipose tissue as an alternative source of cellular material for regenerative medicine

    A. S. Sultanova / O. Ya. Bespalova / O. Yu. Galkin

    The Ukrainian Biochemical Journal, Vol 93, Iss 1, Pp 40-

    2021  Volume 50

    Abstract: Adipose tissue is the most convenient source of cellular material for regenerative medicine as it can be obtained in significant quantities via cosmetic liposuction, lipoaspiration of subcutaneous fat or by excision of fat deposits. Adipose tissue ... ...

    Abstract Adipose tissue is the most convenient source of cellular material for regenerative medicine as it can be obtained in significant quantities via cosmetic liposuction, lipoaspiration of subcutaneous fat or by excision of fat deposits. Adipose tissue consists of adipocytes and cells, which are the part of the stromal-vascular fraction (SVF). Different cell populations can be isolated from SVF, among which the population of adipose tissue stem cells (adipose-derived stem cells, ADSC) is especially important for regenerative medicine. SVF can be obtained relatively easily from adipose tissue (adipose tissue is an alternative to bone marrow in terms of being a source of stem cells) and used to treat various pathologies. Recent studies show that SVF not only has a therapeutic effect similar to that of ADSC, but in some cases is even more effective. The article provides the analysis of the main methods of SVF obtainment, characteristics of SVF cellular composition, its potential for use in clinical medicine and its main advantages over other sources of cellular material, including­ ADSC cultured in vitro, for regenerative medicine.
    Keywords stromal-vascular fraction ; adipose-derived stem cells ; adipocytes ; regenerative medicine ; Biochemistry ; QD415-436 ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
    Document type Article ; Online
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  6. Book ; Online: Improved Data Generation for Enhanced Asset Allocation

    Kubiak, Szymon / Weyde, Tillman / Galkin, Oleksandr / Philps, Dan / Gopal, Ram

    A Synthetic Dataset Approach for the Fixed Income Universe

    2023  

    Abstract: We present a novel process for generating synthetic datasets tailored to assess asset allocation methods and construct portfolios within the fixed income universe. Our approach begins by enhancing the CorrGAN model to generate synthetic correlation ... ...

    Abstract We present a novel process for generating synthetic datasets tailored to assess asset allocation methods and construct portfolios within the fixed income universe. Our approach begins by enhancing the CorrGAN model to generate synthetic correlation matrices. Subsequently, we propose an Encoder-Decoder model that samples additional data conditioned on a given correlation matrix. The resulting synthetic dataset facilitates in-depth analyses of asset allocation methods across diverse asset universes. Additionally, we provide a case study that exemplifies the use of the synthetic dataset to improve portfolios constructed within a simulation-based asset allocation process.
    Keywords Quantitative Finance - Statistical Finance ; Computer Science - Machine Learning
    Publishing date 2023-11-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Klinicheskie i neirofiziologicheskie osobennosti pri alkogol'noi zavisimosti i pri ee komorbidnosti s affektivnymi rasstroistvami.

    Galkin, S A / Roshchina, O V / Kisel, N I / Ivanova, S A / Bokhan, N A

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2020  Volume 120, Issue 10, Page(s) 56–59

    Abstract: ... Test (AUDIT), the General clinical impression scale (CGI-s) were used as psychometric tools. The study ...

    Title translation Clinical and electrophysiological parameters of alcohol dependence and its comorbidity with affective disorders.
    Abstract Objective: To identify characteristics of and possible differences in clinical and electroencephalographic parameters in patients with alcohol dependence with- and without comorbid affective disorders.
    Materials and methods: Ninety-five patients, including 74 with an established diagnosis of alcohol dependence and 21 with alcohol dependence and affective disorders, were examined. Duration of alcohol dependence and affective disorder (years), number of hospitalizations and suicidal attempts were analyzed as anamnestic data. Hamilton's anxiety and depression scale (HDRS), the Alcohol Use Disorders Identification Test (AUDIT), the General clinical impression scale (CGI-s) were used as psychometric tools. The study of bioelectric activity of the brain was carried out using a 16-channel encephalograph. The background electroencephalogram was recorded, the values of absolute spectral power and coherence of theta, alpha and beta rhythms were analyzed.
    Results and conclusion: Patients with comorbidity of alcohol dependence and affective disorders have a significantly higher risk of suicidal behavior, a greater frequency of hospitalizations, higher levels of anxiety compared with patients without affective disorders. Electrophysiological data have shown that patients with comorbidity of alcohol dependence and affective disorders have higher values of spectral power of alpha-rhythm in all parts of the cerebral cortex (except for temporal lobes) and beta-rhythm in the occipital cortex, as well as an increase in interhemispheric coherence in all frequency ranges.
    MeSH term(s) Alcoholism/diagnosis ; Alcoholism/epidemiology ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Comorbidity ; Humans ; Mood Disorders/diagnosis ; Mood Disorders/epidemiology ; Suicide, Attempted
    Language Russian
    Publishing date 2020-11-26
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro202012010156
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    Zs.B 746: Show issues Location:
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    Zs.MO 587: Show issues

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  8. Article: O sviazi biosinteza RNK v mitokhondriiakh s biosintezom belka v tsitoplazme kletok pecheni krys

    Galkin, A P / Mitrokhin, Iu I / Todorov, I N

    Doklady Akademii nauk SSSR

    1974  Volume 217, Issue 6, Page(s) 1427–1430

    Title translation Relation of RNA biosynthesis in mitochondria to protein biosynthesis in cytoplasm of rat liver cells.
    MeSH term(s) Animals ; Carbon Radioisotopes ; Cycloheximide/pharmacology ; Cytoplasm/metabolism ; In Vitro Techniques ; Liver/cytology ; Liver/drug effects ; Liver/metabolism ; Mitochondria, Liver/metabolism ; Orotic Acid/metabolism ; Protein Biosynthesis ; Protein Precursors/metabolism ; RNA/biosynthesis ; Rats ; Tritium ; Uracil Nucleotides/metabolism
    Chemical Substances Carbon Radioisotopes ; Protein Precursors ; Uracil Nucleotides ; Tritium (10028-17-8) ; Orotic Acid (61H4T033E5) ; RNA (63231-63-0) ; Cycloheximide (98600C0908)
    Language Russian
    Publishing date 1974-08-01
    Publishing country Russia (Federation)
    Document type Journal Article
    ISSN 0002-3264
    ISSN 0002-3264
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  9. Article ; Online: Feeding Characteristics of Deep-Sea Acorn Worm (Hemichordata, Enteropneusta, Torquaratoridae) from the Bering Sea.

    Ezhova, O V / Trukhan, M A / Lukinykh, A I / Krylova, E M / Galkin, S V / Gebruk, A V / Malakhov, V V

    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections

    2021  Volume 500, Issue 1, Page(s) 149–152

    Abstract: Deep-sea hemichordates Torquaratoridae gen. sp. reach high abundance up to 12 spec. ... ...

    Abstract Deep-sea hemichordates Torquaratoridae gen. sp. reach high abundance up to 12 spec. m
    MeSH term(s) Animals ; Invertebrates ; Phytoplankton ; Seasons
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1256203-8
    ISSN 1608-3105 ; 0012-4966
    ISSN (online) 1608-3105
    ISSN 0012-4966
    DOI 10.1134/S0012496621050033
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  10. Article ; Online: Features of brain activity in alcohol dependence in the task of inhibitory control

    S. A. Galkin / A. G. Peshkovskaya / O. V. Roshchina / N. I. Kisel / S. A. Ivanova / N. A. Bokhan

    Бюллетень сибирской медицины, Vol 19, Iss 4, Pp 38-

    2021  Volume 45

    Abstract: Objective. To study neurophysiological correlates of inhibitory control to determine the features of inhibitionprocesses in alcohol dependence.Materials and methods. 77 patients with alcohol dependence were examined (42 men and 35 women) (F10.2 according ...

    Abstract Objective. To study neurophysiological correlates of inhibitory control to determine the features of inhibitionprocesses in alcohol dependence.Materials and methods. 77 patients with alcohol dependence were examined (42 men and 35 women) (F10.2 according to ICD-10). Patients were examined using a test to assess inhibitory control – Go/No – go. According to the task performance, patients were divided into two groups: group 1 – without inhibitory control impairments, group 2 – with impaired inhibitory control. During execution of test, electroencephalogram recordings were made according to the 10–20 system. The values of spectral power and coherence of θ-, α- and β-rhythms were analyzed. Statistical processing was carried out using nonparametric Mann–Whitney U-test and Wilcoxon W-test.Results. In patients with impaired inhibitory control, there was a decrease in the spectral power of the α-rhythm in the frontal cortex (p = 0.003), whereas in patients without inhibitory control disorders – in the Central cortex (p = 0.036). Patients with impaired inhibitory control responded by increasing β-power to cognitive stimulus in the occipital (p = 0.014), left temporal (p = 0.009) and right temporal (p = 0.008) cortex, while patients without inhibitory control disorders showed an increase in β-power only in the occipital (p = 0.007) and left temporal (p = 0.002) cortex. According to coherence data, patients with impaired inhibitory control have greater involvement of brain structures during the “Go/No – go” test in all frequency ranges.Conclusions. Patients with and without impaired inhibitory control have regional differences in changes in brain bioelectric activity during the “Go/No – go” test.
    Keywords алкогольная зависимость ; ингибиторный контроль ; электроэнцефалография ; диагностика ; Medicine ; R
    Subject code 150 ; 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Siberian State Medical University (Tomsk)
    Document type Article ; Online
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