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  1. Article ; Online: Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study.

    Terrell, Thomas Roland / Abramson, Ruth / Barth, Jeffery T / Bennett, Ellen / Cantu, Robert C / Sloane, Richard / Laskowitz, Daniel T / Erlanger, David M / McKeag, Douglas / Nichols, Gregory / Valentine, Verle / Galloway, Leslie

    British journal of sports medicine

    2017  

    Abstract: Background/aim: To evaluate the association of genetic polymorphisms APOE, : Methods: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline ... ...

    Abstract Background/aim: To evaluate the association of genetic polymorphisms APOE,
    Methods: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.
    Results: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years
    Conclusions: IL-6R
    Language English
    Publishing date 2017-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 600592-5
    ISSN 1473-0480 ; 0306-3674
    ISSN (online) 1473-0480
    ISSN 0306-3674
    DOI 10.1136/bjsports-2016-097419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: APOE, APOE promoter, and Tau genotypes and risk for concussion in college athletes.

    Terrell, Thomas Roland / Bostick, Roberd M / Abramson, Ruth / Xie, Dawen / Barfield, William / Cantu, Robert / Stanek, Michele / Ewing, Trina

    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

    2008  Volume 18, Issue 1, Page(s) 10–17

    Abstract: Objective: To investigate associations of APOE, APOE promoter (G-219T), and tau protein exon 6 polymorphisms (47 and 53) and a history of self-reported concussion in college athletes.: Design: Multi-center cross-sectional study.: Setting: Male ... ...

    Abstract Objective: To investigate associations of APOE, APOE promoter (G-219T), and tau protein exon 6 polymorphisms (47 and 53) and a history of self-reported concussion in college athletes.
    Design: Multi-center cross-sectional study.
    Setting: Male football and male and female soccer programs at the University of South Carolina, Jacksonville University, Benedict College, and the College of Charleston.
    Participants: Active 18- to 30-year-old (n = 195) intercollegiate male football players and male and female soccer players during 2001 and 2002.
    Assessment of risk factors: Written questionnaires and blood or mouthwash samples for DNA for genotyping by RFLP/PCR.
    Main outcome measurement: Self-reported history of concussions over the previous 8 years.
    Results: A statistically significant, nearly 3-fold increase in risk of a history of concussion for those with the APOE promoter G-219T TT genotype relative to the GG genotype (OR, 2.8; 95% CI, 1.1 to 6.9) adjusted for age, sport, school, and years in their primary sport, a finding that was stronger for Cantu grade 2 and 3 concussions.
    Conclusions: These results suggest that college athletes with an APOE promoter G-219T TT genotype may be at increased risk for having a history of concussions, especially more severe concussions. Although there was some support for the possibility that the tau 53 polymorphism may be associated with increased risk of prior concussion (OR, 2.1; 95% CI, 0.3 to 14.5), there was no support for an association with APOE genotypes. The results of this cross-sectional study support the need for a prospective study of genetic factors, such as APOE promoter polymorphisms, and the incidence of and sequelae from concussions in college athletes.
    MeSH term(s) Adolescent ; Adult ; Apolipoproteins E/genetics ; Brain Concussion/etiology ; Brain Concussion/genetics ; Cross-Sectional Studies ; Exons/genetics ; Female ; Genotype ; Humans ; Male ; Point Mutation/genetics ; Polymorphism, Genetic ; Promoter Regions, Genetic/genetics ; Risk Assessment ; South Carolina ; tau Proteins/genetics
    Chemical Substances Apolipoproteins E ; tau Proteins
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1062530-6
    ISSN 1050-642X
    ISSN 1050-642X
    DOI 10.1097/JSM.0b013e31815c1d4c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3120: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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