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  1. Article ; Online: m-s-m

    McLachlan, Aleisha / Singh, Kulbir / McAlduff, Michael / Marangoni, D Gerrard / Shortall, Samantha / Wettig, Shawn D

    RSC advances

    2020  Volume 10, Issue 6, Page(s) 3221–3232

    Abstract: Micelle formation enthalpies ( ... ...

    Abstract Micelle formation enthalpies (Δ
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra09432f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: m-s-m Cationic Gemini and Zwitterionic Surfactants-Spacer-Dependent Synergistic Interactions.

    McLachlan, Aleisha / Singh, Kulbir / Piggott, Emily / McAlduff, Michael / MacLennan, Shannon / Sandre, Victoria / Reid, Taryn / Marangoni, D Gerrard

    The journal of physical chemistry. B

    2019  Volume 123, Issue 8, Page(s) 1855–1868

    Abstract: ... dimethyldodecyl)-α,ω-alkanediammonium dibromide (12-s-12) systems. The cmc values for the mixed systems were ...

    Abstract Critical micelle concentration (cmc) values were determined for the mixed zwitterionic/cationic gemini systems of N-dodecyl- N, N-dimethyl-3-ammonio-1-propanesulfonate (ZW3-12)/ N, N'-bis(dimethyldodecyl)-α,ω-alkanediammonium dibromide (12-s-12) systems. The cmc values for the mixed systems were determined through conductivity measurements. The degree of nonideality of the interaction in the mixed micelle (β
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.8b09771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The extent and impact of vaccine status miscategorisation on covid-19 vaccine efficacy studies

    Neil, Martin / McLachlan, Scott / Fenton, Norman

    medRxiv

    Abstract: It is recognised that many studies reporting high efficacy for Covid-19 vaccines suffer from various selection biases. Systematic review identified thirty-nine studies that suffered from one particular and serious form of bias called miscategorisation ... ...

    Abstract It is recognised that many studies reporting high efficacy for Covid-19 vaccines suffer from various selection biases. Systematic review identified thirty-nine studies that suffered from one particular and serious form of bias called miscategorisation bias, whereby study participants who have been vaccinated are categorised as unvaccinated up to and until some arbitrarily defined time after vaccination occurred. Simulation demonstrates that this miscategorisation bias artificially boosts vaccine efficacy and infection rates even when a vaccine has zero or negative efficacy. Furthermore, simulation demonstrates that repeated boosters, given every few months, are needed to maintain this misleading impression of efficacy. Given this, any claims of Covid-19 vaccine efficacy based on these studies are likely to be a statistical illusion.
    Keywords covid19
    Language English
    Publishing date 2024-03-16
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.03.09.24304015
    Database COVID19

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  4. Article ; Online: A complementary medicine student-led telehealth clinic: evaluating learning & teaching perceptions.

    Shew, Tracelee / Smith, Catherine / Connolly, Greg / Fleischmann, Michael / McLachlan, Craig S

    BMC research notes

    2024  Volume 17, Issue 1, Page(s) 65

    Abstract: Objectives: This study evaluates a multi-centered complementary medicine (CM) student-led telehealth clinic during the COVID-19 pandemic. Likert and qualitative responses explore student and educator learning and teaching perceptions of the ... ...

    Abstract Objectives: This study evaluates a multi-centered complementary medicine (CM) student-led telehealth clinic during the COVID-19 pandemic. Likert and qualitative responses explore student and educator learning and teaching perceptions of the implementation of a successful telehealth clinic.
    Results: 51 students and 17 educators completed the survey. Respondents agreed that support from educators (90%) and orientation (70%) assisted effective performance. Over 90% (93%) of all respondents supported telehealth in student-led clinics, whilst 87% encountered barriers such as technical and infrastructure issues. Respondents agreed that telehealth practice skills improved in case history taking (90%), treatment (90%) and building patient rapport (60%). Respondents (61%) disagreed that physical examination was effectively performed, and 100% of respondents agreed telehealth was a valuable learning experience. This study is the first to explore student and educator perceptions of telehealth in an Australian University multi-centered CM student-led clinic. To be successful in an educational environment, students and educators require digital literacy and adequate telehealth practice infrastructure. Whilst some in-person practice skills are transferable to telehealth, educators need to adapt curriculum to ensure counselling and physical examination skills are specifically taught for virtual consultations. Telehealth in clinical practice requires continued investigation and educational development.
    MeSH term(s) Humans ; Pandemics ; Australia ; Students ; Telemedicine ; Complementary Therapies
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-024-06728-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The influence of aortic stiffness on carotid stiffness: computational simulations using a human aorta carotid model.

    Petrova, Marjana / Li, Yujie / Gholipour, Alireza / Kiat, Hosen / McLachlan, Craig S

    Royal Society open science

    2024  Volume 11, Issue 3, Page(s) 230264

    Abstract: Increased aortic and carotid stiffness are independent predictors of adverse cardiovascular events. Arterial stiffness is not uniform across the arterial tree and its accurate assessment is challenging. The complex interactions and influence of aortic ... ...

    Abstract Increased aortic and carotid stiffness are independent predictors of adverse cardiovascular events. Arterial stiffness is not uniform across the arterial tree and its accurate assessment is challenging. The complex interactions and influence of aortic stiffness on carotid stiffness have not been investigated. The aim of this study was to evaluate the effect of aortic stiffness on carotid stiffness under physiological pressure conditions. A realistic patient-specific geometry was used based on magnetic resonance images obtained from the OsiriX library. The luminal aortic-carotid model was reconstructed from magnetic resonance images using 3D Slicer. A series of aortic stiffness simulations were performed at different regional aortic areas (levels). By applying variable Young's modulus to the aortic wall under two pulse pressure conditions, one could examine the deformation, compliance and von Mises stress between the aorta and carotid arteries. An increase of Young's modulus in an aortic area resulted in a notable difference in the mechanical properties of the aortic tree. Regional deformation, compliance and von Mises stress changes across the aorta and carotid arteries were noted with an increase of the aortic Young's modulus. Our results indicate that increased carotid stiffness may be associated with increased aortic stiffness. Large-scale clinical validation is warranted to examine the influence of aortic stiffness on carotid stiffness.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.230264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influence of Season on Biodegradation Rates in Rivers.

    Tian, Run / Posselt, Malte / Miaz, Luc T / Fenner, Kathrin / McLachlan, Michael S

    Environmental science & technology

    2024  Volume 58, Issue 16, Page(s) 7144–7153

    Abstract: Biodegradation plays a key role in the fate of chemicals in the environment. The variability of biodegradation in time can cause uncertainty in evaluating the environmental persistence and risk of chemicals. However, the seasonality of biodegradation in ... ...

    Abstract Biodegradation plays a key role in the fate of chemicals in the environment. The variability of biodegradation in time can cause uncertainty in evaluating the environmental persistence and risk of chemicals. However, the seasonality of biodegradation in rivers has not yet been the subject of environmentally relevant testing and systematic investigation for large numbers of chemicals. In this work, we studied the biodegradation of 96 compounds during four seasons at four locations (up- and downstream of WWTPs located on two Swedish rivers). Significant seasonality (ANOVA,
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c10541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Comparison of Parameters for Assessment of Carotid Stiffness and Their Association with Carotid Atherosclerosis in Rural Australian Adults: A Pilot Study.

    Petrova, Marjana / Gavino, Alex / Li, Yujie / McLachlan, Craig S

    Journal of clinical medicine

    2023  Volume 12, Issue 8

    Abstract: Carotid stiffness has been associated with the development and progression of carotid artery disease and is an independent factor for stroke and dementia. There has also been a lack of comparison of different ultrasound-derived carotid stiffness ... ...

    Abstract Carotid stiffness has been associated with the development and progression of carotid artery disease and is an independent factor for stroke and dementia. There has also been a lack of comparison of different ultrasound-derived carotid stiffness parameters and their association with carotid atherosclerosis. This pilot study aimed to investigate the associations between carotid stiffness parameters (derived via ultrasound echo tracking) and the presence of carotid plaques in Australian rural adults. In cross-sectional analyses, we assessed forty-six subjects (68 ± 9 years; mean ± SD) who underwent carotid ultrasound examinations. Carotid stiffness was assessed by a noninvasive echo-tracking method, measuring and comparing multiple carotid stiffness parameters, including stroke change in diameter (ΔD), stroke change in lumen area (ΔA), β- stiffness index, pulse wave velocity beta (PWV-β), compliance coefficient (CC), distensibility coefficient (DC), Young's elastic modulus (YEM), Peterson elastic modulus (Ep), and strain. Carotid atherosclerosis was assessed bilaterally by the presence of plaques in the common and internal carotid arteries, while carotid stiffness was assessed at the right common carotid artery. β-stiffness index, PWV-β, and Ep were significantly higher (
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12082935
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  8. Article ; Online: Immune cell profile and immune-related gene expression of obese peripheral blood and liver tissue.

    Taylor, Jude M / Li, Amy / McLachlan, Craig S

    FEBS letters

    2021  Volume 596, Issue 2, Page(s) 199–210

    Abstract: Obesity is associated with changes in immune cell subpopulations. However, tissue and blood obesity-responsive immune phenotypic pathways have not been contrasted. Here, the local niche immune cell population and gene expression in fatty liver is ... ...

    Abstract Obesity is associated with changes in immune cell subpopulations. However, tissue and blood obesity-responsive immune phenotypic pathways have not been contrasted. Here, the local niche immune cell population and gene expression in fatty liver is compared to peripheral blood of obese individuals. The Cibersort algorithm enumerated increased fractions of memory CD4
    MeSH term(s) Th17 Cells
    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 282: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A framework for understanding the bioconcentration of surfactants in fish.

    McLachlan, Michael S / Ebert, Andrea / Armitage, James M / Arnot, Jon A / Droge, Steven T J

    Environmental science. Processes & impacts

    2023  Volume 25, Issue 7, Page(s) 1238–1251

    Abstract: Surfactants are a class of chemicals released in large quantities to water, and therefore bioconcentration in fish is an important component of their safety assessment. Their structural diversity, which encompasses nonionic, anionic, cationic and ... ...

    Abstract Surfactants are a class of chemicals released in large quantities to water, and therefore bioconcentration in fish is an important component of their safety assessment. Their structural diversity, which encompasses nonionic, anionic, cationic and zwitterionic molecules with a broad range of lipophilicity, makes their evaluation challenging. A strong influence of environmental pH adds a further layer of complexity to their bioconcentration assessment. Here we present a framework that penetrates this complexity. Using simple equations derived from current understanding of the relevant underlying processes, we plot the key bioconcentration parameters (uptake rate constant, elimination rate constant and bioconcentration factor) as a function of its membrane lipid/water distribution ratio and the neutral fraction of the chemical in water at pH 8.1 and at pH 6.1. On this chemical space plot, we indicate boundaries at which four resistance terms (perfusion with water, transcellular, paracellular, and perfusion with blood) limit transport of surfactants across the gills. We then show that the bioconcentration parameters predicted by this framework align well with
    MeSH term(s) Surface-Active Agents/chemistry ; Surface-Active Agents/metabolism ; Fishes/metabolism ; Water Pollutants, Chemical/chemistry ; Water Pollutants, Chemical/metabolism ; Gills/metabolism
    Chemical Substances Surface-Active Agents ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2703814-2
    ISSN 2050-7895 ; 2050-7887
    ISSN (online) 2050-7895
    ISSN 2050-7887
    DOI 10.1039/d3em00070b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7401: Show issues

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  10. Article ; Online: Phelodinium fensomei sp. nov.: a protoperidineacean dinoflagellate cyst from the lower Paleocene (Danian) of the Oyster Bay Formation, Vancouver Island, Canada

    McLachlan, Sandy M. S.

    Palynology. 2021 May 21, v. 46, no. 1 p.1-11

    2021  

    Abstract: Phelodinium fensomei is a new species of organic-walled dinoflagellate cyst described from the Appian Way section of the Oyster Bay Formation, Vancouver Island, British Columbia, Canada. Phelodinium fensomei sp. nov. differs from other species of ... ...

    Abstract Phelodinium fensomei is a new species of organic-walled dinoflagellate cyst described from the Appian Way section of the Oyster Bay Formation, Vancouver Island, British Columbia, Canada. Phelodinium fensomei sp. nov. differs from other species of Phelodinium in its unique combination of characters including an elongate epicyst, bilobate endocyst antapex, and microgranulate to verrucate surface ornamentation. The species occurs exclusively within Dinoflagellate Cyst Zone D4 of the Oyster Bay Formation along with the Danian indicator taxon Danea californica. This is also the first study to perform scanning electron microscopy and epifluorescence analysis on a specimen belonging to the protoperidinioid genus Phelodinium, revealing minute features and a negative response to ultraviolet light exposure, indicating a heterotrophic feeding strategy for the motile cell. Although P. fensomei sp. nov. occurs at markedly low relative and absolute abundances in the examined interval, it is restricted to strata of Danian age suggesting potential biostratigraphic utility.
    Keywords Danian age ; Miozoa ; electron microscopy ; indicator species ; new species ; palynology ; ultraviolet radiation ; British Columbia ; Paleogene ; Paleocene ; North Pacific ; Nanaimo Group ; dinoflagellate cysts ; microfossils ; biostratigraphy
    Language English
    Dates of publication 2021-0521
    Size p. 1-11.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2179197-1
    ISSN 1558-9188 ; 0191-6122
    ISSN (online) 1558-9188
    ISSN 0191-6122
    DOI 10.1080/01916122.2021.1925365
    Database NAL-Catalogue (AGRICOLA)

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