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  1. Article ; Online: Evaluation of clinical effects of a multidisciplinary-collaborated cancer support team for gastrointestinal cancer chemotherapy: prospective observational study protocol of M-CAST study.

    Iimura, Yohei / Nakazawa, Mitsuko / Tsuru, Yukari / Togashi, Hitomi / Honda, Tomoe / Baba, Keisuke / Ishibashi, Masaaki / Sasuga, Chieko / Furukawa, Naoki / Sato, Tomoko / Matsubara, Yasuo / Kamisato, Ayako / Yoshii, Eiko / Kuroda, Seiichiro / Boku, Narikazu

    BMC gastroenterology

    2023  Volume 23, Issue 1, Page(s) 215

    Abstract: Background: Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate ... ...

    Abstract Background: Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate cooperation across multidisciplinary medical staff in our hospital and established clinical evidence of supportive care. This study aimed to prospectively evaluate the clinical activity and effect of MCST in patients with gastrointestinal cancer receiving chemotherapy.
    Methods: This is a single-center, single-arm, observational study. Patients with gastrointestinal cancer scheduled to receive chemotherapy are enrolled and supported by the MCST. The primary endpoints are the number of interventions by medical staff and the number of patients who showed improvement in side effects. The secondary endpoints are the severity of side effects, medical expenses, number of consultations, the acceptance rate of prescription recommendations, adjuvant chemotherapy completion rates, dose intensity, and time required for co-medical intervention. In addition, medical staff and attending physicians evaluate all adverse events.
    Discussion: This study is expected to contribute to establishing new cancer-supportive care teams for patients with gastrointestinal cancer receiving chemotherapy and those with cancer receiving chemotherapy.
    Trial registration: This trial was registered in the Japan Registry of Clinical Trials (jRCT) as jRCT1030220495. The date of first registration, 29/11/2022, https://jrct.niph.go.jp/search.
    MeSH term(s) Humans ; Gastrointestinal Neoplasms/drug therapy ; Chemotherapy, Adjuvant ; Japan ; Prospective Studies ; Observational Studies as Topic
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-023-02849-6
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  2. Article ; Online: Effects of m-Aramid/p-Aramid Blend Ratio on Tensile Strength due to UV Degradation for Firefighter Clothing Fabrics and Development of Predictive Equation for Tensile Strength.

    Wakatsuki, Kaoru / Matsubara, Minami / Watanabe, Norimichi / Bao, Limin / Morikawa, Hideaki

    Polymers

    2022  Volume 14, Issue 16

    Abstract: This study focused on the m-Aramid/p-Aramid blend ratio of the fabrics, clarified the quantitative ... on the combination of p-Aramid and m-Aramid blend percentages. Tensile strength for all blend ratios decreased ... exponentially with UV exposure energy and was within the range of results for fabrics with p-Aramid 100% and m ...

    Abstract This study focused on the m-Aramid/p-Aramid blend ratio of the fabrics, clarified the quantitative relationship between UV exposure and strength retention, and developed a mathematical model to calculate tensile strength from an arbitrary amount of UV exposure energy. The results of tensile strength tests before and after UV exposure showed that the decrease in tensile strength due to UV degradation depended on the combination of p-Aramid and m-Aramid blend percentages. Tensile strength for all blend ratios decreased exponentially with UV exposure energy and was within the range of results for fabrics with p-Aramid 100% and m-Aramid 100%. The retention fraction of tensile strength, which represents the tensile strength after UV exposure relative to the initial tensile strength, decreased exponentially with increasing the fraction of UV exposure energy for all fabrics used in this study. Fitting the retention fraction of tensile strength to the fraction of UV exposure energy, two groups of fabrics were classified based on m-Aramid blends of 40% or more and 60% or less. This model can predict the tensile strength of firefighter clothing fabrics that retain high mechanical strength when exposed to UV light and design the strength of firefighter clothing with consideration of degradation over time.
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14163241
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  3. Article ; Online: Quantitative Assessment of Tensile Strength and Degradation Coefficient of m-Aramid/p-Aramid Blended Yarns Used for Outer Layers of Firefighter Clothing under Ultraviolet Light and Correlation with Fabrics Data.

    Wakatsuki, Kaoru / Onoda, Souta / Matsubara, Minami / Watanabe, Norimichi / Bao, Limin / Morikawa, Hideaki

    Polymers

    2022  Volume 14, Issue 19

    Abstract: ... of tensile strength was investigated on the m-Aramid/p-Aramid blend ratio of spun yarn. An exponential equation ... of degradation coefficients based on the blending ratio of m-Aramid/p-Aramid. The correlation between ...

    Abstract The quantitative relationship between the fraction of UV exposure energy and the retention fraction of tensile strength was investigated on the m-Aramid/p-Aramid blend ratio of spun yarn. An exponential equation to calculate tensile strength from an arbitrary UV exposure energy is evaluated for yarns and fabrics. The spun yarns were exposed to UV light using a xenon-arc weathering meter. The retention fraction of tensile strength decreased exponentially with increasing the fraction of UV exposure energy. Curve fitting of the retention fraction of tensile strength to the fraction of UV exposure energy revealed two groups of degradation coefficients based on the blending ratio of m-Aramid/p-Aramid. The correlation between the degradation coefficients (αy and αf) of spun yarn and fabrics can be linearly regressed. The constant of proportionality in linear regression is considered to be the gap between the structure and the breaking mechanism of the fabric relative to yarn breakage. Based on the correlation between the degradation coefficients of spun yarn and fabrics and a mathematical model of the tensile strength of the spun yarn, the tensile strength of fabrics at a given UV exposure energy can be estimated from the tensile strength of the yarn.
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14193948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: TrmD: A Methyl Transferase for tRNA Methylation With m

    Hou, Ya-Ming / Matsubara, Ryuma / Takase, Ryuichi / Masuda, Isao / Sulkowska, Joanna I

    The Enzymes

    2017  Volume 41, Page(s) 89–115

    Abstract: ... the methylated m ...

    Abstract TrmD is an S-adenosyl methionine (AdoMet)-dependent methyl transferase that synthesizes the methylated m
    MeSH term(s) Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Methylation ; RNA Processing, Post-Transcriptional ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Substrate Specificity ; tRNA Methyltransferases/metabolism
    Chemical Substances Escherichia coli Proteins ; RNA, Transfer (9014-25-9) ; TrmD protein, E coli (EC 2.1.1.-) ; tRNA Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2017-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 0423-2607
    ISSN 0423-2607
    DOI 10.1016/bs.enz.2017.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Real-world efficacy and safety of two doses of cabazitaxel (20 or 25 mg/m

    Matsuyama, Hideyasu / Matsubara, Nobuaki / Kazama, Hirotaka / Seto, Takeshi / Tsukube, Shoko / Suzuki, Kazuhiro

    BMC cancer

    2020  Volume 20, Issue 1, Page(s) 649

    Abstract: ... CRPC) is 25 mg/m: Methods: We compared the safety and efficacy of cabazitaxel between patients ... who received cabazitaxel at starting doses of 25 and 20 mg/m: Results: The C20 and C25 groups comprised 190 ... unfit patients may benefit from a lower starting dose of 20 mg/m: Trial registration: Not applicable. ...

    Abstract Background: The recommended starting dose of cabazitaxel for castration-resistant prostate cancer (CRPC) is 25 mg/m
    Methods: We compared the safety and efficacy of cabazitaxel between patients who received cabazitaxel at starting doses of 25 and 20 mg/m
    Results: The C20 and C25 groups comprised 190 and 159 patients without matching and 112 patients per group after matching. In unmatched patients, any-grade (C25 vs C20: 89.3% vs 78.4%, Fisher's p < 0.01) and grade ≥ 3 (81.1% vs 61.1%) ADRs were more frequent in the C25 group. Neutropenia (any grade: 61.6% vs 54.2%; grade ≥ 3: 55.3% vs 42.6%) and febrile neutropenia (grade ≥ 3: 30.2% vs 14.7%) were more frequent in the C25 group. In matched patients, the PSA response rate (reduction in PSA ≥30% from a baseline ≥5 ng/mL) was 26.4 and 32.0% in the C20 and C25 groups, respectively, median OS was 291 days (95% CI 230-not reached) versus not reached (hazard ratio 0.73, 95% CI 0.50-1.08), and TTF favored C25 (hazard ratio 0.75, 95% CI 0.57-0.99).
    Conclusions: Clinicians should consider the patient's risk of clinically significant ADRs and prophylactic granulocyte colony stimulating factor when selecting the starting dose of cabazitaxel for CRPC. Some patients at high risk of ADRs or unfit patients may benefit from a lower starting dose of 20 mg/m
    Trial registration: Not applicable.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Dose-Response Relationship, Drug ; Follow-Up Studies ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Product Surveillance, Postmarketing/methods ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/epidemiology ; Prostatic Neoplasms, Castration-Resistant/pathology ; Taxoids/therapeutic use ; Treatment Outcome
    Chemical Substances Taxoids ; cabazitaxel (51F690397J)
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-020-07131-6
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  6. Article ; Online: Effects of m-Aramid/p-Aramid Blend Ratio on Tensile Strength due to UV Degradation for Firefighter Clothing Fabrics and Development of Predictive Equation for Tensile Strength

    Kaoru Wakatsuki / Minami Matsubara / Norimichi Watanabe / Limin Bao / Hideaki Morikawa

    Polymers, Vol 14, Iss 16, p

    2022  Volume 3241

    Abstract: This study focused on the m-Aramid/p-Aramid blend ratio of the fabrics, clarified the quantitative ... on the combination of p-Aramid and m-Aramid blend percentages. Tensile strength for all blend ratios decreased ... exponentially with UV exposure energy and was within the range of results for fabrics with p-Aramid 100% and m ...

    Abstract This study focused on the m-Aramid/p-Aramid blend ratio of the fabrics, clarified the quantitative relationship between UV exposure and strength retention, and developed a mathematical model to calculate tensile strength from an arbitrary amount of UV exposure energy. The results of tensile strength tests before and after UV exposure showed that the decrease in tensile strength due to UV degradation depended on the combination of p-Aramid and m-Aramid blend percentages. Tensile strength for all blend ratios decreased exponentially with UV exposure energy and was within the range of results for fabrics with p-Aramid 100% and m-Aramid 100%. The retention fraction of tensile strength, which represents the tensile strength after UV exposure relative to the initial tensile strength, decreased exponentially with increasing the fraction of UV exposure energy for all fabrics used in this study. Fitting the retention fraction of tensile strength to the fraction of UV exposure energy, two groups of fabrics were classified based on m-Aramid blends of 40% or more and 60% or less. This model can predict the tensile strength of firefighter clothing fabrics that retain high mechanical strength when exposed to UV light and design the strength of firefighter clothing with consideration of degradation over time.
    Keywords ultra violet ; tensile strength ; high performance fiber ; aramid ; degradation ; ageing ; Organic chemistry ; QD241-441
    Subject code 690
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Mass ligation: M cross double ligation with the edge picked up.

    Matsubara, Shigeki

    Acta obstetricia et gynecologica Scandinavica

    2011  Volume 91, Issue 1, Page(s) 155–156

    MeSH term(s) Female ; Humans ; Hysterectomy/methods ; Ligation/methods ; Ovary/surgery ; Postpartum Hemorrhage/surgery ; Pregnancy
    Language English
    Publishing date 2011-10-17
    Publishing country United States
    Document type Letter
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/j.1600-0412.2011.01272.x
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    Um I Zs.168: Show issues Location:
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  8. Article ; Online: Authors' reply to Drs M van Blitterswijk, R Rademakers and LH van den Berg.

    Homma, T / Nagaoka, U / Kawata, A / Mochizuki, Y / Kawakami, H / Maruyama, H / Matsubara, S / Komori, T

    Neuropathology and applied neurobiology

    2014  Volume 40, Issue 3, Page(s) 359–360

    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; DNA-Binding Proteins/genetics ; Female ; Humans ; Male
    Chemical Substances DNA-Binding Proteins
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80371-6
    ISSN 1365-2990 ; 0305-1846
    ISSN (online) 1365-2990
    ISSN 0305-1846
    DOI 10.1111/nan.12105
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1241: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Trinuclear ruthenium polyhydride complexes with a triply bridging ligand: [[(eta5-C5Me5)Ru]3(mu3-M)(mu-H)3(mu3-H)] (M=Li, MgiPr, and ZnEt) and [[(eta5-C5Me5)Ru]3(mu3-M)(mu-H)3] (M=AlEt and GaMe).

    Ohashi, Masato / Matsubara, Kouki / Iizuka, Takashi / Suzuki, Hiroharu

    Angewandte Chemie (International ed. in English)

    2003  Volume 42, Issue 8, Page(s) 937–940

    Language English
    Publishing date 2003-02-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.200390249
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  10. Article: Extraction-spectrophotometric determination of vanadium with N-m-tolyl-N-phenylhydroxylamine and its application to coal and coal fly-ash.

    Inoue, S / Hoshi, S / Matsubara, M

    Talanta

    2006  Volume 33, Issue 7, Page(s) 611–613

    Abstract: N-m-Tolyl-N-phenylhydroxylamine is proposed for the spectrophotometric determination ...

    Abstract N-m-Tolyl-N-phenylhydroxylamine is proposed for the spectrophotometric determination of small amounts of vanadium. The reddish-violet complex formed with the reagent in 3-6M hydrochloric acid after extraction with chloroform shows an absorption maximum at 530 nm, and obeys Beer's law for 0-76.5 mug of vanadium in 10 ml of chloroform. The proposed method has been successfully applied to the determination of vanadium in coal and coal fly-ash.
    Language English
    Publishing date 2006-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/0039-9140(86)80139-4
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