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Article ; Online: The greatest challenge for pediatric low-grade glioma.

Moreira, Daniel C / Bouffet, Eric / Qaddoumi, Ibrahim

2024

Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noae004
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Article ; Online: Centralized services and large patient volumes are clinical necessities for a better outcome in pediatric brain tumors.

Qaddoumi, Ibrahim

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2016 Volume 32, Issue 4, Page(s) 591–592

MeSH term(s)	Brain Neoplasms/epidemiology ; Brain Neoplasms/therapy ; Developing Countries ; Humans ; Medical Oncology ; Neurology
Language	English
Publishing date	2016-04
Publishing country	Germany
Document type	Comment ; Letter
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-016-3028-z
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Article ; Online: Psychiatric symptoms in children with low-grade glioma and craniopharyngioma: A systematic review.

Sherman, Sarah J / Tanaka, Ryuma / Qaddoumi, Ibrahim

Journal of psychiatric research

2022 Volume 148, Page(s) 240–249

Abstract: The presentation of psychiatric symptoms in pediatric low-grade brain tumors is challenging because this can delay proper diagnosis and treatment. We performed a systematic review of psychiatric presenting symptoms of low-grade brain tumors in pediatric ... ...

Abstract	The presentation of psychiatric symptoms in pediatric low-grade brain tumors is challenging because this can delay proper diagnosis and treatment. We performed a systematic review of psychiatric presenting symptoms of low-grade brain tumors in pediatric patients. We searched the PubMed and Web of Science databases of studies published in English from 1977 until 2019 reporting patients aged ≤21 years at the time of tumor diagnosis who exhibited psychiatric/behavioral symptoms before diagnosis of low-grade glioma (LGG), pilocytic astrocytoma (PA), or craniopharyngioma (CP). Our systematic search strategy coupled each tumor type with patient age and presenting symptoms by using different variations of the search terms "childhood" and "psychiatric symptoms" or "behavioral symptoms." We identified six unique articles that met our inclusion criteria in the LGG search, 27 in the PA search, and 32 in the CP search. Six patients were included in the LGG articles (age range, 3-16 years), 75 in the PA articles (age range, 0.5-21 years), and 87 in the CP articles (age range, 0.67-21 years). The most common presenting symptoms included eating disorders (n = 64) and behavioral changes (n = 49). Our findings demonstrate the need to establish clear criteria for neuroimaging indications for pediatric patients exhibiting eating disorders.
MeSH term(s)	Adolescent ; Adult ; Brain/pathology ; Brain Neoplasms/complications ; Brain Neoplasms/diagnostic imaging ; Child ; Child, Preschool ; Craniopharyngioma/complications ; Craniopharyngioma/diagnostic imaging ; Craniopharyngioma/pathology ; Glioma/complications ; Glioma/diagnostic imaging ; Glioma/therapy ; Humans ; Infant ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnostic imaging ; Young Adult
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2022.01.056
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Article: Pediatric diencephalic tumors: a constellation of entities and management modalities.

Pinto, Soniya N / Chiang, Jason / Qaddoumi, Ibrahim / Livingston, David / Bag, Asim

Frontiers in oncology

2023 Volume 13, Page(s) 1180267

Abstract: The diencephalon is a complex midline structure consisting of the hypothalamus, neurohypophysis, subthalamus, thalamus, epithalamus, and pineal body. Tumors arising from each of these diencephalic components differ significantly in terms of biology and ... ...

Abstract	The diencephalon is a complex midline structure consisting of the hypothalamus, neurohypophysis, subthalamus, thalamus, epithalamus, and pineal body. Tumors arising from each of these diencephalic components differ significantly in terms of biology and prognosis. The aim of this comprehensive review is to describe the epidemiology, clinical symptoms, imaging, histology, and molecular markers in the context of the
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1180267
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Article ; Online: Smoking-Related Disease Impact in the Eastern Mediterranean Region: A Comprehensive Assessment Using Global Burden of Disease Data.

Sultan, Yaseen / Salman, Zeena / Alzaatreh, Mohammad / Edilbi, Adib / Alani, Ruba / Sultan, Iyad / Alfaar, Ahmad Samir / Qaddoumi, Ibrahim

Asian Pacific journal of cancer prevention : APJCP

2024 Volume 25, Issue 2, Page(s) 495–505

Abstract: Background: Smoking remains a significant risk factor for numerous health issues, including lung cancer, chronic obstructive pulmonary disease, ischemic heart disease, stroke, and respiratory infections. This study investigates the burden of tobacco- ... ...

Abstract	Background: Smoking remains a significant risk factor for numerous health issues, including lung cancer, chronic obstructive pulmonary disease, ischemic heart disease, stroke, and respiratory infections. This study investigates the burden of tobacco-related diseases in the Middle East and North Africa (MENA) region. Methods: Utilizing the GBD data, we examined the risk of smoking and second-hand smoke exposure and their related causes of death and disability in the 22 MENA countries. Smoking prevalence and disease burden data were analyzed with estimates reported as age-standardized rates. Results: Tobacco abuse accounted for 14.5% of all deaths and 23.2% of deaths tied to known risk factors, with an age-standardized death rate of 110.8 per 100,000. Cardiovascular diseases were the primary cause of smoking-related deaths and DALYs, representing 53.4% of all deaths and 50.3% of all DALYs. This was followed by neoplasms (24.6% of all deaths and 20.3% of all DALYs), chronic respiratory diseases(12.4% of all deaths and 11.9% of all DALYs), and respiratory infections and tuberculosis(4% of all deaths and 3.4% of all DALYs). Second-hand smoking caused 20.5% of tobacco-related deaths and 21.5% of tobacco-related DALYs, disproportionately affecting younger individuals. An increasing disease burden was observed in Lebanon, Turkey, Syria, Tunisia, UAE, and Libya, and declining rates were most evident in Oman and Qatar. Conclusion: Our study emphasizes the impact of smoking on cardiovascular disease, the primary cause of smoking-related mortality and morbidity in the MENA region. Our findings highlight the urgent need for effective tobacco control policies and interventions.
MeSH term(s)	Humans ; Global Burden of Disease ; Quality-Adjusted Life Years ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Respiratory Tract Infections ; Smoking/adverse effects ; Smoking/epidemiology ; Lebanon ; Global Health
Language	English
Publishing date	2024-02-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2024.25.2.495
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Article ; Online: Pyrites: An Intraocular Mass.

Lyvannak, Sam / Sreynich, Korb / Khauv, Phara / Qaddoumi, Ibrahim / Jarzembowski, Jason / Camitta, Bruce

Journal of pediatric hematology/oncology

2022 Volume 44, Issue 5, Page(s) 271–272

MeSH term(s)	Humans ; Iron ; Sulfides
Chemical Substances	Sulfides ; pyrite (132N09W4PR) ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002439
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Article ; Online: Prevalence and Risk Factors for Endocrine Disorders in Childhood Brain Tumors From a Single Tertiary Center in Malaysia.

Ng, Yean Joo / Jalaludin, Muhammad Yazid / Foo, Jen Chun / Qaddoumi, Ibrahim / Rajagopal, Revathi

Journal of pediatric hematology/oncology

2022 Volume 44, Issue 4, Page(s) 159–166

Abstract: Patients with childhood brain tumors are at risk of endocrine disorders. The prevalence of endocrine disorders varies across the world but is unknown in Malaysia. This study's objectives were to determine the prevalence of endocrine disorders among ... ...

Abstract	Patients with childhood brain tumors are at risk of endocrine disorders. The prevalence of endocrine disorders varies across the world but is unknown in Malaysia. This study's objectives were to determine the prevalence of endocrine disorders among children with brain tumors in Malaysia and to identify endocrinopathy-associated risk factors. We retrospectively reviewed the clinical data of pediatric patients with brain tumors diagnosed and treated at the University Malaya Medical Center from 1 January 2001 to 31 December 2015, with a follow-up period until the age of 18 years old or at least 3 years from the initial diagnosis. A total of 106 patients were included; 71 patients (66%) were screened for endocrine disorders, and 61% of these had endocrine disorders at a median follow-up of 4 years. Hypothyroidism, short stature, and adrenocortical insufficiency were present in one-third of the patients, followed by central diabetes insipidus (21%), growth hormone deficiency (10%), delayed puberty (9%), and precocious puberty (4%). Radiation therapy and surgical intervention were risk factors for endocrine disorders, but hydrocephalus, supratentorial tumors, and malignant tumors were not. Most endocrinopathies developed within the first 2 years of brain tumor diagnosis. Therefore, standard endocrine-monitoring guidelines aiming for early diagnosis and therapy are essential.
MeSH term(s)	Adolescent ; Brain Neoplasms/drug therapy ; Brain Neoplasms/epidemiology ; Brain Neoplasms/etiology ; Child ; Endocrine System Diseases/epidemiology ; Endocrine System Diseases/etiology ; Humans ; Malaysia/epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002447
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Article ; Online: Torticollis as a presenting symptom of pediatric CNS tumors: A systematic review.

Baklizi, Nadejda / Raswoli, Musthafa / Burges, Michala / Moreira, Daniel C / Qaddoumi, Ibrahim

Seminars in oncology

2022 Volume 49, Issue 5, Page(s) 419–425

Abstract: To assess the frequency of torticollis as a presenting symptom of pediatric CNS tumors and its impact on pre-diagnostic symptom intervals (PSIs) and patient outcomes. We performed a systematic review of studies reporting torticollis in children with ... ...

Abstract	To assess the frequency of torticollis as a presenting symptom of pediatric CNS tumors and its impact on pre-diagnostic symptom intervals (PSIs) and patient outcomes. We performed a systematic review of studies reporting torticollis in children with various CNS tumors. We searched PubMed for studies published from January 1972 to March 2021 in English. Case reports were included in the analysis if the following criteria were met (1) torticollis was the presenting symptom secondary to a CNS tumor (2) children <18 years of age, (3) underwent imaging intervention and (4) outcome data provided. Of 1,365 relevant articles, 45 were eligible for analysis according to our inclusion criteria representing 95 patients. Two independent investigators extracted the data, and a third investigator arbitrated discrepancies. We found that 38.9% of CNS tumors exhibited torticollis as the only presenting symptom. PSI lengths ranged from 0 to 4 years (median, 5 months) for low-grade tumors, and patient age and PSI length were inversely associated. Of patients with low-grade tumors, 23.8% received physiotherapy, in contrast with 0% of patients with high-grade tumors. PSI length also increased for patients who received rehabilitation, and 39.3% and 7.1% of patients with high-grade and low-grade tumors, respectively, died of their disease. Patients with low-grade tumors and torticollis as a primary presenting symptom were more likely to have a prolonged PSI. Therefore, CNS tumors should be considered in the differential diagnosis of acquired torticollis in children.
MeSH term(s)	Child ; Humans ; Torticollis/etiology ; Torticollis/therapy ; Torticollis/diagnosis ; Diagnostic Imaging ; Neoplasms/complications
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	189220-4
ISSN	1532-8708 ; 0093-7754
ISSN (online)	1532-8708
ISSN	0093-7754
DOI	10.1053/j.seminoncol.2022.09.003
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Article ; Online: The clinical and molecular characteristics of progressive hypothalamic/optic pathway pilocytic astrocytoma.

Li, Xiaoyu / Moreira, Daniel C / Bag, Asim K / Qaddoumi, Ibrahim / Acharya, Sahaja / Chiang, Jason

Neuro-oncology

2022 Volume 25, Issue 4, Page(s) 750–760

Abstract: Background: Unresectable hypothalamic/optic pathway pilocytic astrocytoma (PA) often progresses despite multiple therapies. Identifying clinical and molecular characteristics of progressive tumors may aid in prognostication and treatment.: Methods: ... ...

Abstract	Background: Unresectable hypothalamic/optic pathway pilocytic astrocytoma (PA) often progresses despite multiple therapies. Identifying clinical and molecular characteristics of progressive tumors may aid in prognostication and treatment. Methods: We collected 72 unresectable, non-neurofibromatosis type 1-associated hypothalamic/optic pathway PA to identify clinical and biologic factors associated with tumor progression. Tumors that progressed after therapy, metastasized, or resulted in death were categorized into Cohort B; those that did not meet these criteria were categorized into Cohort A. DNA methylation and transcriptome analyses were performed on treatment-naïve tumors, and the findings were validated by immunohistochemistry (IHC). Results: The median follow-up of the entire cohort was 12.3 years. Cohort B was associated with male sex (M:F = 2.6:1), younger age at diagnosis (median 3.2 years vs 6.7 years, P = .005), and high incidence of KIAA1549-BRAF fusion (81.5% vs 38.5%, P = .0032). Cohort B demonstrated decreased CpG methylation and increased RNA expression in mitochondrial genes and genes downstream of E2F and NKX2.3. Transcriptome analysis identified transcription factor TBX3 and protein kinase PIM1 as common downstream targets of E2F and NKX2.3. IHC confirmed increased expression of TBX3 and PIM1 in Cohort B tumors. Gene enrichment analysis identified enrichment of MYC targets and MAPK, PI3K/AKT/mTOR, and p53 pathways, as well as pathways related to mitochondrial function. Conclusions: We identified risk factors associated with progressive PA. Our results support the model in which the p53-PIM1-MYC axis and TBX3 act alongside MAPK and PI3K/AKT/mTOR pathways to promote tumor progression, highlighting potential new targets for combination therapy and refining disease prognostication.
MeSH term(s)	Humans ; Male ; Child, Preschool ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Tumor Suppressor Protein p53 ; Astrocytoma/genetics ; TOR Serine-Threonine Kinases/metabolism ; Brain Neoplasms/genetics ; Proto-Oncogene Proteins B-raf/genetics
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Tumor Suppressor Protein p53 ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noac241
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Article ; Online: The role of neurosurgery in advancing pediatric CNS tumor care worldwide.

Roach, Jordan T / Baticulon, Ronnie E / Campos, Danny A / Andrews, Jared M / Qaddoumi, Ibrahim / Boop, Frederick A / Moreira, Daniel C

Brain & spine

2023 Volume 3, Page(s) 101748

Abstract: Introduction: There is substantial inequity in survival outcomes for pediatric brain tumor patients residing in high-income countries (HICs) compared to low- and middle-income countries (LMICs). To address disparities in pediatric cancer survival, the ... ...

Abstract	Introduction: There is substantial inequity in survival outcomes for pediatric brain tumor patients residing in high-income countries (HICs) compared to low- and middle-income countries (LMICs). To address disparities in pediatric cancer survival, the World Health Organization (WHO) established the Global Initiative for Childhood Cancer (GICC) to expand quality care for children with cancer. Research question: To provide an overview of pediatric neurosurgical capacity and detail the burden of neurosurgical diseases impacting children. Material and methods: A narrative review of the current context of global pediatric neurosurgical capacity as it relates to neurooncology and other diseases relevant to children. Results: In this article, we provide an overview of pediatric neurosurgical capacity and detail the burden of neurosurgical diseases impacting children. We highlight concerted advocacy and legislative efforts aimed at addressing unmet neurosurgical needs in children. Finally, we discuss the potential implications of advocacy efforts on treating pediatric CNS tumors and outline strategies to improve global outcomes for children with brain tumors worldwide in the context of the WHO GICC. Discussion and conclusion: With both global pediatric oncology and neurosurgical initiatives converging on the treatment of pediatric brain tumors, significant strides toward decreasing the burden of pediatric neurosurgical diseases will hopefully be made.
Language	English
Publishing date	2023-05-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2772-5294
ISSN (online)	2772-5294
DOI	10.1016/j.bas.2023.101748
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