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  1. Article ; Online: Special Issue in Honor of Professors John W. Blunt and Murray H. G. Munro.

    Copp, Brent R / Cragg, Gordon M / Newman, David J / Pearce, Cedric J

    Journal of natural products

    2016  Volume 79, Issue 3, Page(s) 453–454

    MeSH term(s) Biological Products ; Humans ; Molecular Structure
    Chemical Substances Biological Products
    Language English
    Publishing date 2016-03-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.6b00079
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    Zs.A 1144: Show issues Location:
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  2. Article ; Online: Molecular Rescue in Pulmonary Arterial Hypertension.

    Newman, John H

    The New England journal of medicine

    2021  Volume 384, Issue 13, Page(s) 1271–1272

    MeSH term(s) Humans ; Hypertension, Pulmonary/drug therapy ; Pulmonary Arterial Hypertension ; Recombinant Fusion Proteins
    Chemical Substances ACE-011 ; Recombinant Fusion Proteins
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2036314
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    Ua VI Zs.34: Show issues Location:
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  3. Article ; Online: Letters to the Editor.

    McDermott, John H / Newman, William G

    Journal of paediatrics and child health

    2023  Volume 59, Issue 3, Page(s) 600

    Language English
    Publishing date 2023-02-13
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16376
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    Zs.A 227: Show issues Location:
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  4. Article ; Online: MT-RNR1 Genotype Should Not Affect Childhood Vaccination-Unintended Consequences of Guidelines.

    McDermott, John H / Wolf, Joshua / Newman, William G

    JAMA pediatrics

    2023  Volume 177, Issue 11, Page(s) 1119–1120

    MeSH term(s) Humans ; Genetic Testing ; Genotype ; Vaccination ; Mutation
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.3263
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    Um IV Zs.74: Show issues Location:
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  5. Article ; Online: Pulmonary Hypertension by the Method of Paul Wood.

    Newman, John H

    Chest

    2020  Volume 158, Issue 3, Page(s) 1164–1171

    Abstract: A physiological approach to the analysis of hemodynamic data in pulmonary hypertension (PH) has the advantage of reducing the large number (well over 100) of potential causal illnesses into four simple mechanisms. A fifth condition is composed of ... ...

    Abstract A physiological approach to the analysis of hemodynamic data in pulmonary hypertension (PH) has the advantage of reducing the large number (well over 100) of potential causal illnesses into four simple mechanisms. A fifth condition is composed of mixtures of the four basic mechanisms. This approach was beautifully described by Paul Wood, the great cardiologist whose name is given to the units of pulmonary vascular resistance (PVR), Wood units. This approach uses well understood physiological contributions to pulmonary vascular pressure. It is powerful, the major uncertainty being in determination of the magnitude of each mechanism in patients that have mixed PH of several causes. It also makes sense of the occasionally awkward clustering of conditions in the clinical classification of the World Symposium, which omits pulmonary vasoconstriction, hyperkinetic states, and the highly prevalent condition of "mixed" PH. This method of analysis is described and demonstrated, much as Wood did in his writings. The method is useful in the office, the ICU, and in consultation. A basic message from this approach is that correct assessment requires measurement of each of the three major inputs, pulmonary arterial pressure (Ppa), pulmonary artery wedge pressure (Pwedge) and cardiac output (CO). Some cases also need left ventricular end diastolic pressure (LVEDP). Other data contributing to analysis will be discussed in each condition. A key to avoiding mistakes is to always remember that PH is simply an elevation in pressure and is not inherently diagnostic of cause.
    MeSH term(s) Cardiac Catheterization ; Hemodynamics/physiology ; Humans ; Hypertension, Pulmonary/physiopathology ; Predictive Value of Tests ; Pulmonary Wedge Pressure/physiology ; Vascular Resistance/physiology
    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.02.035
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Article ; Online: Options for Detecting Risk of Aminoglycoside-Induced Ototoxicity in Neonates-Reply.

    McDermott, John H / Newman, William G

    JAMA pediatrics

    2022  Volume 176, Issue 8, Page(s) 827–828

    MeSH term(s) Aminoglycosides/adverse effects ; Anti-Bacterial Agents/adverse effects ; Humans ; Infant, Newborn ; Ototoxicity
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2022.2062
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    Um IV Zs.74: Show issues Location:
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  7. Article ; Online: Public preferences for pharmacogenetic testing in the NHS: Embedding a discrete choice experiment within service design to better meet user needs.

    McDermott, John H / Sharma, Videha / Newman, William G / Wilson, Paul / Payne, Katherine / Wright, Stuart

    British journal of clinical pharmacology

    2024  

    Abstract: Aims: Genetic testing can be used to improve the safety and effectiveness of commonly prescribed medicines-a concept known as pharmacogenetics. This study aimed to quantify members of the UK public's preferences for a pharmacogenetic service to be ... ...

    Abstract Aims: Genetic testing can be used to improve the safety and effectiveness of commonly prescribed medicines-a concept known as pharmacogenetics. This study aimed to quantify members of the UK public's preferences for a pharmacogenetic service to be delivered in primary care in the National Health Service.
    Methods: Members of the UK population were surveyed via an online panel company. Respondents completed 1 of 2 survey versions, asking respondents to select their preferred pharmacogenetic testing service in the context of a presentation of low mood or pain. A conditional logit model was estimated, before the best functional form for the dataset was identified. Preference heterogeneity was identified via latent class analysis. Coefficients from the final selected models were used to estimate uptake in the context of different hypothetical pharmacogenetic services.
    Results: Responses from 1993 individuals were included in the analysis. There were no differences observed in preference between the 2 clinical scenarios. Conditional logit analysis, using maximum likelihood estimation, indicated that respondents preferred to have noninvasive tests and wanted their data to be shared between different healthcare organizations to guide future prescribing. There was a preference for regional over national data sharing initiatives, and respondents preferred to have access to their data. Predicted uptake varied considerably, ranging from 51% to >99%, depending on design of the service.
    Conclusion: This study identifies public preferences for a pharmacogenetic testing service and demonstrates how predicted uptake can be impacted by relatively minor adaptations. This highlights areas for prioritization during development of future pharmacogenetic services.
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16058
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    Zs.A 1118: Show issues Location:
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  8. Article ; Online: Climate sensitivity of the complex dynamics of the green spruce aphid-Spruce plantation interactions: Insight from a new mechanistic model.

    Thornley, John H M / Newman, Jonathan A

    PloS one

    2022  Volume 17, Issue 2, Page(s) e0252911

    Abstract: Aphids can have a significant impact on the growth and commercial yield of spruce plantations. Here we develop a mechanistic deterministic mathematical model for the dynamics of the green spruce aphid (Elatobium abietum Walker) growing on Sitka spruce ( ... ...

    Abstract Aphids can have a significant impact on the growth and commercial yield of spruce plantations. Here we develop a mechanistic deterministic mathematical model for the dynamics of the green spruce aphid (Elatobium abietum Walker) growing on Sitka spruce (Picea sitchensis (Bong.) Carr.). These grow in a northern British climate in managed plantations, with planting, thinning and a 60-year rotation. Aphid infestation rarely kills the tree but can reduce growth by up to 55%. We used the Edinburgh Forest Model (efm) to simulate spruce tree growth. The aphid sub-model is described in detail in an appendix. The only environmental variable which impacts immediately on aphid dynamics is air temperature which varies diurnally and seasonally. The efm variables that are directly significant for the aphid are leaf area and phloem nitrogen and carbon. Aphid population predictions include dying out, annual, biennual and other complex patterns, including chaos. Predicted impacts on plantation yield of managed forests can be large and variable, as has been observed; they are also much affected by temperature, CO2 concentration and other climate variables. However, in this system, increased CO2 concentration appears to ameliorate the severity of the effects of increasing temperatures coupled to worsening aphid infestations on plantation yield.
    MeSH term(s) Animals ; Aphids/physiology ; Climate ; Ecosystem ; Host-Pathogen Interactions ; Models, Theoretical ; Picea/growth & development ; Picea/parasitology ; Temperature
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0252911
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  9. Article ; Online: The rise of point-of-care genetics: how the SARS-CoV-2 pandemic will accelerate adoption of genetic testing in the acute setting.

    McDermott, John H / Burn, John / Donnai, Dian / Newman, William G

    European journal of human genetics : EJHG

    2021  Volume 29, Issue 6, Page(s) 891–893

    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/genetics ; COVID-19/virology ; Genetic Testing ; Humans ; Pandemics ; Point-of-Care Systems ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-02-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-021-00816-x
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    Zs.A 3589: Show issues Location:
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  10. Article: The Implementation of Pharmacogenetics in the United Kingdom.

    McDermott, John H / Sharma, Videha / Keen, Jessica / Newman, William G / Pirmohamed, Munir

    Handbook of experimental pharmacology

    2023  Volume 280, Page(s) 3–32

    Abstract: There is considerable inter-individual variability in the effectiveness and safety of pharmaceutical interventions. This phenomenon can be attributed to a multitude of factors; however, it is widely acknowledged that common genetic variation affecting ... ...

    Abstract There is considerable inter-individual variability in the effectiveness and safety of pharmaceutical interventions. This phenomenon can be attributed to a multitude of factors; however, it is widely acknowledged that common genetic variation affecting drug absorption or metabolism play a substantial contributory role. This is a concept known as pharmacogenetics. Understanding how common genetic variants influence responses to medications, and using this knowledge to inform prescribing practice, could yield significant advantages for both patients and healthcare systems. Some health services around the world have introduced pharmacogenetics into routine practice, whereas others are less advanced along the implementation pathway. This chapter introduces the field of pharmacogenetics, the existing body of evidence, and discusses barriers to implementation. The chapter will specifically focus on efforts to introduce pharmacogenetics in the NHS, highlighting key challenges related to scale, informatics, and education.
    MeSH term(s) Humans ; Pharmacogenetics ; United Kingdom
    Language English
    Publishing date 2023-06-12
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2023_658
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
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