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Article ; Online: Comparisons of Schlemm's canal and trabecular meshwork morphologies between juvenile and primary open angle glaucoma.

Hamanaka, Teruhiko / Sakurai, Tetsuro / Fuse, Nobuo / Ishida, Nobuo / Kumasaka, Toshio / Tanito, Masaki

2021 Volume 210, Page(s) 108711

Abstract: The histologic differences in Schlemm's canal (SC) and trabecular meshwork (TM), obtained from the trabeculectomy specimens of different age-group glaucoma patients, were compared. This study involved 44 trabeculectomy specimens of 37 juvenile-onset open- ...

Abstract	The histologic differences in Schlemm's canal (SC) and trabecular meshwork (TM), obtained from the trabeculectomy specimens of different age-group glaucoma patients, were compared. This study involved 44 trabeculectomy specimens of 37 juvenile-onset open-angle glaucoma (JOAG) patients (Group A) and 24 trabeculectomy specimens of 24 elderly-onset primary OAG (POAG) patients (age range: 70-79 years, Group B) with no familial history of POAG. Clinical parameters of gender, maximum intraocular pressure (IOP), and the number of glaucoma medications used prior to trabeculectomy were investigated and compared between the two groups. From light microscopy photographs of hematoxylin-eosin, and immunohistochemical staining of markers for SC endothelium (SCE), the total SC length (TSC), comprised of the opened-SC length (OSC) and the closed-SC length (CSC), the percentage of CSC in TSC (%CSC), the percentage of positive SCE marker in CSC (%PinCSC), and the percentage of negative SCE marker in OSC (%NinOSC) were analyzed. Moreover, podoplanin staining patterns in the TM were investigated and compared between the two groups. Among the clinical parameters, the mean maximum IOP in Group A (33.41 ± 9.24 mmHg) was the only significant parameter when compared to that in Group B (22.96 ± 7.17 mmHg, P = 0.000003). TSC in Group A was significantly shorter than that in Group B (P = 0.00092), and %CSC (P = 0.00004) and %PinCSC (P = 0.00342) in Group B were significantly higher than those in Group A. No statistically significant difference in %NinOSC was found between Group A and Group B (P = 0.76060). Juxtacanalicular tissue (JCT) in Group A showed compact and weak staining with podoplanin, while the JCT and closed-SC area in Group B showed intense staining. In the Group A subjects, TSC (P = 0.04819) and OSC (P = 0.02867) were significantly shorter in the non-familial cases than in the familial cases. Platelet coagulations 10-37 μm in size at the defect of the SCE in the inner wall of the SC were observed in 8 eyes (18%) and 4 eyes (17%) in Group A and Group B, respectively. The platelets appeared to repair the SCE damage for maintaining the blood aqueous barrier in both groups of POAG eyes. Smaller SC diameters and accompanying TM abnormality were features observed in the young-onset JOAG patients, thus suggesting developmental abnormalities in the outflow routes. The collapse of SC lumen, presumably due to aging, was the feature observed in the elderly-onset POAG patients. In Group A, the significantly higher IOP, despite of no significant number of topical medications used prior to trabeculectomy, also suggested that JOAG eyes can be categorized as a distinct type of POAG from the eyes of elder-aged POAG patients. The SCE drop out observed in the glaucomatous eyes of the different age groups suggested that worsening of IOP control may possibly occur equally in both groups.
MeSH term(s)	Adult ; Aged ; Aging ; Female ; Fibrosis/pathology ; Glaucoma, Open-Angle/pathology ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure ; Limbus Corneae/pathology ; Male ; Tonometry, Ocular ; Trabecular Meshwork/pathology ; Trabeculectomy
Language	English
Publishing date	2021-08-02
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2021.108711
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Article ; Online: Relationship between nailfold capillaroscopy parameters and the severity of diabetic retinopathy.

Okabe, Tatsu / Kunikata, Hiroshi / Yasuda, Masayuki / Kodama, Shinjiro / Maeda, Yuta / Nakano, Joe / Takeno, Dan / Fuse, Nobuo / Nakazawa, Toru

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2023 Volume 262, Issue 3, Page(s) 759–768

Abstract: Purpose: To determine whether non-invasive measurements of the nailfold capillaries (NCs) are associated with the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes.: Methods: Eighty-three eyes of 83 patients with ... ...

Abstract	Purpose: To determine whether non-invasive measurements of the nailfold capillaries (NCs) are associated with the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Eighty-three eyes of 83 patients with type 2 diabetes were enrolled. Sixty-three age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: non-DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). We used nailfold capillaroscopy to measure NC parameters, including number, length, width, and turbidity. Results: Four NC parameters in the diabetic patients were significantly lower than in the controls (all P < 0.001). There was a statistically significant decrease in the NC parameters along with the increasing severity of DR (number: P = 0.02; all others: P < 0.001). Logistic regression analysis revealed that combining the systemic characteristics of age, sex, systolic blood pressure, estimated glomerular filtration rate, hemoglobin A1c level, and history of hypertension and dyslipidemia could indicate the presence of DR and PDR (the area under the receiver operating characteristic curve [AUC] = 0.81, P = 0.006; AUC = 0.87, P = 0.001, respectively). Furthermore, the discriminative power of DR was significantly improved (P = 0.03) by adding NC length to the systemic findings (AUC = 0.89, P < 0.001). Conclusion: NC measurement is a simple and non-invasive way to assess the risk of DR and its severity.
MeSH term(s)	Humans ; Diabetic Retinopathy/diagnosis ; Microscopic Angioscopy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Eye ; Hypertension
Language	English
Publishing date	2023-10-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-023-06220-z
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Article: Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study.

Nakaya, Kumi / Nakaya, Naoki / Kogure, Mana / Hatanaka, Rieko / Chiba, Ippei / Kanno, Ikumi / Nagaie, Satoshi / Nakamura, Tomohiro / Kanazawa, Motoyori / Ogishima, Soichi / Fuse, Nobuo / Fukudo, Shin / Hozawa, Atsushi

Journal of neurogastroenterology and motility

2024 Volume 30, Issue 2, Page(s) 208–219

Abstract: Background/aims: The objective of this research is to examine factors related to irritable bowel syndrome (IBS) prevalence in a large population-based study.: Methods: A cross-sectional study was conducted with participants in the Miyagi part of the ... ...

Abstract	Background/aims: The objective of this research is to examine factors related to irritable bowel syndrome (IBS) prevalence in a large population-based study. Methods: A cross-sectional study was conducted with participants in the Miyagi part of the Tohoku Medical Megabank Project Community-Based cohort study who completed the Rome II Modular Questionnaire. Multivariate odds ratios (ORs) for the presence of IBS and 95% confidence intervals (95% CIs) for the reference group were calculated for each factor. Additionally, a stratified analysis was performed by sex and age group (20-49 years, 50-64 years, and ≥ 65 years). Results: Among 16 252 participants, 3025 (18.6%) had IBS, comprising 750 men (15.5%) and 2275 women (19.9%). Multivariate ORs for the presence of IBS decreased significantly with each year of age (OR, 0.98; 95% CI, 0.98-0.99). Moreover, compared with the reference group, ORs for the presence of IBS were significantly higher in individuals whose home was partially damaged by the Great East Japan Earthquake, those with < 16 years of education, those who spent less time walking, those with high perceived stress (1.77, 1.57-2.01), those with high psychological distress (1.58, 1.36-1.82), and those with high symptoms of depression (1.76, 1.60-1.94). In stratified analyses, a significant relationship was found between psychological factors and IBS prevalence in all sex and age groups. Conclusions: This large cross-sectional population-based cohort study identified several factors associated with IBS prevalence. Psychological factors were significantly associated with IBS prevalence across all age groups and sexes.
Language	English
Publishing date	2024-03-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2573719-3
ISSN	2093-0887 ; 2093-0879
ISSN (online)	2093-0887
ISSN	2093-0879
DOI	10.5056/jnm23090
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Article ; Online: Relationship between age-related hearing loss and consumption of coffee and tea.

Watarai, Gosuke / Suzuki, Jun / Motoike, Ikuko N / Sakurai, Miyuki / Ikeda, Ryoukichi / Kawase, Tetsuaki / Kinoshita, Kengo / Hozawa, Atsushi / Kuriyama, Shinichi / Fuse, Nobuo / Yamamoto, Masayuki / Katori, Yukio

Geriatrics & gerontology international

2023 Volume 23, Issue 6, Page(s) 453–456

MeSH term(s)	Humans ; Coffee/adverse effects ; Tea/adverse effects ; Hearing Loss/epidemiology ; Risk Factors
Chemical Substances	Coffee ; Tea
Language	English
Publishing date	2023-05-03
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14589
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Article ; Online: Genetic bases for glaucoma.

Fuse, Nobuo

The Tohoku journal of experimental medicine

2010 Volume 221, Issue 1, Page(s) 1–10

Abstract: Glaucoma is the leading cause of visual impairment and blindness throughout the world. Primary open angle glaucoma (POAG; MIM 137760) is the main type of glaucoma in most populations, and more than 20 genetic loci for POAG have been reported. Only three ... ...

Abstract	Glaucoma is the leading cause of visual impairment and blindness throughout the world. Primary open angle glaucoma (POAG; MIM 137760) is the main type of glaucoma in most populations, and more than 20 genetic loci for POAG have been reported. Only three causative genes have been identified in these loci, viz. myocilin (MYOC), optineurin (OPTN), and WD repeat domain 36 (WDR36). However, mutations in these genes account for only a small percentage of the patients with POAG. Some of these glaucoma cases have a Mendelian inheritance pattern, and a considerable fraction of the cases result from a large number of variants in several genes each contributing small effects. Glaucoma is considered to be a common disease such as diabetes mellitus, coronary disease, Crohn disease, and several( )common cancers. The main technological approaches used to identify the genes associated with glaucoma are the candidate gene approach, linkage analysis, case-control association study, and genome-wide association study. Association studies have found about 27 genes related to POAG, but the glaucoma-causing effects of these genes need to be investigated in more detail. The current trend is to use case-control association studies or genome-wide association studies to map the genes associated with glaucoma. Such studies are expected to greatly advance our understanding of the genetic basis of glaucoma, and to provide information on the effectiveness of glaucoma therapy. This review gives an overview on the genetic aspects of glaucoma.
MeSH term(s)	Case-Control Studies ; Causality ; Chromosome Mapping ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Glaucoma, Open-Angle/epidemiology ; Glaucoma, Open-Angle/genetics ; Humans
Language	English
Publishing date	2010-05-15
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.221.1
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Article ; Online: The Health History of First-Degree Relatives' Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia.

Tokutomi, Tomoharu / Yoshida, Akiko / Fukushima, Akimune / Yamamoto, Kayono / Ishigaki, Yasushi / Kawame, Hiroshi / Fuse, Nobuo / Nagami, Fuji / Suzuki, Yoichi / Sakurai-Yageta, Mika / Uruno, Akira / Suzuki, Kichiya / Tanno, Kozo / Ohmomo, Hideki / Shimizu, Atsushi / Yamamoto, Masayuki / Sasaki, Makoto

Genes

2024 Volume 15, Issue 3

Abstract: Genetic testing is key in modern healthcare, particularly for monogenic disorders such as familial hypercholesterolemia. This Tohoku Medical Megabank Project study explored the impact of first-degree relatives' dyslipidemia history on individual ... ...

Abstract	Genetic testing is key in modern healthcare, particularly for monogenic disorders such as familial hypercholesterolemia. This Tohoku Medical Megabank Project study explored the impact of first-degree relatives' dyslipidemia history on individual responses to familial hypercholesterolemia genomic results. Involving 214 participants and using Japan's 3.5KJPN genome reference panel, the study assessed preferences and intentions regarding familial hypercholesterolemia genetic testing results. The data revealed a significant inclination among participants with a family history of dyslipidemia to share their genetic test results, with more than 80% of participants intending to share positive results with their partners and children and 98.1% acknowledging the usefulness of positive results for personal health management. The study underscores the importance of family health history in genetic-testing perceptions, highlighting the need for family-centered approaches in genetic counseling and healthcare. Notable study limitations include the regional scope and reliance on questionnaire data. The study results emphasize the association between family health history and genetic-testing attitudes and decisions.
MeSH term(s)	Child ; Humans ; Intention ; Genetic Testing ; Genetic Counseling ; Hyperlipoproteinemia Type II/genetics ; Genomics
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes15030384
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Article ; Online: Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study.

Noji, Yoshiaki / Hatanaka, Rieko / Nakaya, Naoki / Kogure, Mana / Nakaya, Kumi / Chiba, Ippei / Kanno, Ikumi / Nakamura, Tomohiro / Tsuchiya, Naho / Momma, Haruki / Hamanaka, Yohei / Orui, Masatsugu / Kobayashi, Tomoko / Uruno, Akira / Kodama, Eiichi N / Nagatomi, Ryoichi / Fuse, Nobuo / Kuriyama, Shinichi / Hozawa, Atsushi

BMC public health

2024 Volume 24, Issue 1, Page(s) 714

Abstract: Background: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to ...

Abstract	Background: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. Methods: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. Results: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. Conclusions: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Cohort Studies ; Cross-Sectional Studies ; Leg ; Hand Strength ; Cholesterol, HDL
Chemical Substances	Cholesterol, HDL
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18244-z
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Article ; Online: Cohort Profile: 2001 Cohort of the Longitudinal Survey of Newborns in the 21st Century.

Fuse, Kana / Nishi, Nobuo / Ikeda, Nayu

International journal of epidemiology

2017 Volume 46, Issue 5, Page(s) 1398–1398f

MeSH term(s)	Birth Weight ; Child Development ; Cohort Studies ; Female ; Health Surveys ; History, 21st Century ; Humans ; Infant, Newborn ; Japan ; Longitudinal Studies ; Socioeconomic Factors ; Surveys and Questionnaires
Language	English
Publishing date	2017-11-06
Publishing country	England
Document type	Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyx104
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Article ; Online: Prevalence, Associated Factors, and Inter-Eye Differences of Refractive Errors in a Population-Based Japanese Cohort: The Tohoku Medical Megabank Eye Study.

Miki, Atsuya / Fuse, Nobuo / Fujimoto, Satoko / Taira, Makiko / Saito, Tomo / Okazaki, Tomoyuki / Shiraki, Akihiko / Sato, Shigeru / Kawasaki, Ryo / Nakamura, Tomohiro / Kinoshita, Kengo / Nishida, Kohji / Yamamoto, Masayuki

Ophthalmic epidemiology

2023 Volume 31, Issue 1, Page(s) 46–54

Abstract: Purpose: To investigate the prevalence, associated factors, and inter-eye differences of myopia and astigmatism in an adult Japanese population-based cohort.: Methods: A total of 4282 participants from the Tohoku Medical Megabank Organization Eye ... ...

Abstract	Purpose: To investigate the prevalence, associated factors, and inter-eye differences of myopia and astigmatism in an adult Japanese population-based cohort. Methods: A total of 4282 participants from the Tohoku Medical Megabank Organization Eye Study (ToMMo Eye Study) underwent comprehensive ocular examinations as well as extensive physiological tests and a lifestyle questionnaire. The spherical equivalent (SE) and cylinder power were obtained as refractive parameters. The age- and gender-stratified prevalences of high myopia (SE < -5D), myopia (SE < -0.5D), hyperopia (SE > 0.5D), astigmatism (cylinder power < -0.5D), and anisometropia (SE difference >1D) were calculated. Multivariable analyses were performed to identify associated factors for refractive error (RE). Distribution and associated factors of the inter-eye difference in RE were also investigated. Results: The age-adjusted prevalence of high myopia, myopia, hyperopia, astigmatism, and anisometropia was 15.9%, 63.5%, 14.7%, 51.1%, and 14.7%, respectively. Both myopia and high myopia were more prevalent in the younger age group, while astigmatism was more prevalent in the older age group. Age, education, blood pressure, intraocular pressure, and corneal thickness are significantly associated with myopic refraction. Age, gender, intraocular pressure, and corneal thickness are correlated with astigmatism. Older age was associated with against-the-rule astigmatism. Older age, myopia, and longer education showed a significant correlation with large inter-eye differences in SERE. Conclusions: This study demonstrated the high prevalence of myopia in young Japanese, which may be caused by a generational shift. This study also confirmed the influence of age and education on both the prevalence and inter-eye differences of RE.
MeSH term(s)	Adult ; Humans ; Aged ; Astigmatism/epidemiology ; Prevalence ; Hyperopia/epidemiology ; Anisometropia/epidemiology ; Japan/epidemiology ; Refractive Errors/epidemiology ; Myopia/epidemiology ; Age Distribution
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1213070-9
ISSN	1744-5086 ; 0928-6586
ISSN (online)	1744-5086
ISSN	0928-6586
DOI	10.1080/09286586.2023.2203226
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Article: Pathological variants in genes associated with disorders of sex development and central causes of hypogonadism in a whole-genome reference panel of 8380 Japanese individuals.

Shiga, Naomi / Yamaguchi-Kabata, Yumi / Igeta, Saori / Yasuda, Jun / Tadaka, Shu / Minato, Takamichi / Watanabe, Zen / Kanno, Junko / Tamiya, Gen / Fuse, Nobuo / Kinoshita, Kengo / Kure, Shigeo / Kondo, Akiko / Tachibana, Masahito / Yamamoto, Masayuki / Yaegashi, Nobuo / Sugawara, Junichi

Human genome variation

2022 Volume 9, Issue 1, Page(s) 34

Abstract: Disorders of sex development (DSD) comprises a congenital condition in which chromosomal, gonadal, or anatomical sex development is atypical. In this study, we screened for pathogenic variants in 32 genes associated with DSDs and central causes of ... ...

Abstract	Disorders of sex development (DSD) comprises a congenital condition in which chromosomal, gonadal, or anatomical sex development is atypical. In this study, we screened for pathogenic variants in 32 genes associated with DSDs and central causes of hypogonadism (CHG) in a whole-genome reference panel including 8380 Japanese individuals constructed by Tohoku Medical Megabank Organization. Candidate pathogenic (P) or likely pathogenic (LP) variants were extracted from the ClinVar, InterVar, and Human Gene Mutation databases. Ninety-one candidate pathological variants were found in 25 genes; 28 novel candidate variants were identified. Nearly 1 in 40 (either ClinVar or InterVar P or LP) to 157 (both ClinVar and InterVar P or LP) individuals were found to be carriers of recessive DSD and CHG alleles. In these data, genes implicated in gonadal dysfunction did not show loss-of-function variants, with a relatively high tendency of intolerance for haploinsufficiency based on pLI and Episcore, both of which can be used for estimating haploinsufficiency. We report the types and frequencies of causative variants for DSD and CHG in the general Japanese population. This study furthers our understanding of the genetic causes and helps to refine genetic counseling of DSD and CHG.
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article
ISSN	2054-345X
ISSN	2054-345X
DOI	10.1038/s41439-022-00213-w
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