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  1. Article ; Online: Surgical denervation of the thumb CMC joint: anatomy, technique.

    Rapp, E / Di Sette, P / Rapp, E J

    Hand surgery & rehabilitation

    2021  Volume 40S, Page(s) S33–S37

    Abstract: Surgical denervation of the thumb carpometacarpal (CMC) joint is a theoretical surgical option for thumb CMC arthritis. Some authors have described the nerve branches of thumb CMC joint. We present the innervation of the thumb CMC joint (thenar - ... ...

    Abstract Surgical denervation of the thumb carpometacarpal (CMC) joint is a theoretical surgical option for thumb CMC arthritis. Some authors have described the nerve branches of thumb CMC joint. We present the innervation of the thumb CMC joint (thenar - recurrent - branch of median nerve, palmar branch of median nerve, superficial branch of radial nerve, lateral cutaneous nerve of forearm, deep branch of ulnar nerve) and the surgical techniques to achieve optimal denervation of this joint. While the results have been disappointing, this technique may be combined with conservative surgical procedures (synovectomy, ligament reconstruction) and it allows more invasive surgery in the future if necessary.
    MeSH term(s) Carpometacarpal Joints/innervation ; Carpometacarpal Joints/surgery ; Denervation/methods ; Humans ; Median Nerve/surgery ; Radial Nerve/anatomy & histology ; Thumb/innervation ; Thumb/surgery
    Language English
    Publishing date 2021-01-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 2848776-X
    ISSN 2468-1210
    ISSN (online) 2468-1210
    DOI 10.1016/j.hansur.2020.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1791: Show issues Location:
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  2. Article ; Online: A compact setup for behavioral studies measuring limb acceleration.

    Rapp, J / Sandurkov, B / Müller, P / Jung, N H / Gleich, B

    HardwareX

    2024  Volume 18, Page(s) e00522

    Abstract: Behavioral studies contribute largely to a broader understanding of human brain mechanisms and the process of learning and memory. An established method to quantify motor learning is the analysis of thumb activity. In combination with brain stimulation, ... ...

    Abstract Behavioral studies contribute largely to a broader understanding of human brain mechanisms and the process of learning and memory. An established method to quantify motor learning is the analysis of thumb activity. In combination with brain stimulation, the effect of various treatments on neural plasticity and motor learning can be assessed. So far, the setups for thumb abduction measurements employed consist of bulky amplifiers and digital-to-analog devices to record the data. We developed a compact hardware setup to measure acceleration data which can be integrated into a wearable, including a sensor board and a microcontroller board which can be connected to a PC via USB. Additionally, we provide two software packages including graphical user interfaces, one to communicate with the hardware and one to evaluate and process the data. This work demonstrates the construction and application of our setup at the example of thumb acceleration measurement with a custom made glove and its use for research. Using integrated circuits, the size of the measurement devices is reduced to this wearable. It is simple to construct and can be operated easily by non-technical staff.
    Language English
    Publishing date 2024-04-06
    Publishing country England
    Document type Journal Article
    ISSN 2468-0672
    ISSN (online) 2468-0672
    DOI 10.1016/j.ohx.2024.e00522
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  3. Article ; Online: Optimal pulse configuration for peripheral inductive nerve stimulation.

    Rapp, J / Braun, P / Hemmert, W / Gleich, B

    Biomedical physics & engineering express

    2022  Volume 8, Issue 2

    Abstract: Peripheral magnetic stimulation is a promising technique for several applications like rehabilitation or diagnose of neuronal pathways. However, most available magnetic stimulation devices are designed for transcranial stimulation and require high-power, ...

    Abstract Peripheral magnetic stimulation is a promising technique for several applications like rehabilitation or diagnose of neuronal pathways. However, most available magnetic stimulation devices are designed for transcranial stimulation and require high-power, expensive hardware. Modern technology such as rectangular pulses allows to adapt parameters like pulse shape and duration in order to reduce the required energy. Nevertheless, the effect of different temporal electromagnetic field shapes on neuronal structures is not yet fully understood. We created a simulation environment to find out how peripheral nerves are affected by induced magnetic fields and what pulse shapes have the lowest energy requirements. Using the electric field distribution of a
    MeSH term(s) Action Potentials/physiology ; Computer Simulation ; Magnetic Fields ; Neurons ; Peripheral Nerves/physiology
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2057-1976
    ISSN (online) 2057-1976
    DOI 10.1088/2057-1976/ac52d8
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  4. Article ; Online: Engineering Antigen-Specific Tolerance to an Artificial Protein Hydrogel.

    Rapp, Peter B / Baccile, Joshua A / Galimidi, Rachel P / Vielmetter, Jost

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 4, Page(s) 2188–2199

    Abstract: Artificial protein hydrogels are an emerging class of biomaterials with numerous prospective applications in tissue engineering and regenerative medicine. These materials are likely to be immunogenic due to their frequent incorporation of novel amino ... ...

    Abstract Artificial protein hydrogels are an emerging class of biomaterials with numerous prospective applications in tissue engineering and regenerative medicine. These materials are likely to be immunogenic due to their frequent incorporation of novel amino acid sequence domains, which often serve a functional role within the material itself. We engineered injectable "self" and "nonself" artificial protein hydrogels, which were predicted to have divergent immune outcomes
    MeSH term(s) Animals ; Mice ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Biocompatible Materials ; Tissue Engineering/methods
    Chemical Substances Hydrogels ; Biocompatible Materials
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01430
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  5. Article ; Online: Surgical denervation of the thumb CMC joint

    Rapp, E. / Di Sette, P. / Rapp, E.J.

    Hand Surgery and Rehabilitation

    anatomy, technique

    2021  Volume 40, Page(s) S33–S37

    Keywords Rehabilitation ; Orthopedics and Sports Medicine ; Surgery
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2848776-X
    ISSN 2468-1210 ; 2468-1229
    ISSN (online) 2468-1210
    ISSN 2468-1229
    DOI 10.1016/j.hansur.2020.09.011
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 1791: Show issues Location:
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  6. Article ; Online: Attention challenges in Kabuki syndrome.

    Kalinousky, A J / Rapp, T / Harris, J R

    Journal of intellectual disability research : JIDR

    2023  Volume 68, Issue 2, Page(s) 173–180

    Abstract: ... scores (P = 0.032), which was not explained by lower general cognitive ability.: Conclusions: We found ...

    Abstract Background: Understanding the specific neurobehavioural profile of rare genetic diseases enables clinicians to provide the best possible care for patients and families, including prognostic and treatment advisement. Previous studies suggested that a subset of individuals with Kabuki syndrome (KS), a genetic disorder causing intellectual disability and other neurodevelopmental phenotypes, have attentional deficits. However, these studies looked at relatively small numbers of molecularly confirmed cases and often used retrospective clinical data instead of standardised assessments.
    Methods: Fifty-five individuals or caregivers of individuals with molecularly confirmed KS completed assessments to investigate behaviour and adaptive function. Additionally, information was collected on 23 unaffected biological siblings as controls.
    Results: Attention Problems in children was the only behavioural category that, when averaged, was clinically significant, with the individual scores of nearly 50% of the children with KS falling in the problematic range. Children with KS scored significantly higher than their unaffected sibling on nearly all behavioural categories. A significant correlation was found between Attention Problems scores and adaptive function scores (P = 0.032), which was not explained by lower general cognitive ability.
    Conclusions: We found that the rates of children with attentional deficits are much more elevated than would be expected in the general population, and that attention challenges are negatively correlated with adaptive function. When averaged across KS participants, none of the behavioural categories were in the clinically significant range except Attention Problems for children, which underscores the importance of clinicians screening for attention deficit hyperactivity disorder (ADHD) in children with KS.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Abnormalities, Multiple ; Intellectual Disability ; Hematologic Diseases/complications ; Hematologic Diseases/genetics ; Face/abnormalities ; Vestibular Diseases
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.13100
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    Zs.A 182: Show issues Location:
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  7. Article: Editorial: The psychology of fake news on social media, who falls for it, who shares it, why, and can we help users detect it?

    Robertson, David J / Shephard, Mark P / Anderson, Anthony / Huhe, Narisong / Rapp, David N / Madsen, Jens K

    Frontiers in psychology

    2023  Volume 14, Page(s) 1236748

    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Editorial ; News
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1236748
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  8. Article ; Online: The BioHybrid Assay: A Novel Method for Determining Calcification Propensity.

    Jaminon, Armand M G / Akbulut, Asim C / Rapp, Nikolas / Reutelingsperger, Chris P / Schurgers, Leon J

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2664, Page(s) 317–331

    Abstract: Vascular calcification is an active pathological process, characterised by cellular dysregulation and subsequent changes to the extracellular environment. In vivo detection of vascular calcification is only possible late stage via computed tomography, ... ...

    Abstract Vascular calcification is an active pathological process, characterised by cellular dysregulation and subsequent changes to the extracellular environment. In vivo detection of vascular calcification is only possible late stage via computed tomography, and there is no single biomarker for detecting progression of vascular calcification. There is an unmet clinical need to determine progression of vascular calcification in vulnerable patients. This is especially needed in chronic kidney disease (CKD) patients where there is a correlation of cardiovascular disease with declining renal status. We hypothesised that the entirety of circulating components should be taken into consideration with vessel wall cells to determine real-time vascular calcification development. In this protocol we describe the isolation and characterisation of human primary vascular smooth muscle cells (hpVSMCs), and the addition of human serum or plasma to hpVSMCs in a calcification assay and analysis. The BioHybrid analysis of biological changes to in vitro hpVSMC calcification is reflective of in vivo vascular calcification status. We suggest this analysis can discriminate between CKD patient cohorts and has the potential for wider application for risk factor determination in CKD and the general population.
    MeSH term(s) Humans ; Kidney Failure, Chronic ; Kidney/pathology ; Renal Insufficiency, Chronic/complications ; Vascular Calcification ; Calcification, Physiologic ; Myocytes, Smooth Muscle/pathology
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3179-9_20
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  9. Article ; Online: Frailty-Diagnose als Ausgangspunkt einer Trainingsintervention.

    Benzinger, Petra / Rapp, Kilian / Bauer, Jürgen

    Zeitschrift fur Gerontologie und Geriatrie

    2022  Volume 55, Issue 8, Page(s) 650–654

    Abstract: The concept of frailty describes an older at-risk population, which has a higher probability for the occurrence of unfavorable health outcomes. It is in the interest of frail individuals as well as the healthcare system to improve the prognosis of these ... ...

    Title translation Diagnosis of frailty as starting point for training interventions.
    Abstract The concept of frailty describes an older at-risk population, which has a higher probability for the occurrence of unfavorable health outcomes. It is in the interest of frail individuals as well as the healthcare system to improve the prognosis of these people by targeted interventions. Several systematic reviews and meta-analyses are now available comparing very different interventions in frail older adults. These studies came to the conclusion that training interventions were found to be the most effective. Compared to exercise interventions delivered at participants homes, exercise in groups was found to be more effective. The case finding for such interventions should be carried out with frailty instruments that focus on strength, endurance and/or physical activity. Particularly suitable for this are the frailty criteria of Fried, gait speed or the short physical performance battery (SPPB). From a geriatrics perspective, a comprehensive offer of group training seems to be urgently necessary; however, the implementation requires a large expansion of existing structures and new ways to reach older people with frailty.
    MeSH term(s) Humans ; Aged ; Exercise ; Social Group
    Language German
    Publishing date 2022-09-23
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-022-02113-8
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    Zs.A 497: Show issues Location:
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  10. Article ; Online: Coil Efficiency for Inductive Peripheral Nerve Stimulation.

    Braun, Philipp / Rapp, Jonathan / Hemmert, Werner / Gleich, Bernhard

    IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

    2022  Volume 30, Page(s) 2137–2145

    Abstract: Magnetic stimulation of peripheral nerves is evoked by electric field gradients caused by high-intensity, pulsed magnetic fields created from a coil. Currents required for stimulation are very high, therefore devices are large, expensive, and often too ... ...

    Abstract Magnetic stimulation of peripheral nerves is evoked by electric field gradients caused by high-intensity, pulsed magnetic fields created from a coil. Currents required for stimulation are very high, therefore devices are large, expensive, and often too complex for many applications like rehabilitation therapy. For repetitive stimulation, coil heating due to power loss poses a further limitation. The geometry of the magnetic coil determines field depth and focality, making it the most important factor that determines the current required for neuronal excitation. However, the comparison between different coil geometries is difficult and depends on the specific application. Especially the distance between nerve and coil plays a crucial role. In this investigation, the electric field distribution of 14 different coil geometries was calculated for a typical peripheral nerve stimulation with a 27 mm distance between axon and coil. Coil parameters like field strength and focality were determined with electromagnetic field simulations. In a second analysis, the activating function along the axon was calculated, which quantifies the efficiency of neuronal stimulation. Moreover, coil designs were evaluated concerning power efficacy based on ohmic losses. Our results indicate that power efficacy of magnetic neurostimulation can be improved significantly by up to 40% with optimized coil designs.
    MeSH term(s) Electric Stimulation ; Electromagnetic Fields ; Humans ; Neurons ; Peripheral Nerves ; Transcranial Magnetic Stimulation/methods ; Transcutaneous Electric Nerve Stimulation
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1166307-8
    ISSN 1558-0210 ; 1063-6528 ; 1534-4320
    ISSN (online) 1558-0210
    ISSN 1063-6528 ; 1534-4320
    DOI 10.1109/TNSRE.2022.3192761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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