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Book ; Online ; E-Book: Reconstructive plastic surgery

Murphy, Robert X. / Herman, Charles K.

an atlas of essential procedures

2022

Author's details	Robert X. Murphy Jr., MD, MS, CPE, FACS; Charles K. Herman, MD, MBA, FACS
Keywords	head-to-toe surgical procedures ; how-to guide for trainees ; cleft palate defects and repair ; functional rhinoplasty ; breast reduction/reconstruction techniques ; nerve-related conditions ; trauma ; tumor resection ; burns ; congenital deformities ; degenerative conditions ; 817
Language	English
Size	1 Online-Ressource (xxiv, 411 Seiten), 1412 Illustrationen
Publisher	Thieme
Publishing place	New York
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021137972
ISBN	978-1-626235-18-2 ; 9781626235175 ; 1-626235-18-X ; 1626235171
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Revisiting a (001)-oriented layered lead chloride templated by 1,2,4-triazolium: structural phase transitions, lattice dynamics and broadband photoluminescence.

Mączka, Mirosław / Sobczak, Szymon / Ptak, Maciej / Smółka, Szymon / Fedoruk, Katarzyna / Dybała, Filip / Herman, Artur P / Paraguassu, Waldeci / Zaręba, Jan K / Kudrawiec, Robert / Sieradzki, Adam / Katrusiak, Andrzej

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 16, Page(s) 6906–6919

Abstract: This study revisits a (001)-oriented layered lead chloride templated by 1,2,4-triazolium, ... ...

Abstract	This study revisits a (001)-oriented layered lead chloride templated by 1,2,4-triazolium, Tz
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d4dt00406j
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Article ; Online: Odor identification errors reveal cognitive aspects of age-associated smell loss.

Raj, Rohan / Hörberg, Thomas / Lindroos, Robert / Larsson, Maria / Herman, Pawel / Laukka, Erika J / Olofsson, Jonas K

Cognition

2023 Volume 236, Page(s) 105445

Abstract: Human olfaction can be extraordinarily sensitive, and its most common assessment method is odor identification (OID), where everyday odors are matched to word labels in a multiple-choice format. However, many older persons are unable to identify familiar ...

Abstract	Human olfaction can be extraordinarily sensitive, and its most common assessment method is odor identification (OID), where everyday odors are matched to word labels in a multiple-choice format. However, many older persons are unable to identify familiar odors, a deficit that is associated with the risk of future dementia and mortality. The underlying processes subserving OID in older adults are poorly understood. Here, we analyzed error patterns in OID to test whether errors could be explained by perceptual and/or semantic similarities among the response alternatives. We investigated the OID response patterns in a large, population-based sample of older adults in Sweden (n = 2479; age 60-100 years). Olfaction was assessed by a 'Sniffin ́ TOM OID test with 16 odors; each trial involved matching a target odor to a correct label among three distractors. We analyzed the pattern of misidentifications, and the results showed that some distractors were more frequently selected than others, suggesting cognitive or perceptual factors may be present. Relatedly, we conducted a large online survey of older adults (n = 959, age 60-90 years) who were asked to imagine and rate the perceptual similarity of the target odors and the three corresponding distractors (e.g. "How similar are these smells: apple and mint?"). We then used data from the Swedish web corpus and the Word2Vec neural network algorithm to quantify the semantic association strength between the labels of each target odor and its three distractors. These data sources were used to predict odor identification errors. We found that the error patterns were partly explained by both the semantic similarity between target-distractor pairs, and the imagined perceptual similarity of the target-distractor pair. Both factors had, however, a diminished prediction in older ages, as responses became gradually less systematic. In sum, our results suggest that OID tests not only reflect olfactory perception, but also likely involve the mental processing of odor-semantic associations. This may be the reason why these tests are useful in predicting dementia onset. Our insights into olfactory-language interactions could be harnessed to develop new olfactory tests that are tailored for specific clinical purposes.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Middle Aged ; Odorants ; Anosmia ; Smell/physiology ; Cognition ; Dementia
Language	English
Publishing date	2023-04-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1499940-7
ISSN	1873-7838 ; 0010-0277
ISSN (online)	1873-7838
ISSN	0010-0277
DOI	10.1016/j.cognition.2023.105445
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Article ; Online: A longitudinal multi-scanner multimodal human neuroimaging dataset.

Hawco, Colin / Dickie, Erin W / Herman, Gabrielle / Turner, Jessica A / Argyelan, Miklos / Malhotra, Anil K / Buchanan, Robert W / Voineskos, Aristotle N

Scientific data

2022 Volume 9, Issue 1, Page(s) 332

Abstract: Human neuroimaging has led to an overwhelming amount of research into brain function in healthy and clinical populations. However, a better appreciation of the limitations of small sample studies has led to an increased number of multi-site, multi- ... ...

Abstract	Human neuroimaging has led to an overwhelming amount of research into brain function in healthy and clinical populations. However, a better appreciation of the limitations of small sample studies has led to an increased number of multi-site, multi-scanner protocols to understand human brain function. As part of a multi-site project examining social cognition in schizophrenia, a group of "travelling human phantoms" had structural T1, diffusion, and resting-state functional MRIs obtained annually at each of three sites. Scan protocols were carefully harmonized across sites prior to the study. Due to scanner upgrades at each site (all sites acquired PRISMA MRIs during the study) and one participant being replaced, the end result was 30 MRI scans across 4 people, 6 MRIs, and 4 years. This dataset includes multiple neuroimaging modalities and repeated scans across six MRIs. It can be used to evaluate differences across scanners, consistency of pipeline outputs, or test multi-scanner harmonization approaches.
MeSH term(s)	Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Phantoms, Imaging ; Reproducibility of Results ; Schizophrenia/diagnostic imaging
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-022-01386-3
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Article: Defining incidence and complications of fibrolamellar liver cancer through tiered computational analysis of clinical data.

Zack, Travis / Losert, Kurt P / Maisel, Samantha M / Wild, Jennifer / Yaqubie, Amin / Herman, Michael / Knox, Jennifer J / Mayer, Robert J / Venook, Alan P / Butte, Atul / O'Neill, Allison F / Abou-Alfa, Ghassan K / Gordan, John D

NPJ precision oncology

2023 Volume 7, Issue 1, Page(s) 29

Abstract: The incidence and biochemical consequences of rare tumor subtypes are often hard to study. Fibrolamellar liver cancer (FLC) is a rare malignancy affecting adolescents and young adults. To better characterize the incidence and biochemical consequences of ... ...

Abstract	The incidence and biochemical consequences of rare tumor subtypes are often hard to study. Fibrolamellar liver cancer (FLC) is a rare malignancy affecting adolescents and young adults. To better characterize the incidence and biochemical consequences of this disease, we combined a comprehensive analysis of the electronic medical record and national payer data and found that FLC incidence is likely five to eight times higher than previous estimates. By employing unsupervised learning on clinical laboratory data from patients with hyperammonemia, we find that FLC-associated hyperammonemia mirrors metabolic dysregulation in urea cycle disorders. Our findings demonstrate that advanced computational analysis of rich clinical datasets can provide key clinical and biochemical insights into rare cancers.
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ISSN	2397-768X
ISSN	2397-768X
DOI	10.1038/s41698-023-00371-2
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Article ; Online: Predictors of recurrence and long-term patient reported outcomes following surgical repair of anal fistula, a retrospective analysis.

Khan, Sidrah / Kotcher, Rebecca / Herman, Paul / Wang, Li / Tessler, Robert / Cunningham, Kellie / Celebrezze, James / Medich, David / Holder-Murray, Jennifer

International journal of colorectal disease

2024 Volume 39, Issue 1, Page(s) 37

Abstract: Purpose: Surgery for anal fistulas can result in devastating complications, including reoperations and fecal incontinence. There is limited contemporary evidence comparing outcomes since the adoption of the ligation of intersphincteric fistula tract ... ...

Abstract	Purpose: Surgery for anal fistulas can result in devastating complications, including reoperations and fecal incontinence. There is limited contemporary evidence comparing outcomes since the adoption of the ligation of intersphincteric fistula tract procedure into mainstream practice. The purpose of this study is to compare recurrence rates and long-term outcomes of anal fistula following repair. Methods: Data was collected from the electronic medical records or patient reported outcomes from patients aged 18 or older with a primary or recurrent cryptoglandular anal fistula. Primary outcome was recurrence defined as the identification of at least one fistula os or a high clinical suspicion of anal fistula. Secondary outcomes included fecal incontinence and postoperative quality of life. Results: A total of 171 patients underwent definitive surgical repairs for their anal fistula. So 66.5% had a simple fistula, and 33.5% had a complex fistula. Of the 171 patients, 12.5% had a recurrence. The recurrence rates were 5.9% for simple fistula and 25.4% for complex fistula. Predictors of recurrence included diabetes mellitus, history of anorectal abscess, complex fistula, and sphincter sparing surgery. LIFT or plug/biologic procedures were both associated with a 50% or greater recurrence rate. No significant differences were found in fecal incontinence or associated quality of life between sphincter sparing or non-sphincter sparing surgical resections. Conclusion: The study provides insights into the long-term outcomes of surgical repair for anal fistula. We demonstrate that sphincter sparing operations are associated with increased recurrence, meanwhile, non-sphincter sparing surgeries did not increase the risk of fecal incontinence or worsen quality of life.
MeSH term(s)	Humans ; Fecal Incontinence/etiology ; Retrospective Studies ; Anal Canal/surgery ; Quality of Life ; Treatment Outcome ; Organ Sparing Treatments ; Neoplasm Recurrence, Local ; Rectal Fistula/surgery ; Rectal Fistula/complications ; Ligation/adverse effects ; Ligation/methods ; Patient Reported Outcome Measures ; Recurrence
Language	English
Publishing date	2024-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-024-04602-1
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Article: A Radiomics-Based Classifier for the Progression of Oropharyngeal Cancer Treated with Definitive Radiotherapy.

Garcia, Darwin A / Jeans, Elizabeth B / Morris, Lindsay K / Shiraishi, Satomi / Laughlin, Brady S / Rong, Yi / Rwigema, Jean-Claude M / Foote, Robert L / Herman, Michael G / Qian, Jing

Cancers

2023 Volume 15, Issue 14

Abstract: In this study, we investigated whether radiomics features from pre-treatment positron emission tomography (PET) images could be used to predict disease progression in patients with HPV-positive oropharyngeal cancer treated with definitive proton or x-ray ...

Abstract	In this study, we investigated whether radiomics features from pre-treatment positron emission tomography (PET) images could be used to predict disease progression in patients with HPV-positive oropharyngeal cancer treated with definitive proton or x-ray radiotherapy. Machine learning models were built using a dataset from Mayo Clinic, Rochester, Minnesota (n = 72) and tested on a dataset from Mayo Clinic, Phoenix, Arizona (n = 22). A total of 71 clinical and radiomics features were considered. The Mann-Whitney U test was used to identify the top 2 clinical and top 20 radiomics features that were significantly different between progression and progression-free patients. Two dimensionality reduction methods were used to define two feature sets (manually filtered or machine-driven). A forward feature selection scheme was conducted on each feature set to build models of increased complexity (number of input features from 1 to 6) and evaluate model robustness and overfitting. The machine-driven features had superior performance and were less prone to overfitting compared to the manually filtered features. The four-variable Gaussian Naïve Bayes model using the 'Radiation Type' clinical feature and three machine-driven features achieved a training accuracy of 79% and testing accuracy of 77%. These results demonstrate that radiomics features can provide risk stratification beyond HPV-status to formulate individualized treatment and follow-up strategies.
Language	English
Publishing date	2023-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15143715
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Article ; Online: Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells.

Science advances

2024 Volume 10, Issue 6, Page(s) eadk1827

Abstract: Radiotherapy is hypothesized to have an immune-modulating effect on the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) to sensitize it to anti-PD-1 antibody (a-PD-1) treatment. We collected paired pre- and posttreatment specimens ...

Abstract	Radiotherapy is hypothesized to have an immune-modulating effect on the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) to sensitize it to anti-PD-1 antibody (a-PD-1) treatment. We collected paired pre- and posttreatment specimens from a clinical trial evaluating combination treatment with GVAX vaccine, a-PD-1, and stereotactic body radiation (SBRT) following chemotherapy for locally advanced PDACs (LAPC). With resected PDACs following different neoadjuvant therapies as comparisons, effector cells in PDACs were found to skew toward a more exhausted status in LAPCs following chemotherapy. The combination of GVAX/a-PD-1/SBRT drives TME to favor antitumor immune response including increased densities of GZMB
MeSH term(s)	Humans ; Neoadjuvant Therapy ; CD8-Positive T-Lymphocytes/pathology ; Radioimmunotherapy ; Programmed Cell Death 1 Receptor ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Programmed Cell Death 1 Receptor
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adk1827
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Article ; Online: Mosaic analysis in the nematode Caenorhabditis elegans.

Herman, Robert K

Journal of neurogenetics

2007 Volume 21, Issue 4, Page(s) 219–242

Language	English
Publishing date	2007-10
Publishing country	England
Document type	Journal Article
ZDB-ID	605543-6
ISSN	1563-5260 ; 0167-7063
ISSN (online)	1563-5260
ISSN	0167-7063
DOI	10.1080/01677060701693446
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Article ; Online: Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix.

Smail, Marissa A / Smith, Brittany L / Shukla, Rammohan / Alganem, Khaled / Eby, Hunter M / Bollinger, Justin L / Parikh, Ria K / Chambers, James B / Reigle, James K / Moloney, Rachel D / Nawreen, Nawshaba / Wohleb, Eric S / Pantazopoulos, Harry / McCullumsmith, Robert E / Herman, James P

Molecular psychiatry

2023 Volume 28, Issue 11, Page(s) 4729–4741

Abstract: Psychological loss is a common experience that erodes well-being and negatively impacts quality of life. The molecular underpinnings of loss are poorly understood. Here, we investigate the mechanisms of loss using an environmental enrichment removal (ER) ...

Abstract	Psychological loss is a common experience that erodes well-being and negatively impacts quality of life. The molecular underpinnings of loss are poorly understood. Here, we investigate the mechanisms of loss using an environmental enrichment removal (ER) paradigm in male rats. The basolateral amygdala (BLA) was identified as a region of interest, demonstrating differential Fos responsivity to ER and having an established role in stress processing and adaptation. A comprehensive multi-omics investigation of the BLA, spanning multiple cohorts, platforms, and analyses, revealed alterations in microglia and the extracellular matrix (ECM). Follow-up studies indicated that ER decreased microglia size, complexity, and phagocytosis, suggesting reduced immune surveillance. Loss also substantially increased ECM coverage, specifically targeting perineuronal nets surrounding parvalbumin interneurons, suggesting decreased plasticity and increased inhibition within the BLA following loss. Behavioral analyses suggest that these molecular effects are linked to impaired BLA salience evaluation, leading to a mismatch between stimulus and reaction intensity. These loss-like behaviors could be rescued by depleting BLA ECM during the removal period, helping us understand the mechanisms underlying loss and revealing novel molecular targets to ameliorate its impact.
MeSH term(s)	Rats ; Animals ; Male ; Basolateral Nuclear Complex/physiology ; Neurobiology ; Quality of Life ; Interneurons ; Extracellular Matrix
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02231-8
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