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Artikel: Genetic diagnosis of autosomal dominant polycystic kidney disease: linkage analysis versus direct mutation analysis.

Lee, Kyu-Beck

2016 Band 35, Heft 2, Seite(n) 67–68

Sprache	Englisch
Erscheinungsdatum	2016-05-05
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.1016/j.krcp.2016.04.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genetic diagnosis of autosomal dominant polycystic kidney disease

Kyu-Beck Lee

Kidney Research and Clinical Practice, Vol 35, Iss 2, Pp 67-

linkage analysis versus direct mutation analysis

2016 Band 68

Schlagwörter	Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
Sprache	Englisch
Erscheinungsdatum	2016-06-01T00:00:00Z
Verlag	The Korean Society of Nephrology
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease.

Ko, Ye Eun / Kim, Hyung Woo / Park, Jung Tak / Han, Seung Hyeok / Kang, Shin-Wook / Sung, Suah / Lee, Kyu-Beck / Lee, Joongyub / Oh, Kook-Hwan / Yoo, Tae-Hyun

Kidney research and clinical practice

2024

Abstract: Background: Coronary artery calcification (CAC) is highly prevalent in patients with chronic kidney disease (CKD) and is associated with major adverse cardiovascular events and metabolic disturbances. The triglyceride-glucose index (TyGI), a novel ... ...

Abstract	Background: Coronary artery calcification (CAC) is highly prevalent in patients with chronic kidney disease (CKD) and is associated with major adverse cardiovascular events and metabolic disturbances. The triglyceride-glucose index (TyGI), a novel surrogate marker of metabolic syndrome and insulin resistance, is associated with CAC in the general population and in patients with diabetes. This study investigated the association between the TyGI and CAC progression in patients with CKD, which is unknown. Methods: A total of 1,154 patients with CKD (grades 1-5; age, 52.8 ± 11.9 years; male, 688 [59.6%]) were enrolled from the KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease). The TyGI was calculated as follows: ln (fasting triglycerides × fasting glucose / 2). Patients were classified into tertiles (low, intermediate, high) based on the TyGI. The primary outcome was annualized percentage change in CAC score [(percent change in CAC score + 1)12/follow-up months - 1] of ≥15%, defined as CAC progression. Results: During the 4-year follow-up, the percentage of patients with CAC progression increased across TyGI groups (28.6%, 37.5%, and 46.2% in low, intermediate, and high groups, respectively; p < 0.001). A high TyGI was associated with an increased risk of CAC progression (odds ratio [OR], 2.11; 95% confidence interval [CI], 1.14-3.88; p = 0.02) compared to the low group. Moreover, a 1-point increase in the TyGI was related to increased risk of CAC progression (OR, 1.55; 95% CI, 1.06-1.76; p = 0.02) after adjustment. Conclusion: A high TyGI may be a useful predictor of CAC progression in CKD.
Sprache	Englisch
Erscheinungsdatum	2024-03-18
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.23.264
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Circulating osteoprotegerin levels and cardiovascular outcomes in patients with pre-dialysis chronic kidney disease: results from the KNOW-CKD study.

Suh, Sang Heon / Oh, Tae Ryom / Choi, Hong Sang / Kim, Chang Seong / Bae, Eun Hui / Ma, Seong Kwon / Oh, Kook-Hwan / Lee, Kyu-Beck / Jeong, Jong Cheol / Jung, Ji Yong / Kim, Soo Wan

Scientific reports

2024 Band 14, Heft 1, Seite(n) 4136

Abstract: While the relationship between circulating osteoprotegerin (OPG) and cardiovascular events is well-established in the general population, its association with cardiovascular risks in chronic kidney disease (CKD) patients remains less robust. This study ... ...

Abstract	While the relationship between circulating osteoprotegerin (OPG) and cardiovascular events is well-established in the general population, its association with cardiovascular risks in chronic kidney disease (CKD) patients remains less robust. This study hypothesized that elevated circulating OPG levels might be associated with an increased risk of major adverse cardiac events (MACE) in CKD patients, a total of 2,109 patients with CKD stages 1 through pre-dialysis 5 from the KNOW-CKD cohort were categorized into quartiles based on serum OPG levels. The primary outcome of the study was 3-point MACE, defined as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiac death. The median follow-up duration was 7.9 years. The cumulative incidence of 3-point MACE significantly varied across serum OPG levels in Kaplan-Meier curve analysis (P < 0.001, log-rank test), with the highest incidence observed in the 4th quartile. Cox regression analysis indicated that, relative to the 1st quartile, the risk of 3-point MACE was significantly higher in the 3rd (adjusted hazard ratio 2.901, 95% confidence interval 1.009 to 8.341) and the 4th quartiles (adjusted hazard ratio 4.347, 95% confidence interval 1.410 to 13.395). In conclusion, elevated circulating OPG levels are associated with adverse cardiovascular outcomes in pre-dialysis CKD patients.
Mesh-Begriff(e)	Humans ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular System ; Dialysis ; Myocardial Infarction/epidemiology ; Myocardial Infarction/complications ; Osteoprotegerin/blood ; Osteoprotegerin/chemistry ; Renal Insufficiency, Chronic/complications ; Risk Factors
Chemische Substanzen	Osteoprotegerin
Sprache	Englisch
Erscheinungsdatum	2024-02-19
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54335-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Nutritional Status is Associated With Preserved Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease.

Lee, Jinwoo / Ryu, Hyunjin / Kim, Yong-Chul / Park, Hayne Cho / Ahn, Curie / Lee, Kyu-Beck / Kim, Yeong Hoon / Kim, Yaerim / Han, Seungyeop / Bae, Eun Hui / Oh, Kook-Hwan / Oh, Yun Kyu

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2023 Band 33, Heft 4, Seite(n) 529–537

Abstract: Objective: Malnutrition is a common complication in autosomal dominant polycystic kidney disease (ADPKD). We examined whether nutritional status is associated with the preservation of kidney function, using a cohort of typical ADPKD.: Methods: We ... ...

Abstract	Objective: Malnutrition is a common complication in autosomal dominant polycystic kidney disease (ADPKD). We examined whether nutritional status is associated with the preservation of kidney function, using a cohort of typical ADPKD. Methods: We enrolled ambulatory ADPKD patients in 9 tertiary medical centers in Korea from May 2019 to December 2021. We excluded patients who were aged less than 18 years, who had known end-stage kidney disease at the time of enrollment, who had a diagnosis of atypical ADPKD, and who were Tolvaptan users. The primary outcome was an estimated glomerular filtration rate (eGFR) decline >3 mL/min/1.73 m Results: In total, 805 patients were prospectively enrolled. Among them, 236 patients who had 1-year follow-up data and typical imaging findings were analyzed to evaluate the effect of nutritional status on kidney function. SGA was used to assess the nutritional status. The mean age was 45.0 ± 13.3 years, and 49.6% of the patients were female. The mean eGFR was 81.9 mL/min/1.73 m Conclusion: Good nutritional status is associated with better-preserved kidney function in non-obese typical ADPKD patients who do not take Tolvaptan.
Mesh-Begriff(e)	Humans ; Female ; Adult ; Middle Aged ; Male ; Polycystic Kidney, Autosomal Dominant/complications ; Tolvaptan/pharmacology ; Kidney ; Antidiuretic Hormone Receptor Antagonists/pharmacology ; Nutritional Status ; Glomerular Filtration Rate ; Disease Progression
Chemische Substanzen	Tolvaptan (21G72T1950) ; Antidiuretic Hormone Receptor Antagonists
Sprache	Englisch
Erscheinungsdatum	2023-03-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2023.02.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease.

Suh, Sang Heon / Oh, Tae Ryom / Choi, Hong Sang / Kim, Chang Seong / Lee, Joongyub / Oh, Yun Kyu / Jung, Ji Yong / Lee, Kyu-Beck / Oh, Kook-Hwan / Ma, Seong Kwon / Bae, Eun Hui / Kim, Soo Wan

Frontiers in cardiovascular medicine

2022 Band 8, Seite(n) 789488

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2022-01-13
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.789488
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Factors Associated With the Development and Severity of Polycystic Liver in Patients With Autosomal Dominant Polycystic Kidney Disease.

Kim, Yaerim / Park, Hayne Cho / Ryu, Hyunjin / Kim, Yong Chul / Ahn, Curie / Lee, Kyu-Beck / Kim, Yeong Hoon / Han, Seungyeup / Bae, Eun Hui / Jeong, Kyungjo / Choi, Jungmin / Oh, Kook-Hwan / Oh, Yun Kyu

Journal of Korean medical science

2023 Band 38, Heft 38, Seite(n) e296

Abstract: Background: Factors related to the development and severity of polycystic liver disease (PLD) have not been well established. We aimed to evaluate the genetic and epidemiologic risk factors of PLD in patients with autosomal dominant polycystic kidney ... ...

Abstract	Background: Factors related to the development and severity of polycystic liver disease (PLD) have not been well established. We aimed to evaluate the genetic and epidemiologic risk factors of PLD in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: Adult patients with inherited cystic kidney disease were enrolled from May 2019 to May 2021. Demographic, clinical, and laboratory data were collected at the initial study visit. The severity of PLD was graded based on the height-adjusted total liver volume: < 1,000 mL/m (Gr1), 1,000-1,800 mL/m (Gr2), and > 1,800 mL/m (Gr3). Targeted exome sequencing was done by a gene panel including 89 ciliopathy-related genes. We searched out the relative factors to the presence and the severity of PLD using logistic regression analysis. Results: Of 602 patients with typical ADPKD, 461 (76.6%) patients had PLD. The patients with PLD showed female predominance and a higher frequency of other ADPKD-related complications. The genetic variants with truncating mutation of PKD1 (PKD1-protein-truncating [PT]) or PKD2 commonly affected the development and severity of PLD. An older age, female sex, and higher kidney volume with Mayo classification 1C-1E was significantly associated with the development of PLD, but not with the severity of PLD. On the other hand, higher body mass index, lower hemoglobin, and higher alkaline phosphatase (ALP) were the significant risk factors of severe PLD (≥ Gr2). Conclusion: Hepatic involvement in ADPKD could be related to kidney manifestations and genetic variants including PKD1-PT or PKD2. Monitoring hemoglobin and ALP and evaluating the genetic variants might help predict severe PLD. Trial registration: Clinical Research Information Service Identifier: KCT0005580.
Mesh-Begriff(e)	Adult ; Humans ; Female ; Male ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Polycystic Kidney, Autosomal Dominant/genetics ; Liver ; Kidney ; Body Mass Index ; Laboratories
Sprache	Englisch
Erscheinungsdatum	2023-09-25
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e296
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease

Young Youl Hyun / Hyang Kim / Kyu-Beck Lee

Kidney Research and Clinical Practice, Vol 36, Iss 3, Pp 232-

2017 Band 239

Abstract: Background: Red cell distribution width (RDW) is an emerging marker of inflammation and a predictor of high cardiovascular morbidity and mortality as well as all-cause mortality. A previous cross-sectional study showed that RDW was associated with ... ...

Abstract	Background: Red cell distribution width (RDW) is an emerging marker of inflammation and a predictor of high cardiovascular morbidity and mortality as well as all-cause mortality. A previous cross-sectional study showed that RDW was associated with microalbuminuria, an indicator of target organ damage. However, the longitudinal association of RDW and development of albuminuria is not known. Methods: We analyzed 83,040 participants without chronic kidney disease (CKD) at baseline who underwent two health check-ups at a 4-year interval during 2005 to 2014. Urine albumin was determined by single urine dipstick semi-quantitative analysis, and incident albuminuria was defined as ≥ 1+ dipstick albumin at the second check-up. We used logistic regression analysis to determine the relationship between RDW and incident albuminuria. Results: Participants were divided into quartiles according to baseline RDW. After 4 years, 982 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 0.94, 1.05, 1.18, and 1.62% for the 1st through 4th quartiles of RDW, respectively. Multivariate logistic analysis showed that the odds ratios (95% confidence interval) for incident albuminuria compared to those in the 1st quartile were 1.11 (0.92–1.34), 1.26 (1.04–1.52), and 1.88 (1.58–2.24) for the 2nd, 3rd and 4th quartiles, respectively. Conclusion: RDW was associated with development of albuminuria in relatively healthy Korean adults without CKD. Further research is needed to verify the role of RDW in the development of albuminuria and renal injury.
Schlagwörter	Albuminuria ; Chronic kidney disease ; Red cell distribution width ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
Thema/Rubrik (Code)	616
Sprache	Englisch
Erscheinungsdatum	2017-09-01T00:00:00Z
Verlag	The Korean Society of Nephrology
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Coronary artery calcium and risk of chronic kidney disease in young and middle-aged adults.

Kim, Yejin / Kang, Jeonggyu / Chang, Yoosoo / Hyun, Young Youl / Lee, Kyu-Beck / Shin, Hocheol / Wild, Sarah H / Byrne, Christopher D / Ryu, Seungho

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2022 Band 38, Heft 6, Seite(n) 1439–1447

Abstract: Background: The role of the coronary artery calcium score (CACS) in incident chronic kidney disease (CKD) in asymptomatic young populations remains unclear. The aim of this study was to evaluate the association between CACSs and CKD development in ... ...

Abstract	Background: The role of the coronary artery calcium score (CACS) in incident chronic kidney disease (CKD) in asymptomatic young populations remains unclear. The aim of this study was to evaluate the association between CACSs and CKD development in adults. Methods: A cohort study of 113 171 Korean adults (mean age 40.6 years) without CKD and proteinuria at baseline who underwent a cardiac tomography estimation of CACSs during health screening examinations was performed (median follow-up 4.2 years). The outcome was CKD, defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 and/or the presence of proteinuria. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CKD were estimated using Cox proportional hazards regression analyses. Results: A higher CACS was moderately associated with an increased risk of CKD in a dose-dependent manner. The multivariable-adjusted HRs for CKD comparing CACSs 1-100, 101-300 and >300 with a CACS of 0 were 1.15 (95% CI 1.05-1.25), 1.37 (95% CI 1.13-1.66) and 1.71 (95% CI 1.32-2.22), respectively (P for trend <.001). When CKD was defined using low eGFR and proteinuria separately, corresponding HRs for low eGFR were 1.31 (95% CI 1.05-1.62), 1.41 (95% CI 0.95-2.11) and 1.86 (95% CI 1.16-3.00), respectively (P for trend = .001), while the HRs for proteinuria were 1.11 (95% CI 1.02-1.21), 1.32 (95% CI 1.07-1.64) and 1.57 (95% CI 1.16-2.12), respectively. Conclusions: A higher CACS was progressively associated with an increased risk of CKD, even at low CACSs. Individuals with a CACS >0 appear to have an increased risk of CKD and may benefit from preventive measures to reduce CKD risk.
Mesh-Begriff(e)	Middle Aged ; Adult ; Humans ; Cohort Studies ; Calcium ; Coronary Vessels/diagnostic imaging ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/complications ; Proteinuria/etiology ; Proteinuria/complications ; Glomerular Filtration Rate ; Calcium, Dietary ; Risk Factors ; Coronary Artery Disease/etiology ; Coronary Artery Disease/complications
Chemische Substanzen	Calcium (SY7Q814VUP) ; Calcium, Dietary
Sprache	Englisch
Erscheinungsdatum	2022-09-14
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfac272
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Baseline characteristics of the Korean genetic cohort of inherited cystic kidney disease.

Cho, Jeong Min / Park, Hayne Cho / Lee, Jin Woo / Ryu, Hyunjin / Kim, Yong Chul / Ahn, Curie / Lee, Kyu-Beck / Kim, Yeong Hoon / Han, Seungyeup / Kim, Yaerim / Bae, Eun Hui / Kang, Hee Gyung / Park, Eujin / Jeong, Kyungjo / Kang, Seoon / Choi, Jungmin / Oh, Kook-Hwan / Oh, Yun Kyu

Kidney research and clinical practice

2023 Band 42, Heft 5, Seite(n) 617–627

Abstract: Background: Identifying genetic mutations in individuals with inherited cystic kidney disease is necessary for precise treatment. We aimed to elucidate the genetic characteristics of cystic kidney disease in the Korean population.: Methods: We ... ...

Abstract	Background: Identifying genetic mutations in individuals with inherited cystic kidney disease is necessary for precise treatment. We aimed to elucidate the genetic characteristics of cystic kidney disease in the Korean population. Methods: We conducted a 3-year prospective, multicenter cohort study at eight hospitals from May 2019 to May 2022. Patients with more than three renal cysts were enrolled and classified into two categories, typical autosomal dominant polycystic kidney disease (ADPKD) and atypical PKD. We identified the clinical characteristics and performed a genetic analysis using a targeted gene panel. Results: A total of 725 adult patients were included in the study, of which 560 (77.2%) were diagnosed with typical ADPKD and 165 (22.8%) had atypical PKD. Among the typical ADPKD cases, the Mayo imaging classification was as follows: 1A (55, 9.9%), 1B (149, 26.6%), 1C (198, 35.8%), 1D (90, 16.3%), and 1E (61, 11.0%). The atypical PKD cases were classified as bilateral cystic with bilateral atrophic (31, 37.3%), lopsided (27, 32.5%), unilateral (nine, 10.8%), segmental (eight, 9.6%), bilateral cystic with unilateral atrophic (seven, 8.4%), and asymmetric (one, 1.2%). Pathogenic variants were found in 64.3% of the patients using the ciliopathy-related targeted gene panel. The typical ADPKD group demonstrated a higher discovery rate (62.3%) than the atypical PKD group (41.8%). Conclusion: We present a nationwide genetic cohort's baseline clinical and genetic characteristics for Korean cystic kidney disease.
Sprache	Englisch
Erscheinungsdatum	2023-09-27
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.23.097
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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