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Article: Long-Term Control With Proton Beam Therapy for Recurrent Prostate Cancer in the Right Perineum Following Intensity-Modulated Radiation Therapy: A Case Report.

Ishikawa, Yojiro / Suzuki, Motohisa / Seto, Ichiro / Takagawa, Yoshiaki / Murakami, Masao

2024 Volume 16, Issue 4, Page(s) e58386

Abstract: ... Laboratory tests showed an elevated serum prostate-specific antigen (PSA) level, and pelvic MRI showed a mass ... fractions for the recurrent lesion. Five years after PBT, pelvic MRI showed no mass lesions in the prostate ...

Abstract	Radiation therapy (RT) is commonly used for the treatment of prostate cancer, with intensity-modulated radiation therapy (IMRT) and proton beam therapy (PBT) being the utilized modalities. This case report outlines the treatment course of a recurrent prostate cancer lesion in the right perineal musculature managed with proton therapy following IMRT. A 64-year-old Japanese man, diagnosed with prostate cancer and categorized as high risk according to the National Comprehensive Cancer Network guidelines, underwent six months of androgen deprivation therapy, which included bicalutamide and degarelix acetate. Six months after completing 78 Gy in 39 fractions of IMRT, the patient reported perineal to anal pain. Laboratory tests showed an elevated serum prostate-specific antigen (PSA) level, and pelvic MRI showed a mass lesion in the right perineal musculature. Consequently, the patient was diagnosed with recurrent prostate cancer. Thereafter, the patient underwent eight cycles of systemic chemotherapy with docetaxel; however, his pain progressively worsened. Subsequently, the treatment was switched to 12 cycles of cabazitaxel, which led to gradual pain relief. The patient received PBT at 60 Gy relative biological effectiveness in 30 fractions for the recurrent lesion. Five years after PBT, pelvic MRI showed no mass lesions in the prostate or surrounding tissues. The PSA levels remained low, less than 0.008 ng/ml, and there were no apparent late complications.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.58386
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of spray-drying-based surface-enhanced Raman spectroscopy.

Matsumoto, Chigusa / Gen, Masao / Matsuki, Atsushi / Seto, Takafumi

Scientific reports

2022 Volume 12, Issue 1, Page(s) 4511

Abstract: We report a spray-drying method to fabricate silver nanoparticle (AgNP) aggregates for application in surface-enhanced Raman spectroscopy (SERS). A custom-built system was used to fabricate AgNP aggregates of four sizes, 48, 86, 151, and 218 nm, from ... ...

Abstract	We report a spray-drying method to fabricate silver nanoparticle (AgNP) aggregates for application in surface-enhanced Raman spectroscopy (SERS). A custom-built system was used to fabricate AgNP aggregates of four sizes, 48, 86, 151, and 218 nm, from drying droplets containing AgNPs atomized from an AgNP suspension. Sample solutions of Rhodamine B (RhB) at 10
MeSH term(s)	Metal Nanoparticles/chemistry ; Silver/chemistry ; Spectrum Analysis, Raman/methods
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2022-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-08598-y
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Article ; Online: Development of spray-drying-based surface-enhanced Raman spectroscopy

Chigusa Matsumoto / Masao Gen / Atsushi Matsuki / Takafumi Seto

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 10

Abstract: Abstract We report a spray-drying method to fabricate silver nanoparticle (AgNP) aggregates for application in surface-enhanced Raman spectroscopy (SERS). A custom-built system was used to fabricate AgNP aggregates of four sizes, 48, 86, 151, and 218 nm, ...

Abstract	Abstract We report a spray-drying method to fabricate silver nanoparticle (AgNP) aggregates for application in surface-enhanced Raman spectroscopy (SERS). A custom-built system was used to fabricate AgNP aggregates of four sizes, 48, 86, 151, and 218 nm, from drying droplets containing AgNPs atomized from an AgNP suspension. Sample solutions of Rhodamine B (RhB) at 10–6, 10–8, and 10–10 M concentrations were dropped onto the AgNP aggregates as probe molecules to examine the enhancement of the Raman signals of the RhB. The ordering of the analytical enhancement factors (AEFs) by aggregate size at a 10–6 M RhB was 86 nm > 218 nm > 151 nm > 48 nm. When RhB concentrations are below 10–8 M, the 86 and 151 nm AgNP aggregates show clear RhB peaks. The AEFs of the 86 nm AgNP aggregates were the highest in all four aggregates and higher than those of the 218-nm aggregates, although the 218-nm aggregates had more hot spots where Raman enhancement occurred. This finding was attributable to the deformation and damping of the electron cloud in the highly aggregated AgNPs, reducing the sensitivity for Raman enhancement. When RhB was premixed with the AgNP suspension prior to atomization, the AEFs at 10–8 M RhB rose ~ 100-fold compared to those in the earlier experiments (the post-dropping route). This significant enhancement was probably caused by the increased opportunity for the trapping of the probe molecules in the hot spots.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: XV. Malignant lymphoma as a consequence of clonal evolution.

Seto, Masao

Hematological oncology

2013 Volume 31 Suppl 1, Page(s) 84–88

MeSH term(s)	Chromosome Aberrations ; Clonal Evolution ; Genomics ; Humans ; Leukemia, B-Cell/genetics ; Leukemia-Lymphoma, Adult T-Cell/genetics ; Lymphoma/genetics ; Lymphoma, T-Cell, Peripheral/genetics
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.2073
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Article ; Online: Cyclin D1-negative mantle cell lymphoma.

Seto, Masao

Blood

2013 Volume 121, Issue 8, Page(s) 1249–1250

Abstract: In this issue of Blood, Salaverria et al report that more than half of Cyclin D1- (CCND1) negative SOX11-positive mantle cell lymphoma (MCL) had CCND2 gene rearrangement predominantly with immunoglobulin (IG) light chain genes.(1) ...

Abstract	In this issue of Blood, Salaverria et al report that more than half of Cyclin D1- (CCND1) negative SOX11-positive mantle cell lymphoma (MCL) had CCND2 gene rearrangement predominantly with immunoglobulin (IG) light chain genes.(1)
MeSH term(s)	Cyclin D1/genetics ; Cyclin D2/genetics ; Female ; Gene Rearrangement/genetics ; Humans ; Lymphoma, Mantle-Cell/genetics ; Lymphoma, Mantle-Cell/pathology ; Male
Chemical Substances	CCND1 protein, human ; CCND2 protein, human ; Cyclin D2 ; Cyclin D1 (136601-57-5)
Language	English
Publishing date	2013-02-20
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2013-01-475954
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Article: [Genomic alterations in malignant lymphoma].

Seto, Masao

Rinsho ketsueki] The Japanese journal of clinical hematology

2011 Volume 52, Issue 10, Page(s) 1734–1739

MeSH term(s)	Animals ; Humans ; Lymphoma/genetics ; Translocation, Genetic
Language	Japanese
Publishing date	2011-10
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
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Zs.A 1175: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Establishment of an ATLL cell line (YG-PLL) dependent on IL-2 and IL-4, which are replaced by OX40-ligand

Kagami, Yoshitoyo / Kato, Harumi / Okada, Yasutaka / Seto, Masao / Yamamoto, Kazuhito

Journal of clinical and experimental hematopathology : JCEH

2021 Volume 61, Issue 3, Page(s) 145–151

Abstract: We established an IL-2 and IL-4 (IL2/4) - dependent adult T-cell leukemia/lymphoma (ATLL) cell line (YG-PLL) by adding poly-L-lysine (PLL) to the culture medium. YG-PLL originates from lymphoma cells and contains a defective HTLV-I proviral genome. ... ...

Abstract	We established an IL-2 and IL-4 (IL2/4) - dependent adult T-cell leukemia/lymphoma (ATLL) cell line (YG-PLL) by adding poly-L-lysine (PLL) to the culture medium. YG-PLL originates from lymphoma cells and contains a defective HTLV-I proviral genome. Although YG-PLL cannot survive without IL-2/4, the follicular dendritic cell (FDC)-like cell line HK expressing OX40-ligand gene (OX40L
MeSH term(s)	Cell Line, Tumor ; Dendritic Cells, Follicular/immunology ; Dendritic Cells, Follicular/metabolism ; Dermatan Sulfate/pharmacology ; Gene Expression ; Histidine/pharmacology ; Humans ; Interleukin-2/metabolism ; Interleukin-4/metabolism ; Leukemia-Lymphoma, Adult T-Cell/etiology ; Leukemia-Lymphoma, Adult T-Cell/metabolism ; Leukemia-Lymphoma, Adult T-Cell/pathology ; OX40 Ligand/genetics ; OX40 Ligand/metabolism
Chemical Substances	Interleukin-2 ; OX40 Ligand ; TNFSF4 protein, human ; Interleukin-4 (207137-56-2) ; Dermatan Sulfate (24967-94-0) ; polyhistidine (26062-48-6) ; Histidine (4QD397987E)
Language	English
Publishing date	2021-07-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2395568-5
ISSN	1880-9952 ; 1880-9952
ISSN (online)	1880-9952
ISSN	1880-9952
DOI	10.3960/jslrt.20058
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Article: Outcomes and Prognostic Factors for Locally Recurrent Rectal Cancer Treated With Proton Beam Therapy.

Takagawa, Yoshiaki / Suzuki, Motohisa / Yamaguchi, Hisashi / Seto, Ichiro / Azami, Yusuke / Machida, Masanori / Takayama, Kanako / Tominaga, Takuya / Murakami, Masao

Advances in radiation oncology

2023 Volume 8, Issue 3, Page(s) 101192

Abstract: Purpose: Our objective was to report the outcome and prognostic factors for patients with locally recurrent rectal cancer (LRRC) treated with proton beam therapy (PBT) at our institution.: Methods and materials: The study included PBT-treated ... ...

Abstract	Purpose: Our objective was to report the outcome and prognostic factors for patients with locally recurrent rectal cancer (LRRC) treated with proton beam therapy (PBT) at our institution. Methods and materials: The study included PBT-treated patients with LRRC between December 2008 and December 2019. Treatment response was stratified using an initial imaging test after PBT. Overall survival (OS), progression-free survival (PFS), and local control (LC) were estimated using the Kaplan-Meier method. Each outcome's prognostic factors were verified using the Cox proportional hazards model. Results: Twenty-three patients were enrolled (median follow-up, 37.4 months). There were 11 patients with complete response (CR) or complete metabolic response (CMR), 8 with partial response or partial metabolic response, 2 with stable disease or stable metabolic response, and 2 with progressive disease or progressive metabolic disease. Three- and 5-year OS, PFS, and LC were 72.1% and 44.6%, 37.9% and 37.9%, and 55.0% and 47.2%, respectively, with 54.4 months' median survival time. The maximum standardized uptake value of fluorine-18-fluorodeoxyglucose-positron emission tomography-computed tomography ( Conclusions: The results showed that PBT may have potential to be a good treatment option for LRRC.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2023.101192
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Article: Proton Beam Therapy for Lung Oligometastatic Recurrence in Patients With Esophageal Cancer.

Yamaguchi, Hisashi / Kato, Takahiro / Honda, Michitaka / Hamada, Koichi / Ishikawa, Yojiro / Seto, Ichiro / Takagawa, Yoshiaki / Suzuki, Motohisa / Kikuchi, Yasuhiro / Murakami, Masao

Cureus

2023 Volume 15, Issue 12, Page(s) e50343

Abstract: Local treatment of oligometastatic esophagogastric cancer has been reported to improve overall survival (OS) compared to systemic therapy alone. This study evaluated the feasibility and safety of proton beam therapy (PBT) for the treatment of lung ... ...

Abstract	Local treatment of oligometastatic esophagogastric cancer has been reported to improve overall survival (OS) compared to systemic therapy alone. This study evaluated the feasibility and safety of proton beam therapy (PBT) for the treatment of lung oligometastatic recurrence in esophageal cancer patients. This single-center historical cohort study enrolled 11 patients who underwent PBT for lung oligometastasis from esophageal cancer between 2010 and 2019. The selection criteria were that the primary esophageal cancer was controlled and no more than three lung metastases without outside lung tumors were present. OS, progression-free survival (PFS), and local control (LC) rates and adverse events (AEs) were assessed. Factors that may be related to OS were also investigated. The median follow-up period was 27.8 months (8.8-141.3 months). The one-, two-, and three-year OS rates were 81.8%, 72.7%, and 51.9%, respectively (median OS time: 43.7 months); PFS rates were 45.5%, 27.3%, and 27.3%, respectively (median PFS time: 8.8 months); and LC rates were 92.3%, 72.7%, and 72.7%, respectively. The eighth edition of tumor-node-metastasis (TNM) classification for esophageal cancer was the only significant OS-related factor (p = 0.0309). No grade ≥ 3 AEs were observed. Based on the low incidence of AEs and acceptable LC rate, PBT is a feasible option for the treatment of lung oligometastasis in esophageal cancer patients.
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.50343
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Article ; Online: Proton beam reirradiation for locally recurrent rectal cancer patients with prior pelvic irradiation.

Takagawa, Yoshiaki / Suzuki, Motohisa / Seto, Ichiro / Azami, Yusuke / Machida, Masanori / Takayama, Kanako / Sulaiman, Nor Shazrina / Nakasato, Tatsuhiko / Kikuchi, Yasuhiro / Murakami, Masao / Honda, Michitaka / Teranishi, Yasushi / Kono, Koji

Journal of radiation research

2024

Abstract: The aim of the present study was to report the feasibility of proton beam reirradiation for patients with locally recurrent rectal cancer (LRRC) with prior pelvic irradiation. The study population included patients who were treated with proton beam ... ...

Abstract	The aim of the present study was to report the feasibility of proton beam reirradiation for patients with locally recurrent rectal cancer (LRRC) with prior pelvic irradiation. The study population included patients who were treated with proton beam therapy (PBT) for LRRC between 2008 and December 2019 in our institution. Those who had a history of distant metastases of LRRC, with or without treatment, before reirradiation, were excluded. Overall survival (OS), progression-free survival (PFS) and local control (LC) were estimated using the Kaplan-Meier method. Ten patients were included in the present study. The median follow-up period was 28.7 months, and the median total dose of prior radiotherapy (RT) was 50 Gy (range, 30 Gy-74.8 Gy). The median time from prior RT to reirradiation was 31.5 months (range, 8.1-96.6 months), and the median reirradiation dose was 72 Gy (relative biological effectiveness) (range, 56-77 Gy). The 1-year/2-year OS, PFS and LC rates were 100%/60.0%, 20.0%/10.0% and 70.0%/58.3%, respectively, with a median survival time of 26.0 months. Seven patients developed a Grade 1 acute radiation dermatitis, and no Grade ≥ 2 acute toxicity was recorded. Grade ≥ 3 late toxicity was recorded in only one patient, who had developed a colostomy due to radiation-related intestinal bleeding. Reirradiation using PBT for LRRC patients who had previously undergone pelvic irradiation was feasible. However, the indications for PBT reirradiation for LRRC patients need to be considered carefully due to the risk of severe late GI toxicity.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rrae019
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