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  1. Article ; Online: Use of direct microscopy to diagnose superficial mycoses: a survey of UK dermatology practice.

    Chandler, David J / Yamamoto, Reika / Hay, Rod J

    The British journal of dermatology

    2023  Volume 189, Issue 4, Page(s) 480–481

    MeSH term(s) Humans ; Dermatology ; Microscopy ; Dermatomycoses/diagnosis ; Surveys and Questionnaires ; United Kingdom/epidemiology
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad213
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  2. Article ; Online: Exploring the experiences of high-risk groups during the first UK Covid-19 lockdown through creative methods.

    Wilson, Ceri / Lane, Pauline / Chandler, Rebecca / Teatheredge, Julie

    Arts & health

    2023  , Page(s) 1–22

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2487722-0
    ISSN 1753-3023 ; 1753-3015
    ISSN (online) 1753-3023
    ISSN 1753-3015
    DOI 10.1080/17533015.2023.2237994
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  3. Article ; Online: Attitudes towards innovation survey: early development of a structured method for assessing staff views.

    Sibley, Andrew / Barker, Ruth / Chandler, Jackie / Darnton, Philippa

    BMJ open quality

    2023  Volume 12, Issue 3

    MeSH term(s) Humans ; Attitude of Health Personnel
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2023-002394
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  4. Article ; Online: AP-1 Subunit JUNB Promotes Invasive Phenotypes in Endometriosis.

    Wilson, Mike R / Reske, Jake J / Chandler, Ronald L

    Reproductive sciences (Thousand Oaks, Calif.)

    2022  Volume 29, Issue 11, Page(s) 3266–3277

    Abstract: Endometriosis is a disease defined by the presence of abnormal endometrium at ectopic sites, causing pain and infertility in 10% of women. Mutations in the chromatin remodeling protein ARID1A (AT-rich interactive domain-containing protein 1A) have been ... ...

    Abstract Endometriosis is a disease defined by the presence of abnormal endometrium at ectopic sites, causing pain and infertility in 10% of women. Mutations in the chromatin remodeling protein ARID1A (AT-rich interactive domain-containing protein 1A) have been identified in endometriosis, particularly in the more severe deep infiltrating endometriosis and ovarian endometrioma subtypes. ARID1A has been shown to regulate chromatin at binding sites of the Activator Protein 1 (AP-1) transcription factor, and AP-1 expression has been shown in multiple endometriosis models. Here, we describe a role for AP-1 subunit JUNB in promoting invasive phenotypes in endometriosis. Through a series of knockdown experiments in the 12Z endometriosis cell line, we show that JUNB expression in endometriosis promotes the expression of epithelial-to-mesenchymal transition genes co-regulated by ARID1A including transcription factors SNAI1 and SNAI2, cell adhesion molecules ICAM1 and VCAM1, and extracellular matrix remodelers LOX and LOXL2. In highly invasive ARID1A-deficient endometriotic cells, co-knockdown of JUNB is sufficient to suppress invasion. These results suggest that AP-1 plays an important role in the progression of invasive endometriosis, and that therapeutic inhibition of AP-1 could prevent the occurrence of deep infiltrating endometriosis.
    MeSH term(s) Humans ; Female ; Endometriosis/genetics ; Endometriosis/metabolism ; Transcription Factor AP-1/metabolism ; Endometrium/metabolism ; Epithelial-Mesenchymal Transition ; Phenotype ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Transcription Factor AP-1 ; JunB protein, human ; Transcription Factors
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-022-00974-3
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    Zs.A 4113: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Physicians' Human Papillomavirus Vaccine Communication With Parents of Different Skin Color: Feasibility of Measuring Indicators of Implicit Bias With Virtual Reality.

    Popler, Emily / Rosen, Brittany L / Meisman, Andrea R / Lee, Melody R / Kahn, Jessica A / Chandler, Emmanuel L / Klein, Melissa D / Real, Francis J

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2024  

    Abstract: Purpose: Virtual reality (VR) may be a viable method to observe and describe signals of implicit bias. Using the context of the human papillomavirus vaccine counseling, we sought to describe physicians' communication practices exploring differences when ...

    Abstract Purpose: Virtual reality (VR) may be a viable method to observe and describe signals of implicit bias. Using the context of the human papillomavirus vaccine counseling, we sought to describe physicians' communication practices exploring differences when counseling parents with different skin colors.
    Methods: Physicians (N = 90) at an academic primary care center were recruited for a VR study in which they counseled dark or light-skinned parent avatars who expressed hesitation about human papillomavirus vaccination for their adolescent child. Investigators coded previously recorded simulations. Associations between communication and parent skin color were examined using t-tests and Chi-square tests.
    Results: Both direct (e.g., addressing the concern immediately) and circuitous (e.g., providing alternative information) communication patterns were observed. Physicians used passive voice less commonly when counseling dark-skinned versus light-skinned avatars (p < .05).
    Discussion: VR demonstrated feasibility in capturing clinicians' communication behaviors including measuring eight distinct indicators of implicit bias.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2024.02.017
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    Zs.B 2453: Show issues Location:
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  6. Article ; Online: Emotional Distress in a Marginalized Population as a Function of Household-Level Social Determinants of Health.

    Lushin, Victor / Rivera, Rebecca / Chandler, Marquis / Rees, Jo / Rzewinski, Justyna

    Social work

    2023  Volume 68, Issue 4, Page(s) 287–297

    Abstract: Low-income, underrepresented communities of color are disproportionally affected by emotional distress. Little is known about malleable, household-level determinants of emotional distress, addressable by feasible, stigma-neutral interventions. The ... ...

    Abstract Low-income, underrepresented communities of color are disproportionally affected by emotional distress. Little is known about malleable, household-level determinants of emotional distress, addressable by feasible, stigma-neutral interventions. The present study addressed this knowledge gap by analyzing secondary data from a cross-sectional community needs assessment survey in a marginalized urban community (N = 677). Relying on dominance analyses, authors found that, on average, the largest household-level contributions to respondents' emotional distress included exposures to fellow household members' alcohol use and anger-driven behaviors. Both determinants are arguably feasible to address via household-level interventions and community-level preventive efforts. Household members' physical and serious mental illness and drug use were moderately associated with respondents' emotional distress; household cohesion and communications, residential overcrowding, and child behavior played a minimal role. Article concludes with a discussion of public health implications of the results.
    MeSH term(s) Child ; Humans ; Cross-Sectional Studies ; Social Determinants of Health ; Social Work ; Poverty ; Psychological Distress
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410783-4
    ISSN 1545-6846 ; 0037-8046
    ISSN (online) 1545-6846
    ISSN 0037-8046
    DOI 10.1093/sw/swad024
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    Zs.B 2951: Show issues Location:
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  7. Article ; Online: Connect the Dots-November 2021.

    Burdette, Emily R / Wise, Meredith / Moody, C Chandler / Rouse, Dwight J

    Obstetrics and gynecology

    2023  Volume 138, Issue 5, Page(s) 817–818

    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000004584
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  8. Article ; Online: Let Me Prep You to PREP Me: Amplifying the Voices of Black Women and Their Providers to Consider PrEP as an HIV Prevention Option.

    Chandler, Rasheeta / Guillaume, Dominique / Wells, Jessica / Hernandez, Natalie

    International journal of environmental research and public health

    2022  Volume 19, Issue 3

    Abstract: Despite the high efficacy of pre-exposure prophylaxis (PrEP) in preventing HIV acquisition, PrEP uptake among Black cisgender women remains low. Our qualitative study assessed Black cisgender women's perspectives, attitudes, and acceptability towards ... ...

    Abstract Despite the high efficacy of pre-exposure prophylaxis (PrEP) in preventing HIV acquisition, PrEP uptake among Black cisgender women remains low. Our qualitative study assessed Black cisgender women's perspectives, attitudes, and acceptability towards PrEP, in addition to exploring PrEP-related attitudes, facilitators, and barriers to PrEP access among health care staff. This study was conducted to ascertain data to inform the development of our HIV prevention app-
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Black People ; Female ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Health Knowledge, Attitudes, Practice ; Humans ; Pre-Exposure Prophylaxis
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19031414
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  9. Article: Repeat Surgery for Vestibular Schwannomas: An Institutional Case Series.

    Nandoliya, Khizar R / Winterhalter, Emily J / Karras, Constantine L / Khazanchi, Rushmin / Youngblood, Mark W / Texakalidis, Pavlos / Chandler, James P / Magill, Stephen T

    Journal of neurological surgery reports

    2023  Volume 84, Issue 4, Page(s) e140–e143

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2023-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2653397-2
    ISSN 2193-6366 ; 2193-6358
    ISSN (online) 2193-6366
    ISSN 2193-6358
    DOI 10.1055/s-0043-1776124
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    Zs.A 6973: Show issues Location:
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  10. Article ; Online: Patients' Willingness to Pay for Naloxone: A National Cross-Sectional Survey of Prescription Opioid Users with Chronic Pain in the US.

    Huang, Yinan / Coggins, Toby M / Cirildo, Sarah / Gandy, Chandler / Aparasu, Rajender R / Thornton, J Douglas

    Journal of the American Pharmacists Association : JAPhA

    2024  , Page(s) 102062

    Abstract: Background: Millions of US people have been heavily affected by opioids. In March 2023, the FDA approved naloxone as an OTC medication. This has allowed more access to patients at high risk of opioid overdose. However, the patient's willingness to pay ... ...

    Abstract Background: Millions of US people have been heavily affected by opioids. In March 2023, the FDA approved naloxone as an OTC medication. This has allowed more access to patients at high risk of opioid overdose. However, the patient's willingness to pay for naloxone at the pharmacy counter has not been assessed.
    Objectives: To characterize factors associated with the willingness to pay for naloxone among the patient group.
    Methods: A cross-sectional Qualtrics online panel survey instrument was developed. This survey was distributed to patients in the US, aged ≥18, with any chronic pain and taking opioids. The survey included demographics, and clinical characteristics (pain assessment, opioid use, and knowledge of naloxone. Also, willingness to pay was assessed using a 7-point Likert scale ranging from strongly disagree to strongly agree. An ordinal logistic regression model was used to examine demographic and clinical characteristics.
    Results: 549 subjects completed the survey (women: [53.01%], White or Caucasian (83.61%), age: mean [SD]: 44 [13]). Women were associated with less willingness to pay (adjusted odds ratio [aOR], 0.685; 95% confidence interval (CI), 0.478-0.983; p= 0.0403). Compared to the high household income group (≥ $150,000), low household income ≤ $25,000 (aOR, 0.326; 95% CI, 0.160- 0.662; p=0.0020) or income between $25,000-74,999 (aOR, 0.369; 95% CI, 0.207-0.657; p=0.0007) was associated with less likelihood of willing to pay. Patients with a prior diagnosis of obstructive sleep apnea were associated with a higher likelihood of willingness to pay (adjusted odds ratio [aOR], 1.685; 95% CI, 1.138-2.496; p=0.0092). Each unit increase in pain was also associated with a higher likelihood of willingness to pay (aOR, 1.247; 95% CI 1.139-1.365; p< 0.0001) CONCLUSIONS: Demographics and clinical factors were associated with willingness to pay for naloxone. This study's findings are useful in the development of interventions to address pharmacy-based naloxone distribution programs.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2024.102062
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    Zs.A 1042: Show issues Location:
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