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  1. Article ; Online: In memoriam. Paul S. Martin

    Gerardo SÁNCHEZ-RAMOS / Pedro REYES-CASTILLO / Rodolfo DIRZO

    Acta Zoológica Mexicana, Vol 26, Iss 3, Pp 745-

    incansable luchador de la ciencia y protección de la naturaleza (agosto 22, 1928-septiembre 13, 2010)

    2010  Volume 750

    Keywords Science ; Q ; Biology (General) ; QH301-705.5 ; Zoology ; QL1-991
    Publishing date 2010-12-01T00:00:00Z
    Publisher Instituto de Ecología A.C.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  2. Article ; Online: In memoriam. Paul S. Martin

    Gerardo SÁNCHEZ-RAMOS / Pedro REYES-CASTILLO / Rodolfo DIRZO

    Acta Zoológica Mexicana, Vol 26, Iss 3, Pp 745-

    incansable luchador de la ciencia y protección de la naturaleza (agosto 22, 1928-septiembre 13, 2010)

    2010  Volume 750

    Keywords Science ; Q ; Biology (General) ; QH301-705.5 ; Zoology ; QL1-991
    Publishing date 2010-12-01T00:00:00Z
    Publisher Instituto de Ecología A.C.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: In memoriam. Paul S. Martin

    Gerardo SÁNCHEZ-RAMOS / Pedro REYES-CASTILLO / Rodolfo DIRZO

    Acta Zoológica Mexicana, Vol 26, Iss 3, Pp 745-

    incansable luchador de la ciencia y protección de la naturaleza (agosto 22, 1928-septiembre 13, 2010)

    2010  Volume 750

    Keywords Science ; Q ; Biology (General) ; QH301-705.5 ; Zoology ; QL1-991
    Publishing date 2010-12-01T00:00:00Z
    Publisher Instituto de Ecología A.C.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  4. Article ; Online: IN MEMORIAM. PAUL S. MARTIN

    Gerardo S\u00C1NCHEZ-RAMOS / Pedro REYES-CASTILLO / Rodolfo DIRZO

    Acta Zoologica Mexicana, Vol 26, Iss 3, Pp 745-

    INCANSABLE LUCHADOR DE LA CIENCIA Y PROTECCIÓN DE LA NATURALEZA (AGOSTO 22, 1928 - SEPTIEMBRE 13, 2010)

    2010  Volume 750

    Keywords Zoology ; QL1-991 ; Science ; Q ; Biology (General) ; QH301-705.5
    Language Spanish
    Publishing date 2010-01-01T00:00:00Z
    Publisher Instituto de Ecología, A.C.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Unravelling the complex genetic regulation of immune cells.

    Ramos, Paula S

    Nature reviews. Rheumatology

    2021  Volume 17, Issue 3, Page(s) 131–132

    MeSH term(s) Autoimmunity ; Gene Expression Regulation
    Language English
    Publishing date 2021-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-00563-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6338: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Integrating genetic and social factors to understand health disparities in lupus.

    Ramos, Paula S

    Current opinion in rheumatology

    2021  Volume 33, Issue 6, Page(s) 598–604

    Abstract: Purpose of review: Both social and genetic factors are associated with health outcomes in systemic lupus erythematosus (SLE), thus playing a role in its health disparities. Despite the growing list of social and genetic factors associated with SLE ... ...

    Abstract Purpose of review: Both social and genetic factors are associated with health outcomes in systemic lupus erythematosus (SLE), thus playing a role in its health disparities. Despite the growing list of social and genetic factors associated with SLE outcomes, studies integrating sociocultural and individual determinants of health to understand health disparities in SLE are lacking. We review the contributions of different social and genetic factors to the disparities in SLE, and propose a socioecological model to integrate and examine the complex interactions between individual and social factors in SLE outcomes.
    Recent findings: Multiple studies collecting comprehensive social data and biospecimens from diverse populations are underway, which will contribute to the elucidation of the interplay and underlying mechanisms by which positive and negative social determinants of health influence epigenomic variation, and how the resulting biological changes may contribute to the lupus health disparities.
    Summary: There is growing awareness of the need to integrate genomic and health disparities research to understand how social exposures affect disease outcomes. Understanding the contributions of these factors to the SLE health disparity will inform the development of interventions to eliminate risk exposures and close the health disparity gap.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/genetics ; Social Factors
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3028: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Epigenetics of scleroderma: Integrating genetic, ethnic, age, and environmental effects.

    Ramos, Paula S

    Journal of scleroderma and related disorders

    2019  Volume 4, Issue 3, Page(s) 238–250

    Abstract: Scleroderma or systemic sclerosis is thought to result from the interplay between environmental or non-genetic factors in a genetically susceptible individual. Epigenetic modifications are influenced by genetic variation and environmental exposures, and ... ...

    Abstract Scleroderma or systemic sclerosis is thought to result from the interplay between environmental or non-genetic factors in a genetically susceptible individual. Epigenetic modifications are influenced by genetic variation and environmental exposures, and change with chronological age and between populations. Despite progress in identifying genetic, epigenetic, and environmental risk factors, the underlying mechanism of systemic sclerosis remains unclear. Since epigenetics provides the regulatory mechanism linking genetic and non-genetic factors to gene expression, understanding the role of epigenetic regulation in systemic sclerosis will elucidate how these factors interact to cause systemic sclerosis. Among the cell types under tight epigenetic control and susceptible to epigenetic dysregulation, immune cells are critically involved in early pathogenic events in the progression of fibrosis and systemic sclerosis. This review starts by summarizing the changes in DNA methylation, histone modification, and non-coding RNAs associated with systemic sclerosis. It then discusses the role of genetic, ethnic, age, and environmental effects on epigenetic regulation, with a focus on immune system dysregulation. Given the potential of epigenome editing technologies for cell reprogramming and as a therapeutic approach for durable gene regulation, this review concludes with a prospect on epigenetic editing. Although epigenomics in systemic sclerosis is in its infancy, future studies will help elucidate the regulatory mechanisms underpinning systemic sclerosis and inform the design of targeted epigenetic therapies to control its dysregulation.
    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-1991
    ISSN (online) 2397-1991
    DOI 10.1177/2397198319855872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  8. Article ; Online: Population Genetics and Natural Selection in Rheumatic Disease.

    Ramos, Paula S

    Rheumatic diseases clinics of North America

    2017  Volume 43, Issue 3, Page(s) 313–326

    Abstract: Human genetic diversity is the result of population genetic forces. This genetic variation influences disease risk and contributes to health disparities. Natural selection is an important influence on human genetic variation. Because immune and ... ...

    Abstract Human genetic diversity is the result of population genetic forces. This genetic variation influences disease risk and contributes to health disparities. Natural selection is an important influence on human genetic variation. Because immune and inflammatory function genes are enriched for signals of positive selection, the prevalence of rheumatic disease-risk alleles seen in different populations is partially the result of differing selective pressures (eg, due to pathogens). This review summarizes the genetic regions associated with susceptibility to different rheumatic diseases and concomitant evidence for natural selection, including known agents of selection exerting selective pressure in these regions.
    MeSH term(s) Adaptation, Biological/genetics ; Genetics, Population ; Humans ; Rheumatic Diseases/genetics ; Selection, Genetic
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2017.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 363: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Sustaining connections: feasibility and impact of long-term virtual patient engagement.

    Stefanik-Guizlo, Kelsey / Allen, Claire / Brush, Sarah / Mogk, Jessica / Canada, Starette / Peck, Marina / Ramos, Kathryn / Volpe, Karen / Lozano, Paula

    Research involvement and engagement

    2024  Volume 10, Issue 1, Page(s) 28

    Abstract: ... categorized them using Carman et al.'s 3 types of engagement. They also collected data via semi ...

    Abstract Background: Virtual patient engagement has become more common in recent years. Emerging research suggests virtual engagement can increase accessibility for patients managing long-term health conditions and those living in larger geographic areas, but it can also be challenging to establish relationships and maintain engagement over time. Little is known about virtual engagement lasting more than two years, nor about the specific contributions of patients to virtual engagement projects. Here we describe a project where virtual engagement was sustained over a long period of time (3.5 years), measure patients' contributions to the work, and describe the facilitators and challenges of the project using the Valuing All Voices (VAV) patient engagement framework.
    Methods: Five researchers recruited four patient partners living with persistent pain to work together virtually on a project to improve care for others with long-term pain. Researchers documented engagement activities and patient partner contributions and categorized them using Carman et al.'s 3 types of engagement. They also collected data via semi-structured group interviews with patient partners about the facilitators and challenges of the project using the VAV framework.
    Results: In 3.5 years, patient partners contributed 487 h to the project, averaging 3.0 h per month, and participated in 40 meetings. They contributed to 17 products for patients, health care teams, and researchers. Most products (12 of 17) were created using the more in-depth engagement approaches of involvement or partnership and shared leadership. The group identified facilitators of the project across the five VAV domains of relationship-building, trust, understanding & acceptance, education & communication, and self-awareness, as well as some specific challenges such as keeping track of products across virtual platforms and managing the high volume of project information.
    Conclusions: Long-term virtual patient engagement is feasible and can use more in-depth engagement approaches. Additionally, it can result in substantial contributions from patients in terms of time, effort, and products. These findings can inform future long-term virtual patient engagement efforts and provide insight into how researchers can structure their activities to encourage and maintain deep engagement over time.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2834246-X
    ISSN 2056-7529 ; 2056-7529
    ISSN (online) 2056-7529
    ISSN 2056-7529
    DOI 10.1186/s40900-024-00558-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Long-term Insights: Histopathological Assessment in Polyurethane Implant Capsules up to 24 Years.

    Pontes, Gisela H / Ramos, Clara P W / de Noronha, Lucia / Serra-Guimarães, Fernando / Cavalcanti, Amanda S / Barbosa, Ana Paula F / Duarte, Maria Eugenia L

    Aesthetic surgery journal

    2024  

    Abstract: Background: Polyurethane (PU)-coated breast implants are known for their strong integration into breast tissue and the formation of capsules around them. However, capsular contracture can pose both aesthetic and clinical challenges.: Objectives: To ... ...

    Abstract Background: Polyurethane (PU)-coated breast implants are known for their strong integration into breast tissue and the formation of capsules around them. However, capsular contracture can pose both aesthetic and clinical challenges.
    Objectives: To analyze the biological and morphological characteristics of the capsular tissue surrounding PU-coated implants, irrespective of their contracture status, and to assess their potential suitability as a flap in revision breast surgery for capsular contracture.
    Methods: A total of 23 tissue samples were harvested from the capsules surrounding PU-coated breast implants in 12 female patients during replacement or revision surgery. We evaluated collagen abundance, cellular and vascular density, inflammation, collagen band types and alignment, synovial metaplasia, capsule thickness, and the expression of inflammatory biomarkers and myofibroblasts using immunohistochemical techniques. Scanning electron microscopy was used to assess implant surface characteristics over time.
    Results: We found a significant association of capsule contraction with longer implantation durations and greater implant surface roughness (p = 0.018 and p = 0.033, respectively). Synovial metaplasia was significantly more frequent in noncontracted capsules (p = 0.0049). Both capsule types consisted of paucicellular, type I collagen-rich compact fibrous tissue with low vascularization. There was a marked reduction in inflammatory cells within the foreign body granuloma. The expression of inflammatory biomarkers in the capsular tissue was negligible.
    Conclusions: Given the reduced levels of inflammatory and vascular components within the dense, fibrous capsular tissue, we consider them to be viable alternatives for use as capsular flaps in revision surgery. This strategy has the potential to mimic the reconstruction achieved with acellular dermal matrix.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2087022-X
    ISSN 1527-330X ; 1090-820X ; 1084-0761
    ISSN (online) 1527-330X
    ISSN 1090-820X ; 1084-0761
    DOI 10.1093/asj/sjae057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 570: Show issues

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