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Article ; Online: Ongoing Analytical Procedure Performance Verification Using a Risk-Based Approach to Determine Performance Monitoring Requirements.

Borman, Phil J / Guiraldelli, Amanda M / Weitzel, Jane / Thompson, Sarah / Ermer, Joachim / Roussel, Jean-Marc / Marach, Jaime / Sproule, Stephanie / Pappa, Horacio N

Analytical chemistry

2024 Volume 96, Issue 3, Page(s) 966–979

Abstract: The analytical procedure life cycle (APLC) provides a holistic framework to ensure analytical procedure fitness for purpose. USP's general chapter ... considers the validation activities that take place across the entire analytical procedure lifecycle ...

Abstract	The analytical procedure life cycle (APLC) provides a holistic framework to ensure analytical procedure fitness for purpose. USP's general chapter <1220> considers the validation activities that take place across the entire analytical procedure lifecycle and provides a three-stage framework for its implementation. Performing ongoing analytical procedure performance verification (OPPV) (stage 3) ensures that the procedure remains in a state of control across its lifecycle of use post validation (qualification) and involves an ongoing program to collect and analyze data that relate to the performance of the procedure. Knowledge generated during stages 1 (procedure design) and 2 (procedure performance qualification) is used as the basis for the design of the routine monitoring plan to support performance verification (stage 3). The extent of the routine monitoring required should be defined based on risk assessment, considering the complexity of the procedure, its intended purpose, and knowledge about process/procedure variability. The analytical target profile (ATP) can be used to provide or guide the establishment of acceptance criteria used to verify the procedure performance during routine use (e.g., through a system/sample suitability test (SST) or verification criteria applicable to procedure changes or transfers). An ATP however is not essentially required to perform OPPV, and a procedure performance monitoring program can be implemented even if the full APLC framework has not been applied. In these situations, verification criteria can be derived from existing validation or system suitability criteria. Elements of the life cycle approach can also be applied retrospectively if deemed useful.
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03708
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Article ; Online: The Use of Crisis Services Following the Mass School Shooting in Uvalde, Texas: Quasi-Experimental Event Study.

Weitzel, Kirsty J / Chew, Robert F / Miller, Adam Bryant / Oppenheimer, Caroline W / Lowe, Ashley / Yaros, Anna

JMIR public health and surveillance

2023 Volume 9, Page(s) e42811

Abstract: ... after the exchange) were compared in the 4 days before (n=251) and after (n=417) the shooting to assess ... to forecasted numbers) occurring the day after the shooting (n=159) on May 25, 2022. By May 28, the volume ... reverted to within the 95% CI of the forecasted volume (n=77). Within firearm conversations, "grief" issue ...

Abstract	Background: Mass shootings result in widespread psychological trauma for survivors and members of the affected community. However, less is known about the broader effects of indirect exposure (eg, media) to mass shootings. Crisis lines offer a unique opportunity to examine real-time data on the widespread psychological effects of mass shootings. Objective: Crisis Text Line is a not-for-profit company that provides 24/7 confidential SMS text message-based mental health support and crisis intervention service. This study examines changes in the volume and composition of firearm-related conversations at Crisis Text Line before and after the mass school shooting at Robb Elementary School on May 24, 2022, in Uvalde, Texas. Methods: A quasi-experimental event study design was used to compare the actual volume of firearm-related conversations received by Crisis Text Line post shooting to forecasted firearm conversation volume under the counterfactual scenario that a shooting had not occurred. Conversations related to firearms were identified among all conversations using keyword searches. Firearm conversation volume was predicted using a seasonal autoregressive integrated moving average model trained on the 3 months of data leading up to the shooting. Additionally, proportions of issue tags (topics coded post conversation by volunteer crisis counselors at Crisis Text Line after the exchange) were compared in the 4 days before (n=251) and after (n=417) the shooting to assess changes in conversation characteristics. The 4-day window was chosen to reflect the number of days conversation volume remained above forecasted levels. Results: There was a significant increase in the number of conversations mentioning firearms following the shooting, with the largest spike (compared to forecasted numbers) occurring the day after the shooting (n=159) on May 25, 2022. By May 28, the volume reverted to within the 95% CI of the forecasted volume (n=77). Within firearm conversations, "grief" issue tags showed a significant increase in proportion in the week following the shooting, while "isolation/loneliness," "relationships," and "suicide" issue tags showed a significant decrease in proportions the week following the shooting. Conclusions: The results suggest that the Uvalde school shooting may have contributed to an increase in demand for crisis services, above what would be expected given historical trends. Additionally, we found that these firearm-related crises conversations immediately post event are more likely to be related to grief and less likely to be related to suicide, loneliness, and relationships. Our findings provide some of the first data showing the real-time repercussions for the broader population exposed to school shooting events. This work adds to a growing evidence base documenting and measuring the rippling effects of mass shootings outside of those directly impacted.
MeSH term(s)	Humans ; Wounds, Gunshot/epidemiology ; Texas/epidemiology ; Mass Casualty Incidents ; Firearms ; Schools
Language	English
Publishing date	2023-02-08
Publishing country	Canada
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/42811
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Article ; Online: Continuing Research in the Face of Adversity.

Abrams, Benjamin / Latham, Gregory J / Kertai, Miklos D / Weitzel, Nathaen

Seminars in cardiothoracic and vascular anesthesia

2021 Volume 25, Issue 3, Page(s) 161–163

Language	English
Publishing date	2021-08-11
Publishing country	United States
Document type	Editorial
ZDB-ID	2012371-1
ISSN	1940-5596 ; 1089-2532
ISSN (online)	1940-5596
ISSN	1089-2532
DOI	10.1177/10892532211038779
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Article ; Online: Complete Genome Sequences of 17 Clinical Campylobacter jejuni Strains from Chile.

Bravo, V / Porte, L / Weitzel, T / Varela, C / Blondel, C J / Gonzalez-Escalona, N

Microbiology resource announcements

2020 Volume 9, Issue 30

Abstract: Campylobacter ... ...

Abstract	Campylobacter jejuni
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00535-20
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Article ; Online: Prescription of Opioid Analgesics for Chronic Non-Cancer Pain in Germany despite Contraindications: Administrative Claims Data Analysis.

Niemann, Anja / Schrader, Nils F / Speckemeier, Christian / Abels, Carina / Blase, Nikola / Weitzel, Milena / Neumann, Anja / Riederer, Cordula / Nadstawek, Joachim / Straßmeir, Wolfgang / Wasem, Jürgen / Neusser, Silke

International journal of environmental research and public health

2024 Volume 21, Issue 2

Abstract: In Germany, long-term opioid treatment (L-TOT) for chronic non-tumor pain (CNTP) is discussed as not being performed according to the German guideline on L-TOT for CNTP. In the present analysis, the occurrence and predictors of inappropriate care/overuse ...

Abstract	In Germany, long-term opioid treatment (L-TOT) for chronic non-tumor pain (CNTP) is discussed as not being performed according to the German guideline on L-TOT for CNTP. In the present analysis, the occurrence and predictors of inappropriate care/overuse in a cohort of German insureds with L-TOT for CNTP by the presence of a contraindication with concurrent opioid analgesic (OA) therapy were investigated. We also analyzed whether prescribing physicians themselves diagnosed a contraindication. The retrospective cohort study was based on administrative claims data from a German statutory health insurance. Eight contraindication groups were defined based on the German guideline. Logistic regressions were performed in order to identify predictors for OA prescriptions despite contraindications. The possible knowledge of the prescribing physician about the contraindication was approximated by analyzing concordant unique physician identification numbers of OA prescriptions and contraindication diagnoses. A total of 113,476 individuals (75% female) with a mean age of 72 years were included. The most common documented contraindications were primary headaches (8.7%), severe mood disorders (7.7%) and pain in somatoform disorders (4.5%). The logistic regressions identified a younger age, longer history of OA therapy, opioid related psychological problems, and outpatient psychosomatic primary care as positive predictors for all contraindication groups.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Retrospective Studies ; Analgesics ; Prescriptions ; Germany/epidemiology ; Neoplasms ; Data Analysis ; Practice Patterns, Physicians'
Chemical Substances	Analgesics, Opioid ; Analgesics
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph21020180
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Article ; Online: Refining data–data and data–model vegetation comparisons using the Earth mover's distance (EMD)

M. Chevalier / A. Dallmeyer / N. Weitzel / C. Li / J.-P. Baudouin / U. Herzschuh / X. Cao / A. Hense

Climate of the Past, Vol 19, Pp 1043-

2023 Volume 1060

Abstract: Comparing temporal and spatial vegetation changes between reconstructions or between reconstructions and model simulations requires carefully selecting an appropriate evaluation metric. A common way of comparing reconstructed and simulated vegetation ... ...

Abstract	Comparing temporal and spatial vegetation changes between reconstructions or between reconstructions and model simulations requires carefully selecting an appropriate evaluation metric. A common way of comparing reconstructed and simulated vegetation changes involves measuring the agreement between pollen- or model-derived unary vegetation estimates, such as the biome or plant functional type (PFT) with the highest affinity scores. While this approach based on summarising the vegetation signal into unary vegetation estimates performs well in general, it overlooks the details of the underlying vegetation structure. However, this underlying data structure can influence conclusions since minor variations in pollen percentages modify which biome or PFT has the highest affinity score (i.e. modify the unary vegetation estimate). To overcome this limitation, we propose using the Earth mover's distance (EMD) to quantify the mismatch between vegetation distributions such as biome or PFT affinity scores. The EMD circumvents the issue of summarising the data into unary biome or PFT estimates by considering the entire range of biome or PFT affinity scores to calculate a distance between the compared entities. In addition, each type of mismatch can be given a specific weight to account for case-specific ecological distances or, said differently, to account for the fact that reconstructing a temperate forest instead of a boreal forest is ecologically more coherent than reconstructing a temperate forest instead of a desert. We also introduce two EMD-based statistical tests that determine (1) if the similarity of two samples is significantly better than a random association given a particular context and (2) if the pairing between two datasets is better than might be expected by chance. To illustrate the potential and the advantages of the EMD as well as the tests in vegetation comparison studies, we reproduce different case studies based on previously published simulated and reconstructed biome changes for Europe and ...
Keywords	Environmental pollution ; TD172-193.5 ; Environmental protection ; TD169-171.8 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article ; Online: Managing Critical Events During Cardiothoracic and Transplant Surgery.

Huang, Jiapeng / Kertai, Miklos D / Weitzel, Nathaen

Seminars in cardiothoracic and vascular anesthesia

2019 Volume 23, Issue 3, Page(s) 265–267

MeSH term(s)	Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/methods ; Humans ; Organ Transplantation/adverse effects ; Organ Transplantation/methods ; Perioperative Care/methods ; Thoracic Surgical Procedures/adverse effects ; Thoracic Surgical Procedures/methods
Language	English
Publishing date	2019-10-08
Publishing country	United States
Document type	Editorial
ZDB-ID	2012371-1
ISSN	1940-5596 ; 1089-2532
ISSN (online)	1940-5596
ISSN	1089-2532
DOI	10.1177/1089253219866297
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Article ; Online: Adding Value by Going Beyond.

Rio, J Mauricio Del / Weitzel, Nathaen / Kertai, Miklos D

Seminars in cardiothoracic and vascular anesthesia

2019 Volume 22, Issue 4, Page(s) 341–344

MeSH term(s)	Anesthesiologists/economics ; Anesthesiologists/organization & administration ; Anesthesiology/economics ; Anesthesiology/organization & administration ; Delivery of Health Care/economics ; Delivery of Health Care/organization & administration ; Humans ; Perioperative Care/methods
Language	English
Publishing date	2019-02-14
Publishing country	United States
Document type	Editorial
ZDB-ID	2012371-1
ISSN	1940-5596 ; 1089-2532
ISSN (online)	1940-5596
ISSN	1089-2532
DOI	10.1177/1089253218807796
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Article ; Online: Comparing Anesthesia and Surgery Controlled Time for Primary Total Knee and Hip Arthroplasty Between an Academic Medical Center and a Community Hospital: Retrospective Cohort Study.

Nguyen, Thy B / Weitzel, Nathaen / Hogan, Craig / Kacmar, Rachel M / Williamson, Kayla M / Pattee, Jack / Jevtovic-Todorovic, Vesna / Simmons, Colby G / Faruki, Adeel Ahmad

JMIR perioperative medicine

2024 Volume 7, Page(s) e45126

Abstract: Background: Osteoarthritis is a significant cause of disability, resulting in increased joint replacement surgeries and health care costs. Establishing benchmarks that more accurately predict surgical duration could help to decrease costs, maximize ... ...

Abstract	Background: Osteoarthritis is a significant cause of disability, resulting in increased joint replacement surgeries and health care costs. Establishing benchmarks that more accurately predict surgical duration could help to decrease costs, maximize efficiency, and improve patient experience. We compared the anesthesia-controlled time (ACT) and surgery-controlled time (SCT) of primary total knee (TKA) and total hip arthroplasties (THA) between an academic medical center (AMC) and a community hospital (CH) for 2 orthopedic surgeons. Objective: This study aims to validate and compare benchmarking times for ACT and SCT in a single patient population at both an AMC and a CH. Methods: This retrospective 2-center observational cohort study was conducted at the University of Colorado Hospital (AMC) and UCHealth Broomfield Hospital (CH). Cases with current procedural terminology codes for THA and TKA between January 1, 2019, and December 31, 2020, were assessed. Cases with missing data were excluded. The primary outcomes were ACT and SCT. Primary outcomes were tested for association with covariates of interest. The primary covariate of interest was the location of the procedure (CH vs AMC); secondary covariates of interest included the American Society of Anesthesiologists (ASA) classification and anesthetic type. Linear regression models were used to assess the relationships. Results: Two surgeons performed 1256 cases at the AMC and CH. A total of 10 THA cases and 12 TKA cases were excluded due to missing data. After controlling for surgeon, the ACT was greater at the AMC for THA by 3.77 minutes and for TKA by 3.58 minutes (P<.001). SCT was greater at the AMC for THA by 11.14 minutes and for TKA by 14.04 minutes (P<.001). ASA III/IV classification increased ACT for THA by 3.76 minutes (P<.001) and increased SCT for THA by 6.33 minutes after controlling for surgeon and location (P=.008). General anesthesia use was higher at the AMC for both THA (29.2% vs 7.3%) and TKA (23.8% vs 4.2%). No statistically significant association was observed between either ACT or SCT and anesthetic type (neuraxial or general) after adjusting for surgeon and location (all P>.05). Conclusions: We observed lower ACT and SCT at the CH for both TKA and THA after controlling for the surgeon of record and ASA classification. These findings underscore the efficiency advantages of performing primary joint replacements at the CH, showcasing an average reduction of 16 minutes in SCT and 4 minutes in ACT per case. Overall, establishing more accurate benchmarks to improve the prediction of surgical duration for THA and TKA in different perioperative environments can increase the reliability of surgical duration predictions and optimize scheduling. Future studies with study populations at multiple community hospitals and academic medical centers are needed before extrapolating these findings.
Language	English
Publishing date	2024-02-26
Publishing country	Canada
Document type	Journal Article
ISSN	2561-9128
ISSN (online)	2561-9128
DOI	10.2196/45126
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Book ; Online: Towards Learned Emulation of Interannual Water Isotopologue Variations in General Circulation Models

Wider, Jonathan / Kruse, Jakob / Weitzel, Nils / Bühler, Janica C. / Köthe, Ullrich / Rehfeld, Kira

2023

Abstract: Simulating abundances of stable water isotopologues, i.e. molecules differing in their isotopic composition, within climate models allows for comparisons with proxy data and, thus, for testing hypotheses about past climate and validating climate models ... ...

Abstract	Simulating abundances of stable water isotopologues, i.e. molecules differing in their isotopic composition, within climate models allows for comparisons with proxy data and, thus, for testing hypotheses about past climate and validating climate models under varying climatic conditions. However, many models are run without explicitly simulating water isotopologues. We investigate the possibility to replace the explicit physics-based simulation of oxygen isotopic composition in precipitation using machine learning methods. These methods estimate isotopic composition at each time step for given fields of surface temperature and precipitation amount. We implement convolutional neural networks (CNNs) based on the successful UNet architecture and test whether a spherical network architecture outperforms the naive approach of treating Earth's latitude-longitude grid as a flat image. Conducting a case study on a last millennium run with the iHadCM3 climate model, we find that roughly 40\% of the temporal variance in the isotopic composition is explained by the emulations on interannual and monthly timescale, with spatially varying emulation quality. A modified version of the standard UNet architecture for flat images yields results that are equally good as the predictions by the spherical CNN. We test generalization to last millennium runs of other climate models and find that while the tested deep learning methods yield the best results on iHadCM3 data, the performance drops when predicting on other models and is comparable to simple pixel-wise linear regression. An extended choice of predictor variables and improving the robustness of learned climate--oxygen isotope relationships should be explored in future work.
Keywords	Physics - Atmospheric and Oceanic Physics ; Computer Science - Machine Learning
Subject code	550
Publishing date	2023-01-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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