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Book ; Online ; E-Book: Small fiber neuropathy and related syndromes: pain and neurodegeneration

Hsieh, Sung-Tsang / Praveen, Anand / Gibbons, Christopher H. / Sommer, Claudia

2019

Author's details	Sung-Tsang Hsieh, Anand Praveen, Christopher H. Gibbons, Claudia Sommer editors
Language	English
Size	1 Online-Ressource (xxi, 184 Seiten), Illustrationen
Edition	First edition
Publisher	Springer Nature Singapore
Publishing place	Singapore
Publishing country	Germany
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020045125
ISBN	978-981-13-3546-4 ; 9789811335457 ; 981-13-3546-X ; 9811335451
DOI	10.1007/978-981-13-3546-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Terpenes in

Anand, Uma / Anand, Praveen / Sodergren, Mikael Hans

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: ... Terpenes ... ...

Abstract	Terpenes in
MeSH term(s)	Rats ; Animals ; Capsaicin/pharmacology ; Cannabis/metabolism ; Adenosine Triphosphatases ; Terpenes/pharmacology ; Calcium/metabolism ; Neurons/metabolism ; TRPV Cation Channels ; Ganglia, Spinal/metabolism ; Cells, Cultured
Chemical Substances	Capsaicin (S07O44R1ZM) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Terpenes ; Calcium (SY7Q814VUP) ; TRPV Cation Channels
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216340
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Article ; Online: Phytochemical Molecules Binding with the Proteins of Mycolic Acid Synthesis Pathway of Mycobacterium tuberculosis

Rishabh Gaur / Praveen Kumar Anand

Journal of Molecular Docking, Vol 2, Iss

2022 Volume 2

Abstract: Resistance against anti-tubercular drugs is a significant problem. This elucidates the need for novel drug targets. Altering and targeting the enzymes involved in cell wall synthesis led to fatal damage to the bacterial cell. Mycolic acids are critically ...

Abstract	Resistance against anti-tubercular drugs is a significant problem. This elucidates the need for novel drug targets. Altering and targeting the enzymes involved in cell wall synthesis led to fatal damage to the bacterial cell. Mycolic acids are critically responsible for the virulence of Mycobacterium Tuberculosis. This pathway represents an essential reservoir of novel targets for developing new TB drugs. The study aims to identify phytochemicals with the capacity to bind with enzymes of mycolic acid synthesis pathways. This study shows the interaction between phytochemicals and proteins responsible for mycolic acid synthesis is shown through bioinformatics & molecular docking tools. Docking showed binding affinity between protein molecules of the mycolic acid synthesis pathway and ligand molecules in the study. PKS13 (polyketide synthase) interacts with the ligand beta-amyrin acetate with a vina score of -7.1 Kcal/mol. At the same time, its binding energy with Piperine is -6.8 Kcal/mol. DprE1 (Decaprenylphosphoryl-bet-D-ribose-2-epimerase), the other protein docked with beta-amyrin acetate, showed a vina score of -9.7 Kcal/mol binding energy. Piperine with DprE1 exhibits interaction with a score of -8.3 Kcal/mol. Beta-amyrin acetate is docked with a score of -6.9 Kcal/mol against KasA (Beta-ketoacyl-acyl carrier protein synthase). On the other hand, Piperine with KasA gave a result of -7.0 Kcal/mol. Piperine and Beta-amyrin acetate binds to PKS13, DprE1 & KasA protein/enzymes responsible for mycolic acid biosynthesis.
Keywords	Piperine ; Mycolic acid ; Tuberculosis ; Docking ; β-amyrin acetate ; Pharmacy and materia medica ; RS1-441 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epigenetic Perspective of Immunotherapy for Cancers

Sunita Keshari / Praveen Barrodia / Anand Kamal Singh

Cells, Vol 12, Iss 365, p

2023 Volume 365

Abstract: Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the ...

Abstract	Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the disease, and iRAEs (immune-related adverse effects). The first critical step towards solving these issues is understanding the epigenomic events that play a significant role in the regulation of specific biomolecules in the context of the immune population present in the tumor immune microenvironment (TIME) during various treatments and responses. A prominent advantage of this step is that it would enable researchers to harness the reversibility of epigenetic modifications for their druggability. Therefore, we reviewed the crucial studies in which varying epigenomic events were captured with immuno-oncology set-ups. Finally, we discuss the therapeutic possibilities of their utilization for the betterment of immunotherapy in terms of diagnosis, progression, and cure for cancer patients.
Keywords	cancer ; immunotherapy ; epigenetics ; immune checkpoint drugs ; epigenetic drugs ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recent advancements in the role of histone acetylation dynamics to improve stress responses in plants.

Bajpai, Sanjay Kumar / Nisha / Pandita, Shivali / Bahadur, Anand / Verma, Praveen C

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 413

Abstract: In eukaryotes, transcriptional regulation is determined by the DNA sequence and is facilitated through sophisticated and complex chromatin alterations and histone remodelling. Recent research has shown that the histone acetylation dynamic, an ... ...

Abstract	In eukaryotes, transcriptional regulation is determined by the DNA sequence and is facilitated through sophisticated and complex chromatin alterations and histone remodelling. Recent research has shown that the histone acetylation dynamic, an intermittent and reversible substitution, constitutes a prerequisite for chromatin modification. These changes in chromatin structure modulate genome-wide and specific changes in response to external and internal cues like cell differentiation, development, growth, light temperature, and biotic stresses. Histone acetylation dynamics also control the cell cycle. HATs and HDACs play a critical role in gene expression modulation during plant growth and response to environmental circumstances. It has been well established that HATs and HDACs interact with various distinct transcription factors and chromatin-remodelling proteins (CRPs) involved in the transcriptional regulation of several developmental processes. This review explores recent research on histone acyltransferases and histone deacetylases, mainly focusing on their involvement in plant biotic stress responses. Moreover, we also emphasized the research gaps that must be filled to fully understand the complete function of histone acetylation dynamics during biotic stress responses in plants. A thorough understanding of histone acetylation will make it possible to enhance tolerance against various kinds of stress and decrease yield losses in many crops.
MeSH term(s)	Histones/genetics ; Acetylation ; Plants/genetics ; Protein Processing, Post-Translational ; Chromatin/metabolism ; Histone Acetyltransferases/metabolism
Chemical Substances	Histones ; Chromatin ; Histone Acetyltransferases (EC 2.3.1.48)
Language	English
Publishing date	2024-03-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09300-3
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Article ; Online: Controlling the Morphological Features, Aspect Ratio and Emission Patterns of Supramolecular Copolymers by Restricted Dimensional Growth.

Das, Gourab / Anand, Anjali / Vedhanarayanan, Balaraman / Padmakumar, Akhil / Praveen, Vakayil K / Ajayaghosh, Ayyappanpillai

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 58, Page(s) e202301819

Abstract: One of the bottlenecks associated with supramolecular polymerization of functional π-systems is the spontaneous assembly of monomers leading to one- or two-dimensional (1D or 2D) polymers without control over chain length and optical properties. In the ... ...

Abstract	One of the bottlenecks associated with supramolecular polymerization of functional π-systems is the spontaneous assembly of monomers leading to one- or two-dimensional (1D or 2D) polymers without control over chain length and optical properties. In the case of supramolecular copolymerization of monomers that are structurally too diverse, preferential self-sorting occurs unless they are closely interacting donor-acceptor pairs. Herein, it is established that the spontaneous 1D polymerization of a phenyleneethynylene (PE) derivative and the 2D polymerization of a Bodipy derivative (BODIPY) can be controlled by copolymerizing them in different ratios, leading to unusual spindle-shaped structures with controlled aspect ratio, as evident by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) studies. For example, when the content of BODIPY is 50 % in the BODIPY-PE mixture, the 1D polymerization of PE is significantly restricted to form elongated spindle-like structures having an aspect ratio of 4-6. The addition of 75 % of BODIPY to PE resulted in circular spindles having an aspect ratio of 1-2.5, thereby completely restricting the 1D polymerization of PE monomers. Moreover, the resultant supramolecular copolymers exhibited morphology and aspect ratio dependent emission features as observed by the time-resolved emission studies.
Language	English
Publishing date	2023-09-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301819
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Article ; Online: Capsaicin 8% patch Qutenza and other current treatments for neuropathic pain in chemotherapy-induced peripheral neuropathy (CIPN).

Privitera, Rosario / Anand, Praveen

Current opinion in supportive and palliative care

2021 Volume 15, Issue 2, Page(s) 125–131

Abstract: Purpose of review: Current oral treatments for neuropathic pain associated with chemotherapy-induced peripheral neuropathy (CIPN) have limited clinical efficacy, and undesirable side-effects. Topically delivered treatments have the advantage of avoiding ...

Abstract	Purpose of review: Current oral treatments for neuropathic pain associated with chemotherapy-induced peripheral neuropathy (CIPN) have limited clinical efficacy, and undesirable side-effects. Topically delivered treatments have the advantage of avoiding CNS side-effects, while relieving pain. We have reviewed treatments of neuropathic pain associated with CIPN, focusing on the Capsaicin 8% patch, which can provide pain relief for up to 3 months or longer after a single 30-60-min application. Recent findings: Capsaicin 8% patch is a licensed treatment in the EU/UK for neuropathic pain and shown to be safe and effective in providing pain relief for patients with CIPN. Repeated daily oral or topical administrations are not required, as with other current treatments. The side-effects are transient and restricted to the time around patch application. New evidence suggests the Capsaicin 8% patch can promote the regeneration and restoration of skin nerve fibres in CIPN, in addition to the pain relief. Summary: The Capsaicin 8% patch is now often a preferred a treatment option for localised neuropathic pain conditions, including the feet and hands in patients with CIPN. Capsaicin 8% patch can be repeated three-monthly, if needed, for a year. In addition to pain relief, it may have a disease-modifying effect.
MeSH term(s)	Administration, Topical ; Antineoplastic Agents/adverse effects ; Capsaicin/therapeutic use ; Humans ; Neuralgia/chemically induced ; Neuralgia/drug therapy ; Pain Management
Chemical Substances	Antineoplastic Agents ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2021-04-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2633726-5
ISSN	1751-4266 ; 1751-4258
ISSN (online)	1751-4266
ISSN	1751-4258
DOI	10.1097/SPC.0000000000000545
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Article ; Online: Epigenetic Perspective of Immunotherapy for Cancers.

Keshari, Sunita / Barrodia, Praveen / Singh, Anand Kamal

Cells

2023 Volume 12, Issue 3

Abstract	Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the disease, and iRAEs (immune-related adverse effects). The first critical step towards solving these issues is understanding the epigenomic events that play a significant role in the regulation of specific biomolecules in the context of the immune population present in the tumor immune microenvironment (TIME) during various treatments and responses. A prominent advantage of this step is that it would enable researchers to harness the reversibility of epigenetic modifications for their druggability. Therefore, we reviewed the crucial studies in which varying epigenomic events were captured with immuno-oncology set-ups. Finally, we discuss the therapeutic possibilities of their utilization for the betterment of immunotherapy in terms of diagnosis, progression, and cure for cancer patients.
MeSH term(s)	Humans ; Epigenomics ; Neoplasms/therapy ; Neoplasms/drug therapy ; Immunotherapy/adverse effects ; Medical Oncology ; Epigenesis, Genetic ; Tumor Microenvironment
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12030365
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Article: The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons.

Anand, Uma / Pacchetti, Barbara / Anand, Praveen / Sodergren, Mikael Hans

Journal of pain research

2022 Volume 15, Page(s) 3493–3507

Abstract: Background: The endocannabinoid 2-Arachidonyl glycerol (2-AG) exerts dose-related anti-nociceptive effects, which are potentiated by the related but inactive 2-palmitoyl glycerol (2-PG) and 2-linoleoyl glycerol (2-LG). This potentiation of analgesia and ...

Abstract	Background: The endocannabinoid 2-Arachidonyl glycerol (2-AG) exerts dose-related anti-nociceptive effects, which are potentiated by the related but inactive 2-palmitoyl glycerol (2-PG) and 2-linoleoyl glycerol (2-LG). This potentiation of analgesia and other in vivo measures was described as the "entourage effect". We investigated this effect on TRPV1 signalling in cultured dorsal root ganglion (DRG) nociceptors. Methods: Adult rat DRG neurons were cultured in medium containing NGF and GDNF at 37°C. 48 h later cultures were loaded with 2 µM Fura2AM for calcium imaging, and treated with 2-AG, 2-PG and 2-LG, individually or combined, for 5 min, followed by 1 µMol capsaicin. The amplitude and latency of capsaicin responses were measured (N=3-7 rats, controls N=16), and analysed. Results: In controls, 1 µMol capsaicin elicited immediate calcium influx in a subset of neurons, with average latency of 1.27 ± 0.2 s and amplitude of 0.15 ± 0.01 Units. 2-AG (10-100 µMol) elicited calcium influx in some neurons. In the presence of 2-AG (0.001-100 µMol), capsaicin responses were markedly delayed in 64% neurons by up to 320 s (P<0.001). 2-PG increased capsaicin response latency at 0.1 nMol-100 µMol (P<0.001), in 60% neurons, as did 2-LG at 0.1-100 µMol (P<0.001), in 76% neurons. Increased capsaicin response latency due to 2-AG and 2-PG was sensitive to the CB Conclusion: 2-AG, 2-LG and 2-PG significantly delayed TRPV1 signalling in the majority of capsaicin-sensitive DRG neurons, that was markedly increased following combined application. Further studies of these endocannabinoids are required to identify the underlying mechanisms.
Language	English
Publishing date	2022-11-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S378876
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Article ; Online: Photocatalytic performance of Bi/Zn co‐doped sol–gel synthesized TiO2 nanoparticles

Mishra, Saurav / Chakinala, Nandana / Chakinala, Anand G. / Surolia, Praveen K.

Journal of Chemical Technology & Biotechnology. 2024 Feb., v. 99, no. 2 p.531-539

2024

Abstract: BACKGROUND: Semiconductor photocatalysts based on TiO₂ nanoparticles were synthesized via the sol–gel method and subsequently modified using monometallic (Bi‐TiO₂, Zn‐TiO₂) and bimetallic (Bi/Zn‐TiO₂) doping through the wet‐impregnation technique. The ... ...

Abstract	BACKGROUND: Semiconductor photocatalysts based on TiO₂ nanoparticles were synthesized via the sol–gel method and subsequently modified using monometallic (Bi‐TiO₂, Zn‐TiO₂) and bimetallic (Bi/Zn‐TiO₂) doping through the wet‐impregnation technique. The prepared photocatalysts underwent comprehensive characterization using X‐ray diffraction analysis, Fourier transform infrared spectroscopy, ultraviolet–visible diffuse‐reflectance spectroscopy, field emission scanning electron microscopy, photoluminescence, and thermal gravimetric analysis. The photocatalytic performance of these well‐characterized photocatalysts was assessed for the degradation of the model organic pollutant, nitrobenzene. RESULTS: Among the various doped TiO₂ catalysts, Bi/Zn co‐doping at a ratio of 0.25:0.75 (w/w) exhibited the most remarkable synergistic effect, achieving approximately 82% degradation of a 50 ppm nitrobenzene solution within just 90 min of reaction time under ultraviolet light irradiation. The rate constant for this process was determined to be 1.79 × 10⁻² min⁻¹, suggesting a pseudo‐first‐order kinetics model. CONCLUSION: The successful co‐doping of Bi and Zn metals to TiO₂ resulted in improved photocatalytic performance. The enhanced performance could be attributed to the improved charge transfer facilitated by the synergistic effect among doped metals and TiO₂. This finding highlights the significance of bimetallic doping and its potential applications in improving the photocatalytic efficiency of TiO₂ nanoparticles for environmental remediation. © 2023 Society of Chemical Industry (SCI).
Keywords	Fourier transform infrared spectroscopy ; X-ray diffraction ; biotechnology ; electron microscopy ; irradiation ; models ; nanoparticles ; nitrobenzenes ; photocatalysis ; photocatalysts ; photoluminescence ; pollutants ; reflectance spectroscopy ; remediation ; semiconductors ; sol-gel processing ; synergism ; thermogravimetry ; titanium dioxide ; ultraviolet radiation
Language	English
Dates of publication	2024-02
Size	p. 531-539.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1479465-2
ISSN	1097-4660 ; 0268-2575
ISSN (online)	1097-4660
ISSN	0268-2575
DOI	10.1002/jctb.7555
Database	NAL-Catalogue (AGRICOLA)

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