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  1. Book ; Online: Immunotherapy in Hepatocellular Carcinoma

    Nishida, Naoshi / Kudo, Masatoshi

    2023  

    Keywords Medicine ; Oncology ; cancer immunotherapy ; TCGA ; mutations ; copy number variations ; microRNAs ; PD-1 ; PD-L1 ; hepatocellular carcinoma ; predictive factors ; immunotherapy ; immune checkpoint inhibition ; check-point inhibitors ; liver disease ; outcome ; biomarkers ; combination immunotherapy ; immune-related adverse events (irAEs) ; hepatocellular carcinoma (HCC) ; alpha fetoprotein response ; immune checkpoint inhibitor ; unresectable hepatocellular carcinoma ; a disintegrin and metalloprotease 9 ; nivolumab ; natural killer ; CTLA-4 ; combination therapy ; PD-1 antibody ; PD-L1 antibody ; anti-VEGF inhibitor ; molecular classification ; immune phenotype ; stem cell marker ; oncogenic signal ; β-catenin ; genetic alteration ; liver cancer ; effectiveness ; safety ; HCC ; molecular-targeted agent ; TACE ; tyrosine kinase inhibitor ; CD14+ cells ; programmed death 1 ligands ; translational approaches ; combination therapies ; therapy resistance ; predictive markers ; tissue-resident memory CD8 T cells ; immune checkpoint blockade
    Language English
    Size 1 electronic resource (276 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377297
    ISBN 9783036566900 ; 3036566902
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The role of FGFR inhibitors in the treatment of intrahepatic cholangiocarcinoma-unveiling the future challenges in drug therapy.

    Nishida, Naoshi

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 5, Page(s) 790–794

    Language English
    Publishing date 2023-09-15
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Development and application of artificial intelligence (AI) models for liver diseases].

    Nishida, Naoshi

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2022  Volume 119, Issue 7, Page(s) 626–641

    MeSH term(s) Artificial Intelligence ; Humans ; Liver Diseases/diagnosis ; Liver Diseases/therapy
    Language Japanese
    Publishing date 2022-07-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.119.626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 477: Show issues

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  4. Article: Role of Oncogenic Pathways on the Cancer Immunosuppressive Microenvironment and Its Clinical Implications in Hepatocellular Carcinoma.

    Nishida, Naoshi

    Cancers

    2021  Volume 13, Issue 15

    Abstract: The tumor immune microenvironment, including hepatocellular carcinoma (HCC), is complex, consisting of crosstalk among tumor components such as the cancer cells, stromal cells and immune cells. It is conceivable that phenotypic changes in cancer cells by ...

    Abstract The tumor immune microenvironment, including hepatocellular carcinoma (HCC), is complex, consisting of crosstalk among tumor components such as the cancer cells, stromal cells and immune cells. It is conceivable that phenotypic changes in cancer cells by genetic and epigenetic alterations affect the cancer-stroma interaction and anti-cancer immunity through the expression of immune checkpoint molecules, growth factors, cytokines, chemokines and metabolites that may act on the immune system in tumors. Therefore, predicting the outcome of ICI therapy requires a thorough understanding of the oncogenic signaling pathways in cancer and how they affect tumor immune evasion. In this review, we have detailed how oncogenic signaling pathways can play a role in altering the condition of the cellular components of the tumor immune microenvironment such as tumor-associated macrophages, regulatory T cells and myeloid-derived suppressor cells. The RAS/MAPK, PI3K/Akt, Wnt/β-catenin and JAK/STAT pathways have all been implicated in anti-tumor immunity. We also found that factors that reflect the immune microenvironment of the tumor, including the status of oncogenic pathways such as the volume of tumor-infiltrating T cells, expression of the immune checkpoint protein PD-1 and its ligand PD-L1, and activation of the Wnt/β-catenin signaling pathway, predict a response to ICI therapy in HCC cases.
    Language English
    Publishing date 2021-07-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13153666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical implications of the dual blockade of the PD-1/PD-L1 and vascular endothelial growth factor axes in the treatment of hepatocellular carcinoma.

    Nishida, Naoshi

    Hepatobiliary surgery and nutrition

    2020  Volume 9, Issue 5, Page(s) 640–643

    Language English
    Publishing date 2020-11-08
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2019.10.18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Metabolic disease as a risk of hepatocellular carcinoma.

    Nishida, Naoshi

    Clinical and molecular hepatology

    2020  Volume 27, Issue 1, Page(s) 87–90

    MeSH term(s) Carcinoma, Hepatocellular/diagnosis ; Humans ; Liver Neoplasms/diagnosis ; Metabolic Diseases ; Metabolic Syndrome ; Obesity
    Language English
    Publishing date 2020-12-03
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 2672560-5
    ISSN 2287-285X ; 2287-2728
    ISSN (online) 2287-285X
    ISSN 2287-2728
    DOI 10.3350/cmh.2020.0302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6769: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Long-term prognosis and management of hepatocellular carcinoma after curative treatment.

    Nishida, Naoshi

    Clinical and molecular hepatology

    2020  Volume 26, Issue 4, Page(s) 480–483

    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/therapy ; Hepatectomy ; Humans ; Liver Neoplasms/surgery ; Liver Neoplasms/therapy ; Neoplasm Recurrence, Local ; Prognosis
    Language English
    Publishing date 2020-09-21
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 2672560-5
    ISSN 2287-285X ; 2287-2728
    ISSN (online) 2287-285X
    ISSN 2287-2728
    DOI 10.3350/cmh.2020.0208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6769: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Artificial intelligence models for the diagnosis and management of liver diseases.

    Nishida, Naoshi / Kudo, Masatoshi

    Ultrasonography (Seoul, Korea)

    2022  

    Abstract: With the development of more advanced methods for the diagnosis and treatment of diseases, the data required for medical care are becoming complex, and misinterpretation of information due to human error may result in serious consequences. Human error ... ...

    Abstract With the development of more advanced methods for the diagnosis and treatment of diseases, the data required for medical care are becoming complex, and misinterpretation of information due to human error may result in serious consequences. Human error can be avoided with the support of artificial intelligence (AI). AI models trained with various medical data for diagnosis and management of liver diseases have been applied to hepatitis, fatty liver disease, liver cirrhosis, and liver cancer. Some of these models have been reported to outperform human experts in terms of performance, indicating their potential for supporting clinical practice given their high-speed output. This paper summarizes the recent advances in AI for liver disease and introduces the AI-aided diagnosis of liver tumors using B-mode ultrasonography.
    Language English
    Publishing date 2022-10-14
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2775801-1
    ISSN 2288-5943 ; 2288-5919
    ISSN (online) 2288-5943
    ISSN 2288-5919
    DOI 10.14366/usg.22110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Advances in Immunotherapy for Hepatocellular Carcinoma.

    Hagiwara, Satoru / Nishida, Naoshi / Kudo, Masatoshi

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Immune checkpoint inhibitors (ICIs) aim to induce immune responses against tumors and are less likely to develop drug resistance than molecularly targeted drugs. In addition, they are characterized by a long-lasting antitumor effect. However, since its ... ...

    Abstract Immune checkpoint inhibitors (ICIs) aim to induce immune responses against tumors and are less likely to develop drug resistance than molecularly targeted drugs. In addition, they are characterized by a long-lasting antitumor effect. However, since its effectiveness depends on the tumor's immune environment, it is essential to understand the immune environment of hepatocellular carcinoma to select ICI therapeutic indications and develop biomarkers. A network of diverse cellular and humoral factors establishes cancer immunity. By analyzing individual cases and classifying them from the viewpoint of tumor immunity, attempts have been made to select the optimal therapeutic drug for immunotherapy, including ICIs. ICI treatment is discussed from the viewpoints of immune subclass of HCC, Wnt/β-catenin mutation, immunotherapy in NASH-related HCC, the mechanism of HPD onset, and HBV reactivation.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Improved Tumor Response to Lenvatinib Re-Treatment after Failure of Immune Checkpoint Inhibitors in a Patient with Advanced Hepatocellular Carcinoma.

    Hagiwara, Satoru / Nishida, Naoshi / Kudo, Masatoshi

    Liver cancer

    2021  Volume 10, Issue 5, Page(s) 535–538

    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2666925-0
    ISSN 1664-5553 ; 2235-1795
    ISSN (online) 1664-5553
    ISSN 2235-1795
    DOI 10.1159/000516692
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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